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MAPIWQIVDRPAEFGAVRSALTGNESCGVVLVGDPGVGKTTLARAVAGSLRSQVHWVASTQSSRSIPLGV FAHLVGTSVSRDATALLASARESLVSQGECVVGVDDAHLLDELSATLLHQIAVDQSGRILATVRSGEPVP DAVTSLWKDGYLRRIELQPFSKEQSVRLVESVVGGRLEGLSADLMWESSGGNPLFLRHLVEGSIDAGTLR KVGDVWQLRGPTAVPSGLASLLQDRLDHAGPDVLNALRLLALCEPLDIHALTELAGDDAVDAAEACDLIR FQQDGTVLNARFSHPLVGDVVRDRIGHATERRLKGQLVELLRRRELSTAASRIRMAQLSIDSDQLLDIDL LISATKDAIYLFNMPLGQRLAKVAFDRTGSLEAAELLSRTLLWQGRPAAAEAILARFSPDDLDELQLVRW GTPRASHLFWAMGDVERAHEVISLVRERTTHPSLRLFVEAAAAAMAVHENRIDEGIAAALQVLDNPLAPG QAVEFAAFAAGLAMPVAGRGDEFEPIAARCRADQKPTDGMIRVMVRYCDVLALTHLGELDLAGRRAAEYA DFSSVGQFLAWAIAKIMAGVVATARGEFPDAVTCIEQALAALNAETSLPWQLPGRLLLARAYAALGRTDE AERVLNDAAEHSGPSAAIHEPQRLISRSWYAAAKGMERRALELARAAAEIARQSGQYALEAEALHHATRF GDRSTAPRLAELTGVVHGSVVGLLARHAAAFAAGDAAALDVVSADFESAGLMLSAADAAAQAALLHDSAG DRRRTNESGANALRLAEKCGGATTPAIKAAARPLPLTPREREIAELVAAGLSNRHIAEQLVLSVRTVEGH VYRACFKLDVADRDELAKLIRKKS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4065 | - | - | 100% (864) | response regulator receiver protein |
| M. vanbaalenii PYR-1 | Mvan_0243 | - | e-137 | 35.70% (874) | regulatory protein, LuxR |
| M. vanbaalenii PYR-1 | Mvan_0244 | - | 4e-90 | 30.74% (875) | response regulator receiver protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1236c | - | 3e-77 | 33.81% (565) | hypothetical protein Mb1236c |
| M. gilvum PYR-GCK | Mflv_4479 | - | 1e-152 | 40.05% (839) | regulatory protein, LuxR |
| M. tuberculosis H37Rv | Rv1204c | - | 3e-77 | 33.81% (565) | hypothetical protein Rv1204c |
| M. leprae Br4923 | MLBr_01753 | - | 2e-07 | 23.71% (388) | putative transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_3907c | - | 0.0 | 62.49% (861) | LuxR transcriptional regulator |
| M. marinum M | MMAR_4234 | - | 4e-63 | 30.24% (582) | hypothetical protein MMAR_4234 |
| M. avium 104 | MAV_2364 | - | 1e-141 | 37.66% (863) | TPR repeat-containing protein |
| M. smegmatis MC2 155 | MSMEG_4205 | - | 0.0 | 66.20% (861) | putative transcriptional regulator |
| M. thermoresistible (build 8) | TH_4663 | - | 1e-100 | 35.91% (635) | PUTATIVE putative regulatory protein, LuxR |
| M. ulcerans Agy99 | MUL_0955 | - | 1e-63 | 30.24% (582) | hypothetical protein MUL_0955 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4065|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4205|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3907c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2364|M.avium_104 --------------------------------------------------
MMAR_4234|M.marinum_M --------------------------------------------------
MUL_0955|M.ulcerans_Agy99 --------------------------------------------------
Mb1236c|M.bovis_AF2122/97 --------------------------------------------------
Rv1204c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4479|M.gilvum_PYR-GCK --------------------------------------------------
TH_4663|M.thermoresistible__bu --------------------------------------------------
MLBr_01753|M.leprae_Br4923 MYSLGEMQKPVPVGADYLASCLVARLRSTDVPTDLHRGCTVTLFLGDVEG
Mvan_4065|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4205|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3907c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2364|M.avium_104 --------------------------------------------------
MMAR_4234|M.marinum_M --------------------------------------------------
MUL_0955|M.ulcerans_Agy99 --------------------------------------------------
Mb1236c|M.bovis_AF2122/97 --------------------------------------------------
Rv1204c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4479|M.gilvum_PYR-GCK --------------------------------------------------
TH_4663|M.thermoresistible__bu --------------------------------------------------
MLBr_01753|M.leprae_Br4923 LAELSETQPDEAADAIARLDCVVSEAVAAHGGVQQVVQGVRGNFLATFAR
Mvan_4065|M.vanbaalenii_PYR-1 ---------------------------------MAPIWQIVDRPAEFGAV
MSMEG_4205|M.smegmatis_MC2_155 ---------------------------------MSRQWQLLDRPDEIDAI
MAB_3907c|M.abscessus_ATCC_199 ---MTTTTGTIDGRGQAPRLSPAKVHPDLHSYPMARSWQLLDRQTEFGAV
MAV_2364|M.avium_104 --------------------------------------------MEFRRS
MMAR_4234|M.marinum_M ---------------------------------MPIRWNVPQHAAALEQL
MUL_0955|M.ulcerans_Agy99 ----------------------------------------------MEQL
Mb1236c|M.bovis_AF2122/97 -------------------------------------------MRVWKHV
Rv1204c|M.tuberculosis_H37Rv -------------------------------------------MRVWKHV
Mflv_4479|M.gilvum_PYR-GCK ---------------------------------------MTAGLGLARTQ
TH_4663|M.thermoresistible__bu --------------------------------------------------
MLBr_01753|M.leprae_Br4923 ASDATACALDLQLAPIVPVRFRIALHTGEVQISNDDVNNVVFMMVQAAGL
Mvan_4065|M.vanbaalenii_PYR-1 RSALTGNESCGVVLVGDPGVG-----------KTTLARAVAGSLRSQ---
MSMEG_4205|M.smegmatis_MC2_155 RSALESTDTCGVVLVGAAGVG-----------KTTLARTVTSALTNK---
MAB_3907c|M.abscessus_ATCC_199 RSAMADDSTCGAVLVGAAGVG-----------KTTLARAVTKSLDAD---
MAV_2364|M.avium_104 LAALNNGEFHGVALVGDGGVG-----------KSTLARMLAKTVESAGR-
MMAR_4234|M.marinum_M DVALSDLARPGAVILGPDGVG-----------KSTLARLAAEHFAQRHP-
MUL_0955|M.ulcerans_Agy99 DVALSDLARPGAVILGPDGVG-----------KSTLARLAAEHFAQRHP-
Mb1236c|M.bovis_AF2122/97 EAAVDSPDRCGVVLVGPHGVG-----------KTLLAQLAAEQVMSEDGR
Rv1204c|M.tuberculosis_H37Rv EAAVDSPDRCGVVLVGPHGVG-----------KTLLAQLAAEQVMSEDGR
Mflv_4479|M.gilvum_PYR-GCK VESAIVASRLRAVLVGAAGVG-----------KTSMARKLARDYARKHP-
TH_4663|M.thermoresistible__bu ------------VLVGPAGAG-----------KTELARTVLQHRRREQP-
MLBr_01753|M.leprae_Br4923 LDLACGGQTVLSSITGDLVVDGLPADTWLVDLGSHLLRDLARPVRVMQLC
: * .. : : :
Mvan_4065|M.vanbaalenii_PYR-1 ---VHWVASTQSSRSIPLG------------------------VFAHLVG
MSMEG_4205|M.smegmatis_MC2_155 ---VHWTACTESSRSIPLG------------------------AFAHWVG
MAB_3907c|M.abscessus_ATCC_199 ---VRWVACTESSRSIPLG------------------------VFAHWIQ
MAV_2364|M.avium_104 --TVRFALGTQTGWAVPLG------------------------AFSRAVS
MMAR_4234|M.marinum_M ATVIRWVTGTPTERTVPFG------------------------AFSHLVE
MUL_0955|M.ulcerans_Agy99 ATVIRWVTGTPTERAVPLG------------------------AFSHLVE
Mb1236c|M.bovis_AF2122/97 SGRARWVVGTAPGRAIPFG------------------------AFRHLIS
Rv1204c|M.tuberculosis_H37Rv SGRARWVVGTAPGRAIPFG------------------------AFRHLIS
Mflv_4479|M.gilvum_PYR-GCK RLTSHWVSATASARDIPFA------------------------AFSHLID
TH_4663|M.thermoresistible__bu HTVLHWVAGTASASRIPFG------------------------AFSHLVE
MLBr_01753|M.leprae_Br4923 HRNLRRNLHELGIRTVPGGPSLPVPLTTFVGRAAQIKELQELLTEKRLLT
: :* . . : :
Mvan_4065|M.vanbaalenii_PYR-1 TS----VSRDATALLASARESLVS--------------------------
MSMEG_4205|M.smegmatis_MC2_155 AT----ASRDPIALLASARESLVA--------------------------
MAB_3907c|M.abscessus_ATCC_199 AS----GSRDPTALIAAARESIVS--------------------------
MAV_2364|M.avium_104 LG----VGHEPAIMLAAAHNTLGQ--------------------------
MMAR_4234|M.marinum_M I----AELGKPAALLRAARASLGRKV------------------------
MUL_0955|M.ulcerans_Agy99 I----AELGKPAALLRAARASLGRKV------------------------
Mb1236c|M.bovis_AF2122/97 LPASGADIGRPAALLRAARSSLTG--------------------------
Rv1204c|M.tuberculosis_H37Rv LPASGADIGRPAALLRAARSSLTG--------------------------
Mflv_4479|M.gilvum_PYR-GCK V----SGGEEPTTLLRAARESLR---------------------------
TH_4663|M.thermoresistible__bu T----GGGGEPATVLRTARESLCGPVLR----------------------
MLBr_01753|M.leprae_Br4923 LVGPGGVGKTRLALQVVARVADEFSGELSYFDLAPDTDHDIFPITVLDNL
: *: :
Mvan_4065|M.vanbaalenii_PYR-1 -----QGECVVGVDDAHLLDELSATLLHQIAVDQSGRILATVRSGEPVPD
MSMEG_4205|M.smegmatis_MC2_155 -----DGDVVVGVDDAHLLDQLSATLLHQFAVDHAGHVVATVRNGEPVPD
MAB_3907c|M.abscessus_ATCC_199 -----TANPIIGIDDAHLLDDLSATLLHQIAVDHVGHVVATVRSGEPVPD
MAV_2364|M.avium_104 -----DKNLVVVVDEAQLLDPLSATLVNQLAAGRSARLIVTIRSGEPVLD
MMAR_4234|M.marinum_M ----RQGELLLIVDDAHDLDILSATLVYQLALAGAARMIVTARAEVAP-E
MUL_0955|M.ulcerans_Agy99 ----RQGELLLIVDDAHDLDILSATLVYQLALAGAARMIVTARAEVAP-E
Mb1236c|M.bovis_AF2122/97 ----DAGDLLLVVDDAHNLDPLSATLVYQLARAGAARLVVTVASEAEPPD
Rv1204c|M.tuberculosis_H37Rv ----DAGDLLLVVDDAHNLDPLSATLVYQLARAGAARLVVTVASEAEPPD
Mflv_4479|M.gilvum_PYR-GCK ----SAHGLLLVVDDAHHLDTLSATLVHQLAVTDNAHIMLTVREGEPVPD
TH_4663|M.thermoresistible__bu --DRTRTGLLLIVDDAHHLDTLSATLVHQVAVSTPASLLLTVRDGEPVPD
MLBr_01753|M.leprae_Br4923 RRCIGDRRMLMVLDNCEYLLDVCANVMTTLLG-ACPSLTILATSREPIGV
:: :*:.. * :.*.:: . :
Mvan_4065|M.vanbaalenii_PYR-1 AVTSLWKDGYLRRIELQPFSKEQSVRLVESVVGGRLEGLSADLMWESSGG
MSMEG_4205|M.smegmatis_MC2_155 AVTSLWKDGYLQRFELQPFSKQQSIALIETVLGGTLEGLSADVMWESSGG
MAB_3907c|M.abscessus_ATCC_199 AVTALWKDNYLQRFELDPLTQRQSIALVEKVLGGPLEGLSADVMWRSSRG
MAV_2364|M.avium_104 AVTALLKERLLLTVHVDPFTREQTELLAGAVLGGPVDTRLVDELFERSAG
MMAR_4234|M.marinum_M AIAALWTDNLLDRIDVAPPD------------------------------
MUL_0955|M.ulcerans_Agy99 AIAALCTDNLLDRIDVAPPD------------------------------
Mb1236c|M.bovis_AF2122/97 AIAALWSDDLLTRVAIEPLDRAQTAAFVESALDATLDVADADELFRRSLG
Rv1204c|M.tuberculosis_H37Rv AIAALWSDDLLTRVAIEPLDRAQTAAFVESALDATLDVADADELFRRSLG
Mflv_4479|M.gilvum_PYR-GCK AVTALWKDSILSRHDIAPFDRRESGLLLEQILGGTVEDVSTVRMFEISQG
TH_4663|M.thermoresistible__bu AITALWKDDLLARIDIEPFSQAECERLLADALGGRVESASAERLYAISEG
MLBr_01753|M.leprae_Br4923 AGEVIWRVSMLSPADEAVELFTERAALVQPGFSVTDGNRQIVTEICQRLD
* : *
Mvan_4065|M.vanbaalenii_PYR-1 NPLFLRHLVEGSIDAGTLRKVGDVWQLRGPTAVPSGLASLLQDRLDHAGP
MSMEG_4205|M.smegmatis_MC2_155 NPLFLRNMVEGAVDAGTLTEVNGVWQFRGPTVIPSGLAELLDDRLAHAGE
MAB_3907c|M.abscessus_ATCC_199 NPLFLRHLVEGSMQAGSLTEVNGVWQLRGDAVVPSGLDTLIGDRLEHVDD
MAV_2364|M.avium_104 NLLLLRGFLTAGVESGALVHTEQGWQLQGPLRGDRELHDALEYRLQSLSS
MMAR_4234|M.marinum_M ----------------------------GKTKQS--EPADVDEFIAELPA
MUL_0955|M.ulcerans_Agy99 ----------------------------GQTKQS--EPADVDEFIAELPA
Mb1236c|M.bovis_AF2122/97 NPLYLRHLID----GGGLEHVDGRWRCRDEDRRP--LSGVIDEYLCALPE
Rv1204c|M.tuberculosis_H37Rv NPLYLRHLID----GGGLEHVDGRWRCRDEDRRP--LSGVIDEYLCALPE
Mflv_4479|M.gilvum_PYR-GCK NPLYLRHLVDAALGTGSLRQVEGVWQLRGEMTLSPQLTTLIDAHLTNLPE
TH_4663|M.thermoresistible__bu NPLYLRHLVTGTVASGALREVEGIWQLRGEVALTPQLSTLIDQHLSALPD
MLBr_01753|M.leprae_Br4923 GMPLAIELAAARIRTLSLTEIADG--LDDRFRLLTGGARTAVRRQQTLRA
.
Mvan_4065|M.vanbaalenii_PYR-1 DVLNALRLLALCEPLDIHALTELAG---DDAVDAAEACDLIRFQQD-GTV
MSMEG_4205|M.smegmatis_MC2_155 DVMNALKLLSLCEPLDIDAFAELAG---EEAVDSAEMRGLIRIVTDAGGT
MAB_3907c|M.abscessus_ATCC_199 TVFSALKVLSMCEPLDIDTLCEIAS---DEAVDAAEIADLIRVERD-GVR
MAV_2364|M.avium_104 EEREVVEVLATAELLEWEILRDICD---ADAMASLERRGLIQLVTD-GSH
MMAR_4234|M.marinum_M PARAVLDYLTVEEPLSLADLTVLAGEGAVQQAVELGAAETRVRGEP-DEP
MUL_0955|M.ulcerans_Agy99 PARAVLDYLTVEEPLSLADLTVLAGEGAVQQAVELGAAETRVRGEP-DEP
Mb1236c|M.bovis_AF2122/97 PARAVVDYLAIAEPLARTDLVALVGGEQLDTLGQAEAAGAVRVGPD-SDT
Rv1204c|M.tuberculosis_H37Rv PARAVVDYLAIAEPLARTDLVALVGGEQLDTLGQAEAAGAVRVGPD-SDT
Mflv_4479|M.gilvum_PYR-GCK PVRSVLEFLAIDDPLSVDDLAALTG---IDAVDAAETCGVVTITDR-AGA
TH_4663|M.thermoresistible__bu QIRTVLAYLAIEEPLTVADLSDLVS---PEAVEAAEAAGAVTVDER-GAD
MLBr_01753|M.leprae_Br4923 SMDWSYALLTESERALFRRLSAISGTFDLKVAYAVGHDDLEEPDQVFDRL
*: : : : . .
Mvan_4065|M.vanbaalenii_PYR-1 LNARFSHPLVGDVVRDRIGHATERRLKGQLVELLR--------RRELSTA
MSMEG_4205|M.smegmatis_MC2_155 LTARFAHPLFAEVVRRRVGTASARKLRGRIAKILR--------DRDLSTA
MAB_3907c|M.abscessus_ATCC_199 TVVRFSHPMFGEAVRRRVGTASGRRLRGKLVRVLR--------DRDLGTA
MAV_2364|M.avium_104 TLVQLNHPMLGEAATRHAGVVRSRQLNGILAKTLRKHLRAAGRRSQISDP
MMAR_4234|M.marinum_M AVVYTAHPLFAKRARVALGDDGARQRRTELVTLLS--------QHPNEHL
MUL_0955|M.ulcerans_Agy99 AVVYTAHPLFAKRARVALGDDGARQRRTELVTLLS--------QHPNEHL
Mb1236c|M.bovis_AF2122/97 SEIFVGHPLYADRARAVLTAEHAHALRVSLVAQLA--------KHPSDHV
Rv1204c|M.tuberculosis_H37Rv SEIFVGHPLYADRARAVLTAEHAHALRVSLVAQLA--------KHPSDHV
Mflv_4479|M.gilvum_PYR-GCK LYAHPFHPIYTERVRSSLGLLAMRRLRKLLAGRMS--------VRAPGNL
TH_4663|M.thermoresistible__bu LIVHPAHPLYTETVRAGLGRLTRRSLRTALVARWS--------RRPPDNV
MLBr_01753|M.leprae_Br4923 TMLIDKSLVIVEGRQGGSRYRLLETVRQYAMKKLEE-------SNEVDLV
: . . .
Mvan_4065|M.vanbaalenii_PYR-1 ASRIRMAQLSIDSDQLLD---IDLLISATKDAIYLFNMPLGQRLAKVAFD
MSMEG_4205|M.smegmatis_MC2_155 ASRIRLAQLCIESDRGAD---VDLLITAAKDAVFLSNLPLGEQLARAAFD
MAB_3907c|M.abscessus_ATCC_199 SNRIRLARLSIDCDEPVD---VDLLVTAAKDAVYLSNLPLGEELARAAVD
MAV_2364|M.avium_104 RGRIQLAQFIMRSDLEPD---LDVVIKAAADAMAMSNVVLGEQLATFAVD
MMAR_4234|M.marinum_M SDRLRLASLALDTDALQP---VDDVVESAEQALRLGDLTLAERLAQAALD
MUL_0955|M.ulcerans_Agy99 SDRLRLASLALDTDALQP---VDDVVESAEQALRLGDLTLAERLAQAALD
Mb1236c|M.bovis_AF2122/97 SDQLRLSSLAIDVPASATPAAVTDAATAAGQALRLGDVRLAERLARAALD
Rv1204c|M.tuberculosis_H37Rv SDQLRLSSLAIDVPASATPAAVTDAATAAGQALRLGDVRLAERLARAALD
Mflv_4479|M.gilvum_PYR-GCK STRLRMAALAMGTDEPPS---ADELVGLSWEAMRLGDLALGERLARAALD
TH_4663|M.thermoresistible__bu SDRLRLAALAVNSQTPPP---ATDLIATSWEAMQLGDLLLGEQLARGALG
MLBr_01753|M.leprae_Br4923 LARHRDHYMALGALLDTPG-DIDHEQLVEQVETELDNLRSAFAWSRETGD
: : : : : :: . : : .
Mvan_4065|M.vanbaalenii_PYR-1 RTGSLEAAELLSRTLLWQGRPAAAEAILARFSPDD-----LDELQLVRWG
MSMEG_4205|M.smegmatis_MC2_155 HGGGLPAATLLSRALLWQGHPAQADNILARFPPDH-----MDEMELVQWG
MAB_3907c|M.abscessus_ATCC_199 GGGGLQAAAMLSRSLLWQGRPEQAEEILAAFDPDD-----LDELSLVLWG
MAV_2364|M.avium_104 RGGGLAAALVLAEAVSWQGRGEEADSILLGADVDD-----ADEWLIARWG
MMAR_4234|M.marinum_M RSGGLQARLVLGQALAWRGRGREAGQVLTAVDPGQ-----LSEAELMAWA
MUL_0955|M.ulcerans_Agy99 RSGGLQARLVLGQALAWRGRGREAGQVLTAVDPGQ-----LSEAELMAWA
Mb1236c|M.bovis_AF2122/97 RSDALAARLPLAYALGWQGRGREADAVLAAVNPAE-----LTETELMAWA
Rv1204c|M.tuberculosis_H37Rv RSDALAARLPLAYALGWQGRGREADAVLAAVNPAE-----LTETELMAWA
Mflv_4479|M.gilvum_PYR-GCK QADGLAARLPLAHSLSWQGRGRDADDVLNPVDPDT-----LTQWDLMAWT
TH_4663|M.thermoresistible__bu QSDTLAARLPLAHALAWQGRGREADDVLAAVDPDR-----LTEFDIMAWT
MLBr_01753|M.leprae_Br4923 IAGALQLASSLQPIWFGRGHMYEGLAWFDSIFEHKNIEHLVAPKEVLARA
. * * :*: . : :
Mvan_4065|M.vanbaalenii_PYR-1 TPRASHLFWAMGD-VERAHEVISLVRERTTHPSLRLFVEAAAAAMAVH--
MSMEG_4205|M.smegmatis_MC2_155 IPRLSILFWSMGD-VPLAHQVLGELNSRVTHPILQLIIDATEAGMAVH--
MAB_3907c|M.abscessus_ATCC_199 IPRISIAFWSMGE-NERAHELLALLHERVRHHILKPVVDATDAAIALH--
MAV_2364|M.avium_104 CLRAANLAWGCGD-AEGATRVLAEVKQRLATEGSLQLIDALDVSIGFF--
MMAR_4234|M.marinum_M VPQAANQFWMLGE-PERATAFLQTTRNRVTDLTARTTLDALTATFAMN--
MUL_0955|M.ulcerans_Agy99 VPQAANQFWMLGE-PERATAFLQTTRNRVTDLTARTTLDALTATFAMN--
Mb1236c|M.bovis_AF2122/97 IPRAANRFWMLNE-PERATAFLQTTRSRVTEPTARSTLDALAATFAMN--
Rv1204c|M.tuberculosis_H37Rv IPRAANRFWMLNE-PERATAFLQTTRSRVTEPTARSTLDALAATFAMN--
Mflv_4479|M.gilvum_PYR-GCK LPKAANRFWMLSE-SEEAVEYLRQMRARITERGALHTIDALAATFAMN--
TH_4663|M.thermoresistible__bu LPKAANQFWMLSE-SAEAIALLDRMRTRLHQPAAVTAFDALAATFAMN--
MLBr_01753|M.leprae_Br4923 VANKVMLHAILASSPPDGSDLVTQAQQALTMAREIGDSAVLARALTACGF
. . . : . . :
Mvan_4065|M.vanbaalenii_PYR-1 ----ENRIDEGIAAALQVLDNPLAPGQAVEFAAFAAGLAMPVAGRGDEFE
MSMEG_4205|M.smegmatis_MC2_155 ----ENRITEGLAIAERVLDHPECPRQATDFAAFACGLAMPVAGRGEAFL
MAB_3907c|M.abscessus_ATCC_199 ----ENRFDEGLARAHAVLSDPVAPKQAVEFAAFGVGLTLPVAGRGHEFE
MAV_2364|M.avium_104 ----RGDIARTIELGPRLCEPDVVP-MATVWAAVATCGALTAVGRFSEVG
MMAR_4234|M.marinum_M ----SGNVPRAITLATEVLAEPSADDTAIAWAASAAALASARMGRFADVP
MUL_0955|M.ulcerans_Agy99 ----SGNVPRAITLATEVLAEPSADDTAIAWAASAAALASARMGRFADVP
Mb1236c|M.bovis_AF2122/97 ----SGNLPRAITLATEVLSGPAADDMAVAWAASAAALSSARMGRFGDVD
Rv1204c|M.tuberculosis_H37Rv ----SGNLPRAITLATEVLSGPAADDMAVAWAASAAALSSARMGRFGDVD
Mflv_4479|M.gilvum_PYR-GCK ----AGDPAEAVTVAKGILAADDAQDLAVAWASAAATLSSARMGRFAEVD
TH_4663|M.thermoresistible__bu ----AGQPRTALELAGRVLQTPESQDLAVAWAAATATLSSARMARFDEVE
MLBr_01753|M.leprae_Br4923 SSGYDTEVARPYFAEAVELARTQGDKWTLSQIRLWGVVGFCVSGDPVALR
: . .
Mvan_4065|M.vanbaalenii_PYR-1 PIAARCRADQK-PTDGMIRVMVRYCDVLALTHLGELDLAGRRAAEYADFS
MSMEG_4205|M.smegmatis_MC2_155 PIASRCRAQRK-TTDGMIRIMVFYGEVLALAYTGQFDLARQRAEEYAEFS
MAB_3907c|M.abscessus_ATCC_199 PIAQRCRDDKKRTTDGLIAAMVRYCDVLALTYTGQLDLAEERVAEYTKFS
MAV_2364|M.avium_104 RIAAAGVRATAQCRAGAQRFAIGLAEVMAATAAGDYPAAERIHKRYAALA
MMAR_4234|M.marinum_M QLAQRASEAEH---PGLLRFTVGLAQITTLLMAGEVAQAQELAQRFTDFA
MUL_0955|M.ulcerans_Agy99 QLAQRASEAEH---PGLLRFTVGLAQITTLLMAGEVAQAQELAQRFTDFA
Mb1236c|M.bovis_AF2122/97 RLAERASAAEH---PGLLRFTVGLAQITSLLLAGDVAPAQELAKRFTDFA
Rv1204c|M.tuberculosis_H37Rv RLAERASAAEH---PGLLRFTVGLAQITSLLLAGDVAPAQELAKRFTDFA
Mflv_4479|M.gilvum_PYR-GCK GLAQRGLDAAH---PGLLRFTLGLGQTLALIMNADVASAEHLARHYLSFS
TH_4663|M.thermoresistible__bu THAARGLAAQH---PGLLRFTIGLGQITRLILAGXLTRADFLAHHYLSFC
MLBr_01753|M.leprae_Br4923 AAAEAADDLAQEIGDRFVSLQCRLLLSIAQLWQGDMDGAIVRSGEVVAGA
* . * . .
Mvan_4065|M.vanbaalenii_PYR-1 SVGQFLAWAIAKIMAGVVATARGEFPDAVTCIEQALAALNAETSLPWQL-
MSMEG_4205|M.smegmatis_MC2_155 SAGQFAGWAIAKIMAGAAAMHSGRFRDAISAIEQALAALNAEISLPWQL-
MAB_3907c|M.abscessus_ATCC_199 SAGQFLAWAIARIMAGVVATQRGLFREAIEAFEQALAAQRADRPLPWQL-
MAV_2364|M.avium_104 TG-LPAAEAMVDAMLGVLQLTRGELQEACATLDRSISQLSQGFPLPWQL-
MMAR_4234|M.marinum_M EL-QQPGRAIGEVLLAHVLIVKGEFGAAAAMLEPAAAELERTG-YSWGP-
MUL_0955|M.ulcerans_Agy99 EL-QQPGRAIGEVLLAHVLIVKGEFGTAAAMVEPAAAELERTG-YSWGP-
Mb1236c|M.bovis_AF2122/97 --------------------------------------------------
Rv1204c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4479|M.gilvum_PYR-GCK EF-QQPGRAIGEVLLGHTLLASGRFGDAVTLLRQAAAALTYTG-YSWGP-
TH_4663|M.thermoresistible__bu EF-QQPGRAIGEVLLAHILIARGDLPTATTLLRQAAAALSSTG-YSWGP-
MLBr_01753|M.leprae_Br4923 EAAHDTVTRTFGLYVQTRALVHRDVSAALVTAGLVVEAAAELSGVYQGIG
Mvan_4065|M.vanbaalenii_PYR-1 -PGRLLLARAYAALGRTDEAERVLNDAAEHSG----------PSAAIHEP
MSMEG_4205|M.smegmatis_MC2_155 -PGRLLLARAYAAVGEVIEAERVLDDAMEHSG----------AFMALHEP
MAB_3907c|M.abscessus_ATCC_199 -PARLLLARAYAALGRAVDGERVLDEAREHSG----------PHVAIHMP
MAV_2364|M.avium_104 -VVGALQAQAEGARGDSAAAAVALRRVEEAYG----------PHVAVFLP
MMAR_4234|M.marinum_M -LSLMLLATAIAQQGNIAETAKALRRAETRHG----------TKSALFAP
MUL_0955|M.ulcerans_Agy99 -LSLMLLATAIAQQGNIAETAKALRRAETRHG----------TKSALFAP
Mb1236c|M.bovis_AF2122/97 --------------------------------------------------
Rv1204c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4479|M.gilvum_PYR-GCK -LALTGLAQALGQQGRAADASAVLTRAEASHG----------MRSALYAP
TH_4663|M.thermoresistible__bu -LALMQLTQVLGARGDADGASEALRRAEHSHG----------TRSELYAP
MLBr_01753|M.leprae_Br4923 YAAMVFAALAMGDVAAAVEASEACRPHLGADHGLVAIHLELMAAVALARG
Mvan_4065|M.vanbaalenii_PYR-1 QRLISRSWYAAAKGMERRALELARAAAEIARQSGQYALEAEALHHATRFG
MSMEG_4205|M.smegmatis_MC2_155 QRTLAKACVAAAKGAHRSAIDIARSAADLARSSEQHAVEAEALHHCARFG
MAB_3907c|M.abscessus_ATCC_199 QMMLAKAWLVAARGSDRGAVDAARRAADAAHSAGQYALEAEALHHAARFG
MAV_2364|M.avium_104 ELELARAWERAAAGDTAGAQTQAMQAAQTARKAGMHLVEMRARHAALRFG
MMAR_4234|M.marinum_M ELSLARAWAKATVRDQAGALFDTREAARAAERGKQSAVALCVWHDAVRLG
MUL_0955|M.ulcerans_Agy99 ELSLARAWAKATVRDQAGALFDTREAARAAERGKQSAVALCVWHDAVRLG
Mb1236c|M.bovis_AF2122/97 --------------------------------------------------
Rv1204c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4479|M.gilvum_PYR-GCK DLALARAWTLAAARDLRGAVASARDAVHAAVQSGQDAVALRALQDCARLG
TH_4663|M.thermoresistible__bu ELALX-XXXWRGLRDESGHLAAYRITVDDRLP-----ETLADLWD----G
MLBr_01753|M.leprae_Br4923 DVIVARRLADNSVSATTGWHQMAALTTRARIAMAQGEPELARADIHAALA
Mvan_4065|M.vanbaalenii_PYR-1 DRSTAPRLAELTGVVHGSVVGLLARHAAAFAAGDAAALDVVSADFESAGL
MSMEG_4205|M.smegmatis_MC2_155 DRTVARRLQGLVDRVDGPLARLYAQHAAAVAAADPVALDAVSSAFEQAGL
MAB_3907c|M.abscessus_ATCC_199 DRTVGRRIESLCTRVHGPLTGLYARHALAVAHSDITGLEAVSADFEAAGL
MAV_2364|M.avium_104 DRAQAARVDELASILNSPSAQAVAGHARGLAQHDGDLLDAAAHRFADLGA
MMAR_4234|M.marinum_M DTRALAPVTRLAAEIDCKVGNIVVRHARALADNDAGALASVADELAAIGM
MUL_0955|M.ulcerans_Agy99 DTRALAPVTRLAAEIDCKVGNIVVRHARALANNDAGALASVADELAAIGM
Mb1236c|M.bovis_AF2122/97 --------------------------------------------------
Rv1204c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4479|M.gilvum_PYR-GCK DTHGLATAVRLSDRIGCVTGPLCVAHLRALAAGDGAALDAVSADLETAGL
TH_4663|M.thermoresistible__bu SAAEVWTAIEFS---GTTAHPMITAG----------------CALRSEKK
MLBr_01753|M.leprae_Br4923 CGADIQASLGISDSMELLAELISQGDNHRQAGRLFGAASAQREKTGEVRF
Mvan_4065|M.vanbaalenii_PYR-1 MLSAADAAAQAALLHDSAGDRRRTNESGANALRLAEKCGGATTPAIKAAA
MSMEG_4205|M.smegmatis_MC2_155 MLSAADAAAQAVLLHDKAGHRRQSTESAAHALQLAGRCGGAATPAIRAAA
MAB_3907c|M.abscessus_ATCC_199 LLSAADAAAQAVALRMRAGDRGKGSDAAARVLRMADRCGGVVTPAILAAA
MAV_2364|M.avium_104 LAFAADAAAQAASEHARRGDRRKEVESSTWAHALAGQCG-SRTPALDAAA
MMAR_4234|M.marinum_M HAAAADAAAQAERAGGR---------------------------------
MUL_0955|M.ulcerans_Agy99 HAAAADAAAQAERAGGR---------------------------------
Mb1236c|M.bovis_AF2122/97 --------------------------------------------------
Rv1204c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4479|M.gilvum_PYR-GCK PAAAADAAAQATFAHQRRGDRAGEVASRSRASRLSQVCGAPATPALEQVL
TH_4663|M.thermoresistible__bu PEAAGPLPALTPQRGLHR--PALEALAPTSGRRLPG--------------
MLBr_01753|M.leprae_Br4923 KVWDAGYESAVAVLRGAMGCKDFDSAWAEGAAMPIDDAITYAQRGRGNRK
Mvan_4065|M.vanbaalenii_PYR-1 RPLP----LTPREREIAELVAAGLSNRHIAEQLVLSVRTVEGHVYRACFK
MSMEG_4205|M.smegmatis_MC2_155 RPLP----VTAREREVAALVAQGLLNREIAERLTVSVRTVEGHIYRACIK
MAB_3907c|M.abscessus_ATCC_199 KPLP----ISSREREIAVLIGEGLSDKDIATRLQLSVRTVEGHIYRARMK
MAV_2364|M.avium_104 RPLP----FSGRERQIVNLVAAGLSNREIADRLVISVRTVEGHLYRLFTK
MMAR_4234|M.marinum_M --------------------------------------------------
MUL_0955|M.ulcerans_Agy99 --------------------------------------------------
Mb1236c|M.bovis_AF2122/97 --------------------------------------------------
Rv1204c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4479|M.gilvum_PYR-GCK NPMP----LTGREREVAVMVSQGLTNKAIAQRLSVSVRTVEGHVYRACMK
TH_4663|M.thermoresistible__bu EPVP----LPDGLLDSLFWPVRGVRSTARQRRTARQVETES---------
MLBr_01753|M.leprae_Br4923 RPTTGWESLTPAEHNVIRLVSEGLDTKDIAARLFVSVRTVHTHLTRIYSK
Mvan_4065|M.vanbaalenii_PYR-1 LDVADRDELAKLIRKKS--------
MSMEG_4205|M.smegmatis_MC2_155 LGVADRDELARMIWTDLTPLEADPR
MAB_3907c|M.abscessus_ATCC_199 LDADDREEFAKIVGSDLKPPEAS--
MAV_2364|M.avium_104 LGINNRDQLIQLIRRDAS-------
MMAR_4234|M.marinum_M -------------------------
MUL_0955|M.ulcerans_Agy99 -------------------------
Mb1236c|M.bovis_AF2122/97 -------------------------
Rv1204c|M.tuberculosis_H37Rv -------------------------
Mflv_4479|M.gilvum_PYR-GCK FGVPDRAALASTVGGMHGREGTA--
TH_4663|M.thermoresistible__bu ---VDTAPVSRT-------------
MLBr_01753|M.leprae_Br4923 LGLTSRVQLVQEAARHN--------