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TAGLGLARTQVESAIVASRLRAVLVGAAGVGKTSMARKLARDYARKHPRLTSHWVSATASARDIPFAAFS HLIDVSGGEEPTTLLRAARESLRSAHGLLLVVDDAHHLDTLSATLVHQLAVTDNAHIMLTVREGEPVPDA VTALWKDSILSRHDIAPFDRRESGLLLEQILGGTVEDVSTVRMFEISQGNPLYLRHLVDAALGTGSLRQV EGVWQLRGEMTLSPQLTTLIDAHLTNLPEPVRSVLEFLAIDDPLSVDDLAALTGIDAVDAAETCGVVTIT DRAGALYAHPFHPIYTERVRSSLGLLAMRRLRKLLAGRMSVRAPGNLSTRLRMAALAMGTDEPPSADELV GLSWEAMRLGDLALGERLARAALDQADGLAARLPLAHSLSWQGRGRDADDVLNPVDPDTLTQWDLMAWTL PKAANRFWMLSESEEAVEYLRQMRARITERGALHTIDALAATFAMNAGDPAEAVTVAKGILAADDAQDLA VAWASAAATLSSARMGRFAEVDGLAQRGLDAAHPGLLRFTLGLGQTLALIMNADVASAEHLARHYLSFSE FQQPGRAIGEVLLGHTLLASGRFGDAVTLLRQAAAALTYTGYSWGPLALTGLAQALGQQGRAADASAVLT RAEASHGMRSALYAPDLALARAWTLAAARDLRGAVASARDAVHAAVQSGQDAVALRALQDCARLGDTHGL ATAVRLSDRIGCVTGPLCVAHLRALAAGDGAALDAVSADLETAGLPAAAADAAAQATFAHQRRGDRAGEV ASRSRASRLSQVCGAPATPALEQVLNPMPLTGREREVAVMVSQGLTNKAIAQRLSVSVRTVEGHVYRACM KFGVPDRAALASTVGGMHGREGTA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4479 | - | - | 100% (865) | regulatory protein, LuxR |
| M. gilvum PYR-GCK | Mflv_2183 | - | e-139 | 44.37% (701) | tetratricopeptide TPR_4 |
| M. gilvum PYR-GCK | Mflv_1156 | - | 8e-21 | 25.09% (849) | regulatory protein, LuxR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1236c | - | 1e-125 | 46.09% (562) | hypothetical protein Mb1236c |
| M. tuberculosis H37Rv | Rv1204c | - | 1e-125 | 46.09% (562) | hypothetical protein Rv1204c |
| M. leprae Br4923 | MLBr_01753 | - | 7e-10 | 26.17% (428) | putative transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_3907c | - | 1e-153 | 40.19% (841) | LuxR transcriptional regulator |
| M. marinum M | MMAR_4234 | - | 1e-163 | 44.47% (751) | hypothetical protein MMAR_4234 |
| M. avium 104 | MAV_1348 | - | 1e-151 | 44.04% (763) | TPR repeat-containing protein |
| M. smegmatis MC2 155 | MSMEG_4205 | - | 1e-155 | 39.76% (840) | putative transcriptional regulator |
| M. thermoresistible (build 8) | TH_4663 | - | 0.0 | 59.82% (657) | PUTATIVE putative regulatory protein, LuxR |
| M. ulcerans Agy99 | MUL_0955 | - | 1e-160 | 44.07% (751) | hypothetical protein MUL_0955 |
| M. vanbaalenii PYR-1 | Mvan_4065 | - | 1e-152 | 40.05% (839) | response regulator receiver protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1236c|M.bovis_AF2122/97 --------------------------------------------------
Rv1204c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4234|M.marinum_M --------------------------------------------------
MUL_0955|M.ulcerans_Agy99 --------------------------------------------------
MAV_1348|M.avium_104 --------------------------------------------------
Mflv_4479|M.gilvum_PYR-GCK --------------------------------------------------
TH_4663|M.thermoresistible__bu --------------------------------------------------
MSMEG_4205|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4065|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3907c|M.abscessus_ATCC_199 -------------------------MTTTTGTIDGRGQAPRLSPAKVHPD
MLBr_01753|M.leprae_Br4923 MYSLGEMQKPVPVGADYLASCLVARLRSTDVPTDLHRGCTVTLFLGDVEG
Mb1236c|M.bovis_AF2122/97 ---------------MRVWKHVEAAVDSPDRCG-VVLVGPHGVGKTLLAQ
Rv1204c|M.tuberculosis_H37Rv ---------------MRVWKHVEAAVDSPDRCG-VVLVGPHGVGKTLLAQ
MMAR_4234|M.marinum_M -----MPIRWNVPQHAAALEQLDVALSDLARPG-AVILGPDGVGKSTLAR
MUL_0955|M.ulcerans_Agy99 ------------------MEQLDVALSDLARPG-AVILGPDGVGKSTLAR
MAV_1348|M.avium_104 -----MPIRWNVPRQATAAERLDAALADTAAAAGAVVLGPDGIGKSTLAR
Mflv_4479|M.gilvum_PYR-GCK ------------MTAGLGLARTQVESAIVASRLRAVLVGAAGVGKTSMAR
TH_4663|M.thermoresistible__bu -----------------------------------VLVGPAGAGKTELAR
MSMEG_4205|M.smegmatis_MC2_155 -----MSRQWQLLDRPDEIDAIRSALESTDTCG-VVLVGAAGVGKTTLAR
Mvan_4065|M.vanbaalenii_PYR-1 -----MAPIWQIVDRPAEFGAVRSALTGNESCG-VVLVGDPGVGKTTLAR
MAB_3907c|M.abscessus_ATCC_199 LHSYPMARSWQLLDRQTEFGAVRSAMADDSTCG-AVLVGAAGVGKTTLAR
MLBr_01753|M.leprae_Br4923 LAELSETQPDEAADAIARLDCVVSEAVAAHGGVQQVVQGVRGNFLATFAR
*: * * : :*:
Mb1236c|M.bovis_AF2122/97 LAAEQVMSEDGRSG-------------------------RARWVVGTAPG
Rv1204c|M.tuberculosis_H37Rv LAAEQVMSEDGRSG-------------------------RARWVVGTAPG
MMAR_4234|M.marinum_M LAAEHFAQRHPAT--------------------------VIRWVTGTPTE
MUL_0955|M.ulcerans_Agy99 LAAEHFAQRHPAT--------------------------VIRWVTGTPTE
MAV_1348|M.avium_104 VAAERFAAAHPGT--------------------------RVRWVTGTPTE
Mflv_4479|M.gilvum_PYR-GCK KLARDYARKHPRL--------------------------TSHWVSATASA
TH_4663|M.thermoresistible__bu TVLQHRRREQPHT--------------------------VLHWVAGTASA
MSMEG_4205|M.smegmatis_MC2_155 TVTSALTN-------------------------------KVHWTACTESS
Mvan_4065|M.vanbaalenii_PYR-1 AVAGSLRS-------------------------------QVHWVASTQSS
MAB_3907c|M.abscessus_ATCC_199 AVTKSLDA-------------------------------DVRWVACTESS
MLBr_01753|M.leprae_Br4923 ASDATACALDLQLAPIVPVRFRIALHTGEVQISNDDVNNVVFMMVQAAGL
:
Mb1236c|M.bovis_AF2122/97 RAIPFGAFRHLISLP-------------------ASGADIGRPAALLRAA
Rv1204c|M.tuberculosis_H37Rv RAIPFGAFRHLISLP-------------------ASGADIGRPAALLRAA
MMAR_4234|M.marinum_M RTVPFGAFSHLVEI-----------------------AELGKPAALLRAA
MUL_0955|M.ulcerans_Agy99 RAVPLGAFSHLVEI-----------------------AELGKPAALLRAA
MAV_1348|M.avium_104 RAVPFGAFSHLVRI-----------------------AEIGKPAALLRAA
Mflv_4479|M.gilvum_PYR-GCK RDIPFAAFSHLIDV-----------------------SGGEEPTTLLRAA
TH_4663|M.thermoresistible__bu SRIPFGAFSHLVET-----------------------GGGGEPATVLRTA
MSMEG_4205|M.smegmatis_MC2_155 RSIPLGAFAHWVGA-----------------------TASRDPIALLASA
Mvan_4065|M.vanbaalenii_PYR-1 RSIPLGVFAHLVGT-----------------------SVSRDATALLASA
MAB_3907c|M.abscessus_ATCC_199 RSIPLGVFAHWIQA-----------------------SGSRDPTALIAAA
MLBr_01753|M.leprae_Br4923 LDLACGGQTVLSSITGDLVVDGLPADTWLVDLGSHLLRDLARPVRVMQLC
:. . . :: .
Mb1236c|M.bovis_AF2122/97 RSSLTG--------------------------------------------
Rv1204c|M.tuberculosis_H37Rv RSSLTG--------------------------------------------
MMAR_4234|M.marinum_M RASLGRKV------------------------------------------
MUL_0955|M.ulcerans_Agy99 RASLGRKV------------------------------------------
MAV_1348|M.avium_104 RASLG---------------------------------------------
Mflv_4479|M.gilvum_PYR-GCK RESLR---------------------------------------------
TH_4663|M.thermoresistible__bu RESLCGPVLRD---------------------------------------
MSMEG_4205|M.smegmatis_MC2_155 RESLVA--------------------------------------------
Mvan_4065|M.vanbaalenii_PYR-1 RESLVS--------------------------------------------
MAB_3907c|M.abscessus_ATCC_199 RESIVS--------------------------------------------
MLBr_01753|M.leprae_Br4923 HRNLRRNLHELGIRTVPGGPSLPVPLTTFVGRAAQIKELQELLTEKRLLT
: .:
Mb1236c|M.bovis_AF2122/97 --------------------------------------------------
Rv1204c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4234|M.marinum_M --------------------------------------------------
MUL_0955|M.ulcerans_Agy99 --------------------------------------------------
MAV_1348|M.avium_104 --------------------------------------------------
Mflv_4479|M.gilvum_PYR-GCK --------------------------------------------------
TH_4663|M.thermoresistible__bu --------------------------------------------------
MSMEG_4205|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4065|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3907c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01753|M.leprae_Br4923 LVGPGGVGKTRLALQVVARVADEFSGELSYFDLAPDTDHDIFPITVLDNL
Mb1236c|M.bovis_AF2122/97 ----DAGDLLLVVDDAHNLDPLSATLVYQLARAGAARLVVTVASEAEPPD
Rv1204c|M.tuberculosis_H37Rv ----DAGDLLLVVDDAHNLDPLSATLVYQLARAGAARLVVTVASEAEPPD
MMAR_4234|M.marinum_M ----RQGELLLIVDDAHDLDILSATLVYQLALAGAARMIVTARAEVAP-E
MUL_0955|M.ulcerans_Agy99 ----RQGELLLIVDDAHDLDILSATLVYQLALAGAARMIVTARAEVAP-E
MAV_1348|M.avium_104 -----DAGLLLVVDDAHQLDVLSATLVYQLARAGAARLIVTARADGAP-D
Mflv_4479|M.gilvum_PYR-GCK ----SAHGLLLVVDDAHHLDTLSATLVHQLAVTDNAHIMLTVREGEPVPD
TH_4663|M.thermoresistible__bu ---RTRTGLLLIVDDAHHLDTLSATLVHQVAVSTPASLLLTVRDGEPVPD
MSMEG_4205|M.smegmatis_MC2_155 -----DGDVVVGVDDAHLLDQLSATLLHQFAVDHAGHVVATVRNGEPVPD
Mvan_4065|M.vanbaalenii_PYR-1 -----QGECVVGVDDAHLLDELSATLLHQIAVDQSGRILATVRSGEPVPD
MAB_3907c|M.abscessus_ATCC_199 -----TANPIIGIDDAHLLDDLSATLLHQIAVDHVGHVVATVRSGEPVPD
MLBr_01753|M.leprae_Br4923 RRCIGDRRMLMVLDNCEYLLDVCANVMTTLLG-ACPSLTILATSREPIGV
:: :*:.. * :.*.:: . : .
Mb1236c|M.bovis_AF2122/97 AIAALWSDDLLTRVAIEPLDRAQTAAFVESALDATLDVADADELFRRSLG
Rv1204c|M.tuberculosis_H37Rv AIAALWSDDLLTRVAIEPLDRAQTAAFVESALDATLDVADADELFRRSLG
MMAR_4234|M.marinum_M AIAALWTDNLLDRIDVAPPD------------------------------
MUL_0955|M.ulcerans_Agy99 AIAALCTDNLLDRIDVAPPD------------------------------
MAV_1348|M.avium_104 AIAALWDDGLLTRIDVEAPD------------------------------
Mflv_4479|M.gilvum_PYR-GCK AVTALWKDSILSRHDIAPFDRRESGLLLEQILGGTVEDVSTVRMFEISQG
TH_4663|M.thermoresistible__bu AITALWKDDLLARIDIEPFSQAECERLLADALGGRVESASAERLYAISEG
MSMEG_4205|M.smegmatis_MC2_155 AVTSLWKDGYLQRFELQPFSKQQSIALIETVLGGTLEGLSADVMWESSGG
Mvan_4065|M.vanbaalenii_PYR-1 AVTSLWKDGYLRRIELQPFSKEQSVRLVESVVGGRLEGLSADLMWESSGG
MAB_3907c|M.abscessus_ATCC_199 AVTALWKDNYLQRFELDPLTQRQSIALVEKVLGGPLEGLSADVMWRSSRG
MLBr_01753|M.leprae_Br4923 AGEVIWRVSMLSPADEAVELFTERAALVQPGFSVTDGNRQIVTEICQRLD
* : . *
Mb1236c|M.bovis_AF2122/97 NPLYLRHLIDGGGLE----HVDGRWRCRDEDRRP--LSGVIDEYLCALPE
Rv1204c|M.tuberculosis_H37Rv NPLYLRHLIDGGGLE----HVDGRWRCRDEDRRP--LSGVIDEYLCALPE
MMAR_4234|M.marinum_M ----------------------------GKTKQS--EPADVDEFIAELPA
MUL_0955|M.ulcerans_Agy99 ----------------------------GQTKQS--EPADVDEFIAELPA
MAV_1348|M.avium_104 ----------------------------APTS-----PGEIDAFLAELTP
Mflv_4479|M.gilvum_PYR-GCK NPLYLRHLVDAALGTGSLRQVEGVWQLRGEMTLSPQLTTLIDAHLTNLPE
TH_4663|M.thermoresistible__bu NPLYLRHLVTGTVASGALREVEGIWQLRGEVALTPQLSTLIDQHLSALPD
MSMEG_4205|M.smegmatis_MC2_155 NPLFLRNMVEGAVDAGTLTEVNGVWQFRGPTVIPSGLAELLDDRLAHAGE
Mvan_4065|M.vanbaalenii_PYR-1 NPLFLRHLVEGSIDAGTLRKVGDVWQLRGPTAVPSGLASLLQDRLDHAGP
MAB_3907c|M.abscessus_ATCC_199 NPLFLRHLVEGSMQAGSLTEVNGVWQLRGDAVVPSGLDTLIGDRLEHVDD
MLBr_01753|M.leprae_Br4923 GMPLAIELAAARIRTLSLTEIADG--LDDRFRLLTGGARTAVRRQQTLRA
Mb1236c|M.bovis_AF2122/97 PARAVVDYLAIAEPLARTDLVALVGGEQLDTLGQAEAAGAVRVGPDSDTS
Rv1204c|M.tuberculosis_H37Rv PARAVVDYLAIAEPLARTDLVALVGGEQLDTLGQAEAAGAVRVGPDSDTS
MMAR_4234|M.marinum_M PARAVLDYLTVEEPLSLADLTVLAGEGAVQQAVELGAAETRVRGEPDEPA
MUL_0955|M.ulcerans_Agy99 PARAVLDYLTVEEPLSLADLTVLAGEGAVQQAVELGAAETRVRGEPDEPA
MAV_1348|M.avium_104 PARAVLEYLAVAEPLSVTDLNALAGDGAVAEAQRWGAAETRMRGGTSDDP
Mflv_4479|M.gilvum_PYR-GCK PVRSVLEFLAIDDPLSVDDLAALTGIDAVDAAETCGVVTITDRA---GAL
TH_4663|M.thermoresistible__bu QIRTVLAYLAIEEPLTVADLSDLVSPEAVEAAEAAGAVTVDERG---ADL
MSMEG_4205|M.smegmatis_MC2_155 DVMNALKLLSLCEPLDIDAFAELAGEEAVDSAEMRGLIRIVTDA--GGTL
Mvan_4065|M.vanbaalenii_PYR-1 DVLNALRLLALCEPLDIHALTELAGDDAVDAAEACDLIRFQQD---GTVL
MAB_3907c|M.abscessus_ATCC_199 TVFSALKVLSMCEPLDIDTLCEIASDEAVDAAEIADLIRVERD---GVRT
MLBr_01753|M.leprae_Br4923 SMDWSYALLTESERALFRRLSAISGTFDLKVAYAVGHDDLEEPDQVFDRL
*: : : : . :
Mb1236c|M.bovis_AF2122/97 EIFVGHPLYADRARAVLT--AEHAHALRVSLVAQLAKHPSDHVSDQLRLS
Rv1204c|M.tuberculosis_H37Rv EIFVGHPLYADRARAVLT--AEHAHALRVSLVAQLAKHPSDHVSDQLRLS
MMAR_4234|M.marinum_M VVYTAHPLFAKRARVALG--DDGARQRRTELVTLLSQHPNEHLSDRLRLA
MUL_0955|M.ulcerans_Agy99 VVYTAHPLFAKRARVALG--DDGARQRRTELVTLLSQHPNEHLSDRLRLA
MAV_1348|M.avium_104 VVYTAHPLFAERVRAALD--PDDARQRRTELVTVLARHPSDRLSDRLRLV
Mflv_4479|M.gilvum_PYR-GCK YAHPFHPIYTERVRSSLG--LLAMRRLRKLLAGRMSVRAPGNLSTRLRMA
TH_4663|M.thermoresistible__bu IVHPAHPLYTETVRAGLG--RLTRRSLRTALVARWSRRPPDNVSDRLRLA
MSMEG_4205|M.smegmatis_MC2_155 TARFAHPLFAEVVRRRVG--TASARKLRGRIAKILRDRDLSTAASRIRLA
Mvan_4065|M.vanbaalenii_PYR-1 NARFSHPLVGDVVRDRIG--HATERRLKGQLVELLRRRELSTAASRIRMA
MAB_3907c|M.abscessus_ATCC_199 VVRFSHPMFGEAVRRRVG--TASGRRLRGKLVRVLRDRDLGTASNRIRLA
MLBr_01753|M.leprae_Br4923 TMLIDKSLVIVEGRQGGSRYRLLETVRQYAMKKLEESNEVDLVLARHRDH
:.: * : : . : *
Mb1236c|M.bovis_AF2122/97 SLAIDVPASATPAAVTDAATAAGQALRLGDVRLAERLARAALDRSDALAA
Rv1204c|M.tuberculosis_H37Rv SLAIDVPASATPAAVTDAATAAGQALRLGDVRLAERLARAALDRSDALAA
MMAR_4234|M.marinum_M SLALDTDALQP---VDDVVESAEQALRLGDLTLAERLAQAALDRSGGLQA
MUL_0955|M.ulcerans_Agy99 SLALDTDALQP---VDDVVESAEQALRLGDLTLAERLAQAALDRSGGLQA
MAV_1348|M.avium_104 SLALDSDAPPR---AADVVDAARQALRLGDLALGERLARAALRRSGGLAA
Mflv_4479|M.gilvum_PYR-GCK ALAMGTDEPPS---ADELVGLSWEAMRLGDLALGERLARAALDQADGLAA
TH_4663|M.thermoresistible__bu ALAVNSQTPPP---ATDLIATSWEAMQLGDLLLGEQLARGALGQSDTLAA
MSMEG_4205|M.smegmatis_MC2_155 QLCIESDRGAD---VDLLITAAKDAVFLSNLPLGEQLARAAFDHGGGLPA
Mvan_4065|M.vanbaalenii_PYR-1 QLSIDSDQLLD---IDLLISATKDAIYLFNMPLGQRLAKVAFDRTGSLEA
MAB_3907c|M.abscessus_ATCC_199 RLSIDCDEPVD---VDLLVTAAKDAVYLSNLPLGEELARAAVDGGGGLQA
MLBr_01753|M.leprae_Br4923 YMALGALLDTPG-DIDHEQLVEQVETELDNLRSAFAWSRETGDIAGALQL
:.: * :: . :: : . *
Mb1236c|M.bovis_AF2122/97 RLPLAYALGWQGRGREADAVLAAVNPAE-----LTETELMAWAIPRAANR
Rv1204c|M.tuberculosis_H37Rv RLPLAYALGWQGRGREADAVLAAVNPAE-----LTETELMAWAIPRAANR
MMAR_4234|M.marinum_M RLVLGQALAWRGRGREAGQVLTAVDPGQ-----LSEAELMAWAVPQAANQ
MUL_0955|M.ulcerans_Agy99 RLVLGQALAWRGRGREAGQVLTAVDPGQ-----LSEAELMAWAVPQAANQ
MAV_1348|M.avium_104 RLALAHALGWQGRGREADALLAEVDSTG-----LTEAALMDWALLRAANQ
Mflv_4479|M.gilvum_PYR-GCK RLPLAHSLSWQGRGRDADDVLNPVDPDT-----LTQWDLMAWTLPKAANR
TH_4663|M.thermoresistible__bu RLPLAHALAWQGRGREADDVLAAVDPDR-----LTEFDIMAWTLPKAANQ
MSMEG_4205|M.smegmatis_MC2_155 ATLLSRALLWQGHPAQADNILARFPPDH-----MDEMELVQWGIPRLSIL
Mvan_4065|M.vanbaalenii_PYR-1 AELLSRTLLWQGRPAAAEAILARFSPDD-----LDELQLVRWGTPRASHL
MAB_3907c|M.abscessus_ATCC_199 AAMLSRSLLWQGRPEQAEEILAAFDPDD-----LDELSLVLWGIPRISIA
MLBr_01753|M.leprae_Br4923 ASSLQPIWFGRGHMYEGLAWFDSIFEHKNIEHLVAPKEVLARAVANKVML
* :*: . : . : :: .
Mb1236c|M.bovis_AF2122/97 FWMLNE-PERATAFLQTTRSRVTEPTARSTLDALAATFAMN------SGN
Rv1204c|M.tuberculosis_H37Rv FWMLNE-PERATAFLQTTRSRVTEPTARSTLDALAATFAMN------SGN
MMAR_4234|M.marinum_M FWMLGE-PERATAFLQTTRNRVTDLTARTTLDALTATFAMN------SGN
MUL_0955|M.ulcerans_Agy99 FWMLGE-PERATAFLQTTRNRVTDLTARTTLDALTATFAMN------SGN
MAV_1348|M.avium_104 FWMLSE-PERATAFLRTVRNRVADPGPRTTLDALSATFAMN------TGN
Mflv_4479|M.gilvum_PYR-GCK FWMLSE-SEEAVEYLRQMRARITERGALHTIDALAATFAMN------AGD
TH_4663|M.thermoresistible__bu FWMLSE-SAEAIALLDRMRTRLHQPAAVTAFDALAATFAMN------AGQ
MSMEG_4205|M.smegmatis_MC2_155 FWSMGD-VPLAHQVLGELNSRVTHPILQLIIDATEAGMAVH------ENR
Mvan_4065|M.vanbaalenii_PYR-1 FWAMGD-VERAHEVISLVRERTTHPSLRLFVEAAAAAMAVH------ENR
MAB_3907c|M.abscessus_ATCC_199 FWSMGE-NERAHELLALLHERVRHHILKPVVDATDAAIALH------ENR
MLBr_01753|M.leprae_Br4923 HAILASSPPDGSDLVTQAQQALTMAREIGDSAVLARALTACGFSSGYDTE
. : . . : . . ::
Mb1236c|M.bovis_AF2122/97 LPRAITLATEVLSGPAADDMAVAWAASAAALSSARMGRFGDVDRLAERAS
Rv1204c|M.tuberculosis_H37Rv LPRAITLATEVLSGPAADDMAVAWAASAAALSSARMGRFGDVDRLAERAS
MMAR_4234|M.marinum_M VPRAITLATEVLAEPSADDTAIAWAASAAALASARMGRFADVPQLAQRAS
MUL_0955|M.ulcerans_Agy99 VPRAITLATEVLAEPSADDTAIAWAASAAALASARMGRFADVPQLAQRAS
MAV_1348|M.avium_104 VGHAVKVAGEVLGSPAADDQAVAWAGSAAALCAARQGRFDDVEPLARRAL
Mflv_4479|M.gilvum_PYR-GCK PAEAVTVAKGILAADDAQDLAVAWASAAATLSSARMGRFAEVDGLAQRGL
TH_4663|M.thermoresistible__bu PRTALELAGRVLQTPESQDLAVAWAAATATLSSARMARFDEVETHAARGL
MSMEG_4205|M.smegmatis_MC2_155 ITEGLAIAERVLDHPECPRQATDFAAFACGLAMPVAGRGEAFLPIASRCR
Mvan_4065|M.vanbaalenii_PYR-1 IDEGIAAALQVLDNPLAPGQAVEFAAFAAGLAMPVAGRGDEFEPIAARCR
MAB_3907c|M.abscessus_ATCC_199 FDEGLARAHAVLSDPVAPKQAVEFAAFGVGLTLPVAGRGHEFEPIAQRCR
MLBr_01753|M.leprae_Br4923 VARPYFAEAVELARTQGDKWTLSQIRLWGVVGFCVSGDPVALRAAAEAAD
* : : . . *
Mb1236c|M.bovis_AF2122/97 AAEH---PGLLRFTVGLAQITSLLLAGDVAPAQELAKRFTDFA-------
Rv1204c|M.tuberculosis_H37Rv AAEH---PGLLRFTVGLAQITSLLLAGDVAPAQELAKRFTDFA-------
MMAR_4234|M.marinum_M EAEH---PGLLRFTVGLAQITTLLMAGEVAQAQELAQRFTDFAEL-QQPG
MUL_0955|M.ulcerans_Agy99 EAEH---PGLLRFTVGLAQITTLLMAGEVAQAQELAQRFTDFAEL-QQPG
MAV_1348|M.avium_104 AAEH---PGLLRFTIGLAQTTTLLLAGRLEQARELAQQFTDFAEL-QQPG
Mflv_4479|M.gilvum_PYR-GCK DAAH---PGLLRFTLGLGQTLALIMNADVASAEHLARHYLSFSEF-QQPG
TH_4663|M.thermoresistible__bu AAQH---PGLLRFTIGLGQITRLILAGXLTRADFLAHHYLSFCEF-QQPG
MSMEG_4205|M.smegmatis_MC2_155 AQRK-TTDGMIRIMVFYGEVLALAYTGQFDLARQRAEEYAEFSSAGQFAG
Mvan_4065|M.vanbaalenii_PYR-1 ADQK-PTDGMIRVMVRYCDVLALTHLGELDLAGRRAAEYADFSSVGQFLA
MAB_3907c|M.abscessus_ATCC_199 DDKKRTTDGLIAAMVRYCDVLALTYTGQLDLAEERVAEYTKFSSAGQFLA
MLBr_01753|M.leprae_Br4923 DLAQEIGDRFVSLQCRLLLSIAQLWQGDMDGAIVRSGEVVAGAEAAHDTV
: :: . . * . .
Mb1236c|M.bovis_AF2122/97 --------------------------------------------------
Rv1204c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4234|M.marinum_M RAIGEVLLAHVLIVKGEFGAAAAMLEPAAAELERTG-YSWGPLSLMLLAT
MUL_0955|M.ulcerans_Agy99 RAIGEVLLAHVLIVKGEFGTAAAMVEPAAAELERTG-YSWGPLSLMLLAT
MAV_1348|M.avium_104 RAIGEVLVAHVLLTEGEFASAAALLGPAAATLERTG-YSWGPLSLTLLAT
Mflv_4479|M.gilvum_PYR-GCK RAIGEVLLGHTLLASGRFGDAVTLLRQAAAALTYTG-YSWGPLALTGLAQ
TH_4663|M.thermoresistible__bu RAIGEVLLAHILIARGDLPTATTLLRQAAAALSSTG-YSWGPLALMQLTQ
MSMEG_4205|M.smegmatis_MC2_155 WAIAKIMAGAAAMHSGRFRDAISAIEQALAALNAEISLPWQLPGRLLLAR
Mvan_4065|M.vanbaalenii_PYR-1 WAIAKIMAGVVATARGEFPDAVTCIEQALAALNAETSLPWQLPGRLLLAR
MAB_3907c|M.abscessus_ATCC_199 WAIARIMAGVVATQRGLFREAIEAFEQALAAQRADRPLPWQLPARLLLAR
MLBr_01753|M.leprae_Br4923 TRTFGLYVQTRALVHRDVSAALVTAGLVVEAAAELS-GVYQGIGYAAMVF
Mb1236c|M.bovis_AF2122/97 --------------------------------------------------
Rv1204c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4234|M.marinum_M AIAQQGNIAETAKALRRAETRHGTKS-------------ALFAPELSLAR
MUL_0955|M.ulcerans_Agy99 AIAQQGNIAETAKALRRAETRHGTKS-------------ALFAPELSLAR
MAV_1348|M.avium_104 ALAQLGDTAATAKALSRAETRHGTKS-------------ALFAPELGVAR
Mflv_4479|M.gilvum_PYR-GCK ALGQQGRAADASAVLTRAEASHGMRS-------------ALYAPDLALAR
TH_4663|M.thermoresistible__bu VLGARGDADGASEALRRAEHSHGTRS-------------ELYAPELALX-
MSMEG_4205|M.smegmatis_MC2_155 AYAAVGEVIEAERVLDDAMEHSGAFM-------------ALHEPQRTLAK
Mvan_4065|M.vanbaalenii_PYR-1 AYAALGRTDEAERVLNDAAEHSGPSA-------------AIHEPQRLISR
MAB_3907c|M.abscessus_ATCC_199 AYAALGRAVDGERVLDEAREHSGPHV-------------AIHMPQMMLAK
MLBr_01753|M.leprae_Br4923 AALAMGDVAAAVEASEACRPHLGADHGLVAIHLELMAAVALARGDVIVAR
Mb1236c|M.bovis_AF2122/97 --------------------------------------------------
Rv1204c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4234|M.marinum_M AWAKATVRDQAGALFDTREAARAAERGKQSAVALCVWHDAVRLGDTRALA
MUL_0955|M.ulcerans_Agy99 AWAKATVRDQAGALFDTREAARAAERGKQSAVALCVWHDAVRLGDTRALA
MAV_1348|M.avium_104 AHRLALMRDAHGAVAAARDAARMAERGGQRAVAARVWHEAVRLGDTRAAE
Mflv_4479|M.gilvum_PYR-GCK AWTLAAARDLRGAVASARDAVHAAVQSGQDAVALRALQDCARLGDTHGLA
TH_4663|M.thermoresistible__bu XXXWRGLRDESGHLAAYRITVDDRLP-----ETLADLWD----GSAAEVW
MSMEG_4205|M.smegmatis_MC2_155 ACVAAAKGAHRSAIDIARSAADLARSSEQHAVEAEALHHCARFGDRTVAR
Mvan_4065|M.vanbaalenii_PYR-1 SWYAAAKGMERRALELARAAAEIARQSGQYALEAEALHHATRFGDRSTAP
MAB_3907c|M.abscessus_ATCC_199 AWLVAARGSDRGAVDAARRAADAAHSAGQYALEAEALHHAARFGDRTVGR
MLBr_01753|M.leprae_Br4923 RLADNSVSATTGWHQMAALTTRARIAMAQGEPELARADIHAALACGADIQ
Mb1236c|M.bovis_AF2122/97 --------------------------------------------------
Rv1204c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4234|M.marinum_M PVTRLAAEIDCKVGNIVVRHARALADNDAGALASVADELAAIGMHAAAAD
MUL_0955|M.ulcerans_Agy99 PVTRLAAEIDCKVGNIVVRHARALANNDAGALASVADELAAIGMHAAAAD
MAV_1348|M.avium_104 PLARLCDEIDCAAARIALAHARALAAGDEAALLAVSEELTSIGMRAAAAD
Mflv_4479|M.gilvum_PYR-GCK TAVRLSDRIGCVTGPLCVAHLRALAAGDGAALDAVSADLETAGLPAAAAD
TH_4663|M.thermoresistible__bu TAIEFS---GTTAHPMITAG----------------CALRSEKKPEAAGP
MSMEG_4205|M.smegmatis_MC2_155 RLQGLVDRVDGPLARLYAQHAAAVAAADPVALDAVSSAFEQAGLMLSAAD
Mvan_4065|M.vanbaalenii_PYR-1 RLAELTGVVHGSVVGLLARHAAAFAAGDAAALDVVSADFESAGLMLSAAD
MAB_3907c|M.abscessus_ATCC_199 RIESLCTRVHGPLTGLYARHALAVAHSDITGLEAVSADFEAAGLLLSAAD
MLBr_01753|M.leprae_Br4923 ASLGISDSMELLAELISQGDNHRQAGRLFGAASAQREKTGEVRFKVWDAG
Mb1236c|M.bovis_AF2122/97 --------------------------------------------------
Rv1204c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4234|M.marinum_M AAAQAERAGGR---------------------------------------
MUL_0955|M.ulcerans_Agy99 AAAQAERAGGR---------------------------------------
MAV_1348|M.avium_104 AAAQARRGAAAQPLR-----------------------------------
Mflv_4479|M.gilvum_PYR-GCK AAAQATFAHQRRGDRAGEVASRSRASRLSQVCGAPATPALEQVLNPMP--
TH_4663|M.thermoresistible__bu LPALTPQRGLHR--PALEALAPTSGRRLPG--------------EPVP--
MSMEG_4205|M.smegmatis_MC2_155 AAAQAVLLHDKAGHRRQSTESAAHALQLAGRCGGAATPAIRAAARPLP--
Mvan_4065|M.vanbaalenii_PYR-1 AAAQAALLHDSAGDRRRTNESGANALRLAEKCGGATTPAIKAAARPLP--
MAB_3907c|M.abscessus_ATCC_199 AAAQAVALRMRAGDRGKGSDAAARVLRMADRCGGVVTPAILAAAKPLP--
MLBr_01753|M.leprae_Br4923 YESAVAVLRGAMGCKDFDSAWAEGAAMPIDDAITYAQRGRGNRKRPTTGW
Mb1236c|M.bovis_AF2122/97 --------------------------------------------------
Rv1204c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4234|M.marinum_M --------------------------------------------------
MUL_0955|M.ulcerans_Agy99 --------------------------------------------------
MAV_1348|M.avium_104 --------------------------------------------------
Mflv_4479|M.gilvum_PYR-GCK --LTGREREVAVMVSQGLTNKAIAQRLSVSVRTVEGHVYRACMKFGVPDR
TH_4663|M.thermoresistible__bu --LPDGLLDSLFWPVRGVRSTARQRRTARQVETES------------VDT
MSMEG_4205|M.smegmatis_MC2_155 --VTAREREVAALVAQGLLNREIAERLTVSVRTVEGHIYRACIKLGVADR
Mvan_4065|M.vanbaalenii_PYR-1 --LTPREREIAELVAAGLSNRHIAEQLVLSVRTVEGHVYRACFKLDVADR
MAB_3907c|M.abscessus_ATCC_199 --ISSREREIAVLIGEGLSDKDIATRLQLSVRTVEGHIYRARMKLDADDR
MLBr_01753|M.leprae_Br4923 ESLTPAEHNVIRLVSEGLDTKDIAARLFVSVRTVHTHLTRIYSKLGLTSR
Mb1236c|M.bovis_AF2122/97 -------------------
Rv1204c|M.tuberculosis_H37Rv -------------------
MMAR_4234|M.marinum_M -------------------
MUL_0955|M.ulcerans_Agy99 -------------------
MAV_1348|M.avium_104 -------------------
Mflv_4479|M.gilvum_PYR-GCK AALASTVGGMHGREGTA--
TH_4663|M.thermoresistible__bu APVSRT-------------
MSMEG_4205|M.smegmatis_MC2_155 DELARMIWTDLTPLEADPR
Mvan_4065|M.vanbaalenii_PYR-1 DELAKLIRKKS--------
MAB_3907c|M.abscessus_ATCC_199 EEFAKIVGSDLKPPEAS--
MLBr_01753|M.leprae_Br4923 VQLVQEAARHN--------