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TISVEKPSSDAQAGGKVPLVELKNVGKSYGNITALKDICLRVHAGEVTGILGDNGAGKSTLIKIIAGLHQ QTEGQLLVDGEPTKFASPAEALGKGIATVYQNLAVVPLMPVWRNFFLGQELRKKSFPFSLDADAMRATTL TELSKMGIDLPDVDVPIGSLSGGQKQCVAIARAVFFGARVLILDEPTAALGVKQSGVVLKYITAAKEAGF GVVFITHNPHHAHLVGDHFVLLNRGRQKLDCTYDDITLEHLTQEMAGGDELEALTHELRAAKS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4009 | - | - | 100% (274) | ABC transporter-related protein |
| M. vanbaalenii PYR-1 | Mvan_5292 | - | 1e-43 | 38.71% (248) | ABC transporter-related protein |
| M. vanbaalenii PYR-1 | Mvan_3387 | - | 9e-23 | 31.56% (225) | spermidine/putrescine ABC transporter ATPase subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2419c | cysA1 | 5e-20 | 31.75% (211) | sulfate-transport ATP-binding protein ABC transporter CysA1 |
| M. gilvum PYR-GCK | Mflv_2607 | - | 1e-147 | 94.14% (273) | ABC transporter related |
| M. tuberculosis H37Rv | Rv2397c | cysA1 | 5e-20 | 31.75% (211) | sulfate-transport ATP-binding protein ABC transporter CysA1 |
| M. leprae Br4923 | MLBr_01089 | - | 4e-21 | 31.25% (224) | putative ABC-transport protein, ATP-binding component |
| M. abscessus ATCC 19977 | MAB_4237c | - | 9e-26 | 33.04% (227) | amino acid ABC transporter ATP-binding protein |
| M. marinum M | MMAR_0922 | - | 9e-21 | 32.14% (224) | ABC transporter, ATP-binding protein |
| M. avium 104 | MAV_1377 | sugC | 2e-20 | 31.33% (233) | ABC transporter, ATP-binding protein SugC |
| M. smegmatis MC2 155 | MSMEG_4656 | - | 1e-120 | 77.70% (269) | sugar ABC transporter ATP-binding protein |
| M. thermoresistible (build 8) | TH_1784 | - | 3e-22 | 29.71% (239) | ABC transporter, ATP-binding protein GluA |
| M. ulcerans Agy99 | MUL_3658 | cysA1 | 1e-20 | 32.42% (219) | sulfate-transport ATP-binding protein ABC transporter CysA1 |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_4237c|M.abscessus_ATCC_199 -----------------MSTIEVRGVRKSYG----QVTALRDVNLTVHQG
TH_1784|M.thermoresistible__bu MDSAGADVAVADPAAEAVPMISMRGVNKYFG----SLHVLRDINLDVARG
MMAR_0922|M.marinum_M -------MTRAQAPTSPRGGVSLHGVDKTFGTAAASVHALRGIDLDIEPG
Mb2419c|M.bovis_AF2122/97 ----------MT------YAIVVADATKRYG----DFVALDHVDFVVPTG
Rv2397c|M.tuberculosis_H37Rv ----------MT------YAIVVADATKRYG----DFVALDHVDFVVPTG
MUL_3658|M.ulcerans_Agy99 ----------MTGPGTGGHAIVVRDAFKQYG----DFVALDHVDFVVPAG
MLBr_01089|M.leprae_Br4923 -----------------MAEIVLEHVNKNYP---NGATAVHDLSITVADG
MAV_1377|M.avium_104 -----------------MAEIVLDHVSKSYP---DGATAVRDLNLTIADG
Mvan_4009|M.vanbaalenii_PYR-1 MTISVEKPSSDAQAGGKVPLVELKNVGKSYG----NITALKDICLRVHAG
Mflv_2607|M.gilvum_PYR-GCK MTISVEKASSDSKPGGKVPLVELKNIGKSYG----NITALKDISLRVHAG
MSMEG_4656|M.smegmatis_MC2_155 MSTTAEAPIAETPSGGAVPLVEFKGVGKSYG----NIIALKDINLRVGAG
: . * : .: : : : *
MAB_4237c|M.abscessus_ATCC_199 EVTVIIGPSGSGKSTLLRALNHLEKVDAGTIRIDGELIGYRQRGSVLYEL
TH_1784|M.thermoresistible__bu QVVVVLGPSGSGKSTLCRTLNRLEPIDSGAISIDG--VALPAEG------
MMAR_0922|M.marinum_M ELVAIVGESGSGKTTLLNVIGGIEEANSGSINVAG--QDISGCRP-----
Mb2419c|M.bovis_AF2122/97 SLTALLGPSGSGKSTLLRTIAGLDQPDTGTITING--RDVTRVPP-----
Rv2397c|M.tuberculosis_H37Rv SLTALLGPSGSGKSTLLRTIAGLDQPDTGTITING--RDVTRVPP-----
MUL_3658|M.ulcerans_Agy99 SLTALLGPSGSGKSTLLRTIAGLDQPDSGNITING--RDVTRVPP-----
MLBr_01089|M.leprae_Br4923 EFLILIGPSGCGKTTTLNMIAGLEDISSGELRIDG--DRVNEKAP-----
MAV_1377|M.avium_104 EFLILVGPSGCGKTTTLNMIAGLEDISSGELRIGG--ERVNEKAP-----
Mvan_4009|M.vanbaalenii_PYR-1 EVTGILGDNGAGKSTLIKIIAGLHQQTEGQLLVDGEPTKFASPAE-----
Mflv_2607|M.gilvum_PYR-GCK EVTGILGDNGAGKSTLIKIIAGLHQQTDGELLVDGEPTRFASPAD-----
MSMEG_4656|M.smegmatis_MC2_155 EVTCVLGDNGAGKSTLIKIIAGLHKPTEGEVLIDGKPTVFESPKD-----
.. ::* .*.**:* . : :. * : : *
MAB_4237c|M.abscessus_ATCC_199 PERAILRQR-SQVGFVFQNFNLFPHLTVLENVIEAPLAARRAPRAELEAE
TH_1784|M.thermoresistible__bu --RELARLR-ADVGMVFQQFNLFAHKTIVDNVALGPMKVRKTPREQARAE
MMAR_0922|M.marinum_M --RALSKFRRDHVGFIFQFFNLIPTLTAKENVEVIVELTGRGDRR----R
Mb2419c|M.bovis_AF2122/97 --------QRRGIGFVFQHYAAFKHLTVRDNVAFG-LKIRKRPKAEIKAK
Rv2397c|M.tuberculosis_H37Rv --------QRRGIGFVFQHYAAFKHLTVRDNVAFG-LKIRKRPKAEIKAK
MUL_3658|M.ulcerans_Agy99 --------QRRGIGFVFQHYAAFKHLTVRDNVAYG-LKIRKRPKAEIRDK
MLBr_01089|M.leprae_Br4923 --------KDRDIAMVFQSYALYPHMTVRQNIAFP-LMLAKVKKAEIAQK
MAV_1377|M.avium_104 --------KDRDIAMVFQSYALYPHMTVRQNIAFP-LTLAKMKKPEIAQK
Mvan_4009|M.vanbaalenii_PYR-1 -------ALGKGIATVYQNLAVVPLMPVWRNFFLGQELRKKSFPFSLDAD
Mflv_2607|M.gilvum_PYR-GCK -------ALGKGIATVYQNLAVVPLMPVWRNFFLGQELRKKRFPFSLDAN
MSMEG_4656|M.smegmatis_MC2_155 -------ALNAGIATVYQDLAVVSLMPVWRNFFLGNELRKKNILRSLDIN
:. ::* . *. :
MAB_4237c|M.abscessus_ATCC_199 ATRLLERVGVADKAAQYP------RRLSGGQQQRVAIARALALRPKVILF
TH_1784|M.thermoresistible__bu AMALLERVGVADQADKYP------AQLSGGQQQRVAIARSLAMNPKVMLF
MMAR_0922|M.marinum_M ATELLDAVGLADRAGSFP------GQLSGGQQQRVAIARALITDPDLLLA
Mb2419c|M.bovis_AF2122/97 VDNLLQVVGLSGFQSRYP------NQLSGGQRQRMALARALAVDPEVLLL
Rv2397c|M.tuberculosis_H37Rv VDNLLQVVGLSGFQSRYP------NQLSGGQRQRMALARALAVDPEVLLL
MUL_3658|M.ulcerans_Agy99 VDNLLEVVGLSGFHGRYP------DQLSGGQRQRMALARALAVDPEVLLL
MLBr_01089|M.leprae_Br4923 VSETAQILDLTDLLDRKP------SQLSGGQRQRVAMGRAIVRHPKAFLM
MAV_1377|M.avium_104 VAETAKILDLTDFLDRKP------SQLSGGQRQRVAMGRAIVRHPKAFLM
Mvan_4009|M.vanbaalenii_PYR-1 AMRATTLTELSKMGIDLPDVDVPIGSLSGGQKQCVAIARAVFFGARVLIL
Mflv_2607|M.gilvum_PYR-GCK AMRATTLTELAKMGIDLPDVDVPIGSLSGGQKQCVAIARAVFFGARVLIL
MSMEG_4656|M.smegmatis_MC2_155 GMRATTISELQKMGIDLPDVDAPIGSLSGGQRQCVAIARAIFFGARVLIL
: * *****:* :*:.*:: . ::
MAB_4237c|M.abscessus_ATCC_199 DEPTSALDPELVTEVLDVIAQLARDG-ATLVIVTHEIGLAREIADTVVFM
TH_1784|M.thermoresistible__bu DEPTSALDPEMINEVLAVMSALAADG-MTMLVVTHEMGFARRASDRVVFM
MMAR_0922|M.marinum_M DEPMGALDVATGRRVLELLQQTNRSG-LGVIMVTHNR-AAADVADRIIQM
Mb2419c|M.bovis_AF2122/97 DEPFGALDAKVREELRAWLRRLHDEVHVTTVLVTHDQAEALDVADRIAVL
Rv2397c|M.tuberculosis_H37Rv DEPFGALDAKVREELRAWLRRLHDEVHVTTVLVTHDQAEALDVADRIAVL
MUL_3658|M.ulcerans_Agy99 DEPFGALDAKVREDLRAWLRRLHDEVHVTTVLVTHDQAEALDVADRIAVL
MLBr_01089|M.leprae_Br4923 DEPLSNLDAKLRVRTRGEIARLQRRLGATTVYVTHDQTEAMTLGDRVVVM
MAV_1377|M.avium_104 DEPLSNLDAKLRVQMRGEIARLQKRLGTTTVYVTHDQTEAMTLGDRVVVM
Mvan_4009|M.vanbaalenii_PYR-1 DEPTAALGVKQSGVVLKYITAAKEAG-FGVVFITHNPHHAHLVGDHFVLL
Mflv_2607|M.gilvum_PYR-GCK DEPTAALGVKQSGVVLKYITAAKEAG-FGVVFITHNPHHAHLVGDHFVLL
MSMEG_4656|M.smegmatis_MC2_155 DEPTAALGVKQSGMVLRYITAAKDQG-FGVIFITHNPHHAYMVGDHFILL
*** . *. : : :**: * .* . :
MAB_4237c|M.abscessus_ATCC_199 DRGAIVEQGPPKEVLDSPSHPRTASFLS------------------KVLS
TH_1784|M.thermoresistible__bu SDGAIVEDAEPARFFEDPQTDRARDFLG------------------KILH
MMAR_0922|M.marinum_M RDGAIVEQRRNS----APAEASSVRW------------------------
Mb2419c|M.bovis_AF2122/97 HKGRIEQVGSPTDVYDAPANAFVMSFLG------------------AVST
Rv2397c|M.tuberculosis_H37Rv HKGRIEQVGSPTDVYDAPANAFVMSFLG------------------AVST
MUL_3658|M.ulcerans_Agy99 NSGRIEQVGSPTEVYDAPTNAFVMSFLG------------------AVSA
MLBr_01089|M.leprae_Br4923 RSGVVQQIGTPDELYERPVNLFVAGFIGSPVMNFFPAKLTPNGLTLPLGE
MAV_1377|M.avium_104 HSGVAQQIGTPDELYENPANLFVAGFIGSPAMNFFPATLTPIGLKVPFGE
Mvan_4009|M.vanbaalenii_PYR-1 NRGRQKLDCTYDDITLEHLTQEMAGGDE-------------------LEA
Mflv_2607|M.gilvum_PYR-GCK NRGRQKLDCSYDDITLEHLTQQMAGGDE-------------------LEA
MSMEG_4656|M.smegmatis_MC2_155 NRGRQKLDCTYDEISLETLTQEMAGGNE-------------------LEA
*
MAB_4237c|M.abscessus_ATCC_199 --------------------------------------------------
TH_1784|M.thermoresistible__bu H-------------------------------------------------
MMAR_0922|M.marinum_M --------------------------------------------------
Mb2419c|M.bovis_AF2122/97 LNGSLVRPHDIRVGRTPNMAVAAADGTAGSTGVLRAVVDRVVVLGFEVRV
Rv2397c|M.tuberculosis_H37Rv LNGSLVRPHDIRVGRTPNMAVAAADGTAGSTGVLRAVVDRVVVLGFEVRV
MUL_3658|M.ulcerans_Agy99 LNGALVRPHDIRVGRTPEMAVAAADGTGESTGVTRAVVDRIVVLGFEVRV
MLBr_01089|M.leprae_Br4923 LNLSRDVQAMIGQHPVPDRVIVGVRPEHLTDAKLIDAHQHGTVLTFKVKV
MAV_1377|M.avium_104 VMLTPEVQQVIAEHPEPDNVIVGARPEHLSDAALIDGYQRIRALTFEVKV
Mvan_4009|M.vanbaalenii_PYR-1 LTHELRAAKS----------------------------------------
Mflv_2607|M.gilvum_PYR-GCK LSHELRAAKQ----------------------------------------
MSMEG_4656|M.smegmatis_MC2_155 LSHELGRK------------------------------------------
MAB_4237c|M.abscessus_ATCC_199 --------------------------------------------------
TH_1784|M.thermoresistible__bu --------------------------------------------------
MMAR_0922|M.marinum_M --------------------------------------------------
Mb2419c|M.bovis_AF2122/97 ELTSAATGGAFTAQITRGDAEALALREGDTVYVRATRVPPIAGGVSGVDD
Rv2397c|M.tuberculosis_H37Rv ELTSAATGGAFTAQITRGDAEALALREGDTVYVRATRVPPIAGGVSGVDD
MUL_3658|M.ulcerans_Agy99 ELTSAATGGAFTAQITRGDAEALALQEGDTVYVRATRVPPIAGAAPAVPD
MLBr_01089|M.leprae_Br4923 DLVESLGADKYIYFTTTGCDVYSAQLDELASELEVRENQFVARVSAESKM
MAV_1377|M.avium_104 DMVESLGADKYVYFSTAAWAAHSTQLDELAAEADAHENQFVARVPAESKA
Mvan_4009|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2607|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4656|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4237c|M.abscessus_ATCC_199 -----------------------------------
TH_1784|M.thermoresistible__bu -----------------------------------
MMAR_0922|M.marinum_M -----------------------------------
Mb2419c|M.bovis_AF2122/97 AGVERVKVTST------------------------
Rv2397c|M.tuberculosis_H37Rv AGVERVKVTST------------------------
MUL_3658|M.ulcerans_Agy99 DGAGSTPRAAQIGVGGQ------------------
MLBr_01089|M.leprae_Br4923 AIGESIELAFGTAKIAVFDADSGVNLTVSAPTDA-
MAV_1377|M.avium_104 AIGQTVELALDTTKLMVFDADSGVNLTV-APSDSP
Mvan_4009|M.vanbaalenii_PYR-1 -----------------------------------
Mflv_2607|M.gilvum_PYR-GCK -----------------------------------
MSMEG_4656|M.smegmatis_MC2_155 -----------------------------------