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MTPLRRCLGAMLIPLTVLLATGCTQWRGLNSLPMPGTQGRGDGSFLIQVQMPDVSNIEPNSRVRVGDVSV GTVTRIERQDWHALLTVTLDGDVDLPANATVKLGQTSLLGSLHLELAPPTDEPPQGQLAAGSLIPLSHSG SYPSTEETLAAVSSVLNGGGLGHVQDITEAFSTAFRGREQDLRSLIGELDTFTADLDDQTPDIIAATDSL NQLASKFAARKPVLDRALETIPDALAELNQQKEDLINAADQFAKFSALTVDTVNQTKDNLVAQLQQIGPV LESLADAGPSLTRSLSLIPTFPFPNETIENWQRGDYANLTAIVDLTLSRIDAGLFTGTRWEGDLTELEMQ WGRTIGQFPSPYTQGNPLVAPYRWDQGP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0367 | - | - | 100% (378) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_3978 | - | e-160 | 72.19% (374) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_4600 | - | e-145 | 68.58% (366) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0179 | lprK | 1e-69 | 41.19% (369) | MCE-family lipoprotein LprK |
| M. gilvum PYR-GCK | Mflv_0648 | - | 1e-143 | 65.95% (373) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1970 | lprM | 1e-148 | 69.23% (377) | MCE-family lipoprotein LprM |
| M. leprae Br4923 | MLBr_02593 | lprK | 6e-62 | 37.43% (342) | putative lipoprotein |
| M. abscessus ATCC 19977 | MAB_4149c | - | 2e-67 | 40.95% (337) | MCE-family protein LprN |
| M. marinum M | MMAR_2886 | lprM | 1e-152 | 70.56% (377) | MCE family lipoprotein LprM |
| M. avium 104 | MAV_2536 | - | 1e-133 | 61.74% (379) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0350 | - | 1e-149 | 66.67% (378) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_4336 | - | 1e-147 | 66.21% (367) | PUTATIVE MCE-family lipoprotein LprM_1 |
| M. ulcerans Agy99 | MUL_2866 | lprM | 1e-151 | 70.03% (377) | MCE family lipoprotein LprM |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2886|M.marinum_M -----MRVRHRRRVAPRLATVLVTMVTLAAVSGCGWRGLNSLPLPGTEGN
MUL_2866|M.ulcerans_Agy99 -----MRVRQRRRVAPRLATVLVTMVTLAAVSGCGWRGLNSLPLPGTEGN
Rv1970|M.tuberculosis_H37Rv -----MRIG------------LTLVMIAAVVASCGWRGLNSLPLPGTQGN
Mvan_0367|M.vanbaalenii_PYR-1 -----MTPLRR-----CLGAMLIPLTVLLATGCTQWRGLNSLPMPGTQGR
MSMEG_0350|M.smegmatis_MC2_155 -----MTHMRR----VVACAATVAALMIGVTGCSNWRGLNSVSLPGTEGG
Mflv_0648|M.gilvum_PYR-GCK -----MTGKRF----ARAAAVIMIALTVAGLSGCGFRGLNSFRLPGTQGQ
TH_4336|M.thermoresistible__bu --------MRS----ATVSALALVVLSAALLAGCGWQGLNSVPLPGTQGR
MAV_2536|M.avium_104 ---MSQSPLRR-----RVMAALLAAVALATLSGCGFRGLNSFNLPGTKGG
MAB_4149c|M.abscessus_ATCC_199 -----MSRN-------VLRAAVMGVGVAVVVSGCQFNGLNSLNLPGTAGH
Mb0179|M.bovis_AF2122/97 ---MMSVLARMRVMRHRAWQGLVLLVLALLLSSCGWRGISNVAIPGGPGT
MLBr_02593|M.leprae_Br4923 MRRAMSVVHTSRVR-HQTWRGLVMLVAALLLSSCGWRGISNVSIPGGPGS
. :.*:... :** *
MMAR_2886|M.marinum_M GPGSFVIQAQMPDVNNIQPNSRVRVADVTVGHVARIERQ-----GWHALV
MUL_2866|M.ulcerans_Agy99 GPGSFVIQAQMPDVNNIQPNSRVRVADVTVGHVARIERQ-----GWHALV
Rv1970|M.tuberculosis_H37Rv GPGSFAVQAQLPDVNNIQPNSRVRVADVTVGHVTKIERQ-----GWHALV
Mvan_0367|M.vanbaalenii_PYR-1 GDGSFLIQVQMPDVSNIEPNSRVRVGDVSVGTVTRIERQ-----DWHALL
MSMEG_0350|M.smegmatis_MC2_155 GPGAFDIQVQMPDITNLQPNSRVRVADVTVGTVTKVERQ-----GWHALL
Mflv_0648|M.gilvum_PYR-GCK GQGSYTIQAEMPDVETLQPNSRVRVGDVNVGTVTKIERR-----GWHALL
TH_4336|M.thermoresistible__bu GADAFTIQAQLPDVNNLQQNSRVRVGDVDVGTVAKIERQ-----GWHALV
MAV_2536|M.avium_104 GPGAYTIRAQMPDVQNLQRNSRVRVNDVTVGNVIDIELQ-----GWNALV
MAB_4149c|M.abscessus_ATCC_199 GSRSYTVTVELPDVTTLPQNSPVMVDDVTVGSVSGIDAFQKPDGSWYAGV
Mb0179|M.bovis_AF2122/97 GPGSYTIYVQMPDTLAINGNSRVMVADVWVGSIRAIKLK-----NWVATL
MLBr_02593|M.leprae_Br4923 GKGAYTIYVQVPDTLAINGNSKVMVADVTVGSIRAINLK-----NWVATL
* :: : .::** : ** * * ** ** : :. .* * :
MMAR_2886|M.marinum_M TIRLDAGVALPANATARIGTTSLLGSYHIELAAPKHEAPQGRLREGSLIP
MUL_2866|M.ulcerans_Agy99 TIRLDAGVALPANATARIGTTSLLGSYHIELAAPKHDAPQGRLRKGSLIP
Rv1970|M.tuberculosis_H37Rv TMRLDGDVDLPANATAKIGTTSLLGSYHIELAPPKGEARQGKLRDGSLIA
Mvan_0367|M.vanbaalenii_PYR-1 TVTLDGDVDLPANATVKLGQTSLLGSLHLELAPPTDEPPQGQLAAGSLIP
MSMEG_0350|M.smegmatis_MC2_155 TLRLNGDVNLPANCTATIGQTSLLGSLHVELAPPAAAPPQGRLHQGSLIP
Mflv_0648|M.gilvum_PYR-GCK TLALNGDVDLPANSTVSLGQTSLLGSLHIELAPPTDVRPAGKLRAGSLIP
TH_4336|M.thermoresistible__bu TIRLNGDVDLPANSTVTVGQTSLLGSLHVELAPPVDEPPQGSLRDGAFIP
MAV_2536|M.avium_104 TMTIDGDVDLPANATATLGQTSLLGSVHVELAPPAGVAPQGKLKNGSLIP
MAB_4149c|M.abscessus_ATCC_199 KVSLEPEVHLPANAVAKVAQTSLLGSQHIELAAPVGEPAVGKLTGGATIP
Mb0179|M.bovis_AF2122/97 TLSLKKDVTLPKNATAKIGQTSLLGSQHVELAAPPD-PSPVPLKDGDTIP
MLBr_02593|M.leprae_Br4923 TLGLNKDVQLPKNTTAKIGQTSLLGSQHVELAAPAN-PSLELLKNGDTIP
.: :. * ** * .. :. ****** *:***.* * * *.
MMAR_2886|M.marinum_M LSRGGAYPSTEQTLAALSLVLNGGGLGQVQDITEALSTAFRGREHDVRSL
MUL_2866|M.ulcerans_Agy99 LSRGGAYPSTEQTLAALSLVLNGGGLGQVQDITEALSTAFRGREHEVRSL
Rv1970|M.tuberculosis_H37Rv LSHGSAYPSTEQTLAALSLVLNGGGLGQVQDITEALSTAFAGREHDLRGL
Mvan_0367|M.vanbaalenii_PYR-1 LSHSGSYPSTEETLAAVSSVLNGGGLGHVQDITEAFSTAFRGREQDLRSL
MSMEG_0350|M.smegmatis_MC2_155 LADSTTHPTTEQTLAAVSMLLNGGGLGQMQDITKALSTALRGREADLRNL
Mflv_0648|M.gilvum_PYR-GCK LTSAGAYPSTEQTLASVSLLLNGGGVGQVQDITTALTSALGGREADFRSL
TH_4336|M.thermoresistible__bu LDSGGAYPSTEQTLAAVSLLLNGGGLGQVQDITRALSTAFGGREDELRSL
MAV_2536|M.avium_104 LSSAGAYPSTERTLAAVSLLLNGGGLGQVQDITKTLSTAFSGREQDLRNL
MAB_4149c|M.abscessus_ATCC_199 LSRTGKYPSTEEVLSALSVVVNKGNLGALQDITDETYNLFKGRTGNLTQV
Mb0179|M.bovis_AF2122/97 LKRSSAYPTTEQTLASIATLLRGGGLVNLEGIQQEINAIVTGRADQIRAF
MLBr_02593|M.leprae_Br4923 LKNSSVFPTTEQTLASLSLILRGGGIPNLETLTNEVFNIFHGRADQIHAF
* .*:**..*:::: ::. *.: :: : . ** :. .
MMAR_2886|M.marinum_M IAQLDSFTATLDDQSDDIIEATESLNRLVGKFAEQQPVLDRALATIPDAL
MUL_2866|M.ulcerans_Agy99 IAQLDSFTATLDDQSDDIIEATESLNRLVGKFAEQQPVLDRALATIPDAL
Rv1970|M.tuberculosis_H37Rv IGQLDTFTAYLNNQSGDIIAATDSLNRLVGKFADQQPVFDRALATIPDAL
Mvan_0367|M.vanbaalenii_PYR-1 IGELDTFTADLDDQTPDIIAATDSLNQLASKFAARKPVLDRALETIPDAL
MSMEG_0350|M.smegmatis_MC2_155 IGQLETFVAKTNDQTGDIIEATEKLNRLTGKFAAQQPVVDKAVRTIPDAL
Mflv_0648|M.gilvum_PYR-GCK LTQLDTFTANVNGQIGDIIAATQSLNDLVAQFAAQKPIIDKALETIPDAL
TH_4336|M.thermoresistible__bu MSRLETFTSRINDQTDDVIAATEALNRLVAQFSSQRPVVDKALDTIPAAL
MAV_2536|M.avium_104 LNQLDTFVGYLNDQKSDIIAATDHLNNLVGQFADQKPIIDKALKTIPQAL
MAB_4149c|M.abscessus_ATCC_199 LPKLATLISSLNSQRDDIISAIEGIDKFSRVLAEHKESLGRAIDSIEPAL
Mb0179|M.bovis_AF2122/97 LGKLDTFTDELNQQRDDITRAIDSTNRLLAYVGGRSEVLNRVLTDLPPLI
MLBr_02593|M.leprae_Br4923 LTKLDTFASQLNQQRDDITHAIDSTNRLLTYVGGRSDVLDQILTDIPPLI
: .* :: : * *: * : : : .. : ..: : : :
MMAR_2886|M.marinum_M TVLNDERDKLVTAADQLSKFSALTADSVNKTKANLVSELQQLGPVLESLA
MUL_2866|M.ulcerans_Agy99 AVLNDERDKLVTAADQLSKFSALTADSVNKTKANLVSELRQLGPVLESLA
Rv1970|M.tuberculosis_H37Rv AVLADERDTLVEAAEQLSKFSALTVDSVNKTTANLVTELRQLGPVLESLA
Mvan_0367|M.vanbaalenii_PYR-1 AELNQQKEDLINAADQFAKFSALTVDTVNQTKDNLVAQLQQIGPVLESLA
MSMEG_0350|M.smegmatis_MC2_155 EVLKDQRDNLTAALDQLGRFSALAADSTRQTKDSLVREFRNIGPVLESLA
Mflv_0648|M.gilvum_PYR-GCK AVINAERDQLVEAVDQLGKFSALAADTVNQSQESLIQILNDMGPVLESLA
TH_4336|M.thermoresistible__bu AVLNSEREELIEAVEELGTFNELAADTIDQTRDAVVEELRDMGPVLESLA
MAV_2536|M.avium_104 TVLKDERENLANALGEVGQLSALAADSVNKTKENLIKELKDLGPVLQSLA
MAB_4149c|M.abscessus_ATCC_199 KVLNENRANIIEAFRSVGNLAKITDRVLRTTKDDIVADLKGLYPVVRALA
Mb0179|M.bovis_AF2122/97 KHFADKQELLINASDAVGRLSQSADQYLSAARGDLHQDLQALQCPLKELR
MLBr_02593|M.leprae_Br4923 KHFADTKNLLINAVGSVGQLSQAVDQYLSEARGPLHTDLQALACPLRELG
: : : * .. : . : : :. : :. *
MMAR_2886|M.marinum_M NAGPSLTRSLSLLATFPFPNETFQNFQRGDYANLTAIVDLTLSRIDQGLL
MUL_2866|M.ulcerans_Agy99 NAGPSLTRSLSLLATFPFPNETFQNFQRGDYANLTAIVDLTLSRIDQGLL
Rv1970|M.tuberculosis_H37Rv NSGPALTRSLSLLATFPFPNETFQNFQRGEYANLTAIVDLTLSRIDQGLL
Mvan_0367|M.vanbaalenii_PYR-1 DAGPSLTRSLSLIPTFPFPNETIENWQRGDYANLTAIVDLTLSRIDAGLF
MSMEG_0350|M.smegmatis_MC2_155 NAGPNMTRALSILTTYPFPNETLEKWLRGDYGNMTAIVDLTLSRIDAGFF
Mflv_0648|M.gilvum_PYR-GCK NAGPALTRSLNLFTTIPFVKDNLTKWWRGDYANITTIVDLTLSRIDAGLF
TH_4336|M.thermoresistible__bu NAGPALTRSLSLFTTFPFPKETLTKWMRGDYANITVVADLTLSRMDSALF
MAV_2536|M.avium_104 DAGPALTRSLGFLGTFPFPAETLSKWIRGDYANLTAVIDLTLSRLDASFL
MAB_4149c|M.abscessus_ATCC_199 ENRDVLIDSLDLLPTFPFSTKYLRNAVRGDYLNVFVTFDLTARRLGETLF
Mb0179|M.bovis_AF2122/97 RAAPYLVGALKLILTQPFDVDTVPQLVRGDYMNLSLTLDLTYSAIDNAFL
MLBr_02593|M.leprae_Br4923 RGAPYFIGAMKLILTQPYDVDTVPKIMRGDYQNVSLTLDVTYSAMDNAVL
: :: :: * *: . . : **:* *: *:* :. .:
MMAR_2886|M.marinum_M TGTRWECHLTELELQWGRTIGQFPSPCTAGYRGTPGNPLTVPYHWDQGP-
MUL_2866|M.ulcerans_Agy99 TGTRWECHLTELELQWGRTIGQFPSPCTAGYRGTPGNPLTVPYHWDQGP-
Rv1970|M.tuberculosis_H37Rv TGTRWECHLTQLELQWGRTIGQFPSPCTAGYRGTPGNPLTIAYRWDQGP-
Mvan_0367|M.vanbaalenii_PYR-1 TGTRWEGDLTELEMQWGRTIGQFPSPYTQ------GNPLVAPYRWDQGP-
MSMEG_0350|M.smegmatis_MC2_155 TGTRWEGDLTELEMQWGRTIGQLPSPYTA------VNPLVAPYRWDQGR-
Mflv_0648|M.gilvum_PYR-GCK TGTRFEGHLTELELQWGRTIGQLPSPYTA------RNPLIVPYRLDQGP-
TH_4336|M.thermoresistible__bu TGTRWEGDLTELEMQWGRTIGQLPSPYTA------ANPLLAPYRWNQGP-
MAV_2536|M.avium_104 TGTRFECNLTELELQWGRTIGQLPSPCTGGGPYNPGNPLVVPYHFDQGR-
MAB_4149c|M.abscessus_ATCC_199 TTSFFDPNMQHFNDVVNPPEWLIGSMANLNGKETSPFDLPAPAAPQGGGR
Mb0179|M.bovis_AF2122/97 TGTGFSGALRALEQSFGRDPETMIPDIRYTPNPNDAPGGPLVERGNRQC-
MLBr_02593|M.leprae_Br4923 TGTGLSGALRALEQSFGRDPETMIPDVRYTTNPNDAPGGPLVERADRRC-
* : . : :: . : . :