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MEKPAATPSAGYRALVVDDEVPLAEVVASYLRREQFDVSLAHSGADALAQAREIDPDVVILDLALPGIDG VEVCRQLRTFSDAYVVMLTARDTEMDTIVGLSVGADDYVTKPFSPRELVARIRAMLRRPRTVATPISAAT AADEPPPRAFGPLAIDVAGRQVFIDDEPVLLTRTEFDILAALSSRPAVVFSRRQLLEAVWGDSWGGNEHL VDVHIGHLRRKLADDPADPRYVITVRGVGYRMGSGQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3674 | - | - | 100% (246) | two component transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_1834 | - | 4e-99 | 72.98% (248) | two component transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_1752 | - | 3e-51 | 46.55% (232) | two component transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3274c | mtrA | 3e-51 | 46.12% (232) | two component sensory transduction transcriptional |
| M. gilvum PYR-GCK | Mflv_0893 | - | 2e-98 | 73.09% (249) | two component transcriptional regulator |
| M. tuberculosis H37Rv | Rv3246c | mtrA | 4e-51 | 46.12% (232) | two component sensory transduction transcriptional |
| M. leprae Br4923 | MLBr_00773 | mtrA | 3e-51 | 46.12% (232) | putative two-component response regulator |
| M. abscessus ATCC 19977 | MAB_3339 | - | 5e-99 | 72.61% (241) | putative sensory transduction protein |
| M. marinum M | MMAR_1299 | mtrA | 7e-51 | 46.12% (232) | two-component sensory transduction transcriptional |
| M. avium 104 | MAV_4209 | - | 4e-51 | 46.12% (232) | DNA-binding response regulator MtrA |
| M. smegmatis MC2 155 | MSMEG_1874 | mtrA | 5e-52 | 46.98% (232) | DNA-binding response regulator MtrA |
| M. thermoresistible (build 8) | TH_4129 | - | 1e-52 | 46.98% (232) | PUTATIVE DNA-binding response regulator MtrA |
| M. ulcerans Agy99 | MUL_2582 | mtrA | 1e-50 | 45.69% (232) | two component sensory transduction transcriptional |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_00773|M.leprae_Br4923 -------MD----------IMRQRILVVDDDASLAEMLTIVLRGEGFDTA
MMAR_1299|M.marinum_M --------------------MRQRILVVDDDASLAEMLTIVLRGEGFDTA
MUL_2582|M.ulcerans_Agy99 -------MD----------TMRQRILVVDDDASLAEMLTIVLRGEGFDTA
Mb3274c|M.bovis_AF2122/97 -------MD----------TMRQRILVVDDDASLAEMLTIVLRGEGFDTA
Rv3246c|M.tuberculosis_H37Rv -------MD----------TMRQRILVVDDDASLAEMLTIVLRGEGFDTA
MAV_4209|M.avium_104 -------MD----------SMRQRILVVDDDASLAEMLTIVLRGEGFDTA
MSMEG_1874|M.smegmatis_MC2_155 -------MD----------TMRQRILVVDDDPSLAEMLTIVLRGEGFDTA
TH_4129|M.thermoresistible__bu LSRFGDNMD----------TMRQRILVVDDDPSLAEMLTIVLRGEGFDTA
Mvan_3674|M.vanbaalenii_PYR-1 -------MEKPAATP----SAGYRALVVDDEVPLAEVVASYLRREQFDVS
Mflv_0893|M.gilvum_PYR-GCK ----MMTMDHHPGTPPE-RAKGYRALVVDDELPLAEVVASYLEREQFEAV
MAB_3339|M.abscessus_ATCC_1997 -------MDGSSRTAAAGPVPDYRALVVDDEVPLAEVVASYLKRESFEVH
* *****: .***::: *. * *:.
MLBr_00773|M.leprae_Br4923 VIGDGTQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLT
MMAR_1299|M.marinum_M VIGDGTQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLT
MUL_2582|M.ulcerans_Agy99 VIGDGTQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLT
Mb3274c|M.bovis_AF2122/97 VIGDGTQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLT
Rv3246c|M.tuberculosis_H37Rv VIGDGTQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLT
MAV_4209|M.avium_104 VIGDGTQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLT
MSMEG_1874|M.smegmatis_MC2_155 VIGDGSQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLT
TH_4129|M.thermoresistible__bu VIGDGSQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLT
Mvan_3674|M.vanbaalenii_PYR-1 LAHSGADALAQAREIDPDVVILDLALPGIDGVEVCRQLRTFSDAYVVMLT
Mflv_0893|M.gilvum_PYR-GCK VADNGVDAIAVARDLDPDVVILDIGLPGIDGLEVCRQLRTFSDAYVVMLT
MAB_3339|M.abscessus_ATCC_1997 LAHDGRRALDLAREVDPDVVILDIGLPGVDGIEVCRQLRVFSDAYVVMLT
: .* *: .*:: **:*:**: ***::*::*** **. *.. :****
MLBr_00773|M.leprae_Br4923 AKTDTVDVVLGLESGADDYIMKPFKPKELVARVRARLRR-----------
MMAR_1299|M.marinum_M AKTDTVDVVLGLESGADDYIMKPFKPKELVARVRARLRR-----------
MUL_2582|M.ulcerans_Agy99 AKTDTVDVVLGLESGADDYIMKPFKPKELVARVRARLRR-----------
Mb3274c|M.bovis_AF2122/97 AKTDTVDVVLGLESGADDYIMKPFKPKELVARVRARLRR-----------
Rv3246c|M.tuberculosis_H37Rv AKTDTVDVVLGLESGADDYIMKPFKPKELVARVRARLRR-----------
MAV_4209|M.avium_104 AKTDTVDVVLGLESGADDYIMKPFKPKELVARVRARLRR-----------
MSMEG_1874|M.smegmatis_MC2_155 AKTDTVDVVLGLESGADDYVMKPFKPKELVARVRARLRR-----------
TH_4129|M.thermoresistible__bu AKSDTVDVVLGLESGADDYVVKPFKPKELVARVRARLRR-----------
Mvan_3674|M.vanbaalenii_PYR-1 ARDTEMDTIVGLSVGADDYVTKPFSPRELVARIRAMLRRPRTVATPISAA
Mflv_0893|M.gilvum_PYR-GCK ARDTEIDTVLGLTVGADDYITKPFSPRELVARIRAMLRRPRVLQS-ATAT
MAB_3339|M.abscessus_ATCC_1997 ARDTEVDTIVGLSVGADDYVTKPFSPREVVARVRAMLRRPRRAPE-SPAA
*: :*.::** *****: ***.*:*:***:** ***
MLBr_00773|M.leprae_Br4923 NDDEPAEMLSIADVDIDVPAHKVTRNGEHISLTPLEFDLLVALARKPRQV
MMAR_1299|M.marinum_M NDDEPAEMLSIADVDIDVPAHKVTRNGEQISLTPLEFDLLVALARKPRQV
MUL_2582|M.ulcerans_Agy99 NDDEPAEMLSIADVDIDVPAHKATRNGEQISLTPLEFDLLVALARKPRQV
Mb3274c|M.bovis_AF2122/97 NDDEPAEMLSIADVEIDVPAHKVTRNGEQISLTPLEFDLLVALARKPRQV
Rv3246c|M.tuberculosis_H37Rv NDDEPAEMLSIADVEIDVPAHKVTRNGEQISLTPLEFDLLVALARKPRQV
MAV_4209|M.avium_104 NDDEPAEMLSIADVEIDVPAHKVTRNGEQISLTPLEFDLLVALARKPRQV
MSMEG_1874|M.smegmatis_MC2_155 NEDEPAEMLSIGDVEIDVPAHKVTRQGEQISLTPLEFDLLVALARKPRQV
TH_4129|M.thermoresistible__bu NEDEPAEMLSIGDIDIDVPAHKVTRNGEQIQLTPLEFDLLVALARKPRQV
Mvan_3674|M.vanbaalenii_PYR-1 TAADEPPPRAFGPLAIDVAGRQVFIDDEPVLLTRTEFDILAALSSRPAVV
Mflv_0893|M.gilvum_PYR-GCK AGIDVAPPRRFGALSIDVAAREVRIDDEQILLTRTEFDILEALSGRPGNV
MAB_3339|M.abscessus_ATCC_1997 VTPELSPPRVFGALRINVDGREVHVGERPVTLTRTEFDVLAALSSRPGIV
: . :. : *:* .::. . : ** ***:* **: :* *
MLBr_00773|M.leprae_Br4923 FTRDVLLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPTVVLTVRGVG
MMAR_1299|M.marinum_M FTRDVLLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPTVVLTVRGVG
MUL_2582|M.ulcerans_Agy99 FTRDVLLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPTVVLTVRGVG
Mb3274c|M.bovis_AF2122/97 FTRDVLLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPTVVLTVRGVG
Rv3246c|M.tuberculosis_H37Rv FTRDVLLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPTVVLTVRGVG
MAV_4209|M.avium_104 FTRDVLLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPTVVLTVRGVG
MSMEG_1874|M.smegmatis_MC2_155 FTRDVLLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPQVVLTVRGVG
TH_4129|M.thermoresistible__bu FTRDVLLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPQVVLTVRGVG
Mvan_3674|M.vanbaalenii_PYR-1 FSRRQLLEAVWGDSWGGNEHLVDVHIGHLRRKLADDPADPRYVITVRGVG
Mflv_0893|M.gilvum_PYR-GCK LSRRQLLEIVRDGPWVGNEHLVDVHIGHLRRKLGDDAASPRYIATVRGVG
MAB_3339|M.abscessus_ATCC_1997 LSRKQLLDTVWGDTWVGNDNIVDVHVGHLRQKLGDSPSQPRYVMTVRGVG
::* **: * . .: .:*:**: :** *: ... .* : ******
MLBr_00773|M.leprae_Br4923 YKAGPP-
MMAR_1299|M.marinum_M YKAGPP-
MUL_2582|M.ulcerans_Agy99 YKAGPP-
Mb3274c|M.bovis_AF2122/97 YKAGPP-
Rv3246c|M.tuberculosis_H37Rv YKAGPP-
MAV_4209|M.avium_104 YKAGPP-
MSMEG_1874|M.smegmatis_MC2_155 YKAGPP-
TH_4129|M.thermoresistible__bu YKAGPP-
Mvan_3674|M.vanbaalenii_PYR-1 YRMGSGQ
Mflv_0893|M.gilvum_PYR-GCK YRMGSGQ
MAB_3339|M.abscessus_ATCC_1997 YRMGTGS
*: *.