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LADLVAAVAAGGGGAPDVQVTGVTLRGQDAQPGDLFAALPGSRAHGGRYAAEAVGRGAVAVLTDAAGEAE IASRGAPDVPVLVHPDPRAVLGELASAVYGRPSQHLRVIGVTGTSGKTTTTYLVEAGLRAAGRVAGLIGT VGVRIDGRQQPGGLTTPEAPELQALLATMLEQGVDTVVMEVSSHALTLGRVDGVSFAVGGFTNLSRDHLD FHPTMEDYFDAKARLFDPACATHAARSVICVDDEWGRAMAARARRPVTVSTTGPADWRAEQVRSAGGGAQ DFVAVDPAGVHHGLEIGLPGGYNVANCLLAIALLDAVGVSPEQAAPGVRDATVPGRLESVDRGQPFLALV DYAHKPGALRAVLQTLREQCTGRLAVVFGAGGNRDQGKREPMGRVAAELADLVVVTDDNPRDEDPAVIRA AILAGAAGARAEVVEIGDRRAAIGHAAGWARAGDIVLIAGKGHEAGQTSGGQTRPFDDRDELAAALEARG ARGAGG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3528 | murE | - | 100% (497) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase |
| M. vanbaalenii PYR-1 | Mvan_3527 | - | 1e-19 | 28.54% (487) | UDP-N-acetylmuramoylalanyl-D-glutamyl-2, |
| M. vanbaalenii PYR-1 | Mvan_3522 | murC | 5e-18 | 27.86% (499) | UDP-N-acetylmuramate--L-alanine ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2182c | murE | 0.0 | 69.49% (495) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate |
| M. gilvum PYR-GCK | Mflv_2983 | murE | 0.0 | 84.07% (496) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate |
| M. tuberculosis H37Rv | Rv2158c | murE | 0.0 | 69.49% (495) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate |
| M. leprae Br4923 | MLBr_00909 | murE | 1e-180 | 66.26% (495) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate |
| M. abscessus ATCC 19977 | MAB_2001 | murE | 1e-174 | 65.06% (498) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate |
| M. marinum M | MMAR_3198 | murE | 0.0 | 70.62% (497) | UDP-N-acetylmuramoylalanyl-D-glutamate-2,6- diaminopimelate |
| M. avium 104 | MAV_2331 | murE | 0.0 | 70.38% (503) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate |
| M. smegmatis MC2 155 | MSMEG_4232 | murE | 0.0 | 74.45% (501) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate |
| M. thermoresistible (build 8) | TH_1516 | - | 4e-09 | 31.21% (157) | Probable UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD |
| M. ulcerans Agy99 | MUL_3506 | murE | 0.0 | 70.02% (497) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3528|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2983|M.gilvum_PYR-GCK ----------------------------------------------MNLR
MSMEG_4232|M.smegmatis_MC2_155 --------------------------------------------MAMKLR
Mb2182c|M.bovis_AF2122/97 --------------------MSSLARGISR---RRTEVATQVEAAPTGLR
Rv2158c|M.tuberculosis_H37Rv --------------------MSSLARGISR---RRTEVATQVEAAPTGLR
MMAR_3198|M.marinum_M --------------------------------------MSEVESV---LR
MUL_3506|M.ulcerans_Agy99 MGSRRGAGWVRHRVVTGRDWVGCHGRPVSPGVGRRTEVVSEVESV---LR
MAV_2331|M.avium_104 -----------------------------------------MVSVPTGLR
MLBr_00909|M.leprae_Br4923 --------------------------------------MTEVVAVPVRLR
MAB_2001|M.abscessus_ATCC_1997 -----------------------------------------MAASGTHRF
TH_1516|M.thermoresistible__bu --------------------------------------------------
Mvan_3528|M.vanbaalenii_PYR-1 ----------MLADLVAAVAAG-----GGGAPDVQVTGVTLRGQDAQPGD
Mflv_2983|M.gilvum_PYR-GCK PSHPVGMPLGALADLVCAEPAD-----AGPVPDLQVTGVTLRGQHAQAGD
MSMEG_4232|M.smegmatis_MC2_155 PSRPVGHHLAPLAAAVGAVASENPAGSSSDLAAVHVTGVTLRGQDAQPGD
Mb2182c|M.bovis_AF2122/97 PNAVVGVRLAALADQVGAALAEG-PAQRAVTEDRTVTGVTLRAQDVSPGD
Rv2158c|M.tuberculosis_H37Rv PNAVVGVRLAALADQVGAALAEG-PAQRAVTEDRTVTGVTLRAQDVSPGD
MMAR_3198|M.marinum_M PSAGPGVPLAELAVQVGAVLADG-PHRAAAVPDTLITGMTLRAQAVQPGD
MUL_3506|M.ulcerans_Agy99 PSAGPGVPLAELAVQVGAVLADG-PHRAAAVPDTLITGMTLRAQAVQPGD
MAV_2331|M.avium_104 PSAVPGVRLPALADQVGAVMAG--PDRRAAVPDVTVTGVTLRAQDVLPGD
MLBr_00909|M.leprae_Br4923 PSATAGVRLPELVAQVGAVLADG-PGQAATVPDIPVTGVTLRAQEVLSGD
MAB_2001|M.abscessus_ATCC_1997 LPRTHQHLVSDLASLVSAELHGP--------SATTVGGVTLRAQDARTGD
TH_1516|M.thermoresistible__bu --------------------------------------------------
Mvan_3528|M.vanbaalenii_PYR-1 LFAALPGSRAHGGRYAAEAVGRGAVAVLTDAAGEAEIASR--GAPDVPVL
Mflv_2983|M.gilvum_PYR-GCK LFAALPGSKAHGARYAADAVERGAVAVLTDADGVSEIAAH--GGPAVPIL
MSMEG_4232|M.smegmatis_MC2_155 LFAALPGASAHGARFAADAVAAGAVAVLTDPSGADLLA----GTLDVPVL
Mb2182c|M.bovis_AF2122/97 LFAALTGSTTHGARHVGDAIARGAVAVLTDPAGVAEIAGR----AAVPVL
Rv2158c|M.tuberculosis_H37Rv LFAALTGSTTHGARHVGDAIARGAVAVLTDPAGVAEIAGR----AAVPVL
MMAR_3198|M.marinum_M LFAALAGSATHGARHAADAIERGAVAVLTDPAGVTAISALGCVPGTVPVL
MUL_3506|M.ulcerans_Agy99 LFAALAGSATHGARHTADAIERGAVAVLTDPAGVTAISALGCVPGTVPVL
MAV_2331|M.avium_104 LFAALPGATTHGARHAAEAIERGAVAVLTDAAGVAQLTGG----RTTPTL
MLBr_00909|M.leprae_Br4923 LFAALAGASTHGARYAGVALERGAVAVLTDVAGVAELTAQ---ASSVPIL
MAB_2001|M.abscessus_ATCC_1997 LFAALPGTSTHGAQFASEAVSAGAAAVLTDAAGAELVAGQG---LDIAVL
TH_1516|M.thermoresistible__bu ------------------------------------------------XP
Mvan_3528|M.vanbaalenii_PYR-1 VHPDPRAVLGELASAVYGRPSQHLRVIGVTGTSGKTTTTYLVEAGLRAAG
Mflv_2983|M.gilvum_PYR-GCK VHPAPRSVLGEVAAAVFGRPSEHLRVIGVTGTSGKTTTTYLVEAGLRSAG
MSMEG_4232|M.smegmatis_MC2_155 VHPAPRSVLGEAAAIVYGRPAERLRVVGVTGTSGKTTTTYLAEAGLRAAG
Mb2182c|M.bovis_AF2122/97 VHPAPRGVLGGLAATVYGHPSERLTVIGITGTSGKTTTTYLVEAGLRAAG
Rv2158c|M.tuberculosis_H37Rv VHPAPRGVLGGLAATVYGHPSERLTVIGITGTSGKTTTTYLVEAGLRAAG
MMAR_3198|M.marinum_M VHPAPRGVLGEAAALVYGHPSDRLTVVGITGTSGKTTTTYLVEAGLRAAG
MUL_3506|M.ulcerans_Agy99 VHPAPRGVLGEAAALVYGHPSDRLTVVGITGTSGKTTTTYLVEAGLRAAG
MAV_2331|M.avium_104 LHPRPRSVLGELAAAVYAHPSERLTVIGITGTSGKTTTTYLVESGLRAAG
MLBr_00909|M.leprae_Br4923 IHPEPRSVLGGLAAAAYGHPSNRMTVVGITGTSGKTTTTYMVEAGLRAGG
MAB_2001|M.abscessus_ATCC_1997 VHPVPRSVLGELAATVYGEPSRHLQVVGVTGTSGKTTTTYLVEAGLRAAG
TH_1516|M.thermoresistible__bu VWGDVELAWRLDAAGRFGAPRRWLVVT---GTNGKTTTTSMLQAMLLADG
: . . *: :. * : * **.****** : :: * : *
Mvan_3528|M.vanbaalenii_PYR-1 RVAGLIGTVGVRIDGRQQPGGLTTPEAPELQALLATMLEQGVDTVVMEVS
Mflv_2983|M.gilvum_PYR-GCK RVAGLIGTVGVRIDGRAQPGGLTTPEAPDLQALLAAMLEQGVDTVVMEVS
MSMEG_4232|M.smegmatis_MC2_155 RVAGLIGTVGVRIDGTDLPSALTTPEAPALQALLALMVERGVDTVVMEVS
Mb2182c|M.bovis_AF2122/97 RVAGLIGTIGIRVGGADLPSALTTPEAPTLQAMLAAMVERGVDTVVMEVS
Rv2158c|M.tuberculosis_H37Rv RVAGLIGTIGIRVGGADLPSALTTPEAPTLQAMLAAMVERGVDTVVMEVS
MMAR_3198|M.marinum_M RVAGLIGTIGIRIDGADIPSTLTTPEAPALQAMLAAMVERGVDTVVMEVS
MUL_3506|M.ulcerans_Agy99 RVAGLIGTIGIRIDGADIPSTLTTPEAPTLQAMLAAMVERGVDTVVMEVS
MAV_2331|M.avium_104 RTAGLIGTVGIRIDGADIPSALTTPEAPALQALLAAMAEQRVDTVVMEVS
MLBr_00909|M.leprae_Br4923 RVVGLVGTIGIRIDGADIPSFLTTPEAPALQAMLAAMVERGVETVVMEVS
MAB_2001|M.abscessus_ATCC_1997 KRVGLIGTVGVRIDGEDVPSALTTPEAPALQELLAEMVQRGVDTVVMEVS
TH_1516|M.thermoresistible__bu RRSALCGNIGN--------------------PVLDVLTEP-VDLFAVELS
: .* *.:* :* : : *: ..:*:*
Mvan_3528|M.vanbaalenii_PYR-1 SHALTLGRVDGVSFAVGGFTNLSRDHLDFHPTMEDYFDAKARLFDPACAT
Mflv_2983|M.gilvum_PYR-GCK SHALTLGRVDGVSFAVGGFTNLSRDHLDFHPTMQDYFEAKARLVDPTSPT
MSMEG_4232|M.smegmatis_MC2_155 SHALAQGRVDGIGFAVGGFTNLSRDHLDFHPTMADYFEAKARLFDPQSPN
Mb2182c|M.bovis_AF2122/97 SHALALGRVDGTRFAVGAFTNLSRDHLDFHPSMADYFEAKASLFDPDSAL
Rv2158c|M.tuberculosis_H37Rv SHALALGRVDGTRFAVGAFTNLSRDHLDFHPSMADYFEAKASLFDPDSAL
MMAR_3198|M.marinum_M SHALTLGRVDGIRFAVGGFTNLSRDHLDFHPTMADYFEAKALLFDPASAL
MUL_3506|M.ulcerans_Agy99 SHALTLGRVDGIRFAVGGFTNLSRDHLDFHPTMADYFEAKALLFDPASAL
MAV_2331|M.avium_104 SHALALGRVDGTRFAVGGFTNLSRDHLDFHPTMADYFEAKALLFDPNSPL
MLBr_00909|M.leprae_Br4923 SHALSLGRVEGTQFAVAGFTNLSRDHLDFHPDMEEYFEAKAVLFDPHSLL
MAB_2001|M.abscessus_ATCC_1997 SHALALNRVDGTRFAVGAFTNLSRDHLDFHPDMQDYFATKARLFRRDSPQ
TH_1516|M.thermoresistible__bu --SFQLHWAPSVRPYAGVVLNIAEDHLDWHGSLTAYAQAKARVLG-----
:: . . .. . *::.****:* : * :** :.
Mvan_3528|M.vanbaalenii_PYR-1 HAARSVICVDDEWGRAMAARARRP----VTVS-TTG-PADWRAEQVRSAG
Mflv_2983|M.gilvum_PYR-GCK HAARSVICVDDEWGRAMAARADAP----VTVS-VTG-DADWWVQEVRALD
MSMEG_4232|M.smegmatis_MC2_155 HAAAAVICVDDQYGVQMAARAETP----LTVS-TSGAAADWRVEKITTAG
Mb2182c|M.bovis_AF2122/97 RARTAVVCIDDDAGRAMAARAADA----ITVS-AADRPAHWRATDVAPTD
Rv2158c|M.tuberculosis_H37Rv RARTAVVCIDDDAGRAMAARAADA----ITVS-AADRPAHWRATDVAPTD
MMAR_3198|M.marinum_M RGHSVVVCIDDEAGRAMADRAGAA----ITVS-ATGQPAHWRATDVAPVG
MUL_3506|M.ulcerans_Agy99 RGHSVVVCIDDEAGRAMADRAGVA----ITVS-ATGQPAHWRATDVAPVG
MAV_2331|M.avium_104 RAHRAVVCIDDEAGREMAARAGDA----VTVS-AEGQPAHWRAVEVAPLG
MLBr_00909|M.leprae_Br4923 RARTVVVCIDDDAGRATAARAGDA----ITVS-ALGQPASWRATDIRSPG
MAB_2001|M.abscessus_ATCC_1997 RAHRSVVCIDDDAGRAMAELAREAGPDVTTVSSLDGGVADWRCSNVAVGH
TH_1516|M.thermoresistible__bu -GTVAVAGVDDPMAARLLAAAAAP-----------------RKVGFRLGA
. * :** . * . .
Mvan_3528|M.vanbaalenii_PYR-1 GGAQDFVAVDPAGVHHGLEIGLPGGYNVANCLLAIALLDAVGVSPEQAAP
Mflv_2983|M.gilvum_PYR-GCK GGVQDFLAVDPAGVHHALEIGLPGGYNVANCLLAVALLDAVDVSPEQAAP
MSMEG_4232|M.smegmatis_MC2_155 PGAQEFVLVDPGGMHHQLGVGLPGRYNVANAALAVALLDAVGVSPEQAAP
Mb2182c|M.bovis_AF2122/97 AGGQQFTAIDPAGVGHHIGIRLPGRYNVANCLVALAILDTVGVSPEQAVP
Rv2158c|M.tuberculosis_H37Rv AGGQQFTAIDPAGVGHHIGIRLPGRYNVANCLVALAILDTVGVSPEQAVP
MMAR_3198|M.marinum_M AGGQEFTALDPAGVGHRVRIGLPGHYNVANCLLALAILDAVGVSPEQAAP
MUL_3506|M.ulcerans_Agy99 AGGQEFTALDPAGVGHRVRIGSPGHYNVSNCLLALAILDAVGVSPEQAAP
MAV_2331|M.avium_104 TGGQQFTVIDPAGVQHRAGIRLPGHYNVANCLVALALLDAVGVSPEQAAP
MLBr_00909|M.leprae_Br4923 VGAQEFTAVDPAGVQHRVGIRLPGRYNVANCLVALAILDVVGVSPEQASL
MAB_2001|M.abscessus_ATCC_1997 DGGQRFVANGP-DRDTELTIALPGHYNVANCLVAIAILDVLGVSAATAAP
TH_1516|M.thermoresistible__bu PAADELGVADGMLVDRAFADGLP-----------LVAVDRIPVAXX----
. : : . * :. :* : *:
Mvan_3528|M.vanbaalenii_PYR-1 GVRDATVPGRLESVDRGQPFLALVDYAHKPGALRAVLQTLREQCTGRLAV
Mflv_2983|M.gilvum_PYR-GCK GLRDATVPGRLEAVDRGQPFLALVDYAHKPGALAAVLQTLREQCAGRLAV
MSMEG_4232|M.smegmatis_MC2_155 GLRTATVPGRLESIDLGQDFLALVDYAHKPGALQAVLETLRAAEPRRIAV
Mb2182c|M.bovis_AF2122/97 GLREIRVPGRLEQIDRGQGFLALVDYAHKPEALRSVLTTLAHP-DRRLAV
Rv2158c|M.tuberculosis_H37Rv GLREIRVPGRLEQIDRGQGFLALVDYAHKPEALRSVLTTLAHP-DRRLAV
MMAR_3198|M.marinum_M GLRETRVPGRLEQVDRGQDFLALVDYAHKPGALREVLSTLRNP-QRRLAV
MUL_3506|M.ulcerans_Agy99 GLRETRVPGRLEQVDRGQDFLALVDYAHKPGALREVLSTLRNP-QRRLAV
MAV_2331|M.avium_104 GLLQTRVPGRMEEIDAGQDFLALVDYAHKPGALRAVLSSLKRP-DRRLAV
MLBr_00909|M.leprae_Br4923 GFRDIRIPGRLERIDCGQDFLALVDYAHKPGALHSVLTALLQP-DHRLAV
MAB_2001|M.abscessus_ATCC_1997 GIATAGVPGRMEAVAAGQPFLAVVDYAHKPGALRAVLESLRSHRDGRLAV
TH_1516|M.thermoresistible__bu -----------------------------------------------XXR
Mvan_3528|M.vanbaalenii_PYR-1 VFGAGGNRDQGKREPMGRVAAELADLVVVTDDNPRDEDPAVIRAAILAGA
Mflv_2983|M.gilvum_PYR-GCK VFGAGGDRDQGKREPMGRVAAELADLVVVTDDNPRGEDPAVIRAAILRGA
MSMEG_4232|M.smegmatis_MC2_155 VFGAGGDRDPGKREPMGRVTAELADLVVVTDDNPRSEDPATIRSAILAGA
Mb2182c|M.bovis_AF2122/97 VFGAGGDRDPGKRAPMGRIAAQLADLVVVTDDNPRDEDPTAIRREILAGA
Rv2158c|M.tuberculosis_H37Rv VFGAGGDRDPGKRAPMGRIAAQLADLVVVTDDNPRDEDPTAIRREILAGA
MMAR_3198|M.marinum_M VFGAGGDRDPGKRGPMGRIAAELADLVVVTDDNPRGEDPGAIRRTIVAGA
MUL_3506|M.ulcerans_Agy99 VFGAGGDRDPGKRGPMGRIAAELADLVVVTDDNPRGEDPGAIRRTIVAGA
MAV_2331|M.avium_104 VFGAGGERDPGKRAPMGATAAELADLVVVTDDNPRGEDPAAIRREILAGA
MLBr_00909|M.leprae_Br4923 VFGAGGERDPGKRAPMGEIAAELADLVVVTDDNPRGEDPAAIRRDILTGT
MAB_2001|M.abscessus_ATCC_1997 VFGAGGNRDRGKRADMGKVAAELADLVVVTDDNPRNEEPAAIRTEIISGT
TH_1516|M.thermoresistible__bu VLHGEVDPHPARR-------------------------------------
*: . : . .:*
Mvan_3528|M.vanbaalenii_PYR-1 AGAR--AEVVEIGDRRAAIGHAAGWARAGDIVLIAGKGHEAGQTSGGQTR
Mflv_2983|M.gilvum_PYR-GCK SG----AQTVEIGDRRAAIVHAVQWAREGDIVLIAGKGHEAGQTSQGRTR
MSMEG_4232|M.smegmatis_MC2_155 RAVASDAEIVEIGDRRAAIDHAVAWAQPGDIVLIAGKGHESGQTVGDHTR
Mb2182c|M.bovis_AF2122/97 AEVGGDAQVVEIADRRDAIRHAVAWARPGDVVLIAGKGHETGQRGGGRVR
Rv2158c|M.tuberculosis_H37Rv AEVGGDAQVVEIADRRDAIRHAVAWARPGDVVLIAGKGHETGQRGGGRVR
MMAR_3198|M.marinum_M AESGGAAQVVEIADRGEAIGYAVDWARTGDVVLIAGKGHETGQRGGAEVR
MUL_3506|M.ulcerans_Agy99 AESGGAAQVVEIADRGEAIGYAVDWARTGDVVLIAGKGHETGQRGGAEVR
MAV_2331|M.avium_104 TESGCAAEVIEIGDRRAAIRHAVAWAGPGDVVLVAGKGHETGQRTGEHTR
MLBr_00909|M.leprae_Br4923 VAAGGAAQVVEIGDRRAAIQYAVAWAGPDDVVLVAGKGHETGQRGAAETC
MAB_2001|M.abscessus_ATCC_1997 TGS--EAQIIEIGDRRAAIDFATLWARPGDTVLVAGKGHESGQKTGDVTV
TH_1516|M.thermoresistible__bu --------------------------------------------------
Mvan_3528|M.vanbaalenii_PYR-1 PFDDRDELAAAL-EARGARGAGG------
Mflv_2983|M.gilvum_PYR-GCK PFDDRDELAAAL-ETLQTSGTSGASQ---
MSMEG_4232|M.smegmatis_MC2_155 PFDDRDELAAAL-EASGKTRDRSS-----
Mb2182c|M.bovis_AF2122/97 PFDDRVELAAAL-EALERRA---------
Rv2158c|M.tuberculosis_H37Rv PFDDRVELAAAL-EALERRA---------
MMAR_3198|M.marinum_M PFDDRVELARAL-EALESCT---------
MUL_3506|M.ulcerans_Agy99 PFDDRVELARAL-EALESCT---------
MAV_2331|M.avium_104 PFDDRVELAEALREAVGPRKAQG------
MLBr_00909|M.leprae_Br4923 PFDDRVELARAL-QVRDARLLPAPGRACQ
MAB_2001|M.abscessus_ATCC_1997 PFDDRVELRAAL-EALGSLDD--------
TH_1516|M.thermoresistible__bu -----------------------------