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TVPGHRTDLPAELQRVHMVGIGGAGMSGIARILLDRGGLVSGSDAKESRGVIALRARGAEIRIGHDPSAL DMLAGGPTAVVTTHAAIPKTNPELVEARRRGIPVLLRPAVLARLMAGHTTLMVTGTHGKTTTTSMLIVAL QHSGFDPSFAVGGDLGEAGTNAHHGSGSSFVAEADESDGSLLEYRPDIVVVTNIEADHLDFFGSVEAYTE VFDRFAGRIDPGGALVVCVDDPGARALAERLSGSGLRVLRYGSTGTGALDATLLEWTQQGTGAVASIALR TEARPLTMRLSVPGRHMALNALGALLAAREAGADLESVLDGLAGFEGVRRRFELVGSANGVRVFDDYAHH PTEVRATLTALRAVVDQAGSGRAIVVFQPHLYSRTVTFASEFGAALSAADEVFVLDVYAAREQPLAGVSG ATVADAVSAPVTYLPDFSAVAARVAASVAPGDVVVTMGAGDVTLLGREILAEVEARA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3522 | murC | - | 100% (478) | UDP-N-acetylmuramate--L-alanine ligase |
| M. vanbaalenii PYR-1 | Mvan_3527 | - | 2e-20 | 27.91% (430) | UDP-N-acetylmuramoylalanyl-D-glutamyl-2, |
| M. vanbaalenii PYR-1 | Mvan_3528 | murE | 5e-18 | 27.86% (499) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2176c | murC | 0.0 | 75.47% (477) | UDP-N-acetylmuramate--L-alanine ligase |
| M. gilvum PYR-GCK | Mflv_2989 | murC | 0.0 | 81.45% (469) | UDP-N-acetylmuramate--L-alanine ligase |
| M. tuberculosis H37Rv | Rv2152c | murC | 0.0 | 75.47% (477) | UDP-N-acetylmuramate--L-alanine ligase |
| M. leprae Br4923 | MLBr_00915 | murC | 0.0 | 71.55% (478) | UDP-N-acetylmuramate--L-alanine ligase |
| M. abscessus ATCC 19977 | MAB_2007 | murC | 0.0 | 70.74% (475) | UDP-N-acetylmuramate--L-alanine ligase |
| M. marinum M | MMAR_3192 | murC | 0.0 | 78.56% (471) | UDP-N-acetylmuramate-alanine ligase MurC |
| M. avium 104 | MAV_2337 | murC | 0.0 | 76.76% (482) | UDP-N-acetylmuramate--L-alanine ligase |
| M. smegmatis MC2 155 | MSMEG_4226 | murC | 0.0 | 80.56% (468) | UDP-N-acetylmuramate--L-alanine ligase |
| M. thermoresistible (build 8) | TH_1476 | - | 1e-118 | 81.75% (252) | Probable UDP-N-acetylmuramate-alanine ligase MurC |
| M. ulcerans Agy99 | MUL_3500 | murC | 0.0 | 77.92% (471) | UDP-N-acetylmuramate--L-alanine ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3522|M.vanbaalenii_PYR-1 MTVPGHRTDLPAELQRVHMVGIGGAGMSGIARILLDRGGLVSGSDAKESR
Mflv_2989|M.gilvum_PYR-GCK MTGQ-QPASLPPELARVHMVGIGGAGMSGVARILLDRGGQVSGSDAKDSR
Mb2176c|M.bovis_AF2122/97 MSTE----QLPPDLRRVHMVGIGGAGMSGIARILLDRGGLVSGSDAKESR
Rv2152c|M.tuberculosis_H37Rv MSTE----QLPPDLRRVHMVGIGGAGMSGIARILLDRGGLVSGSDAKESR
MLBr_00915|M.leprae_Br4923 MNAG----QLPPELQRVHMVGIGGSGMSGIARILLDRGGLVSGSDAKESR
MAV_2337|M.avium_104 MTTD----QLPAELERVHMVGIGGAGMSGIARILLDRGGLVSGSDAKESR
MMAR_3192|M.marinum_M MTAE----QLPPELQRVHMVGIGGAGMSGIARILLDRGGLVSGSDAKESR
MUL_3500|M.ulcerans_Agy99 MTAE----QLPPELQRVHMVGIGGAGMAGIARILLDRGGLVSGSDAKESR
MSMEG_4226|M.smegmatis_MC2_155 MTGI----SLPPELQRVHMVGIGGAGMSGVARILLDRGGLVSGSDAKESR
MAB_2007|M.abscessus_ATCC_1997 MNAG----PLPEHLRRVHMVGIGGAGMSGIARILLDRGAQVSGSDAKESR
TH_1476|M.thermoresistible__bu VTQA----SLPAELRRVHMVGIGGAGMSGIARILLDRGALVSGSDAKESR
:. ** .* *********:**:*:********. *******:**
Mvan_3522|M.vanbaalenii_PYR-1 GVIALRARGAEIRIGHDPSALDMLAGGPTAVVTTHAAIPKTNPELVEARR
Mflv_2989|M.gilvum_PYR-GCK GLIALRARGAQVRIGHDPSALDMLPGGPTAVVTTHAAIPKTNPELVEARR
Mb2176c|M.bovis_AF2122/97 GVHALRARGALIRIGHDASSLDLLPGGATAVVTTHAAIPKTNPELVEARR
Rv2152c|M.tuberculosis_H37Rv GVHALRARGALIRIGHDASSLDLLPGGATAVVTTHAAIPKTNPELVEARR
MLBr_00915|M.leprae_Br4923 VVHALRARGALIRIGHDASLLDLLPGGATAVITIRTAIPKTNPELVEARR
MAV_2337|M.avium_104 GIHALRARGAQIRIGHDASSLDLLPGGPTAVITTHAAIPKTNPELVEARR
MMAR_3192|M.marinum_M GVHALRARGALIRIGHDASALDLLPGGVTSVITTHAAIPKTNPELVEASR
MUL_3500|M.ulcerans_Agy99 GVHALRARGALIRIGHDASALDLLPGGVTSVITTHAAIPKTNPELVEARR
MSMEG_4226|M.smegmatis_MC2_155 GVVALRARGAEIRIGHDASSLDLLPGGPTAVVTTHAAIPKTNPELVEARK
MAB_2007|M.abscessus_ATCC_1997 GVLALRARGALVNIGHDGDALDLLPGGPTVVVTTHAAIPKTNPELVEANR
TH_1476|M.thermoresistible__bu GLVALRARGAQVRVGHDESSLDLLPGGPTAVVTTHAAIPKTNPELVEARR
: ******* :.:*** . **:*.** * *:* ::************ :
Mvan_3522|M.vanbaalenii_PYR-1 RGIPVLLRPAVLARLMAGHTTLMVTGTHGKTTTTSMLIVALQHSGFDPSF
Mflv_2989|M.gilvum_PYR-GCK RGIPVILRPAVLARLMDDRTSLLVTGTHGKTSTTSMIIVALQHCGFDPSF
Mb2176c|M.bovis_AF2122/97 RGIPVVLRPAVLAKLMAGRTTLMVTGTHGKTTTTSMLIVALQHCGLDPSF
Rv2152c|M.tuberculosis_H37Rv RGIPVVLRPAVLAKLMAGRTTLMVTGTHGKTTTTSMLIVALQHCGLDPSF
MLBr_00915|M.leprae_Br4923 RGIPVLLRSAVLARLMDGCTTLMVAGTHGKTTTTSMLVVALQHCGCDPSF
MAV_2337|M.avium_104 RGIPVILRPAVLAKLMDGRTTLMVTGTHGKTTTTSMLIVALQHCGRDPSF
MMAR_3192|M.marinum_M RGIPVMLRPLVLAKLMDGRTTVMVTGTHGKTTTTSMVIVALQHCGRDPSF
MUL_3500|M.ulcerans_Agy99 RGVPVMLRPVVLAKLMDGRITVMVTGTHGKTTTTSMAIVALQHCGRDPSF
MSMEG_4226|M.smegmatis_MC2_155 RGIPVILRPVVLAKLMTGYTTLMVTGTHGKTTTTSMLIVALQHSGFDPSF
MAB_2007|M.abscessus_ATCC_1997 RGIPVLLRPVVLADLMAGYRTLMVTGTHGKTSTTSMLIVALQHCGYDPSF
TH_1476|M.thermoresistible__bu RGIPVILRPVVLAKLMAGYTTLMVTGTHGKTSTTSMLTVALQHGGFDPSF
**:**:**. *** ** . :::*:******:**** ***** * ****
Mvan_3522|M.vanbaalenii_PYR-1 AVGGDLGEAGTNAHHGSGSSFVAEADESDGSLLEYRPDIVVVTNIEADHL
Mflv_2989|M.gilvum_PYR-GCK AVGGDLGQAGTNAHHGSGSTFVAEADESDGSLLEYSPDVAVVTNIEADHL
Mb2176c|M.bovis_AF2122/97 AVGGELGEAGTNAHHGSGDCFVAEADESDGSLLQYTPHVAVITNIESDHL
Rv2152c|M.tuberculosis_H37Rv AVGGELGEAGTNAHHGSGDCFVAEADESDGSLLQYTPHVAVITNIESDHL
MLBr_00915|M.leprae_Br4923 VVGGELAVVGTNAHHGLGACFVAEADESDGSLLEYTPNVAVVTNIDSDHL
MAV_2337|M.avium_104 AVGGEMGEAGTNAHHGSGDCFVAEADESDGSLLEYTPDVAVVTNIETDHL
MMAR_3192|M.marinum_M AVGGELGEAGTNAHHGSGDYFVAEADESDGSLLEYTPHVAVVTNIEADHL
MUL_3500|M.ulcerans_Agy99 AVGGELGEAGTNAHHGSGDYFVAEADESDGSLLEYTPHVAVVTNIEADHL
MSMEG_4226|M.smegmatis_MC2_155 AVGGELGEAGTNAHHGSGTTFVAEADESDGSLLEYTPNVAVVTNIEADHL
MAB_2007|M.abscessus_ATCC_1997 AVGGELNEAGTNAHHGSGDVFVAEADESDGSLLQYRPNLIIVTNIEADHL
TH_1476|M.thermoresistible__bu AVGGDLGEAGTNAHHGSGTVFVAEADESDGSLLEYTPDVVVVTNIEADHL
.***:: .******* * *************:* *.: ::***::***
Mvan_3522|M.vanbaalenii_PYR-1 DFFGSVEAYTEVFDRFAGRIDPGGALVVCVDDPGARALAERLSGSGLRVL
Mflv_2989|M.gilvum_PYR-GCK DFYGTVENYTAVFDQFVDRIKPVGALVVCVDDPGAAALAERTAALGIRVL
Mb2176c|M.bovis_AF2122/97 DFYGSVEAYVAVFDSFVERIVPGGALVVCTDDPGGAALAQRATELGIRVL
Rv2152c|M.tuberculosis_H37Rv DFYGSVEAYVAVFDSFVERIVPGGALVVCTDDPGGAALAQRATELGIRVL
MLBr_00915|M.leprae_Br4923 DFYGSVDAYIRVFDSFVERFALGGALVVCNDDPGAAALARRTAELGIRVL
MAV_2337|M.avium_104 DFYGSADAYVAVFDAFVERLAPGGALVVCVDDPGAAALARRTAELGIRVL
MMAR_3192|M.marinum_M DFYGSTEAYVGVFDAFVERLAPGGALVVCADDPGSAALAERSAELGIRVL
MUL_3500|M.ulcerans_Agy99 DFYGSTEAYVGVFDAFVERLAPGGALVVCADDPGSAALAERSAELGIRVL
MSMEG_4226|M.smegmatis_MC2_155 DFFGSEQAYTAVFDSFVERIAPGGALVVCTDDPGAAALADRTDALGIRVL
MAB_2007|M.abscessus_ATCC_1997 DHFGSVEAYSAVFDEFAETLGSEGVLVVCLDDPGAAALARRAHERGIRVR
TH_1476|M.thermoresistible__bu DFFGSPQAYTAVFDDFMERLAPGGVLIACVDDPGAAALADRTAALGIRVL
*.:*: : * *** * : *.*:.* ****. *** * *:**
Mvan_3522|M.vanbaalenii_PYR-1 RYGSTGTG------ALDATLLEWTQQGTGAVASIALRTEAR----PLTMR
Mflv_2989|M.gilvum_PYR-GCK RYGSAPG--------LDATLLDWSQLGTGAVAEISVRAEDR----PRTMR
Mb2176c|M.bovis_AF2122/97 RYGSVP------GETMAATLVSWQQQGVGAVAHIRLASELATAQGPRVMR
Rv2152c|M.tuberculosis_H37Rv RYGSVP------GETMAATLVSWQQQGVGAVAHIRLASELATAQGPRVMR
MLBr_00915|M.leprae_Br4923 RYGSDDR----IGETLAARLLSWEQQGTGAVAHIQLAGQPN----SRVMR
MAV_2337|M.avium_104 RYGSGPHGQAPSGEPLAATLVSWQQQGTEAVAQIRLAGEQQ---HPLVMR
MMAR_3192|M.marinum_M RYGSAGH----AEAALAATLVSWEQRGTGAVAQIQLAGEAD----PRSMR
MUL_3500|M.ulcerans_Agy99 RYGSAGH----AGAALAATLVSWEQRGTGAVAQIQLAGEAD----PRSMR
MSMEG_4226|M.smegmatis_MC2_155 RYGSTG-------DNLAGTLLSWEQQGTGAVAHIRLAGEHN----PRAVR
MAB_2007|M.abscessus_ATCC_1997 GYGSADQAEAG-DVPVAGQLRDWQFKDTGATAQIQLAGESA----PRTMR
TH_1476|M.thermoresistible__bu RYGSPAP----------------------GRPATELAGAXX---------
*** . . :
Mvan_3522|M.vanbaalenii_PYR-1 LSVPGRHMALNALGALLAAREAGADLESVLDGLAGFEGVRRRFELVGSAN
Mflv_2989|M.gilvum_PYR-GCK LSVPGRHMALNALGALLAATQAGADIDAVLDGLAGFDGVRRRFELVGTAG
Mb2176c|M.bovis_AF2122/97 LSVPGRHMALNALGALLAAVQIGAPADEVLDGLAGFEGVRRRFELVGTCG
Rv2152c|M.tuberculosis_H37Rv LSVPGRHMALNALGALLAAVQIGAPADEVLDGLAGFEGVRRRFELVGTCG
MLBr_00915|M.leprae_Br4923 LPVPGRHMALNALGALLAAIEIGASTDEVLDGLAGFRGVRRRFELVGTSG
MAV_2337|M.avium_104 LSVPGRHMALNALGALLAAIEIGAPTEAVLDGLAGFEGVRRRFELVGTAG
MMAR_3192|M.marinum_M LSVPGRHMALNALGALLAAIEVGAPVGEVLDGLAGFEGVRRRFELVGTAE
MUL_3500|M.ulcerans_Agy99 LSVPGRHMALNVLGALLAAIEVGAPVGEVLDGLAGFEGVRRRFELVGTAE
MSMEG_4226|M.smegmatis_MC2_155 LSVPGRHMALNALAALLAAREIGAPTDSVLDGLAGFEGVRRRFELVGTAA
MAB_2007|M.abscessus_ATCC_1997 LSVPGRHMALNALAAVVTAAEIGAAVDDVLDGLAGFEGVRRRFELVGSVE
TH_1476|M.thermoresistible__bu -XAPG--CGRCSAGAGTAATAPPAQAATVVTAVS----------------
.** . .* :* * *: .::
Mvan_3522|M.vanbaalenii_PYR-1 G-------VRVFDDYAHHPTEVRATLTALRAVVDQAGSGRAIVVFQPHLY
Mflv_2989|M.gilvum_PYR-GCK G-------VRVFDDYAHHPTEVRAAITALRAVAEQTPGARTVAVFQPHLY
Mb2176c|M.bovis_AF2122/97 VGKAS---VRVFDDYAHHPTEISATLAAARMVLEQGDGGRCMVVFQPHLY
Rv2152c|M.tuberculosis_H37Rv VGKAS---VRVFDDYAHHPTEISATLAAARMVLEQGDGGRCMVVFQPHLY
MLBr_00915|M.leprae_Br4923 VGQASNSLVRVFDDYAHHPTEISATLAAFRIMLEQSGGGRCIVVFQPHLY
MAV_2337|M.avium_104 -GSAPSSTVRVFDDYAHHPTEIAATLAAVRTLLEQSGGGRSIAVFQPHLY
MMAR_3192|M.marinum_M -------SVRVFDDYAHHPTEVRATLEAVRSVVRQSGSGRLLVVFQPHLY
MUL_3500|M.ulcerans_Agy99 -------SVRVFDDYAHHPTEVRATLEAVRSVVRQSGSGRLLVVFQPHLY
MSMEG_4226|M.smegmatis_MC2_155 G-------ARVFDDYAHHPTEVRATLEAARTVVDQNG-GRVVVAFQPHLY
MAB_2007|M.abscessus_ATCC_1997 S-------VRVFDDYAHHPTEVRTVLQAVSGIVAQQGFGRSVVVFQPHLY
TH_1476|M.thermoresistible__bu ---------------------SRSSAAAVTAAPVGKGPGAATAAAS----
: * . .. .
Mvan_3522|M.vanbaalenii_PYR-1 SRTVTFASEFGAALSAADEVFVLDVYAAREQPLAGVSGATVADAVS-APV
Mflv_2989|M.gilvum_PYR-GCK SRTETFATEFAASLSTADEVFVLDVYAAREQPLPGVSGATIADGVS-APV
Mb2176c|M.bovis_AF2122/97 SRTKAFAAEFGRALNAADEVFVLDVYGAREQPLAGVSGASVAEHVT-VPM
Rv2152c|M.tuberculosis_H37Rv SRTKAFAAEFGRALNAADEVFVLDVYGAREQPLAGVSGASVAEHVT-VPM
MLBr_00915|M.leprae_Br4923 SRTKALSREFGRALSAADEVFIVGVNGAREQPLAGVSGASVAKHVS-VPV
MAV_2337|M.avium_104 SRTKAFAEEFGHALDAADEVFVLDVYGAREQPLAGVSGASVAEHVS-VPV
MMAR_3192|M.marinum_M SRTKAFAAEFGSALDAADEVFVLDVYAAREQPLTGISGASVAEHVT-VPV
MUL_3500|M.ulcerans_Agy99 SRTKAFAAEFGSALDAADEVFVLDVYAAREQPLTGISGASVAEHVT-VPV
MSMEG_4226|M.smegmatis_MC2_155 SRTATFAHEFGAALSVADQVVVLDVYAAREQPMAGVSGATVADHVT-APV
MAB_2007|M.abscessus_ATCC_1997 SRTAAFATEFADALSIADLVFVLDVYGAREAPLPGVTGALIVEQIAGAPV
TH_1476|M.thermoresistible__bu ----------ACSPSSAAAVTVVPVGWTATAAAVGVPGSSRS--------
. : . * * :: * : . *:.*:
Mvan_3522|M.vanbaalenii_PYR-1 TYLPDFSAVAARVAASVAPGDVVVTMGAGDVTLLGREILAEVEARA----
Mflv_2989|M.gilvum_PYR-GCK TYIADFSAVAARVAAVVSAGDVVVTMGAGDVTMLGQEILAEVRARA----
Mb2176c|M.bovis_AF2122/97 RYVPDFSAVAQQVAAAASPGDVIVTMGAGDVTLLGPEILTALRVRANRSA
Rv2152c|M.tuberculosis_H37Rv RYVPDFSAVAQQVAAAASPGDVIVTMGAGDVTLLGPEILTALRVRANRSA
MLBr_00915|M.leprae_Br4923 RYIPDYSAVVIEVAAAAGPGDVIVTMGIGDVGLLGPEIVAALRVRANCNT
MAV_2337|M.avium_104 RYLPDFSAAAEQVAAAAAPGDVIVTMGAGDVTLLGPEIVTALRVRANRGA
MMAR_3192|M.marinum_M RYLRDFSAVAEVVAAAAGPGDVVVTMGAGDVTLLGPEIVAALRMRADRSE
MUL_3500|M.ulcerans_Agy99 RYLRDFSAVAEVVAAAAGPGDVVVTMGAGDVTLLGPEIVAALRMRADRSE
MSMEG_4226|M.smegmatis_MC2_155 TYVPDFSAVAAHVASIARSGDVILTMGAGDVTMLGGEILSELRLKDNRGM
MAB_2007|M.abscessus_ATCC_1997 HYLPDLSTVAQQVAAATAPGDLVITMGAGDVTLQGKEIVRALRARANDWP
TH_1476|M.thermoresistible__bu ------SAAAVTVVTAAWAATAVTAVEPGSSRC-----------------
*:.. *.: . .. : :: *.
Mvan_3522|M.vanbaalenii_PYR-1 --------
Mflv_2989|M.gilvum_PYR-GCK --------
Mb2176c|M.bovis_AF2122/97 PGRPGVLG
Rv2152c|M.tuberculosis_H37Rv PGRPGVLG
MLBr_00915|M.leprae_Br4923 PGCSGVLQ
MAV_2337|M.avium_104 PG---ALR
MMAR_3192|M.marinum_M PGRPGVLQ
MUL_3500|M.ulcerans_Agy99 PGRPGVLQ
MSMEG_4226|M.smegmatis_MC2_155 PGAGAS--
MAB_2007|M.abscessus_ATCC_1997 PPGNGR--
TH_1476|M.thermoresistible__bu --------