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MNLRPSHPVGMPLGALADLVCAEPADAGPVPDLQVTGVTLRGQHAQAGDLFAALPGSKAHGARYAADAVE RGAVAVLTDADGVSEIAAHGGPAVPILVHPAPRSVLGEVAAAVFGRPSEHLRVIGVTGTSGKTTTTYLVE AGLRSAGRVAGLIGTVGVRIDGRAQPGGLTTPEAPDLQALLAAMLEQGVDTVVMEVSSHALTLGRVDGVS FAVGGFTNLSRDHLDFHPTMQDYFEAKARLVDPTSPTHAARSVICVDDEWGRAMAARADAPVTVSVTGDA DWWVQEVRALDGGVQDFLAVDPAGVHHALEIGLPGGYNVANCLLAVALLDAVDVSPEQAAPGLRDATVPG RLEAVDRGQPFLALVDYAHKPGALAAVLQTLREQCAGRLAVVFGAGGDRDQGKREPMGRVAAELADLVVV TDDNPRGEDPAVIRAAILRGASGAQTVEIGDRRAAIVHAVQWAREGDIVLIAGKGHEAGQTSQGRTRPFD DRDELAAALETLQTSGTSGASQ
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_2983 | murE | - | 100% (512) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase |
M. gilvum PYR-GCK | Mflv_2984 | - | 8e-23 | 28.97% (504) | UDP-N-acetylmuramoylalanyl-D-glutamyl-2, |
M. gilvum PYR-GCK | Mflv_2986 | murD | 1e-16 | 28.63% (454) | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2182c | murE | 0.0 | 67.65% (510) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate |
M. tuberculosis H37Rv | Rv2158c | murE | 0.0 | 67.65% (510) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate |
M. leprae Br4923 | MLBr_00909 | murE | 1e-175 | 64.05% (509) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate |
M. abscessus ATCC 19977 | MAB_2001 | murE | 1e-164 | 64.24% (495) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate |
M. marinum M | MMAR_3198 | murE | 0.0 | 69.20% (513) | UDP-N-acetylmuramoylalanyl-D-glutamate-2,6- diaminopimelate |
M. avium 104 | MAV_2331 | murE | 0.0 | 69.11% (505) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate |
M. smegmatis MC2 155 | MSMEG_4232 | murE | 0.0 | 73.33% (510) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate |
M. thermoresistible (build 8) | TH_1329 | murF | 1e-11 | 25.90% (444) | Probable UDP-N-acetylmuramoylalanyl-D-glutamyl-2, |
M. ulcerans Agy99 | MUL_3506 | murE | 0.0 | 68.42% (513) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate |
M. vanbaalenii PYR-1 | Mvan_3528 | murE | 0.0 | 84.07% (496) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_2983|M.gilvum_PYR-GCK ----------------------------------------------MNLR Mvan_3528|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4232|M.smegmatis_MC2_155 --------------------------------------------MAMKLR Mb2182c|M.bovis_AF2122/97 --------------------MSSLARGISR---RRTEVATQVEAAPTGLR Rv2158c|M.tuberculosis_H37Rv --------------------MSSLARGISR---RRTEVATQVEAAPTGLR MMAR_3198|M.marinum_M --------------------------------------MSEVESV---LR MUL_3506|M.ulcerans_Agy99 MGSRRGAGWVRHRVVTGRDWVGCHGRPVSPGVGRRTEVVSEVESV---LR MAV_2331|M.avium_104 -----------------------------------------MVSVPTGLR MLBr_00909|M.leprae_Br4923 --------------------------------------MTEVVAVPVRLR MAB_2001|M.abscessus_ATCC_1997 -----------------------------------------MAASGTHRF TH_1329|M.thermoresistible__bu ------------------------VTTEPGAVVSDLGQAARRSAVRTPVT Mflv_2983|M.gilvum_PYR-GCK PSHPVGMPLGALADLVCAEPAD----------AGPVPDLQVTGVTLRGQH Mvan_3528|M.vanbaalenii_PYR-1 ----------MLADLVAAVAAG----------GGGAPDVQVTGVTLRGQD MSMEG_4232|M.smegmatis_MC2_155 PSRPVGHHLAPLAAAVGAVASENP-----AGSSSDLAAVHVTGVTLRGQD Mb2182c|M.bovis_AF2122/97 PNAVVGVRLAALADQVGAALAEG------PAQRAVTEDRTVTGVTLRAQD Rv2158c|M.tuberculosis_H37Rv PNAVVGVRLAALADQVGAALAEG------PAQRAVTEDRTVTGVTLRAQD MMAR_3198|M.marinum_M PSAGPGVPLAELAVQVGAVLADG------PHRAAAVPDTLITGMTLRAQA MUL_3506|M.ulcerans_Agy99 PSAGPGVPLAELAVQVGAVLADG------PHRAAAVPDTLITGMTLRAQA MAV_2331|M.avium_104 PSAVPGVRLPALADQVGAVMAG-------PDRRAAVPDVTVTGVTLRAQD MLBr_00909|M.leprae_Br4923 PSATAGVRLPELVAQVGAVLADG------PGQAATVPDIPVTGVTLRAQE MAB_2001|M.abscessus_ATCC_1997 LPRTHQHLVSDLASLVSAELHGP-------------SATTVGGVTLRAQD TH_1329|M.thermoresistible__bu AGSGGGYPRLDLTACPGLVVVAARPDDELLGLGGAIAALVDLGVEVRVVS *. *: :* Mflv_2983|M.gilvum_PYR-GCK AQAGDLFAALPGSKAHG---------ARYAADAVERGAVAVLTDADGVSE Mvan_3528|M.vanbaalenii_PYR-1 AQPGDLFAALPGSRAHG---------GRYAAEAVGRGAVAVLTDAAGEAE MSMEG_4232|M.smegmatis_MC2_155 AQPGDLFAALPGASAHG---------ARFAADAVAAGAVAVLTDPSGADL Mb2182c|M.bovis_AF2122/97 VSPGDLFAALTGSTTHG---------ARHVGDAIARGAVAVLTDPAGVAE Rv2158c|M.tuberculosis_H37Rv VSPGDLFAALTGSTTHG---------ARHVGDAIARGAVAVLTDPAGVAE MMAR_3198|M.marinum_M VQPGDLFAALAGSATHG---------ARHAADAIERGAVAVLTDPAGVTA MUL_3506|M.ulcerans_Agy99 VQPGDLFAALAGSATHG---------ARHTADAIERGAVAVLTDPAGVTA MAV_2331|M.avium_104 VLPGDLFAALPGATTHG---------ARHAAEAIERGAVAVLTDAAGVAQ MLBr_00909|M.leprae_Br4923 VLSGDLFAALAGASTHG---------ARYAGVALERGAVAVLTDVAGVAE MAB_2001|M.abscessus_ATCC_1997 ARTGDLFAALPGTSTHG---------AQFASEAVSAGAAAVLTDAAGAEL TH_1329|M.thermoresistible__bu VCDRDATLTLTGLPALDRQIPDQRFDQRVAAEILGVKELHHLGLPADDLD . * :*.* : . : .. : * . Mflv_2983|M.gilvum_PYR-GCK IAAH--GGPAVPILVHP-----APRSVLGEVAAAVFGRPSEH------LR Mvan_3528|M.vanbaalenii_PYR-1 IASR--GAPDVPVLVHP-----DPRAVLGELASAVYGRPSQH------LR MSMEG_4232|M.smegmatis_MC2_155 LA----GTLDVPVLVHP-----APRSVLGEAAAIVYGRPAER------LR Mb2182c|M.bovis_AF2122/97 IAGR----AAVPVLVHP-----APRGVLGGLAATVYGHPSER------LT Rv2158c|M.tuberculosis_H37Rv IAGR----AAVPVLVHP-----APRGVLGGLAATVYGHPSER------LT MMAR_3198|M.marinum_M ISALGCVPGTVPVLVHP-----APRGVLGEAAALVYGHPSDR------LT MUL_3506|M.ulcerans_Agy99 ISALGCVPGTVPVLVHP-----APRGVLGEAAALVYGHPSDR------LT MAV_2331|M.avium_104 LTGG----RTTPTLLHP-----RPRSVLGELAAAVYAHPSER------LT MLBr_00909|M.leprae_Br4923 LTAQ---ASSVPILIHP-----EPRSVLGGLAAAAYGHPSNR------MT MAB_2001|M.abscessus_ATCC_1997 VAGQG---LDIAVLVHP-----VPRSVLGELAATVYGEPSRH------LQ TH_1329|M.thermoresistible__bu RHAAGLADDLTELLVGPGLWCAAPWAGDGDPDSTVVARAAXXXLVAGGLR *: * * . * : . ...: : Mflv_2983|M.gilvum_PYR-GCK VIGVTGTSGKTTTTYLVEAGLRSAGRVAGLIGTVGVRIDGRAQPGGLTTP Mvan_3528|M.vanbaalenii_PYR-1 VIGVTGTSGKTTTTYLVEAGLRAAGRVAGLIGTVGVRIDGRQQPGGLTTP MSMEG_4232|M.smegmatis_MC2_155 VVGVTGTSGKTTTTYLAEAGLRAAGRVAGLIGTVGVRIDGTDLPSALTTP Mb2182c|M.bovis_AF2122/97 VIGITGTSGKTTTTYLVEAGLRAAGRVAGLIGTIGIRVGGADLPSALTTP Rv2158c|M.tuberculosis_H37Rv VIGITGTSGKTTTTYLVEAGLRAAGRVAGLIGTIGIRVGGADLPSALTTP MMAR_3198|M.marinum_M VVGITGTSGKTTTTYLVEAGLRAAGRVAGLIGTIGIRIDGADIPSTLTTP MUL_3506|M.ulcerans_Agy99 VVGITGTSGKTTTTYLVEAGLRAAGRVAGLIGTIGIRIDGADIPSTLTTP MAV_2331|M.avium_104 VIGITGTSGKTTTTYLVESGLRAAGRTAGLIGTVGIRIDGADIPSALTTP MLBr_00909|M.leprae_Br4923 VVGITGTSGKTTTTYMVEAGLRAGGRVVGLVGTIGIRIDGADIPSFLTTP MAB_2001|M.abscessus_ATCC_1997 VVGVTGTSGKTTTTYLVEAGLRAAGKRVGLIGTVGVRIDGEDVPSALTTP TH_1329|M.thermoresistible__bu IVGVTGSSGKTSTKDLLAAVLAPLGSVVAPPGSFNNELG--HPWTVLRAD ::*:**:****:*. : : * . * .. *:.. .:. * : Mflv_2983|M.gilvum_PYR-GCK EAPDLQALLAAMLEQGVDTVVMEVSSHALTLGRVDGVSFAVGGFTNLSRD Mvan_3528|M.vanbaalenii_PYR-1 EAPELQALLATMLEQGVDTVVMEVSSHALTLGRVDGVSFAVGGFTNLSRD MSMEG_4232|M.smegmatis_MC2_155 EAPALQALLALMVERGVDTVVMEVSSHALAQGRVDGIGFAVGGFTNLSRD Mb2182c|M.bovis_AF2122/97 EAPTLQAMLAAMVERGVDTVVMEVSSHALALGRVDGTRFAVGAFTNLSRD Rv2158c|M.tuberculosis_H37Rv EAPTLQAMLAAMVERGVDTVVMEVSSHALALGRVDGTRFAVGAFTNLSRD MMAR_3198|M.marinum_M EAPALQAMLAAMVERGVDTVVMEVSSHALTLGRVDGIRFAVGGFTNLSRD MUL_3506|M.ulcerans_Agy99 EAPTLQAMLAAMVERGVDTVVMEVSSHALTLGRVDGIRFAVGGFTNLSRD MAV_2331|M.avium_104 EAPALQALLAAMAEQRVDTVVMEVSSHALALGRVDGTRFAVGGFTNLSRD MLBr_00909|M.leprae_Br4923 EAPALQAMLAAMVERGVETVVMEVSSHALSLGRVEGTQFAVAGFTNLSRD MAB_2001|M.abscessus_ATCC_1997 EAPALQELLAEMVQRGVDTVVMEVSSHALALNRVDGTRFAVGAFTNLSRD TH_1329|M.thermoresistible__bu RDTDYLVLEMSARHRGNIAALAEIAPP------------SVGVVLNVGTA . . : .: :.: *::. :*. . *:. Mflv_2983|M.gilvum_PYR-GCK HLDFHPTMQDYFEAKARLVDPTSPTHAARSVICVDDEWGRAMAARADAP- Mvan_3528|M.vanbaalenii_PYR-1 HLDFHPTMEDYFDAKARLFDPACATHAARSVICVDDEWGRAMAARARRP- MSMEG_4232|M.smegmatis_MC2_155 HLDFHPTMADYFEAKARLFDPQSPNHAAAAVICVDDQYGVQMAARAETP- Mb2182c|M.bovis_AF2122/97 HLDFHPSMADYFEAKASLFDPDSALRARTAVVCIDDDAGRAMAARAADA- Rv2158c|M.tuberculosis_H37Rv HLDFHPSMADYFEAKASLFDPDSALRARTAVVCIDDDAGRAMAARAADA- MMAR_3198|M.marinum_M HLDFHPTMADYFEAKALLFDPASALRGHSVVVCIDDEAGRAMADRAGAA- MUL_3506|M.ulcerans_Agy99 HLDFHPTMADYFEAKALLFDPASALRGHSVVVCIDDEAGRAMADRAGVA- MAV_2331|M.avium_104 HLDFHPTMADYFEAKALLFDPNSPLRAHRAVVCIDDEAGREMAARAGDA- MLBr_00909|M.leprae_Br4923 HLDFHPDMEEYFEAKAVLFDPHSLLRARTVVVCIDDDAGRATAARAGDA- MAB_2001|M.abscessus_ATCC_1997 HLDFHPDMQDYFATKARLFRRDSPQRAHRSVVCIDDDAGRAMAELAREAG TH_1329|M.thermoresistible__bu HLGEFGSRDAIAATKAELAEAVPS--TGLVVLNADDPAVAAMAERTAAR- **. . :** * *: ** * : Mflv_2983|M.gilvum_PYR-GCK ---VTVS--VTG-DADWWVQEVRALDGGVQDFLAVDPAGVHHALEIGLPG Mvan_3528|M.vanbaalenii_PYR-1 ---VTVS--TTG-PADWRAEQVRSAGGGAQDFVAVDPAGVHHGLEIGLPG MSMEG_4232|M.smegmatis_MC2_155 ---LTVS--TSGAAADWRVEKITTAGPGAQEFVLVDPGGMHHQLGVGLPG Mb2182c|M.bovis_AF2122/97 ---ITVS--AADRPAHWRATDVAPTDAGGQQFTAIDPAGVGHHIGIRLPG Rv2158c|M.tuberculosis_H37Rv ---ITVS--AADRPAHWRATDVAPTDAGGQQFTAIDPAGVGHHIGIRLPG MMAR_3198|M.marinum_M ---ITVS--ATGQPAHWRATDVAPVGAGGQEFTALDPAGVGHRVRIGLPG MUL_3506|M.ulcerans_Agy99 ---ITVS--ATGQPAHWRATDVAPVGAGGQEFTALDPAGVGHRVRIGSPG MAV_2331|M.avium_104 ---VTVS--AEGQPAHWRAVEVAPLGTGGQQFTVIDPAGVQHRAGIRLPG MLBr_00909|M.leprae_Br4923 ---ITVS--ALGQPASWRATDIRSPGVGAQEFTAVDPAGVQHRVGIRLPG MAB_2001|M.abscessus_ATCC_1997 PDVTTVSS-LDGGVADWRCSNVAVGHDGGQRFVANGP-DRDTELTIALPG TH_1329|M.thermoresistible__bu --VVRVAQDPGERQVDVWAERVSLDELARPRFTLRTP-DGAVEVALTVHG *: . : . * * . : * Mflv_2983|M.gilvum_PYR-GCK GYNVANCLLAVALLDAVDVSPEQAAPGLRDAT--VPGRLEAVDRGQPFLA Mvan_3528|M.vanbaalenii_PYR-1 GYNVANCLLAIALLDAVGVSPEQAAPGVRDAT--VPGRLESVDRGQPFLA MSMEG_4232|M.smegmatis_MC2_155 RYNVANAALAVALLDAVGVSPEQAAPGLRTAT--VPGRLESIDLGQDFLA Mb2182c|M.bovis_AF2122/97 RYNVANCLVALAILDTVGVSPEQAVPGLREIR--VPGRLEQIDRGQGFLA Rv2158c|M.tuberculosis_H37Rv RYNVANCLVALAILDTVGVSPEQAVPGLREIR--VPGRLEQIDRGQGFLA MMAR_3198|M.marinum_M HYNVANCLLALAILDAVGVSPEQAAPGLRETR--VPGRLEQVDRGQDFLA MUL_3506|M.ulcerans_Agy99 HYNVSNCLLALAILDAVGVSPEQAAPGLRETR--VPGRLEQVDRGQDFLA MAV_2331|M.avium_104 HYNVANCLVALALLDAVGVSPEQAAPGLLQTR--VPGRMEEIDAGQDFLA MLBr_00909|M.leprae_Br4923 RYNVANCLVALAILDVVGVSPEQASLGFRDIR--IPGRLERIDCGQDFLA MAB_2001|M.abscessus_ATCC_1997 HYNVANCLVAIAILDVLGVSAATAAPGIATAG--VPGRMEAVAAGQPFLA TH_1329|M.thermoresistible__bu EHQVSNALAAAAVALHCGATLEQVVAALAGAGPASPRRMQVSTRSDGVTV ::*:*. * *: ..: . .. * *:: .: . . Mflv_2983|M.gilvum_PYR-GCK LVD-YAHKPGALAAVLQTLREQCAGRLAVVFGAGGDRDQGKREPMGRVAA Mvan_3528|M.vanbaalenii_PYR-1 LVD-YAHKPGALRAVLQTLREQCTGRLAVVFGAGGNRDQGKREPMGRVAA MSMEG_4232|M.smegmatis_MC2_155 LVD-YAHKPGALQAVLETLRAAEPRRIAVVFGAGGDRDPGKREPMGRVTA Mb2182c|M.bovis_AF2122/97 LVD-YAHKPEALRSVLTTLAHP-DRRLAVVFGAGGDRDPGKRAPMGRIAA Rv2158c|M.tuberculosis_H37Rv LVD-YAHKPEALRSVLTTLAHP-DRRLAVVFGAGGDRDPGKRAPMGRIAA MMAR_3198|M.marinum_M LVD-YAHKPGALREVLSTLRNP-QRRLAVVFGAGGDRDPGKRGPMGRIAA MUL_3506|M.ulcerans_Agy99 LVD-YAHKPGALREVLSTLRNP-QRRLAVVFGAGGDRDPGKRGPMGRIAA MAV_2331|M.avium_104 LVD-YAHKPGALRAVLSSLKRP-DRRLAVVFGAGGERDPGKRAPMGATAA MLBr_00909|M.leprae_Br4923 LVD-YAHKPGALHSVLTALLQP-DHRLAVVFGAGGERDPGKRAPMGEIAA MAB_2001|M.abscessus_ATCC_1997 VVD-YAHKPGALRAVLESLRSHRDGRLAVVFGAGGNRDRGKRADMGKVAA TH_1329|M.thermoresistible__bu INDAYNANPDSMRAALKSLVWM-----AKAGGRAGGPPRRSWAVLGEMAE : * * :* :: .* :* * . * .* . :* : Mflv_2983|M.gilvum_PYR-GCK ELADLVVVTDDNPRGEDPAVIRAAILRGASG----AQTVEIGDRRAAIVH Mvan_3528|M.vanbaalenii_PYR-1 ELADLVVVTDDNPRDEDPAVIRAAILAGAAGAR--AEVVEIGDRRAAIGH MSMEG_4232|M.smegmatis_MC2_155 ELADLVVVTDDNPRSEDPATIRSAILAGARAVASDAEIVEIGDRRAAIDH Mb2182c|M.bovis_AF2122/97 QLADLVVVTDDNPRDEDPTAIRREILAGAAEVGGDAQVVEIADRRDAIRH Rv2158c|M.tuberculosis_H37Rv QLADLVVVTDDNPRDEDPTAIRREILAGAAEVGGDAQVVEIADRRDAIRH MMAR_3198|M.marinum_M ELADLVVVTDDNPRGEDPGAIRRTIVAGAAESGGAAQVVEIADRGEAIGY MUL_3506|M.ulcerans_Agy99 ELADLVVVTDDNPRGEDPGAIRRTIVAGAAESGGAAQVVEIADRGEAIGY MAV_2331|M.avium_104 ELADLVVVTDDNPRGEDPAAIRREILAGATESGCAAEVIEIGDRRAAIRH MLBr_00909|M.leprae_Br4923 ELADLVVVTDDNPRGEDPAAIRRDILTGTVAAGGAAQVVEIGDRRAAIQY MAB_2001|M.abscessus_ATCC_1997 ELADLVVVTDDNPRNEEPAAIRTEIISGTTGS--EAQIIEIGDRRAAIDF TH_1329|M.thermoresistible__bu LGDDAITEHDNIGRLAVRLDVSRLIVVGTGRAMSAMHHGAVMEGSWGAES * :. *: * : *: *: . : : . Mflv_2983|M.gilvum_PYR-GCK AVQWAREGDIVLIAGKGHEAGQTSQGRTRPFDDRDELAAAL-ETLQTSGT Mvan_3528|M.vanbaalenii_PYR-1 AAGWARAGDIVLIAGKGHEAGQTSGGQTRPFDDRDELAAAL-EARGARGA MSMEG_4232|M.smegmatis_MC2_155 AVAWAQPGDIVLIAGKGHESGQTVGDHTRPFDDRDELAAAL-EASGKTRD Mb2182c|M.bovis_AF2122/97 AVAWARPGDVVLIAGKGHETGQRGGGRVRPFDDRVELAAAL-EALERRA- Rv2158c|M.tuberculosis_H37Rv AVAWARPGDVVLIAGKGHETGQRGGGRVRPFDDRVELAAAL-EALERRA- MMAR_3198|M.marinum_M AVDWARTGDVVLIAGKGHETGQRGGAEVRPFDDRVELARAL-EALESCT- MUL_3506|M.ulcerans_Agy99 AVDWARTGDVVLIAGKGHETGQRGGAEVRPFDDRVELARAL-EALESCT- MAV_2331|M.avium_104 AVAWAGPGDVVLVAGKGHETGQRTGEHTRPFDDRVELAEALREAVGPRKA MLBr_00909|M.leprae_Br4923 AVAWAGPDDVVLVAGKGHETGQRGAAETCPFDDRVELARAL-QVRDARLL MAB_2001|M.abscessus_ATCC_1997 ATLWARPGDTVLVAGKGHESGQKTGDVTVPFDDRVELRAAL-EALGSLDD TH_1329|M.thermoresistible__bu TMVSDADAALRLLR-SELQAGDVVLVKASNAAGLGALADALAAESGDTGR : *: . ::*: . . * ** Mflv_2983|M.gilvum_PYR-GCK SGASQ--- Mvan_3528|M.vanbaalenii_PYR-1 GG------ MSMEG_4232|M.smegmatis_MC2_155 RSS----- Mb2182c|M.bovis_AF2122/97 -------- Rv2158c|M.tuberculosis_H37Rv -------- MMAR_3198|M.marinum_M -------- MUL_3506|M.ulcerans_Agy99 -------- MAV_2331|M.avium_104 QG------ MLBr_00909|M.leprae_Br4923 PAPGRACQ MAB_2001|M.abscessus_ATCC_1997 -------- TH_1329|M.thermoresistible__bu --------