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GSRRGAGWVRHRVVTGRDWVGCHGRPVSPGVGRRTEVVSEVESVLRPSAGPGVPLAELAVQVGAVLADGP HRAAAVPDTLITGMTLRAQAVQPGDLFAALAGSATHGARHTADAIERGAVAVLTDPAGVTAISALGCVPG TVPVLVHPAPRGVLGEAAALVYGHPSDRLTVVGITGTSGKTTTTYLVEAGLRAAGRVAGLIGTIGIRIDG ADIPSTLTTPEAPTLQAMLAAMVERGVDTVVMEVSSHALTLGRVDGIRFAVGGFTNLSRDHLDFHPTMAD YFEAKALLFDPASALRGHSVVVCIDDEAGRAMADRAGVAITVSATGQPAHWRATDVAPVGAGGQEFTALD PAGVGHRVRIGSPGHYNVSNCLLALAILDAVGVSPEQAAPGLRETRVPGRLEQVDRGQDFLALVDYAHKP GALREVLSTLRNPQRRLAVVFGAGGDRDPGKRGPMGRIAAELADLVVVTDDNPRGEDPGAIRRTIVAGAA ESGGAAQVVEIADRGEAIGYAVDWARTGDVVLIAGKGHETGQRGGAEVRPFDDRVELARALEALESCT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3506 | murE | - | 100% (559) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase |
| M. ulcerans Agy99 | MUL_3505 | murF | 3e-20 | 27.82% (514) | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6- |
| M. ulcerans Agy99 | MUL_3503 | murD | 9e-20 | 29.84% (429) | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2182c | murE | 0.0 | 79.09% (526) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate |
| M. gilvum PYR-GCK | Mflv_2983 | murE | 0.0 | 68.42% (513) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate |
| M. tuberculosis H37Rv | Rv2158c | murE | 0.0 | 79.09% (526) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate |
| M. leprae Br4923 | MLBr_00909 | murE | 0.0 | 73.75% (522) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate |
| M. abscessus ATCC 19977 | MAB_2001 | murE | 1e-161 | 62.81% (484) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate |
| M. marinum M | MMAR_3198 | murE | 0.0 | 99.04% (521) | UDP-N-acetylmuramoylalanyl-D-glutamate-2,6- diaminopimelate |
| M. avium 104 | MAV_2331 | murE | 0.0 | 76.85% (514) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate |
| M. smegmatis MC2 155 | MSMEG_4232 | murE | 0.0 | 67.06% (513) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate |
| M. thermoresistible (build 8) | TH_1516 | - | 5e-09 | 32.48% (157) | Probable UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD |
| M. vanbaalenii PYR-1 | Mvan_3528 | murE | 0.0 | 70.02% (497) | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2983|M.gilvum_PYR-GCK ----------------------------------------------MNLR
Mvan_3528|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4232|M.smegmatis_MC2_155 --------------------------------------------MAMKLR
MUL_3506|M.ulcerans_Agy99 MGSRRGAGWVRHRVVTGRDWVGCHGRPVSPGVGRRTEVVSEVESV---LR
MMAR_3198|M.marinum_M --------------------------------------MSEVESV---LR
Mb2182c|M.bovis_AF2122/97 --------------------MSSLARGISR---RRTEVATQVEAAPTGLR
Rv2158c|M.tuberculosis_H37Rv --------------------MSSLARGISR---RRTEVATQVEAAPTGLR
MAV_2331|M.avium_104 -----------------------------------------MVSVPTGLR
MLBr_00909|M.leprae_Br4923 --------------------------------------MTEVVAVPVRLR
MAB_2001|M.abscessus_ATCC_1997 -----------------------------------------MAASGTHRF
TH_1516|M.thermoresistible__bu --------------------------------------------------
Mflv_2983|M.gilvum_PYR-GCK PSHPVGMPLGALADLVCAEPAD-----AGPVPDLQVTGVTLRGQHAQAGD
Mvan_3528|M.vanbaalenii_PYR-1 ----------MLADLVAAVAAG-----GGGAPDVQVTGVTLRGQDAQPGD
MSMEG_4232|M.smegmatis_MC2_155 PSRPVGHHLAPLAAAVGAVASENPAGSSSDLAAVHVTGVTLRGQDAQPGD
MUL_3506|M.ulcerans_Agy99 PSAGPGVPLAELAVQVGAVLADG-PHRAAAVPDTLITGMTLRAQAVQPGD
MMAR_3198|M.marinum_M PSAGPGVPLAELAVQVGAVLADG-PHRAAAVPDTLITGMTLRAQAVQPGD
Mb2182c|M.bovis_AF2122/97 PNAVVGVRLAALADQVGAALAEG-PAQRAVTEDRTVTGVTLRAQDVSPGD
Rv2158c|M.tuberculosis_H37Rv PNAVVGVRLAALADQVGAALAEG-PAQRAVTEDRTVTGVTLRAQDVSPGD
MAV_2331|M.avium_104 PSAVPGVRLPALADQVGAVMAG--PDRRAAVPDVTVTGVTLRAQDVLPGD
MLBr_00909|M.leprae_Br4923 PSATAGVRLPELVAQVGAVLADG-PGQAATVPDIPVTGVTLRAQEVLSGD
MAB_2001|M.abscessus_ATCC_1997 LPRTHQHLVSDLASLVSAELHGP--------SATTVGGVTLRAQDARTGD
TH_1516|M.thermoresistible__bu --------------------------------------------------
Mflv_2983|M.gilvum_PYR-GCK LFAALPGSKAHGARYAADAVERGAVAVLTDADGVSEIAAH--GGPAVPIL
Mvan_3528|M.vanbaalenii_PYR-1 LFAALPGSRAHGGRYAAEAVGRGAVAVLTDAAGEAEIASR--GAPDVPVL
MSMEG_4232|M.smegmatis_MC2_155 LFAALPGASAHGARFAADAVAAGAVAVLTDPSGADLLA----GTLDVPVL
MUL_3506|M.ulcerans_Agy99 LFAALAGSATHGARHTADAIERGAVAVLTDPAGVTAISALGCVPGTVPVL
MMAR_3198|M.marinum_M LFAALAGSATHGARHAADAIERGAVAVLTDPAGVTAISALGCVPGTVPVL
Mb2182c|M.bovis_AF2122/97 LFAALTGSTTHGARHVGDAIARGAVAVLTDPAGVAEIAGR----AAVPVL
Rv2158c|M.tuberculosis_H37Rv LFAALTGSTTHGARHVGDAIARGAVAVLTDPAGVAEIAGR----AAVPVL
MAV_2331|M.avium_104 LFAALPGATTHGARHAAEAIERGAVAVLTDAAGVAQLTGG----RTTPTL
MLBr_00909|M.leprae_Br4923 LFAALAGASTHGARYAGVALERGAVAVLTDVAGVAELTAQ---ASSVPIL
MAB_2001|M.abscessus_ATCC_1997 LFAALPGTSTHGAQFASEAVSAGAAAVLTDAAGAELVAGQG---LDIAVL
TH_1516|M.thermoresistible__bu ------------------------------------------------XP
Mflv_2983|M.gilvum_PYR-GCK VHPAPRSVLGEVAAAVFGRPSEHLRVIGVTGTSGKTTTTYLVEAGLRSAG
Mvan_3528|M.vanbaalenii_PYR-1 VHPDPRAVLGELASAVYGRPSQHLRVIGVTGTSGKTTTTYLVEAGLRAAG
MSMEG_4232|M.smegmatis_MC2_155 VHPAPRSVLGEAAAIVYGRPAERLRVVGVTGTSGKTTTTYLAEAGLRAAG
MUL_3506|M.ulcerans_Agy99 VHPAPRGVLGEAAALVYGHPSDRLTVVGITGTSGKTTTTYLVEAGLRAAG
MMAR_3198|M.marinum_M VHPAPRGVLGEAAALVYGHPSDRLTVVGITGTSGKTTTTYLVEAGLRAAG
Mb2182c|M.bovis_AF2122/97 VHPAPRGVLGGLAATVYGHPSERLTVIGITGTSGKTTTTYLVEAGLRAAG
Rv2158c|M.tuberculosis_H37Rv VHPAPRGVLGGLAATVYGHPSERLTVIGITGTSGKTTTTYLVEAGLRAAG
MAV_2331|M.avium_104 LHPRPRSVLGELAAAVYAHPSERLTVIGITGTSGKTTTTYLVESGLRAAG
MLBr_00909|M.leprae_Br4923 IHPEPRSVLGGLAAAAYGHPSNRMTVVGITGTSGKTTTTYMVEAGLRAGG
MAB_2001|M.abscessus_ATCC_1997 VHPVPRSVLGELAATVYGEPSRHLQVVGVTGTSGKTTTTYLVEAGLRAAG
TH_1516|M.thermoresistible__bu VWGDVELAWRLDAAGRFGAPRRWLVVT---GTNGKTTTTSMLQAMLLADG
: . . *: :. * : * **.****** : :: * : *
Mflv_2983|M.gilvum_PYR-GCK RVAGLIGTVGVRIDGRAQPGGLTTPEAPDLQALLAAMLEQGVDTVVMEVS
Mvan_3528|M.vanbaalenii_PYR-1 RVAGLIGTVGVRIDGRQQPGGLTTPEAPELQALLATMLEQGVDTVVMEVS
MSMEG_4232|M.smegmatis_MC2_155 RVAGLIGTVGVRIDGTDLPSALTTPEAPALQALLALMVERGVDTVVMEVS
MUL_3506|M.ulcerans_Agy99 RVAGLIGTIGIRIDGADIPSTLTTPEAPTLQAMLAAMVERGVDTVVMEVS
MMAR_3198|M.marinum_M RVAGLIGTIGIRIDGADIPSTLTTPEAPALQAMLAAMVERGVDTVVMEVS
Mb2182c|M.bovis_AF2122/97 RVAGLIGTIGIRVGGADLPSALTTPEAPTLQAMLAAMVERGVDTVVMEVS
Rv2158c|M.tuberculosis_H37Rv RVAGLIGTIGIRVGGADLPSALTTPEAPTLQAMLAAMVERGVDTVVMEVS
MAV_2331|M.avium_104 RTAGLIGTVGIRIDGADIPSALTTPEAPALQALLAAMAEQRVDTVVMEVS
MLBr_00909|M.leprae_Br4923 RVVGLVGTIGIRIDGADIPSFLTTPEAPALQAMLAAMVERGVETVVMEVS
MAB_2001|M.abscessus_ATCC_1997 KRVGLIGTVGVRIDGEDVPSALTTPEAPALQELLAEMVQRGVDTVVMEVS
TH_1516|M.thermoresistible__bu RRSALCGNIGN--------------------PVLDVLTEP-VDLFAVELS
: .* *.:* :* : : *: ..:*:*
Mflv_2983|M.gilvum_PYR-GCK SHALTLGRVDGVSFAVGGFTNLSRDHLDFHPTMQDYFEAKARLVDPTSPT
Mvan_3528|M.vanbaalenii_PYR-1 SHALTLGRVDGVSFAVGGFTNLSRDHLDFHPTMEDYFDAKARLFDPACAT
MSMEG_4232|M.smegmatis_MC2_155 SHALAQGRVDGIGFAVGGFTNLSRDHLDFHPTMADYFEAKARLFDPQSPN
MUL_3506|M.ulcerans_Agy99 SHALTLGRVDGIRFAVGGFTNLSRDHLDFHPTMADYFEAKALLFDPASAL
MMAR_3198|M.marinum_M SHALTLGRVDGIRFAVGGFTNLSRDHLDFHPTMADYFEAKALLFDPASAL
Mb2182c|M.bovis_AF2122/97 SHALALGRVDGTRFAVGAFTNLSRDHLDFHPSMADYFEAKASLFDPDSAL
Rv2158c|M.tuberculosis_H37Rv SHALALGRVDGTRFAVGAFTNLSRDHLDFHPSMADYFEAKASLFDPDSAL
MAV_2331|M.avium_104 SHALALGRVDGTRFAVGGFTNLSRDHLDFHPTMADYFEAKALLFDPNSPL
MLBr_00909|M.leprae_Br4923 SHALSLGRVEGTQFAVAGFTNLSRDHLDFHPDMEEYFEAKAVLFDPHSLL
MAB_2001|M.abscessus_ATCC_1997 SHALALNRVDGTRFAVGAFTNLSRDHLDFHPDMQDYFATKARLFRRDSPQ
TH_1516|M.thermoresistible__bu --SFQLHWAPSVRPYAGVVLNIAEDHLDWHGSLTAYAQAKARVLG-----
:: . . .. . *::.****:* : * :** :.
Mflv_2983|M.gilvum_PYR-GCK HAARSVICVDDEWGRAMAARADAP----VTVS-VTG-DADWWVQEVRALD
Mvan_3528|M.vanbaalenii_PYR-1 HAARSVICVDDEWGRAMAARARRP----VTVS-TTG-PADWRAEQVRSAG
MSMEG_4232|M.smegmatis_MC2_155 HAAAAVICVDDQYGVQMAARAETP----LTVS-TSGAAADWRVEKITTAG
MUL_3506|M.ulcerans_Agy99 RGHSVVVCIDDEAGRAMADRAGVA----ITVS-ATGQPAHWRATDVAPVG
MMAR_3198|M.marinum_M RGHSVVVCIDDEAGRAMADRAGAA----ITVS-ATGQPAHWRATDVAPVG
Mb2182c|M.bovis_AF2122/97 RARTAVVCIDDDAGRAMAARAADA----ITVS-AADRPAHWRATDVAPTD
Rv2158c|M.tuberculosis_H37Rv RARTAVVCIDDDAGRAMAARAADA----ITVS-AADRPAHWRATDVAPTD
MAV_2331|M.avium_104 RAHRAVVCIDDEAGREMAARAGDA----VTVS-AEGQPAHWRAVEVAPLG
MLBr_00909|M.leprae_Br4923 RARTVVVCIDDDAGRATAARAGDA----ITVS-ALGQPASWRATDIRSPG
MAB_2001|M.abscessus_ATCC_1997 RAHRSVVCIDDDAGRAMAELAREAGPDVTTVSSLDGGVADWRCSNVAVGH
TH_1516|M.thermoresistible__bu -GTVAVAGVDDPMAARLLAAAAAP-----------------RKVGFRLGA
. * :** . * . .
Mflv_2983|M.gilvum_PYR-GCK GGVQDFLAVDPAGVHHALEIGLPGGYNVANCLLAVALLDAVDVSPEQAAP
Mvan_3528|M.vanbaalenii_PYR-1 GGAQDFVAVDPAGVHHGLEIGLPGGYNVANCLLAIALLDAVGVSPEQAAP
MSMEG_4232|M.smegmatis_MC2_155 PGAQEFVLVDPGGMHHQLGVGLPGRYNVANAALAVALLDAVGVSPEQAAP
MUL_3506|M.ulcerans_Agy99 AGGQEFTALDPAGVGHRVRIGSPGHYNVSNCLLALAILDAVGVSPEQAAP
MMAR_3198|M.marinum_M AGGQEFTALDPAGVGHRVRIGLPGHYNVANCLLALAILDAVGVSPEQAAP
Mb2182c|M.bovis_AF2122/97 AGGQQFTAIDPAGVGHHIGIRLPGRYNVANCLVALAILDTVGVSPEQAVP
Rv2158c|M.tuberculosis_H37Rv AGGQQFTAIDPAGVGHHIGIRLPGRYNVANCLVALAILDTVGVSPEQAVP
MAV_2331|M.avium_104 TGGQQFTVIDPAGVQHRAGIRLPGHYNVANCLVALALLDAVGVSPEQAAP
MLBr_00909|M.leprae_Br4923 VGAQEFTAVDPAGVQHRVGIRLPGRYNVANCLVALAILDVVGVSPEQASL
MAB_2001|M.abscessus_ATCC_1997 DGGQRFVANGP-DRDTELTIALPGHYNVANCLVAIAILDVLGVSAATAAP
TH_1516|M.thermoresistible__bu PAADELGVADGMLVDRAFADGLP-----------LVAVDRIPVAXX----
. : : . * :. :* : *:
Mflv_2983|M.gilvum_PYR-GCK GLRDATVPGRLEAVDRGQPFLALVDYAHKPGALAAVLQTLREQCAGRLAV
Mvan_3528|M.vanbaalenii_PYR-1 GVRDATVPGRLESVDRGQPFLALVDYAHKPGALRAVLQTLREQCTGRLAV
MSMEG_4232|M.smegmatis_MC2_155 GLRTATVPGRLESIDLGQDFLALVDYAHKPGALQAVLETLRAAEPRRIAV
MUL_3506|M.ulcerans_Agy99 GLRETRVPGRLEQVDRGQDFLALVDYAHKPGALREVLSTLRNP-QRRLAV
MMAR_3198|M.marinum_M GLRETRVPGRLEQVDRGQDFLALVDYAHKPGALREVLSTLRNP-QRRLAV
Mb2182c|M.bovis_AF2122/97 GLREIRVPGRLEQIDRGQGFLALVDYAHKPEALRSVLTTLAHP-DRRLAV
Rv2158c|M.tuberculosis_H37Rv GLREIRVPGRLEQIDRGQGFLALVDYAHKPEALRSVLTTLAHP-DRRLAV
MAV_2331|M.avium_104 GLLQTRVPGRMEEIDAGQDFLALVDYAHKPGALRAVLSSLKRP-DRRLAV
MLBr_00909|M.leprae_Br4923 GFRDIRIPGRLERIDCGQDFLALVDYAHKPGALHSVLTALLQP-DHRLAV
MAB_2001|M.abscessus_ATCC_1997 GIATAGVPGRMEAVAAGQPFLAVVDYAHKPGALRAVLESLRSHRDGRLAV
TH_1516|M.thermoresistible__bu -----------------------------------------------XXR
Mflv_2983|M.gilvum_PYR-GCK VFGAGGDRDQGKREPMGRVAAELADLVVVTDDNPRGEDPAVIRAAILRGA
Mvan_3528|M.vanbaalenii_PYR-1 VFGAGGNRDQGKREPMGRVAAELADLVVVTDDNPRDEDPAVIRAAILAGA
MSMEG_4232|M.smegmatis_MC2_155 VFGAGGDRDPGKREPMGRVTAELADLVVVTDDNPRSEDPATIRSAILAGA
MUL_3506|M.ulcerans_Agy99 VFGAGGDRDPGKRGPMGRIAAELADLVVVTDDNPRGEDPGAIRRTIVAGA
MMAR_3198|M.marinum_M VFGAGGDRDPGKRGPMGRIAAELADLVVVTDDNPRGEDPGAIRRTIVAGA
Mb2182c|M.bovis_AF2122/97 VFGAGGDRDPGKRAPMGRIAAQLADLVVVTDDNPRDEDPTAIRREILAGA
Rv2158c|M.tuberculosis_H37Rv VFGAGGDRDPGKRAPMGRIAAQLADLVVVTDDNPRDEDPTAIRREILAGA
MAV_2331|M.avium_104 VFGAGGERDPGKRAPMGATAAELADLVVVTDDNPRGEDPAAIRREILAGA
MLBr_00909|M.leprae_Br4923 VFGAGGERDPGKRAPMGEIAAELADLVVVTDDNPRGEDPAAIRRDILTGT
MAB_2001|M.abscessus_ATCC_1997 VFGAGGNRDRGKRADMGKVAAELADLVVVTDDNPRNEEPAAIRTEIISGT
TH_1516|M.thermoresistible__bu VLHGEVDPHPARR-------------------------------------
*: . : . .:*
Mflv_2983|M.gilvum_PYR-GCK SG----AQTVEIGDRRAAIVHAVQWAREGDIVLIAGKGHEAGQTSQGRTR
Mvan_3528|M.vanbaalenii_PYR-1 AGAR--AEVVEIGDRRAAIGHAAGWARAGDIVLIAGKGHEAGQTSGGQTR
MSMEG_4232|M.smegmatis_MC2_155 RAVASDAEIVEIGDRRAAIDHAVAWAQPGDIVLIAGKGHESGQTVGDHTR
MUL_3506|M.ulcerans_Agy99 AESGGAAQVVEIADRGEAIGYAVDWARTGDVVLIAGKGHETGQRGGAEVR
MMAR_3198|M.marinum_M AESGGAAQVVEIADRGEAIGYAVDWARTGDVVLIAGKGHETGQRGGAEVR
Mb2182c|M.bovis_AF2122/97 AEVGGDAQVVEIADRRDAIRHAVAWARPGDVVLIAGKGHETGQRGGGRVR
Rv2158c|M.tuberculosis_H37Rv AEVGGDAQVVEIADRRDAIRHAVAWARPGDVVLIAGKGHETGQRGGGRVR
MAV_2331|M.avium_104 TESGCAAEVIEIGDRRAAIRHAVAWAGPGDVVLVAGKGHETGQRTGEHTR
MLBr_00909|M.leprae_Br4923 VAAGGAAQVVEIGDRRAAIQYAVAWAGPDDVVLVAGKGHETGQRGAAETC
MAB_2001|M.abscessus_ATCC_1997 TGS--EAQIIEIGDRRAAIDFATLWARPGDTVLVAGKGHESGQKTGDVTV
TH_1516|M.thermoresistible__bu --------------------------------------------------
Mflv_2983|M.gilvum_PYR-GCK PFDDRDELAAAL-ETLQTSGTSGASQ---
Mvan_3528|M.vanbaalenii_PYR-1 PFDDRDELAAAL-EARGARGAGG------
MSMEG_4232|M.smegmatis_MC2_155 PFDDRDELAAAL-EASGKTRDRSS-----
MUL_3506|M.ulcerans_Agy99 PFDDRVELARAL-EALESCT---------
MMAR_3198|M.marinum_M PFDDRVELARAL-EALESCT---------
Mb2182c|M.bovis_AF2122/97 PFDDRVELAAAL-EALERRA---------
Rv2158c|M.tuberculosis_H37Rv PFDDRVELAAAL-EALERRA---------
MAV_2331|M.avium_104 PFDDRVELAEALREAVGPRKAQG------
MLBr_00909|M.leprae_Br4923 PFDDRVELARAL-QVRDARLLPAPGRACQ
MAB_2001|M.abscessus_ATCC_1997 PFDDRVELRAAL-EALGSLDD--------
TH_1516|M.thermoresistible__bu -----------------------------