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MAMSAKASDDIAWLPATAQLAVLAAKKVSSAELVELYLSRIDTYNASLNAIVTVDPDAARRVAKRSDAAR ARGDELGPLHGLPITVKDSYETAGMRTTCGRRDLADYVPTQDAEAVARLRRAGAIIMGKTNMPTGNQDVQ ASNPVFGRTNNPWDAARTSGGSAGGGAAATAAGLTSFDYGSEIGGSTRIPAHYCGLYGHKSTWRSVPLVG HIPSAPGNPGRWGQADMACAGVQVRGARDIIPALEATVGPMRADGGFSYALAPPRAGALKDFRVAVWAED PHCPIDADVRRAMDDAVAALRAAGAHVVEQPATIPVDMAVSHNIFQSLVFGAFAVDRSTLSPASAAALGL RAVRHPRGEAANALGATLQSHRAWLFADAARHEMRDRWAGFFNEFDVLLLPVTPTPAPLHHNKDHDRLGR TIDVDGVSRSYWDQLKWNALANIAGTPATTMPITTTATGLPIGIQAMGPAGGDRTTVEFAALLTEVLGGF RVPPL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3175 | - | - | 100% (495) | amidase |
| M. tuberculosis H37Rv | Rv2363 | amiA2 | 2e-40 | 33.06% (481) | amidase |
| M. tuberculosis H37Rv | Rv1263 | amiB2 | 3e-38 | 32.43% (478) | amidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3200 | - | 0.0 | 100.00% (495) | amidase |
| M. gilvum PYR-GCK | Mflv_2712 | - | 2e-41 | 31.91% (492) | amidase |
| M. leprae Br4923 | MLBr_01702 | gatA | 1e-32 | 28.72% (491) | aspartyl/glutamyl-tRNA amidotransferase subunit A |
| M. abscessus ATCC 19977 | MAB_3341c | gatA | 2e-38 | 30.41% (490) | aspartyl/glutamyl-tRNA amidotransferase subunit A |
| M. marinum M | MMAR_2765 | - | 2e-51 | 31.46% (499) | amidase |
| M. avium 104 | MAV_1414 | - | 3e-41 | 32.37% (482) | amidase |
| M. smegmatis MC2 155 | MSMEG_3970 | - | 3e-63 | 34.09% (484) | glutamyl-tRNA(Gln) amidotransferase subunit A |
| M. thermoresistible (build 8) | TH_4482 | - | 2e-42 | 33.47% (484) | PUTATIVE Amidase |
| M. ulcerans Agy99 | MUL_3616 | amiA2 | 1e-37 | 31.48% (486) | amidase |
| M. vanbaalenii PYR-1 | Mvan_3824 | - | 7e-41 | 32.65% (487) | amidase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3175|M.tuberculosis_H37Rv MAMSAKASDDIAWLPAT------------------------AQLAVLAAK
Mb3200|M.bovis_AF2122/97 MAMSAKASDDIAWLPAT------------------------AQLAVLAAK
MMAR_2765|M.marinum_M -------MTELCHLSAH------------------------ELVGLMSTG
MSMEG_3970|M.smegmatis_MC2_155 ------MSTDIIYSDAT------------------------GLAELIRSR
Mflv_2712|M.gilvum_PYR-GCK -----------------MP-DSS-ARSTSRNRFPDRFPTVANQLFQLASG
Mvan_3824|M.vanbaalenii_PYR-1 -----------------MA-DTAYSRITSRR----RFPTLGNQLFQLASG
TH_4482|M.thermoresistible__bu -----------------MV-DAYKPPAK--------LPTLTDLLYQLASG
MUL_3616|M.ulcerans_Agy99 -----------------MVGASGFASGAVSGSGGPRLPTLTDLLYQLASG
MAV_1414|M.avium_104 -----------------MN-DLAFAGAA-------------AQARMLANG
MLBr_01702|M.leprae_Br4923 ---MIGSLHEIIRL--DAS----------------------TLAAKIVAK
MAB_3341c|M.abscessus_ATCC_199 -------MTDLIRQ--DAA----------------------ALAALIHSG
:
Rv3175|M.tuberculosis_H37Rv KVSSAELVELYLSRIDTYNASLNAIVTVD-PDAARRVAKRSDAARARGD-
Mb3200|M.bovis_AF2122/97 KVSSAELVELYLSRIDTYNASLNAIVTVD-PDAARRVAKRSDAARARGD-
MMAR_2765|M.marinum_M SVSCREVIQQHLARIRAVNPALNALVEADDPERCLRQADHADECVARGA-
MSMEG_3970|M.smegmatis_MC2_155 QLSPVEVVQAHLDRIEAVNPKINAIVTVA--ERALAQARSAEAAVMRGD-
Mflv_2712|M.gilvum_PYR-GCK TATSVDLVRRSLVAIEASQPTLNAFRVVL-AERALADAAEADRLRAAGHD
Mvan_3824|M.vanbaalenii_PYR-1 TATSVDLVSRSLQAIEASQPTLNAFRVVL-TEQALADAAEADRKRAAGAD
TH_4482|M.thermoresistible__bu AVTSQELVRRSLRAIEASQSTLNAFRVVL-ADRALAEAAEADRKRAAG--
MUL_3616|M.ulcerans_Agy99 SVTSVELTRRSLREIEVSQSTLNAFRVVL-TESALADAAAADRRRAAG--
MAV_1414|M.avium_104 DLSAPELLEVYLERIARLDSQLRCYRVVL-ADRARREAAAAQSRLDAG--
MLBr_01702|M.leprae_Br4923 ELSSVEITQACLDQIEATDDTYRAFLHVA-AEKALSAAAAVDKAVAAGG-
MAB_3341c|M.abscessus_ATCC_199 EVSSVEVTRAHLDQIASTDETYRAFLHVA-GEQALAAAKDVDDAIAAG--
: :: * * : .. . : . * : *
Rv3175|M.tuberculosis_H37Rv -ELGPLHGLPITVKDSYETAGMRTTCGRRDLADYVPTQDAEAVARLRRAG
Mb3200|M.bovis_AF2122/97 -ELGPLHGLPITVKDSYETAGMRTTCGRRDLADYVPTQDAEAVARLRRAG
MMAR_2765|M.marinum_M -PLGAAHGLPVVIKDVMQVAGLACSGGSPGLR-AVADTDATVVSRLRAQG
MSMEG_3970|M.smegmatis_MC2_155 -DLPPLHGVPFTVKDSIDTADVLTQRGSPIFAGRIPQTDAVSVARLKAAG
Mflv_2712|M.gilvum_PYR-GCK RARRPLLGIPIAVKDDVDVAGVPTRFG-ASGEVPEAVADAEVVRRLRAAG
Mvan_3824|M.vanbaalenii_PYR-1 LSRHPLLGVPIAVKDDVDVAGVPTRFG-ADGEVPPAEADAEVVRRLRAAG
TH_4482|M.thermoresistible__bu -EHLPLLGVPIAVKDDVDIAGVPTRFG-AVGDVPPATEDAEVVRRLRAAG
MUL_3616|M.ulcerans_Agy99 -DAAPLLGIPIAVKDDVDVAGVPTAFG-TQGYVQPAAHDSEVVRRLKAAG
MAV_1414|M.avium_104 -ERLPLLGVPVAIKDDVDVAGEVTTFG-SGGHGPAVSSDAEVVRRLRAAG
MLBr_01702|M.leprae_Br4923 QLSSTLAGVPLALKDVFTTVDMPTTCGSKILQGWHSPYDATVTTRLRAAG
MAB_3341c|M.abscessus_ATCC_199 SVPSGLAGVPLALKDVFTTRDMPTTCGSKILENWVPPYDATVTARLRGAG
*:*..:** . * *: . **: *
Rv3175|M.tuberculosis_H37Rv AIIMGKTNMPTGNQDVQASNPVFGRTNNPWDAARTSGGSAGGGAAATAAG
Mb3200|M.bovis_AF2122/97 AIIMGKTNMPTGNQDVQASNPVFGRTNNPWDAARTSGGSAGGGAAATAAG
MMAR_2765|M.marinum_M AIVLGMTNVPEMSRGGESNNNLYGRTNNPYDLTRTPGGSSGGSAALVAAG
MSMEG_3970|M.smegmatis_MC2_155 AIVLAKTNLPEFSYSTETDNLLTGRSNNPWNLDRTPGGSSGGESAAIAAG
Mflv_2712|M.gilvum_PYR-GCK AVIVGKTNTCELGQWPFTSGPAFGHTRNPWSREHTPGGSSGGSAAAVAAG
Mvan_3824|M.vanbaalenii_PYR-1 AVIVGKTNTCELGQWPFTSGPAFGHTRNPWSREHTPGGSSGGSAAAVAAG
TH_4482|M.thermoresistible__bu AVIVGKTHTCELGQWPFTSGPAFGHTRNPWSPRHTPGGSSGGSAAAVAAG
MUL_3616|M.ulcerans_Agy99 AVIIGKTNTCELGQWPFTSGPGFGHTRNPWARRHTPGGSSGGSAAAVAAG
MAV_1414|M.avium_104 AVIIGKTNVPELMMMPYTESLTFGATRNPWDPRRTPGGSSGGSAAAVAAG
MLBr_01702|M.leprae_Br4923 IPILGKTNMDEFAMGSSTENSAYGPTRNPWNVDRVPGGSGGGSAAALAAF
MAB_3341c|M.abscessus_ATCC_199 IPILGKTNMDEFAMGSSTENSAYGPTRNPWDVERVPGGSGGGSAAALAAF
::. *: :.. * :.**: :..***.** :* **
Rv3175|M.tuberculosis_H37Rv LTSFDYGSEIGGSTRIPAHYCGLYGHKSTWRSVPLVGHIPSAPGNPGRWG
Mb3200|M.bovis_AF2122/97 LTSFDYGSEIGGSTRIPAHYCGLYGHKSTWRSVPLVGHIPSAPGNPGRWG
MMAR_2765|M.marinum_M GAALSVGSDGGGSIRQPCHNTGIAGLKPTHGRIPRTGSVFGDALGV----
MSMEG_3970|M.smegmatis_MC2_155 LSPLGLGTDLAISVRGPAAQTGIAALKATHGRIPMTG-VWPRVP------
Mflv_2712|M.gilvum_PYR-GCK LVAAAIGSDGAGSVRIPAAWTHLVGIKPQRGRISTSPLPEAFNG------
Mvan_3824|M.vanbaalenii_PYR-1 LVAAAIGSDGAGSVRIPAAWTHLVGIKPQRGRISTWPLTEAFNG------
TH_4482|M.thermoresistible__bu LVTAAIGSDGAGSVRIPAAWTHLVGIKPQRGRISTWPLPEAFNG------
MUL_3616|M.ulcerans_Agy99 LVTAAIGSDGAGSIRVPAAWTHLVGIKPQRGRISTWPWPETFNG------
MAV_1414|M.avium_104 LAPLALGSDGGGSIRIPSTWCGLFGLKPQRDRVSLEPHDDAWYG------
MLBr_01702|M.leprae_Br4923 QAPLAIGSDTGGSIRQPAALTATVGVKPTYGTVSRYGLVACASS------
MAB_3341c|M.abscessus_ATCC_199 QAPLAIGTDTGGSIRQPAALTATVGVKPTYGTVSRFGLVACASS------
. *:: . * * *. . *. :.
Rv3175|M.tuberculosis_H37Rv QADMACAGVQVRGARDIIPALEATVGPMRADG-GFSYALAPPRAGALKDF
Mb3200|M.bovis_AF2122/97 QADMACAGVQVRGARDIIPALEATVGPMRADG-GFSYALAPPRAGALKDF
MMAR_2765|M.marinum_M FSPFVCYGPLARSVRDLFLGLSIMNGPDLADPYTAPAPLGSPDDVELGTL
MSMEG_3970|M.smegmatis_MC2_155 -RRFWHVGPMARTVRDLALAYELLAGPDGADAFAISPVRFDAGTAAVDSL
Mflv_2712|M.gilvum_PYR-GCK ---ITVNGVLARTVSDAAMVLDAAAGNAAGDLHTPAPVTVSDFVSRAPGP
Mvan_3824|M.vanbaalenii_PYR-1 ---ITVHGVLARTVSDAALLLDAASGNAPGELHTPPPVRVSDYVSRAPGP
TH_4482|M.thermoresistible__bu ---ITVHGVLARTVTDAALVLDAASGNAPGDLHQPPPVRVSDYVGQAPGP
MUL_3616|M.ulcerans_Agy99 ---ITVNGVLARTVADAALVLDAASGNAEGDLHKPAPLTASDYVGIAPGP
MAV_1414|M.avium_104 ---LSVNGPIARTVIDAAVFLDATS-TVPG-----PEGEFVAAATREPGR
MLBr_01702|M.leprae_Br4923 ---LDQGGPCARTVLDTALLHAVIAGHDARDSTSVEAAVPDIVGAAKAGE
MAB_3341c|M.abscessus_ATCC_199 ---LDQGGPCARTVLDTALLHQVIAGHDPRDSTSVDEPVPDVVAAARAGA
: * .* . *
Rv3175|M.tuberculosis_H37Rv RVAVWAEDPHCPIDADVRRAMDDAVAALRAAGAHVVEQPATIPVDMAVSH
Mb3200|M.bovis_AF2122/97 RVAVWAEDPHCPIDADVRRAMDDAVAALRAAGAHVVEQPATIPVDMAVSH
MMAR_2765|M.marinum_M RVAAYLDDGISPPSEEVTAVVTAAVEALREVVAVIDHA-----VPPCLNR
MSMEG_3970|M.smegmatis_MC2_155 RVGWLVEPGFGPIDAEVAATVRAAAEALSSIGLAVEPV-----RIPALER
Mflv_2712|M.gilvum_PYR-GCK LR--VAVSTRFPFTGFRATLHPEIRSALDGVADQLSQLGHTVLNADPDY-
Mvan_3824|M.vanbaalenii_PYR-1 LR--IAMSTKFPFTVFRAGLHPEIRTALQNVADQLTQLGHTIVAADPDY-
TH_4482|M.thermoresistible__bu LR--IAVSTKFPFTLFRAKLHPEIRAAVQTVADQLEQLGHTVFPADPEY-
MUL_3616|M.ulcerans_Agy99 LK--IAMSTRFPYTGFRAKLHPEILASTRRVGEQLQLLGHTVERGNPDY-
MAV_1414|M.avium_104 LR--IALSTKVP-TPLPVRVGKPELAAVQQAGALLRDLGHDVVTADPEYP
MLBr_01702|M.leprae_Br4923 SGDLHGVRVGVVRQLRGEGYQSGVLASFQAAVEQLIALGATVSEVDCPHF
MAB_3341c|M.abscessus_ATCC_199 SGDLKGVRVGVVTQLRGDGYQPGVMASFDAAVEQLTALGADVVEVSCPHF
: :
Rv3175|M.tuberculosis_H37Rv NIFQSLVFGAFAVDR-------------------STLSPASAAALGLRAV
Mb3200|M.bovis_AF2122/97 NIFQSLVFGAFAVDR-------------------STLSPASAAALGLRAV
MMAR_2765|M.marinum_M TTDLLWTSIFLGGDR-------------------GRGFEEDLGAIGTTAP
MSMEG_3970|M.smegmatis_MC2_155 DFALDVFMRLHVMEL-------------------KPAFAEATAGRGD---
Mflv_2712|M.gilvum_PYR-GCK TLGMSWNFLARSTSG----------------------IPEWMDRLGHRVT
Mvan_3824|M.vanbaalenii_PYR-1 HLRMSWNFLSRSTSG----------------------IPEWMDRLGRGVN
TH_4482|M.thermoresistible__bu TVGMSWSFLSRSTAG----------------------LLDWSRRLGDNVL
MUL_3616|M.ulcerans_Agy99 GLRLSWDFLARSTAG----------------------LWEWAECLGNGVT
MAV_1414|M.avium_104 AAAILGNYLPRYLRG----------------------ICDDADSLAHPER
MLBr_01702|M.leprae_Br4923 DYALAAYYLILPSEVSSNLARFDAMRYGLRVGDDGSRSAEEVIALTRAAG
MAB_3341c|M.abscessus_ATCC_199 EYALPAYYLILPSEVSSNLARFDAMRYGMRVGDDGTHSAEEVMALTRAAG
Rv3175|M.tuberculosis_H37Rv RHPRGEAANALGATLQSHRAWLFADAARHEMRDRWAGFFNEFDVLLLPVT
Mb3200|M.bovis_AF2122/97 RHPRGEAANALGATLQSHRAWLFADAARHEMRDRWAGFFNEFDVLLLPVT
MMAR_2765|M.marinum_M SEELAEFTAQARQVDFSLTEARRRLVDIDHYRIQMLAFMADYDVIIGPAM
MSMEG_3970|M.smegmatis_MC2_155 EELFAISKRILATPDTSIQDFVEAEQAGERLRDGFADYFSRYDALLAPVL
Mflv_2712|M.gilvum_PYR-GCK WDSRTRSNARMGRLLSQH-TLRKARAREAAAQQRIGWIFNLADVVVAPTT
Mvan_3824|M.vanbaalenii_PYR-1 WDSRTRSNARMGWLLSQN-VLRKARAGEAASQQRIGWIFNLADVVLAPTT
TH_4482|M.thermoresistible__bu WDKRTVANMRLGRLLSES-ALRKARAREAAAQRRMSWIFNIADVVLAPTT
MUL_3616|M.ulcerans_Agy99 LDPRTVTNMRAGHALSQA-ILRNARHHEAAAQRRVGSIFDIVDVVLAPTT
MAV_1414|M.avium_104 LEARTRNMARMGSFFSDR-RMAAIRAGEGPLIARIQAIFDDVDVVVTPGT
MLBr_01702|M.leprae_Br4923 FGPEVKRRIMIGAYALSA-GYYDSYYSQAQKVRTLIARDLDKAYRSVDVL
MAB_3341c|M.abscessus_ATCC_199 FGPEVKRRIMIGTYALSA-GYYDAYYGRAQKVRTLIKRDLERAYEQVDVL
.
Rv3175|M.tuberculosis_H37Rv PTPAPLHHNKDHDRLGRTIDVDGVSRSYWDQLKWNALANIAGTPATTMPI
Mb3200|M.bovis_AF2122/97 PTPAPLHHNKDHDRLGRTIDVDGVSRSYWDQLKWNALANIAGTPATTMPI
MMAR_2765|M.marinum_M PTPAKPHH-------HGLVEIS----DFSHLM----VHNLTGWPAAVVRC
MSMEG_3970|M.smegmatis_MC2_155 PVPAHEHR-------AKEFDINGQTVDATYIMGATVPFNVTGLPALSLRF
Mflv_2712|M.gilvum_PYR-GCK AQPPPEAH------AFDGLGGLATDRMMIRACPVTWPWNLLGWPSINVPA
Mvan_3824|M.vanbaalenii_PYR-1 ALPPPEVR------AFDDLGGLATDRMMIKACPVTWPWNLLGWPSINVPA
TH_4482|M.thermoresistible__bu ALPPPEVH------AFDQLGGLATDRLMIKACPVTWPWNLLGWPSINVPA
MUL_3616|M.ulcerans_Agy99 AQPPPLAR------AFDDMGGLATDRAIIAACPLTWPWNLLGWPSINVPA
MAV_1414|M.avium_104 AAGPSRVG------AYQRRGAVSTLLRVGQCVPYQQIWNLTGQPAAVVPW
MLBr_01702|M.leprae_Br4923 VSPATPTT------AFSLGEKADDPLAMYLFDLCTLPLNLAGHCGMSVPS
MAB_3341c|M.abscessus_ATCC_199 VTPATPTT------AFRLGEKVDDPLAMYQFDLCTLPLNLAGHCGMSVPS
. *: * . :
Rv3175|M.tuberculosis_H37Rv TTTATG-LPIGIQAMGPAGGDRTTVEFAALLTEVLGG-FRVPPL------
Mb3200|M.bovis_AF2122/97 TTTATG-LPIGIQAMGPAGGDRTTVEFAALLTEVLGG-FRVPPL------
MMAR_2765|M.marinum_M GTSPGG-LPIGVQIAARPWHDGTALAVASHLEAIFGG-WQAPGLLVT---
MSMEG_3970|M.smegmatis_MC2_155 GTSSAG-LPINVQLISTWLAESTVLNLASLLESVSPVRNQHPGI------
Mflv_2712|M.gilvum_PYR-GCK GFTSDG-LPIGVQLMGPADSEPLLISLAAALEAINGWATLQPENWWAPQP
Mvan_3824|M.vanbaalenii_PYR-1 GFTSDG-LPIGVQLMGPANSEPLLVSLAAALEAINGWAVHQPEDWWTPQP
TH_4482|M.thermoresistible__bu GFTSDG-LPIGVQLMGPANSEPLLVSLAAALEGINGWAARQPRPWWLT-P
MUL_3616|M.ulcerans_Agy99 GFTVDG-LPIGVQLMGPAESEGLLISLAAELEAVSGWATKQPKVWWNTGT
MAV_1414|M.avium_104 DFDADG-LPMSVQLVGRPYDEATLLSLSAQIEAARPWALRRPPVC-----
MLBr_01702|M.leprae_Br4923 GLSSDDDLPVGLQIMAPALADDRLYRVGAAYEAARGPLPSAI--------
MAB_3341c|M.abscessus_ATCC_199 GLSADDGLPVGLQIMAPALADDRLYRVGAAYETARGALPAAL--------
. **:.:* . : ..:
Rv3175|M.tuberculosis_H37Rv ---------------------
Mb3200|M.bovis_AF2122/97 ---------------------
MMAR_2765|M.marinum_M ---------------------
MSMEG_3970|M.smegmatis_MC2_155 ---------------------
Mflv_2712|M.gilvum_PYR-GCK PTEPDL----TAPDSVTGQVA
Mvan_3824|M.vanbaalenii_PYR-1 PPEPDLGSNVAAPASVEGQVA
TH_4482|M.thermoresistible__bu PAAPXX----XASAAAS----
MUL_3616|M.ulcerans_Agy99 STPPIH----SVRPPRR----
MAV_1414|M.avium_104 ---------------------
MLBr_01702|M.leprae_Br4923 ---------------------
MAB_3341c|M.abscessus_ATCC_199 ---------------------