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MNPGVFDVIDMMTGYQPAAALTAAARLGVFDVLADAPLPADAVAARLGTEPRATRALLDALTGLGLLGTD DGGYTAAPVARRLGRDGDLRLIAEKEAFFAEAWLSLADSVRTGRPRLDPWRSRLAADPEQVRRFLEALVV LARETGPDLTRLPGVGPGVRIADLGGGLGSYAVPLAAAGAQVTLVDLPPVAEWARDRLAGSGVPGHIEVR AVDLLGPDAAERVGTDAGYDVVLLAHLLHDLGDDDCAAVLQVAATVCRPGGQAVVFELPGDPPGAFGPMF DLMMRVETEGRARRADELVALLRAAGFTGVHESSAYRRPHGVFIASR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3149 | - | - | 100% (327) | methyltransferase type 12 |
| M. vanbaalenii PYR-1 | Mvan_2460 | - | 9e-23 | 30.94% (320) | O-methyltransferase family protein |
| M. vanbaalenii PYR-1 | Mvan_2287 | - | 1e-08 | 32.41% (145) | methyltransferase type 11 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0582 | - | 1e-16 | 28.38% (296) | methyltransferase/methylase |
| M. gilvum PYR-GCK | Mflv_3940 | - | 8e-28 | 33.64% (321) | O-methyltransferase family protein |
| M. tuberculosis H37Rv | Rv0567 | - | 2e-16 | 28.38% (296) | methyltransferase/methylase |
| M. leprae Br4923 | MLBr_02273 | ubiE | 2e-05 | 30.09% (113) | ubiquinone/menaquinone biosynthesis methyltransferase |
| M. abscessus ATCC 19977 | MAB_0867c | - | 1e-05 | 33.01% (103) | putative transferase |
| M. marinum M | MMAR_0934 | - | 4e-16 | 28.04% (296) | methyltransferase/methylase |
| M. avium 104 | MAV_3373 | - | 3e-12 | 35.56% (135) | methyltransferase, UbiE/COQ5 family protein |
| M. smegmatis MC2 155 | MSMEG_0367 | - | 4e-21 | 28.80% (316) | O-demethylpuromycin-O-methyltransferase |
| M. thermoresistible (build 8) | TH_3698 | - | 3e-24 | 28.48% (323) | PUTATIVE hydroxyneurosporene-O-methyltransferase |
| M. ulcerans Agy99 | MUL_0686 | - | 9e-16 | 28.04% (296) | methyltransferase/methylase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0582|M.bovis_AF2122/97 ----------------------------------------MELS-PDRIM
Rv0567|M.tuberculosis_H37Rv ----------------------------------------MELS-PDRIM
MMAR_0934|M.marinum_M ----------------------------------------MDQSSPDRIM
MUL_0686|M.ulcerans_Agy99 ----------------------------------------MDQSRPDRIM
Mflv_3940|M.gilvum_PYR-GCK MTHTSTPRGSAARSAPNRVPPVRLIRAVDRLRAGLQRLHRSTAPGNVALM
MSMEG_0367|M.smegmatis_MC2_155 ------------------MPPARLVRAVERARHHVRRLWLRSVPPEAAML
TH_3698|M.thermoresistible__bu MVSRHTFARTTTTHSP-TIPPPALVRAVETVRTGLQRVRARMAPPFAGVL
Mvan_3149|M.vanbaalenii_PYR-1 -----------------------------------------MNPGVFDVI
MAB_0867c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_3373|M.avium_104 --------------------------------------------------
MLBr_02273|M.leprae_Br4923 -----------------------------------------MPPGSVDVV
Mb0582|M.bovis_AF2122/97 AIGGGYGPSKVLLTAVGLGLFTELGDEAMTAEAIADRLGLLKRPAIDFLD
Rv0567|M.tuberculosis_H37Rv AIGGGYGPSKVLLTAVGLGLFTELGDEAMTAEAIADRLGLLKRPAIDFLD
MMAR_0934|M.marinum_M AIGAGYGPSKVLLTAVGLGLFTELGDRAMTAQAIAELLGLVPRPATDFLD
MUL_0686|M.ulcerans_Agy99 AIGAGYGPSKVLLTAVGLGLFTELGDRAMTAQALAELLGLVPRPATDFLD
Mflv_3940|M.gilvum_PYR-GCK ELATGAWTTQVLYVAATLGIPDELADGPAHAADVATRVGADAGAVYRLMR
MSMEG_0367|M.smegmatis_MC2_155 ELLLGAWLAQGITAAAQLGVADALSGGPLRADELARRVGADADALDRLMR
TH_3698|M.thermoresistible__bu DLAMGYAVSHAVQAAARLAIADVFDDGPLSVERIAERIDADAHAVRRLLR
Mvan_3149|M.vanbaalenii_PYR-1 DMMTGYQPAAALTAAARLGVFDVLADAPLPADAVAARLGTEPRATRALLD
MAB_0867c|M.abscessus_ATCC_199 ------------MGAPTQNIFEDLYRDSLHEG--GPIVPWDSKDAKPRIK
MAV_3373|M.avium_104 --MTLDTTTADASVAARHRTVWALGDYALMAEEVMAPLGPTLVEAAGIGP
MLBr_02273|M.leprae_Br4923 SRAALDKDPRDVVAMFDDVAHRYDLTNTVLSLGQDRYWRRATRSALRIGP
.
Mb0582|M.bovis_AF2122/97 ALVSLDLLARDGDGPGSHYRNTPETAHFLDEARPTYAGGLLKIWNERNYR
Rv0567|M.tuberculosis_H37Rv ALVSLDLLARDGDGPGSHYRNTPETAHFLDEARPTYAGGLLKIWNERNYR
MMAR_0934|M.marinum_M ALVSLDLLARDGDGPDARYRNTAETARYLDEASPEYQGGLLKIWDQRNYR
MUL_0686|M.ulcerans_Agy99 ALVSLDLLARDGDGPDARYRNTAETARYLDEASPEYQGGLLKIWDQRNYR
Mflv_3940|M.gilvum_PYR-GCK AMVSRGALREERDG---RFALTPVGDALRTDSEGSLRDMVLFIGHPARWA
MSMEG_0367|M.smegmatis_MC2_155 ALVGEGVFRRTRDG---RYALNPLGDTLRTDAQVSMAGMAKFVGAAQHRE
TH_3698|M.thermoresistible__bu VLASHQIFRERRDG---RFEMTPMSHALRSDAPVSIRPLLMMISHPFYTE
Mvan_3149|M.vanbaalenii_PYR-1 ALTGLGLLGTDDGG----YTAAPVARRLGRDGD----LRLIAEKEAFFAE
MAB_0867c|M.abscessus_ATCC_199 ELALLGAIRG---------DVLDIGCGLG-------DNAIYLAQQGFNVT
MAV_3373|M.avium_104 GVRVLDVAAGS--------GNITLPAAAAGASVVSTDLTPELLQRSRDRA
MLBr_02273|M.leprae_Br4923 GQKVLDLAAGT--------AVSTAELSKSGAWCVAADFSVRMLATGGARK
Mb0582|M.bovis_AF2122/97 FWADLTEALKTGKAQSEVKQTGRPFFEALYADPRRLEAFMAAMDAASRRN
Rv0567|M.tuberculosis_H37Rv FWADLTEALKTGKAQSEVKQTGRPFFEALYADPRRLEAFMAAMDAASRRN
MMAR_0934|M.marinum_M FWADLTDALQTGKPQNEIKQTGRPFFETVYADPRRLEVFLGAMDSASRRN
MUL_0686|M.ulcerans_Agy99 FWADLTDALQTGKPQNEIKQTGRPFFETVYADPRRLEVFLGAMDSASRRN
Mflv_3940|M.gilvum_PYR-GCK DWGSLEYSVRTGEPAADMLR-GMPFFDYLDTDPEFATVFNNAMTAASGLS
MSMEG_0367|M.smegmatis_MC2_155 HWSHLADAVRTGESAIRTLR-GMEPFDYIASQPELGTIFNDAMTSMSELA
TH_3698|M.thermoresistible__bu HFARLPDVVRTGRTSVESTY-GAGLFDCLEQDPDAAAVFNDAMTCVTAMA
Mvan_3149|M.vanbaalenii_PYR-1 AWLSLADSVRTGRPRLDPWR------SRLAADPEQVRRFLEALVVLARET
MAB_0867c|M.abscessus_ATCC_199 GLDFAPSAIEQAKGRAAAAG---VAVDFQVADATTLDGWDARFDTVIDSG
MAV_3373|M.avium_104 AGMGLTIDYREANAQALPFG--------DGEFDAVVSAIGVQFAPDHQRA
MLBr_02273|M.leprae_Br4923 VPKVAADATQLPFSDG--------------VFDAVTISFGLRNIADYQAA
.
Mb0582|M.bovis_AF2122/97 IELLAKRFPFERYRRLCDVGCADGLLSRIVAAAHPHLQCVSLDLPAVTEI
Rv0567|M.tuberculosis_H37Rv IELLAKRFPFERYRRLCDVGCADGLLSRIVAAAHPHLQCVSFDLPAVTEI
MMAR_0934|M.marinum_M CELLVKRFPFQRYGSLCDVGGANGLLSRTAAAAHPHLQCISFDLPAVTDI
MUL_0686|M.ulcerans_Agy99 CELLVKRFPFQRYGSLCDVGGANGLLSRTAAAAHPHLQCISFDLPAVTDI
Mflv_3940|M.gilvum_PYR-GCK DDVALQACDFTGARLVVDVGGGHGAVLATILRSAAGARGILFDLPAVVAG
MSMEG_0367|M.smegmatis_MC2_155 ITPLIAAYDFTRFGTIADVGGGHGRLLSAILGSAPQAKGVLYDLPNVVEG
TH_3698|M.thermoresistible__bu VPPVLAAYDFTDAETIVDVGGGAGQLLAAVLNAAPQARGVLFEQSSLKDH
Mvan_3149|M.vanbaalenii_PYR-1 GPDLTRLPGVGPGVRIADLGGGLGSYAVPLAAAG--AQVTLVDLPPVAEW
MAB_0867c|M.abscessus_ATCC_199 VYHCFDAEGHTEYASALHRATRPG----ARWYIWCFAQGAVHGVPTPFQN
MAV_3373|M.avium_104 ADELVRVCRPGGRIGLISWT-PEGFFGRMLATIRPYRPSLSHPVPPAALW
MLBr_02273|M.leprae_Br4923 LREMARVTRPGGQLVVCEFSTPTN-----ALVANVYTEYLMRALPQVARL
. .
Mb0582|M.bovis_AF2122/97 ARRKLTAEGLGERVQAC--AGDFL-------ADPLPAADVITMGQILHDW
Rv0567|M.tuberculosis_H37Rv ARRKLTAEGLGERVQAC--AGDFL-------ADPLPAADVITMGQILHDW
MMAR_0934|M.marinum_M TRRKLSEQGLGDRVRAV--SGDFF-------ADPLPSADVITMGQILHDW
MUL_0686|M.ulcerans_Agy99 TRRKLSEQGLGDRVRAV--SGDFF-------ADPLPSADVITMGQILHDW
Mflv_3940|M.gilvum_PYR-GCK AAPLLADAGVADRCTVS--GGSFL-------ESVPAGGDVYVMKNIVHDW
MSMEG_0367|M.smegmatis_MC2_155 APEMLARHGVADRVQVI--PGSFF-------DEVPDGADLYVMKNIIHDW
TH_3698|M.thermoresistible__bu AQRVFESAGVADRATIE--TGSFF-------EAVPEGGDIYLLKHVVHDW
Mvan_3149|M.vanbaalenii_PYR-1 ARDRLAGSGVPGHIEVR--AVDLLGPDAAERVGTDAGYDVVLLAHLLHDL
MAB_0867c|M.abscessus_ATCC_199 GQRAEEIEQVLTTSGWS--VLQIN-------PTTMSAPKAEFLNAIRGSY
MAV_3373|M.avium_104 GRPGYVRALLGERIGEITTARG------------MLPVNRFGSAEDVHAY
MLBr_02273|M.leprae_Br4923 VSS--------------------------------NPDAYIYLAESIRAW
Mb0582|M.bovis_AF2122/97 NLDRKQQLVAKAYEALSKEGAFIVIETLIDDARRENTTGLMMSLNMLIEF
Rv0567|M.tuberculosis_H37Rv NLDRKQQLVAKAYEALSKEGAFIVIETLIDDARRENTTGLMMSLNMLIEF
MMAR_0934|M.marinum_M NLDGKQRLIAKAYEALPEGGAFIAIETLIDDARRKNTAGLMMSLNMLIEF
MUL_0686|M.ulcerans_Agy99 NLDGKQRLIAKAYEALPEGGAFTAIETLIDDARRKNTAGLMMSLNMLIEF
Mflv_3940|M.gilvum_PYR-GCK DDTDAATILRNVRTAIAEGGKLVLLEMVLPERAS-SFIGHMLDLEMLLML
MSMEG_0367|M.smegmatis_MC2_155 ADAPAAEILRNVRAAARTGATLLLVEGVIPDHDR-AFPLKWVDMEMLIGN
TH_3698|M.thermoresistible__bu DDRQAAAILATVRESMSPNARLLLAETVIPPGNR-PHFGKLLDLDMLVFA
Mvan_3149|M.vanbaalenii_PYR-1 GDDDCAAVLQVAATVCRPGGQAVVFELPG---DPPGAFGPMFDLMMRVET
MAB_0867c|M.abscessus_ATCC_199 RGDP--AVLDRLDQDVTDPLLHVPVYTVIAERM-----------------
MAV_3373|M.avium_104 FKQHYGPTIEAYANIGHNRVLAAELDAQLVELAAQHLSDGTMGWEYLLVT
MLBr_02273|M.leprae_Br4923 PDQVTLACQLSRTGWASPRWRNLTGGIVALHAADKPVR------------
Mb0582|M.bovis_AF2122/97 GDAFDYSAADFRGWCGEAGFR-SFEVIPLAGGSSAAVAYK-
Rv0567|M.tuberculosis_H37Rv GDAFDYSAADFRGWCGEAGFR-SFEVIPLAGGSSAAVAYK-
MMAR_0934|M.marinum_M GDAFDYTGADFRKWCGAAGFR-SFEVIALAAGSSAAVAYK-
MUL_0686|M.ulcerans_Agy99 GDAFDYTGADFRKWCGAAGFR-SFEVIALAAGSSAAVAYK-
Mflv_3940|M.gilvum_PYR-GCK R-GKERTRAQYSELLEAAGFQ-LTRVIPTVSPISVIEARAV
MSMEG_0367|M.smegmatis_MC2_155 A-ARERTEAQYRKLYTEAGFR-LTRVVPTACPYSLIEGVAI
TH_3698|M.thermoresistible__bu G-GRERTAPEFTDLLTGSGFT-PPRIIPTAIHLSLLEAVPN
Mvan_3149|M.vanbaalenii_PYR-1 E-GRARRADELVALLRAAGFTGVHESSAYRRPHGVFIASR-
MAB_0867c|M.abscessus_ATCC_199 -----------------------------------------
MAV_3373|M.avium_104 AEKRSG-----------------------------------
MLBr_02273|M.leprae_Br4923 -----------------------------------------