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KLVTIDDVRAAAERIRPNVVRTPLLAARWGDRERPLWIKPENLQPIGAFKVRGAFNAIGAVRENSDGRDA VTDVVAYSSGNHAQAVAYAAAAFGLRAHIVMPEETPEVKVAATRGLGARVVLCAAGQREAVAEQTAHDTG GVMIPPFDHPDVIAGQGTAGLEIAEDLPSVRNVLIPVSGGGLASGIGTAIRALCPAAKIFGVEPELAADT AEGLRLGHRVDWPVGDRNRTIADGLRSQPSELTFAHLQQVLDGMITVSEAEIRSAVRELVHRAHLVAEPS GAVALAAYRQGVTPPGDTVLILSGGNVEPQMLRQILAD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3022 | - | - | 100% (319) | pyridoxal-5'-phosphate-dependent enzyme, beta subunit |
| M. vanbaalenii PYR-1 | Mvan_2783 | - | 1e-32 | 31.38% (325) | threonine dehydratase |
| M. vanbaalenii PYR-1 | Mvan_4291 | - | 6e-10 | 30.11% (176) | cysteine synthases |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1585 | ilvA | 5e-34 | 32.11% (327) | threonine dehydratase |
| M. gilvum PYR-GCK | Mflv_3301 | - | 1e-142 | 80.38% (316) | pyridoxal-5'-phosphate-dependent enzyme, beta subunit |
| M. tuberculosis H37Rv | Rv1559 | ilvA | 6e-34 | 32.11% (327) | threonine dehydratase |
| M. leprae Br4923 | MLBr_01209 | ilvA | 2e-34 | 32.29% (319) | threonine dehydratase |
| M. abscessus ATCC 19977 | MAB_1199 | - | 2e-54 | 39.33% (328) | threonine dehydratase |
| M. marinum M | MMAR_2374 | ilvA | 2e-32 | 30.75% (322) | threonine dehydratase IlvA |
| M. avium 104 | MAV_3217 | ilvA | 4e-31 | 30.46% (325) | threonine dehydratase |
| M. smegmatis MC2 155 | MSMEG_3532 | - | 1e-121 | 70.44% (318) | serine/threonine dehydratase family protein |
| M. thermoresistible (build 8) | TH_1800 | ilvA | 7e-32 | 31.23% (333) | Probable threonine dehydratase ilvA |
| M. ulcerans Agy99 | MUL_1550 | ilvA | 3e-33 | 31.06% (322) | threonine dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1585|M.bovis_AF2122/97 MSAELSQSPSSSPLFSLSGADIDRAAKRIAPVVTPTPLQPSDRLSAITGA
Rv1559|M.tuberculosis_H37Rv MSAELSQSPSSSPLFSLSGADIDRAAKRIAPVVTPTPLQPSDRLSAITGA
MMAR_2374|M.marinum_M MSAELSQTPSRSP---LSAADIDNAAERIAPVITPTPLQLCERLSDITGA
MUL_1550|M.ulcerans_Agy99 MSAELSQTPSRSP---LSAADIDNAAERIAPVITPTPLQLCERLSDITGA
MAV_3217|M.avium_104 MSAELSQSPSVAP---LSAADIDDAAKRIAAVVTPTPLQFSDRLSAITGA
MLBr_01209|M.leprae_Br4923 MSAEPSRNPRTPP---VSAVDIDGAAKRIAPVVTPTPLQLSDRLSAITGA
TH_1800|M.thermoresistible__bu VTADLTHSLRRSDQSPLSAADIDEAAARLAGVVTRTPLQFCDRLSEATGA
Mvan_3022|M.vanbaalenii_PYR-1 -------------MKLVTIDDVRAAAERIRPNVVRTPLLAARWGDRER--
Mflv_3301|M.gilvum_PYR-GCK -------------MERVTIDDIRAAAERIRPHVVRTPLLAARWGDAER--
MSMEG_3532|M.smegmatis_MC2_155 -------------MDLVTLDDISGAAARIAADIVRTPLLAADWGDPRC--
MAB_1199|M.abscessus_ATCC_1997 -----MAMETSGAIGLVTVQEIQEVAERLAPVIRRTPMVAFRALSDRCGH
:: :: .* *: : **: .
Mb1585|M.bovis_AF2122/97 TVYLKREDLQTVRSYKLRGAYNLLVQLSD----EELAAGVVCSSAGNHAQ
Rv1559|M.tuberculosis_H37Rv TVYLKREDLQTVRSYKLRGAYNLLVQLSD----EELAAGVVCSSAGNHAQ
MMAR_2374|M.marinum_M TVYLKREDLQIVRSYKLRGAYNLLVQLTA----EELAAGVVCSSAGNHAQ
MUL_1550|M.ulcerans_Agy99 TVYLKREDLQIVRSYKLRGAYNLLVQLTA----EELAAGVVCSSAGNHAQ
MAV_3217|M.avium_104 QVYLKREDLQIVRSYKLRGAYNLLVQLSE----TELAAGVVCSSAGNHAQ
MLBr_01209|M.leprae_Br4923 AVYLKREDLQTVRSYKLRGAYNLLVQLTD----EEIAAGVVCSSAGNHAQ
TH_1800|M.thermoresistible__bu NIYLKREDLQAVRSYKLRGAYNLLSQLTE----EEKAAGVVCSSAGNHAQ
Mvan_3022|M.vanbaalenii_PYR-1 PLWIKPENLQPIGAFKVRGAFNAIGAVRENSDGRDAVTDVVAYSSGNHAQ
Mflv_3301|M.gilvum_PYR-GCK PLWVKPESLQPIGAFKMRGAFNAVGTVR------GSTSDVVAYSSGNHAQ
MSMEG_3532|M.smegmatis_MC2_155 PLWLKAETLQPIGAFKIRGAFNALGRLDT----HTRARGVVAYSSGNHAQ
MAB_1199|M.abscessus_ATCC_1997 EVRLKCENLQRTGSFKPRGAYNRISQLPG----EQRVNGVVAASAGNHAQ
: :* * ** ::* ***:* : : . .**. *:*****
Mb1585|M.bovis_AF2122/97 GFAYACRCLGVHGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGSTYDLAA
Rv1559|M.tuberculosis_H37Rv GFAYACRCLGVHGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGSTYDLAA
MMAR_2374|M.marinum_M GFAFACKTLGVHGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGETYDLAA
MUL_1550|M.ulcerans_Agy99 GFAFACKTLGVRGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGETYDLAA
MAV_3217|M.avium_104 GFAYACRMLQVHGRVYVPAKTPLQKRDRIRYHGGEFIELIVGGTTYDQAA
MLBr_01209|M.leprae_Br4923 GVAYACRSLGVHGRVYVPAKTPKQKWDRIRYHGGAFIELIVGRSTYDLAA
TH_1800|M.thermoresistible__bu GFALACRMMGIHGRIYIPAKTPKQKRQRIRYHGREFIELIAVGRTYDLAA
Mvan_3022|M.vanbaalenii_PYR-1 AVAYAAAAFGLRAHIVMPEETPEVKVAATRGLG---ARVVLCAAGQREA-
Mflv_3301|M.gilvum_PYR-GCK AVAYAAAAFGLRAHIVMPRETPNIKVQATRDLG---ARVVLSEAGQRET-
MSMEG_3532|M.smegmatis_MC2_155 AVAYAAAAYGVPAHIVMPEETPAVKVEATRRRG---AHVVLCGAGERER-
MAB_1199|M.abscessus_ATCC_1997 GVAWAATTLGIPSTVFMPVGAALPKIVATRAYG---ATVHLTGSTIDDAL
..* *. : . : :* :. * * * :
Mb1585|M.bovis_AF2122/97 AAALEDVERTGATLVPPFDDLRTIAGQGTIAVEVLGQLEDE--------P
Rv1559|M.tuberculosis_H37Rv AAALEDVERTGATLVPPFDDLRTIAGQGTIAVEVLGQLEDE--------P
MMAR_2374|M.marinum_M AAAREDVERTGATLVPPYDDLRTMAGQGTIAVELLAELDAE--------P
MUL_1550|M.ulcerans_Agy99 AAAREDVERTGATLVPPYDDLRTMAGQGTIAVELLAELDAE--------P
MAV_3217|M.avium_104 EAALADVASTGATLVPPYDDLRTIAGQGTIAVELLDQLDTE--------P
MLBr_01209|M.leprae_Br4923 AAAVDDIERTGATLVPPYDDVRVIAGQGTIAVELLEQLNTE--------P
TH_1800|M.thermoresistible__bu AAALADVERTGATLVHPYDDPRTIAGQGTIATEILEQLDAEDGPGGGGEP
Mvan_3022|M.vanbaalenii_PYR-1 -VAEQTAHDTGGVMIPPFDHPDVIAGQGTAGLEIAEDLPSVR--------
Mflv_3301|M.gilvum_PYR-GCK -VAAEVLADTGGVMIPPFDHPDVIAGQGTAGLEIAEDLPSVR--------
MSMEG_3532|M.smegmatis_MC2_155 -TAAELVEKTGAVLIPPFDHPDIIAGQGTIGIEIAEDLPELA--------
MAB_1199|M.abscessus_ATCC_1997 LAATEFAAETGAVLIHPFDHRDVVAGQATVGLEILEQLPEVG--------
.* **..:: *:*. :***.* . *: :*
Mb1585|M.bovis_AF2122/97 DLVVVPVGGGGCIAGITTYLAERTTNTAVLGVEPAGAAAMMAALAAGEPV
Rv1559|M.tuberculosis_H37Rv DLVVVPVGGGGCIAGITTYLAERTTNTAVLGVEPAGAAAMMAALAAGEPV
MMAR_2374|M.marinum_M DLVVVPVGGGGCIAGITSYLAERTTKTAVLGIEPAGAAAMMAALAAGEPV
MUL_1550|M.ulcerans_Agy99 DLVVVPVGGGGCIAGITSYLAERTTKTAVLGIEPAGAAAMMAALAAGEPV
MAV_3217|M.avium_104 DLVVVPVGGGGCIAGITTYLAERTDTTAVLGVEPAGAAAMMAALAAGEPV
MLBr_01209|M.leprae_Br4923 DLVVVPVGGGGCIAGMTTYLAERTANTAVLGVEPAGAAAMMAALAAGEPV
TH_1800|M.thermoresistible__bu DLVIVPVGGGGCIAGITTYLAERTRNTAVLGVEPAGAASMMAALAAGEPV
Mvan_3022|M.vanbaalenii_PYR-1 -NVLIPVSGGGLASGIGTAIRALCPAAKIFGVEPELAADTAEGLRLGHRV
Mflv_3301|M.gilvum_PYR-GCK -TVLIPVSGGGLASGVGTAIRALCPQARIFGVEPELAGDTAESLRAGRRV
MSMEG_3532|M.smegmatis_MC2_155 -TVLIPVSGGGLASGIGTAIRALRPKAKIFAVEPELAADTAESLALGSIV
MAB_1199|M.abscessus_ATCC_1997 -TIVVPAGGGGLVAGVAAVVKAARPAVRIVAVQAAGAAAWPVSLKAGHPV
:::*..*** :*: : : . :..::. *. .* * *
Mb1585|M.bovis_AF2122/97 TLDHVDQFVDGAAVNRAGTLTYAALAAAGDMVS-LTTVDEGAVCTAMLDL
Rv1559|M.tuberculosis_H37Rv TLDHVDQFVDGAAVNRAGTLTYAALAAAGDMVS-LTTVDEGAVCTAMLDL
MMAR_2374|M.marinum_M TLDHVDQFVDGAAVNRAGTLPYAALSAAGDMVS-ITTVDEGAVCTAMLDL
MUL_1550|M.ulcerans_Agy99 TLDHVDQFVDGAAVNRAGALPYAALSAAGDMVS-ITTVDEGAVCTAMLDL
MAV_3217|M.avium_104 TLDHVDQFVDGAAVRRAGDLTYAALAAAGDMVS-ITTVDEGAVCTAMLDL
MLBr_01209|M.leprae_Br4923 TLDYVDQFVDGAAVNRVGTLPYAALTAAGDMVS-ITTVDEGAVCTAMLDL
TH_1800|M.thermoresistible__bu TLDHVDQFVDGAAVNRAGTYTHAALAAAGDMVS-ITTVDEGAVCTAMLDL
Mvan_3022|M.vanbaalenii_PYR-1 DWPVGDRNRTIADGLRS-QPSELTFAHLQQVLDGMITVSEAEIRSAVREL
Mflv_3301|M.gilvum_PYR-GCK DWSIEDRNRTIADGLRS-QPSELTFAHLQRVLDGVITVTEDEIRSAVREY
MSMEG_3532|M.smegmatis_MC2_155 EWPVAKRNRTIADGLRS-TPSELTFAHLRQVIDDVITVSEDEIRSAVREL
MAB_1199|M.abscessus_ATCC_1997 ALESMD---TMADGIAVGKPGAVPFEHVAALVDDVVTVSEEALSRGLLLC
. * .: ::. : ** * : .:
Mb1585|M.bovis_AF2122/97 YQNEGIIAEPAGALSVAGLLEADIEP---GSTVVCLISGGNNDVSRYGEV
Rv1559|M.tuberculosis_H37Rv YQNEGIIAEPAGALSVAGLLEADIEP---GSTVVCLISGGNNDVSRYGEV
MMAR_2374|M.marinum_M YQHEGIIAEPAGALSVAGLLEADIEP---GSTVVCLISGGNNDVSRYGEI
MUL_1550|M.ulcerans_Agy99 YQHEGIIAEPAGALSVAGLLEADIEP---GSTVVCLISGGNNDVSRYGEI
MAV_3217|M.avium_104 YQNEGIIAEPAGALSVTGLLEADIEP---GSTVVCLISGGNNDVSRYGEV
MLBr_01209|M.leprae_Br4923 YQNEGIIAEPAGALSVAGLLETDIEP---GSTVVCLISGGNNDVLRYGEV
TH_1800|M.thermoresistible__bu YQNEGIIAEPAGALAVTGLSEAEIEP---GSTVVCLISGGNNDVSRYNEV
Mvan_3022|M.vanbaalenii_PYR-1 VHRAHLVAEPSGAVALAAYRQGVTPP----GDTVLILSGGNVEPQMLRQI
Mflv_3301|M.gilvum_PYR-GCK AYRGRLVAEPSGAVALAGYRQGGTGD----GDTAVILSGGNIEPSTLRQI
MSMEG_3532|M.smegmatis_MC2_155 ALRARLVAEPSGAVSLAGYRKAALPD----GSAVAIVSGGNIEPAQLAAI
MAB_1199|M.abscessus_ATCC_1997 LERAKLVVEPAGAAAVAALLTLSAEELGLTGPVCAVLSGGNIDPLLLTHV
. ::.**:** :::. . . ::**** : :
Mb1585|M.bovis_AF2122/97 LERSLVHLGLKHYFLVDFPQEPGALRRFLDDVLGPND---DITLFEYVKR
Rv1559|M.tuberculosis_H37Rv LERSLVHLGLKHYFLVDFPQEPGALRRFLDDVLGPND---DITLFEYVKR
MMAR_2374|M.marinum_M LERSLVHLGLKHYFLVDFPQEPGALRRFLDEVLGPND---DITLFEYVKR
MUL_1550|M.ulcerans_Agy99 LERSLVHLGLKHYFLVDFPQEPGALRRFLDEVLGPND---DITLFEYVKR
MAV_3217|M.avium_104 LERSLVHLGLKHYFLVDFPQEPGALRRFLDEVLGPND---DITLFEYVKR
MLBr_01209|M.leprae_Br4923 LERSLIHLGLKHYFLVDFPQKPGALRRFLDEVLGPND---DITLFEYVKR
TH_1800|M.thermoresistible__bu LERSLVHLGLKHYFLVDFPQEPGSLRRFLDEVLGEGD---DITLFEYVKR
Mvan_3022|M.vanbaalenii_PYR-1 LAD-----------------------------------------------
Mflv_3301|M.gilvum_PYR-GCK LTEAAPT-------------------------------------------
MSMEG_3532|M.smegmatis_MC2_155 LAGG----------------------------------------------
MAB_1199|M.abscessus_ATCC_1997 ITHGLRAAGRYLTVRVTVADAPGGLSGLLDVFRASGASVVDVTHWRNSER
:
Mb1585|M.bovis_AF2122/97 NNRETGEALVGIELGSAADLDGLLARMRATDIHVEALEPGSPAYRYLL-
Rv1559|M.tuberculosis_H37Rv NNRETGEALVGIELGSAADLDGLLARMRATDIHVEALEPGSPAYRYLL-
MMAR_2374|M.marinum_M NNRETGEALVGVELGSAANLDGLLARMHETEVHVEPLAPGSPAYRYLL-
MUL_1550|M.ulcerans_Agy99 NNRETGEALVGVELGSAANLDGLLARMRETEVHVEPLAPGSPAYRYLL-
MAV_3217|M.avium_104 NNRETGEALVGIQLGSSADLDGLLARMRATELHVETLKPGSPAYRYLLL
MLBr_01209|M.leprae_Br4923 NNRETGEALVGIQLGSAVDLDVLLARMQGTEMHVETLQPGSPAYRYLLL
TH_1800|M.thermoresistible__bu NNRETGEALVGIELSSAADLDGLLARMEASDIHVERLEPGSPAYRYLT-
Mvan_3022|M.vanbaalenii_PYR-1 -------------------------------------------------
Mflv_3301|M.gilvum_PYR-GCK -------------------------------------------------
MSMEG_3532|M.smegmatis_MC2_155 -------------------------------------------------
MAB_1199|M.abscessus_ATCC_1997 LRLGEVDVLATVETRGPEHRQAVLDAIVAAGLTVQEER-----------