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M. vanbaalenii PYR-1 Mvan_3022 (-)

annotation: pyridoxal-5'-phosphate-dependent enzyme, beta subunit
coordinates: 3188162 - 3189121
length: 319

KLVTIDDVRAAAERIRPNVVRTPLLAARWGDRERPLWIKPENLQPIGAFKVRGAFNAIGAVRENSDGRDA
VTDVVAYSSGNHAQAVAYAAAAFGLRAHIVMPEETPEVKVAATRGLGARVVLCAAGQREAVAEQTAHDTG
GVMIPPFDHPDVIAGQGTAGLEIAEDLPSVRNVLIPVSGGGLASGIGTAIRALCPAAKIFGVEPELAADT
AEGLRLGHRVDWPVGDRNRTIADGLRSQPSELTFAHLQQVLDGMITVSEAEIRSAVRELVHRAHLVAEPS
GAVALAAYRQGVTPPGDTVLILSGGNVEPQMLRQILAD*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. vanbaalenii PYR-1Mvan_3022--100% (319)pyridoxal-5'-phosphate-dependent enzyme, beta subunit
M. vanbaalenii PYR-1Mvan_2783-1e-3231.38% (325) threonine dehydratase
M. vanbaalenii PYR-1Mvan_4291-6e-1030.11% (176) cysteine synthases

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1585ilvA5e-3432.11% (327) threonine dehydratase
M. gilvum PYR-GCKMflv_3301-1e-14280.38% (316) pyridoxal-5'-phosphate-dependent enzyme, beta subunit
M. tuberculosis H37RvRv1559ilvA6e-3432.11% (327) threonine dehydratase
M. leprae Br4923MLBr_01209ilvA2e-3432.29% (319) threonine dehydratase
M. abscessus ATCC 19977MAB_1199-2e-5439.33% (328) threonine dehydratase
M. marinum MMMAR_2374ilvA2e-3230.75% (322) threonine dehydratase IlvA
M. avium 104MAV_3217ilvA4e-3130.46% (325) threonine dehydratase
M. smegmatis MC2 155MSMEG_3532-1e-12170.44% (318) serine/threonine dehydratase family protein
M. thermoresistible (build 8)TH_1800ilvA7e-3231.23% (333) Probable threonine dehydratase ilvA
M. ulcerans Agy99MUL_1550ilvA3e-3331.06% (322) threonine dehydratase

CLUSTAL 2.0.9 multiple sequence alignment


Mb1585|M.bovis_AF2122/97            MSAELSQSPSSSPLFSLSGADIDRAAKRIAPVVTPTPLQPSDRLSAITGA
Rv1559|M.tuberculosis_H37Rv         MSAELSQSPSSSPLFSLSGADIDRAAKRIAPVVTPTPLQPSDRLSAITGA
MMAR_2374|M.marinum_M               MSAELSQTPSRSP---LSAADIDNAAERIAPVITPTPLQLCERLSDITGA
MUL_1550|M.ulcerans_Agy99           MSAELSQTPSRSP---LSAADIDNAAERIAPVITPTPLQLCERLSDITGA
MAV_3217|M.avium_104                MSAELSQSPSVAP---LSAADIDDAAKRIAAVVTPTPLQFSDRLSAITGA
MLBr_01209|M.leprae_Br4923          MSAEPSRNPRTPP---VSAVDIDGAAKRIAPVVTPTPLQLSDRLSAITGA
TH_1800|M.thermoresistible__bu      VTADLTHSLRRSDQSPLSAADIDEAAARLAGVVTRTPLQFCDRLSEATGA
Mvan_3022|M.vanbaalenii_PYR-1       -------------MKLVTIDDVRAAAERIRPNVVRTPLLAARWGDRER--
Mflv_3301|M.gilvum_PYR-GCK          -------------MERVTIDDIRAAAERIRPHVVRTPLLAARWGDAER--
MSMEG_3532|M.smegmatis_MC2_155      -------------MDLVTLDDISGAAARIAADIVRTPLLAADWGDPRC--
MAB_1199|M.abscessus_ATCC_1997      -----MAMETSGAIGLVTVQEIQEVAERLAPVIRRTPMVAFRALSDRCGH
                                                    ::  ::  .* *:   :  **:      .     

Mb1585|M.bovis_AF2122/97            TVYLKREDLQTVRSYKLRGAYNLLVQLSD----EELAAGVVCSSAGNHAQ
Rv1559|M.tuberculosis_H37Rv         TVYLKREDLQTVRSYKLRGAYNLLVQLSD----EELAAGVVCSSAGNHAQ
MMAR_2374|M.marinum_M               TVYLKREDLQIVRSYKLRGAYNLLVQLTA----EELAAGVVCSSAGNHAQ
MUL_1550|M.ulcerans_Agy99           TVYLKREDLQIVRSYKLRGAYNLLVQLTA----EELAAGVVCSSAGNHAQ
MAV_3217|M.avium_104                QVYLKREDLQIVRSYKLRGAYNLLVQLSE----TELAAGVVCSSAGNHAQ
MLBr_01209|M.leprae_Br4923          AVYLKREDLQTVRSYKLRGAYNLLVQLTD----EEIAAGVVCSSAGNHAQ
TH_1800|M.thermoresistible__bu      NIYLKREDLQAVRSYKLRGAYNLLSQLTE----EEKAAGVVCSSAGNHAQ
Mvan_3022|M.vanbaalenii_PYR-1       PLWIKPENLQPIGAFKVRGAFNAIGAVRENSDGRDAVTDVVAYSSGNHAQ
Mflv_3301|M.gilvum_PYR-GCK          PLWVKPESLQPIGAFKMRGAFNAVGTVR------GSTSDVVAYSSGNHAQ
MSMEG_3532|M.smegmatis_MC2_155      PLWLKAETLQPIGAFKIRGAFNALGRLDT----HTRARGVVAYSSGNHAQ
MAB_1199|M.abscessus_ATCC_1997      EVRLKCENLQRTGSFKPRGAYNRISQLPG----EQRVNGVVAASAGNHAQ
                                     : :* * **   ::* ***:* :  :         . .**. *:*****

Mb1585|M.bovis_AF2122/97            GFAYACRCLGVHGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGSTYDLAA
Rv1559|M.tuberculosis_H37Rv         GFAYACRCLGVHGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGSTYDLAA
MMAR_2374|M.marinum_M               GFAFACKTLGVHGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGETYDLAA
MUL_1550|M.ulcerans_Agy99           GFAFACKTLGVRGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGETYDLAA
MAV_3217|M.avium_104                GFAYACRMLQVHGRVYVPAKTPLQKRDRIRYHGGEFIELIVGGTTYDQAA
MLBr_01209|M.leprae_Br4923          GVAYACRSLGVHGRVYVPAKTPKQKWDRIRYHGGAFIELIVGRSTYDLAA
TH_1800|M.thermoresistible__bu      GFALACRMMGIHGRIYIPAKTPKQKRQRIRYHGREFIELIAVGRTYDLAA
Mvan_3022|M.vanbaalenii_PYR-1       AVAYAAAAFGLRAHIVMPEETPEVKVAATRGLG---ARVVLCAAGQREA-
Mflv_3301|M.gilvum_PYR-GCK          AVAYAAAAFGLRAHIVMPRETPNIKVQATRDLG---ARVVLSEAGQRET-
MSMEG_3532|M.smegmatis_MC2_155      AVAYAAAAYGVPAHIVMPEETPAVKVEATRRRG---AHVVLCGAGERER-
MAB_1199|M.abscessus_ATCC_1997      GVAWAATTLGIPSTVFMPVGAALPKIVATRAYG---ATVHLTGSTIDDAL
                                    ..* *.    : . : :*  :.  *    *  *     :           

Mb1585|M.bovis_AF2122/97            AAALEDVERTGATLVPPFDDLRTIAGQGTIAVEVLGQLEDE--------P
Rv1559|M.tuberculosis_H37Rv         AAALEDVERTGATLVPPFDDLRTIAGQGTIAVEVLGQLEDE--------P
MMAR_2374|M.marinum_M               AAAREDVERTGATLVPPYDDLRTMAGQGTIAVELLAELDAE--------P
MUL_1550|M.ulcerans_Agy99           AAAREDVERTGATLVPPYDDLRTMAGQGTIAVELLAELDAE--------P
MAV_3217|M.avium_104                EAALADVASTGATLVPPYDDLRTIAGQGTIAVELLDQLDTE--------P
MLBr_01209|M.leprae_Br4923          AAAVDDIERTGATLVPPYDDVRVIAGQGTIAVELLEQLNTE--------P
TH_1800|M.thermoresistible__bu      AAALADVERTGATLVHPYDDPRTIAGQGTIATEILEQLDAEDGPGGGGEP
Mvan_3022|M.vanbaalenii_PYR-1       -VAEQTAHDTGGVMIPPFDHPDVIAGQGTAGLEIAEDLPSVR--------
Mflv_3301|M.gilvum_PYR-GCK          -VAAEVLADTGGVMIPPFDHPDVIAGQGTAGLEIAEDLPSVR--------
MSMEG_3532|M.smegmatis_MC2_155      -TAAELVEKTGAVLIPPFDHPDIIAGQGTIGIEIAEDLPELA--------
MAB_1199|M.abscessus_ATCC_1997      LAATEFAAETGAVLIHPFDHRDVVAGQATVGLEILEQLPEVG--------
                                     .*      **..:: *:*.   :***.* . *:  :*            

Mb1585|M.bovis_AF2122/97            DLVVVPVGGGGCIAGITTYLAERTTNTAVLGVEPAGAAAMMAALAAGEPV
Rv1559|M.tuberculosis_H37Rv         DLVVVPVGGGGCIAGITTYLAERTTNTAVLGVEPAGAAAMMAALAAGEPV
MMAR_2374|M.marinum_M               DLVVVPVGGGGCIAGITSYLAERTTKTAVLGIEPAGAAAMMAALAAGEPV
MUL_1550|M.ulcerans_Agy99           DLVVVPVGGGGCIAGITSYLAERTTKTAVLGIEPAGAAAMMAALAAGEPV
MAV_3217|M.avium_104                DLVVVPVGGGGCIAGITTYLAERTDTTAVLGVEPAGAAAMMAALAAGEPV
MLBr_01209|M.leprae_Br4923          DLVVVPVGGGGCIAGMTTYLAERTANTAVLGVEPAGAAAMMAALAAGEPV
TH_1800|M.thermoresistible__bu      DLVIVPVGGGGCIAGITTYLAERTRNTAVLGVEPAGAASMMAALAAGEPV
Mvan_3022|M.vanbaalenii_PYR-1       -NVLIPVSGGGLASGIGTAIRALCPAAKIFGVEPELAADTAEGLRLGHRV
Mflv_3301|M.gilvum_PYR-GCK          -TVLIPVSGGGLASGVGTAIRALCPQARIFGVEPELAGDTAESLRAGRRV
MSMEG_3532|M.smegmatis_MC2_155      -TVLIPVSGGGLASGIGTAIRALRPKAKIFAVEPELAADTAESLALGSIV
MAB_1199|M.abscessus_ATCC_1997      -TIVVPAGGGGLVAGVAAVVKAARPAVRIVAVQAAGAAAWPVSLKAGHPV
                                      :::*..***  :*: : :      . :..::.  *.    .*  *  *

Mb1585|M.bovis_AF2122/97            TLDHVDQFVDGAAVNRAGTLTYAALAAAGDMVS-LTTVDEGAVCTAMLDL
Rv1559|M.tuberculosis_H37Rv         TLDHVDQFVDGAAVNRAGTLTYAALAAAGDMVS-LTTVDEGAVCTAMLDL
MMAR_2374|M.marinum_M               TLDHVDQFVDGAAVNRAGTLPYAALSAAGDMVS-ITTVDEGAVCTAMLDL
MUL_1550|M.ulcerans_Agy99           TLDHVDQFVDGAAVNRAGALPYAALSAAGDMVS-ITTVDEGAVCTAMLDL
MAV_3217|M.avium_104                TLDHVDQFVDGAAVRRAGDLTYAALAAAGDMVS-ITTVDEGAVCTAMLDL
MLBr_01209|M.leprae_Br4923          TLDYVDQFVDGAAVNRVGTLPYAALTAAGDMVS-ITTVDEGAVCTAMLDL
TH_1800|M.thermoresistible__bu      TLDHVDQFVDGAAVNRAGTYTHAALAAAGDMVS-ITTVDEGAVCTAMLDL
Mvan_3022|M.vanbaalenii_PYR-1       DWPVGDRNRTIADGLRS-QPSELTFAHLQQVLDGMITVSEAEIRSAVREL
Mflv_3301|M.gilvum_PYR-GCK          DWSIEDRNRTIADGLRS-QPSELTFAHLQRVLDGVITVTEDEIRSAVREY
MSMEG_3532|M.smegmatis_MC2_155      EWPVAKRNRTIADGLRS-TPSELTFAHLRQVIDDVITVSEDEIRSAVREL
MAB_1199|M.abscessus_ATCC_1997      ALESMD---TMADGIAVGKPGAVPFEHVAALVDDVVTVSEEALSRGLLLC
                                         .     *           .:     ::. : ** *  :  .:   

Mb1585|M.bovis_AF2122/97            YQNEGIIAEPAGALSVAGLLEADIEP---GSTVVCLISGGNNDVSRYGEV
Rv1559|M.tuberculosis_H37Rv         YQNEGIIAEPAGALSVAGLLEADIEP---GSTVVCLISGGNNDVSRYGEV
MMAR_2374|M.marinum_M               YQHEGIIAEPAGALSVAGLLEADIEP---GSTVVCLISGGNNDVSRYGEI
MUL_1550|M.ulcerans_Agy99           YQHEGIIAEPAGALSVAGLLEADIEP---GSTVVCLISGGNNDVSRYGEI
MAV_3217|M.avium_104                YQNEGIIAEPAGALSVTGLLEADIEP---GSTVVCLISGGNNDVSRYGEV
MLBr_01209|M.leprae_Br4923          YQNEGIIAEPAGALSVAGLLETDIEP---GSTVVCLISGGNNDVLRYGEV
TH_1800|M.thermoresistible__bu      YQNEGIIAEPAGALAVTGLSEAEIEP---GSTVVCLISGGNNDVSRYNEV
Mvan_3022|M.vanbaalenii_PYR-1       VHRAHLVAEPSGAVALAAYRQGVTPP----GDTVLILSGGNVEPQMLRQI
Mflv_3301|M.gilvum_PYR-GCK          AYRGRLVAEPSGAVALAGYRQGGTGD----GDTAVILSGGNIEPSTLRQI
MSMEG_3532|M.smegmatis_MC2_155      ALRARLVAEPSGAVSLAGYRKAALPD----GSAVAIVSGGNIEPAQLAAI
MAB_1199|M.abscessus_ATCC_1997      LERAKLVVEPAGAAAVAALLTLSAEELGLTGPVCAVLSGGNIDPLLLTHV
                                      .  ::.**:** :::.            . .  ::**** :      :

Mb1585|M.bovis_AF2122/97            LERSLVHLGLKHYFLVDFPQEPGALRRFLDDVLGPND---DITLFEYVKR
Rv1559|M.tuberculosis_H37Rv         LERSLVHLGLKHYFLVDFPQEPGALRRFLDDVLGPND---DITLFEYVKR
MMAR_2374|M.marinum_M               LERSLVHLGLKHYFLVDFPQEPGALRRFLDEVLGPND---DITLFEYVKR
MUL_1550|M.ulcerans_Agy99           LERSLVHLGLKHYFLVDFPQEPGALRRFLDEVLGPND---DITLFEYVKR
MAV_3217|M.avium_104                LERSLVHLGLKHYFLVDFPQEPGALRRFLDEVLGPND---DITLFEYVKR
MLBr_01209|M.leprae_Br4923          LERSLIHLGLKHYFLVDFPQKPGALRRFLDEVLGPND---DITLFEYVKR
TH_1800|M.thermoresistible__bu      LERSLVHLGLKHYFLVDFPQEPGSLRRFLDEVLGEGD---DITLFEYVKR
Mvan_3022|M.vanbaalenii_PYR-1       LAD-----------------------------------------------
Mflv_3301|M.gilvum_PYR-GCK          LTEAAPT-------------------------------------------
MSMEG_3532|M.smegmatis_MC2_155      LAGG----------------------------------------------
MAB_1199|M.abscessus_ATCC_1997      ITHGLRAAGRYLTVRVTVADAPGGLSGLLDVFRASGASVVDVTHWRNSER
                                    :                                                 

Mb1585|M.bovis_AF2122/97            NNRETGEALVGIELGSAADLDGLLARMRATDIHVEALEPGSPAYRYLL-
Rv1559|M.tuberculosis_H37Rv         NNRETGEALVGIELGSAADLDGLLARMRATDIHVEALEPGSPAYRYLL-
MMAR_2374|M.marinum_M               NNRETGEALVGVELGSAANLDGLLARMHETEVHVEPLAPGSPAYRYLL-
MUL_1550|M.ulcerans_Agy99           NNRETGEALVGVELGSAANLDGLLARMRETEVHVEPLAPGSPAYRYLL-
MAV_3217|M.avium_104                NNRETGEALVGIQLGSSADLDGLLARMRATELHVETLKPGSPAYRYLLL
MLBr_01209|M.leprae_Br4923          NNRETGEALVGIQLGSAVDLDVLLARMQGTEMHVETLQPGSPAYRYLLL
TH_1800|M.thermoresistible__bu      NNRETGEALVGIELSSAADLDGLLARMEASDIHVERLEPGSPAYRYLT-
Mvan_3022|M.vanbaalenii_PYR-1       -------------------------------------------------
Mflv_3301|M.gilvum_PYR-GCK          -------------------------------------------------
MSMEG_3532|M.smegmatis_MC2_155      -------------------------------------------------
MAB_1199|M.abscessus_ATCC_1997      LRLGEVDVLATVETRGPEHRQAVLDAIVAAGLTVQEER-----------