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KLVTIDDVRAAAERIRPNVVRTPLLAARWGDRERPLWIKPENLQPIGAFKVRGAFNAIGAVRENSDGRDA VTDVVAYSSGNHAQAVAYAAAAFGLRAHIVMPEETPEVKVAATRGLGARVVLCAAGQREAVAEQTAHDTG GVMIPPFDHPDVIAGQGTAGLEIAEDLPSVRNVLIPVSGGGLASGIGTAIRALCPAAKIFGVEPELAADT AEGLRLGHRVDWPVGDRNRTIADGLRSQPSELTFAHLQQVLDGMITVSEAEIRSAVRELVHRAHLVAEPS GAVALAAYRQGVTPPGDTVLILSGGNVEPQMLRQILAD*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. vanbaalenii PYR-1 | Mvan_3022 | - | - | 100% (319) | pyridoxal-5'-phosphate-dependent enzyme, beta subunit |
M. vanbaalenii PYR-1 | Mvan_2783 | - | 1e-32 | 31.38% (325) | threonine dehydratase |
M. vanbaalenii PYR-1 | Mvan_4291 | - | 6e-10 | 30.11% (176) | cysteine synthases |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1585 | ilvA | 5e-34 | 32.11% (327) | threonine dehydratase |
M. gilvum PYR-GCK | Mflv_3301 | - | 1e-142 | 80.38% (316) | pyridoxal-5'-phosphate-dependent enzyme, beta subunit |
M. tuberculosis H37Rv | Rv1559 | ilvA | 6e-34 | 32.11% (327) | threonine dehydratase |
M. leprae Br4923 | MLBr_01209 | ilvA | 2e-34 | 32.29% (319) | threonine dehydratase |
M. abscessus ATCC 19977 | MAB_1199 | - | 2e-54 | 39.33% (328) | threonine dehydratase |
M. marinum M | MMAR_2374 | ilvA | 2e-32 | 30.75% (322) | threonine dehydratase IlvA |
M. avium 104 | MAV_3217 | ilvA | 4e-31 | 30.46% (325) | threonine dehydratase |
M. smegmatis MC2 155 | MSMEG_3532 | - | 1e-121 | 70.44% (318) | serine/threonine dehydratase family protein |
M. thermoresistible (build 8) | TH_1800 | ilvA | 7e-32 | 31.23% (333) | Probable threonine dehydratase ilvA |
M. ulcerans Agy99 | MUL_1550 | ilvA | 3e-33 | 31.06% (322) | threonine dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment Mb1585|M.bovis_AF2122/97 MSAELSQSPSSSPLFSLSGADIDRAAKRIAPVVTPTPLQPSDRLSAITGA Rv1559|M.tuberculosis_H37Rv MSAELSQSPSSSPLFSLSGADIDRAAKRIAPVVTPTPLQPSDRLSAITGA MMAR_2374|M.marinum_M MSAELSQTPSRSP---LSAADIDNAAERIAPVITPTPLQLCERLSDITGA MUL_1550|M.ulcerans_Agy99 MSAELSQTPSRSP---LSAADIDNAAERIAPVITPTPLQLCERLSDITGA MAV_3217|M.avium_104 MSAELSQSPSVAP---LSAADIDDAAKRIAAVVTPTPLQFSDRLSAITGA MLBr_01209|M.leprae_Br4923 MSAEPSRNPRTPP---VSAVDIDGAAKRIAPVVTPTPLQLSDRLSAITGA TH_1800|M.thermoresistible__bu VTADLTHSLRRSDQSPLSAADIDEAAARLAGVVTRTPLQFCDRLSEATGA Mvan_3022|M.vanbaalenii_PYR-1 -------------MKLVTIDDVRAAAERIRPNVVRTPLLAARWGDRER-- Mflv_3301|M.gilvum_PYR-GCK -------------MERVTIDDIRAAAERIRPHVVRTPLLAARWGDAER-- MSMEG_3532|M.smegmatis_MC2_155 -------------MDLVTLDDISGAAARIAADIVRTPLLAADWGDPRC-- MAB_1199|M.abscessus_ATCC_1997 -----MAMETSGAIGLVTVQEIQEVAERLAPVIRRTPMVAFRALSDRCGH :: :: .* *: : **: . Mb1585|M.bovis_AF2122/97 TVYLKREDLQTVRSYKLRGAYNLLVQLSD----EELAAGVVCSSAGNHAQ Rv1559|M.tuberculosis_H37Rv TVYLKREDLQTVRSYKLRGAYNLLVQLSD----EELAAGVVCSSAGNHAQ MMAR_2374|M.marinum_M TVYLKREDLQIVRSYKLRGAYNLLVQLTA----EELAAGVVCSSAGNHAQ MUL_1550|M.ulcerans_Agy99 TVYLKREDLQIVRSYKLRGAYNLLVQLTA----EELAAGVVCSSAGNHAQ MAV_3217|M.avium_104 QVYLKREDLQIVRSYKLRGAYNLLVQLSE----TELAAGVVCSSAGNHAQ MLBr_01209|M.leprae_Br4923 AVYLKREDLQTVRSYKLRGAYNLLVQLTD----EEIAAGVVCSSAGNHAQ TH_1800|M.thermoresistible__bu NIYLKREDLQAVRSYKLRGAYNLLSQLTE----EEKAAGVVCSSAGNHAQ Mvan_3022|M.vanbaalenii_PYR-1 PLWIKPENLQPIGAFKVRGAFNAIGAVRENSDGRDAVTDVVAYSSGNHAQ Mflv_3301|M.gilvum_PYR-GCK PLWVKPESLQPIGAFKMRGAFNAVGTVR------GSTSDVVAYSSGNHAQ MSMEG_3532|M.smegmatis_MC2_155 PLWLKAETLQPIGAFKIRGAFNALGRLDT----HTRARGVVAYSSGNHAQ MAB_1199|M.abscessus_ATCC_1997 EVRLKCENLQRTGSFKPRGAYNRISQLPG----EQRVNGVVAASAGNHAQ : :* * ** ::* ***:* : : . .**. *:***** Mb1585|M.bovis_AF2122/97 GFAYACRCLGVHGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGSTYDLAA Rv1559|M.tuberculosis_H37Rv GFAYACRCLGVHGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGSTYDLAA MMAR_2374|M.marinum_M GFAFACKTLGVHGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGETYDLAA MUL_1550|M.ulcerans_Agy99 GFAFACKTLGVRGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGETYDLAA MAV_3217|M.avium_104 GFAYACRMLQVHGRVYVPAKTPLQKRDRIRYHGGEFIELIVGGTTYDQAA MLBr_01209|M.leprae_Br4923 GVAYACRSLGVHGRVYVPAKTPKQKWDRIRYHGGAFIELIVGRSTYDLAA TH_1800|M.thermoresistible__bu GFALACRMMGIHGRIYIPAKTPKQKRQRIRYHGREFIELIAVGRTYDLAA Mvan_3022|M.vanbaalenii_PYR-1 AVAYAAAAFGLRAHIVMPEETPEVKVAATRGLG---ARVVLCAAGQREA- Mflv_3301|M.gilvum_PYR-GCK AVAYAAAAFGLRAHIVMPRETPNIKVQATRDLG---ARVVLSEAGQRET- MSMEG_3532|M.smegmatis_MC2_155 AVAYAAAAYGVPAHIVMPEETPAVKVEATRRRG---AHVVLCGAGERER- MAB_1199|M.abscessus_ATCC_1997 GVAWAATTLGIPSTVFMPVGAALPKIVATRAYG---ATVHLTGSTIDDAL ..* *. : . : :* :. * * * : Mb1585|M.bovis_AF2122/97 AAALEDVERTGATLVPPFDDLRTIAGQGTIAVEVLGQLEDE--------P Rv1559|M.tuberculosis_H37Rv AAALEDVERTGATLVPPFDDLRTIAGQGTIAVEVLGQLEDE--------P MMAR_2374|M.marinum_M AAAREDVERTGATLVPPYDDLRTMAGQGTIAVELLAELDAE--------P MUL_1550|M.ulcerans_Agy99 AAAREDVERTGATLVPPYDDLRTMAGQGTIAVELLAELDAE--------P MAV_3217|M.avium_104 EAALADVASTGATLVPPYDDLRTIAGQGTIAVELLDQLDTE--------P MLBr_01209|M.leprae_Br4923 AAAVDDIERTGATLVPPYDDVRVIAGQGTIAVELLEQLNTE--------P TH_1800|M.thermoresistible__bu AAALADVERTGATLVHPYDDPRTIAGQGTIATEILEQLDAEDGPGGGGEP Mvan_3022|M.vanbaalenii_PYR-1 -VAEQTAHDTGGVMIPPFDHPDVIAGQGTAGLEIAEDLPSVR-------- Mflv_3301|M.gilvum_PYR-GCK -VAAEVLADTGGVMIPPFDHPDVIAGQGTAGLEIAEDLPSVR-------- MSMEG_3532|M.smegmatis_MC2_155 -TAAELVEKTGAVLIPPFDHPDIIAGQGTIGIEIAEDLPELA-------- MAB_1199|M.abscessus_ATCC_1997 LAATEFAAETGAVLIHPFDHRDVVAGQATVGLEILEQLPEVG-------- .* **..:: *:*. :***.* . *: :* Mb1585|M.bovis_AF2122/97 DLVVVPVGGGGCIAGITTYLAERTTNTAVLGVEPAGAAAMMAALAAGEPV Rv1559|M.tuberculosis_H37Rv DLVVVPVGGGGCIAGITTYLAERTTNTAVLGVEPAGAAAMMAALAAGEPV MMAR_2374|M.marinum_M DLVVVPVGGGGCIAGITSYLAERTTKTAVLGIEPAGAAAMMAALAAGEPV MUL_1550|M.ulcerans_Agy99 DLVVVPVGGGGCIAGITSYLAERTTKTAVLGIEPAGAAAMMAALAAGEPV MAV_3217|M.avium_104 DLVVVPVGGGGCIAGITTYLAERTDTTAVLGVEPAGAAAMMAALAAGEPV MLBr_01209|M.leprae_Br4923 DLVVVPVGGGGCIAGMTTYLAERTANTAVLGVEPAGAAAMMAALAAGEPV TH_1800|M.thermoresistible__bu DLVIVPVGGGGCIAGITTYLAERTRNTAVLGVEPAGAASMMAALAAGEPV Mvan_3022|M.vanbaalenii_PYR-1 -NVLIPVSGGGLASGIGTAIRALCPAAKIFGVEPELAADTAEGLRLGHRV Mflv_3301|M.gilvum_PYR-GCK -TVLIPVSGGGLASGVGTAIRALCPQARIFGVEPELAGDTAESLRAGRRV MSMEG_3532|M.smegmatis_MC2_155 -TVLIPVSGGGLASGIGTAIRALRPKAKIFAVEPELAADTAESLALGSIV MAB_1199|M.abscessus_ATCC_1997 -TIVVPAGGGGLVAGVAAVVKAARPAVRIVAVQAAGAAAWPVSLKAGHPV :::*..*** :*: : : . :..::. *. .* * * Mb1585|M.bovis_AF2122/97 TLDHVDQFVDGAAVNRAGTLTYAALAAAGDMVS-LTTVDEGAVCTAMLDL Rv1559|M.tuberculosis_H37Rv TLDHVDQFVDGAAVNRAGTLTYAALAAAGDMVS-LTTVDEGAVCTAMLDL MMAR_2374|M.marinum_M TLDHVDQFVDGAAVNRAGTLPYAALSAAGDMVS-ITTVDEGAVCTAMLDL MUL_1550|M.ulcerans_Agy99 TLDHVDQFVDGAAVNRAGALPYAALSAAGDMVS-ITTVDEGAVCTAMLDL MAV_3217|M.avium_104 TLDHVDQFVDGAAVRRAGDLTYAALAAAGDMVS-ITTVDEGAVCTAMLDL MLBr_01209|M.leprae_Br4923 TLDYVDQFVDGAAVNRVGTLPYAALTAAGDMVS-ITTVDEGAVCTAMLDL TH_1800|M.thermoresistible__bu TLDHVDQFVDGAAVNRAGTYTHAALAAAGDMVS-ITTVDEGAVCTAMLDL Mvan_3022|M.vanbaalenii_PYR-1 DWPVGDRNRTIADGLRS-QPSELTFAHLQQVLDGMITVSEAEIRSAVREL Mflv_3301|M.gilvum_PYR-GCK DWSIEDRNRTIADGLRS-QPSELTFAHLQRVLDGVITVTEDEIRSAVREY MSMEG_3532|M.smegmatis_MC2_155 EWPVAKRNRTIADGLRS-TPSELTFAHLRQVIDDVITVSEDEIRSAVREL MAB_1199|M.abscessus_ATCC_1997 ALESMD---TMADGIAVGKPGAVPFEHVAALVDDVVTVSEEALSRGLLLC . * .: ::. : ** * : .: Mb1585|M.bovis_AF2122/97 YQNEGIIAEPAGALSVAGLLEADIEP---GSTVVCLISGGNNDVSRYGEV Rv1559|M.tuberculosis_H37Rv YQNEGIIAEPAGALSVAGLLEADIEP---GSTVVCLISGGNNDVSRYGEV MMAR_2374|M.marinum_M YQHEGIIAEPAGALSVAGLLEADIEP---GSTVVCLISGGNNDVSRYGEI MUL_1550|M.ulcerans_Agy99 YQHEGIIAEPAGALSVAGLLEADIEP---GSTVVCLISGGNNDVSRYGEI MAV_3217|M.avium_104 YQNEGIIAEPAGALSVTGLLEADIEP---GSTVVCLISGGNNDVSRYGEV MLBr_01209|M.leprae_Br4923 YQNEGIIAEPAGALSVAGLLETDIEP---GSTVVCLISGGNNDVLRYGEV TH_1800|M.thermoresistible__bu YQNEGIIAEPAGALAVTGLSEAEIEP---GSTVVCLISGGNNDVSRYNEV Mvan_3022|M.vanbaalenii_PYR-1 VHRAHLVAEPSGAVALAAYRQGVTPP----GDTVLILSGGNVEPQMLRQI Mflv_3301|M.gilvum_PYR-GCK AYRGRLVAEPSGAVALAGYRQGGTGD----GDTAVILSGGNIEPSTLRQI MSMEG_3532|M.smegmatis_MC2_155 ALRARLVAEPSGAVSLAGYRKAALPD----GSAVAIVSGGNIEPAQLAAI MAB_1199|M.abscessus_ATCC_1997 LERAKLVVEPAGAAAVAALLTLSAEELGLTGPVCAVLSGGNIDPLLLTHV . ::.**:** :::. . . ::**** : : Mb1585|M.bovis_AF2122/97 LERSLVHLGLKHYFLVDFPQEPGALRRFLDDVLGPND---DITLFEYVKR Rv1559|M.tuberculosis_H37Rv LERSLVHLGLKHYFLVDFPQEPGALRRFLDDVLGPND---DITLFEYVKR MMAR_2374|M.marinum_M LERSLVHLGLKHYFLVDFPQEPGALRRFLDEVLGPND---DITLFEYVKR MUL_1550|M.ulcerans_Agy99 LERSLVHLGLKHYFLVDFPQEPGALRRFLDEVLGPND---DITLFEYVKR MAV_3217|M.avium_104 LERSLVHLGLKHYFLVDFPQEPGALRRFLDEVLGPND---DITLFEYVKR MLBr_01209|M.leprae_Br4923 LERSLIHLGLKHYFLVDFPQKPGALRRFLDEVLGPND---DITLFEYVKR TH_1800|M.thermoresistible__bu LERSLVHLGLKHYFLVDFPQEPGSLRRFLDEVLGEGD---DITLFEYVKR Mvan_3022|M.vanbaalenii_PYR-1 LAD----------------------------------------------- Mflv_3301|M.gilvum_PYR-GCK LTEAAPT------------------------------------------- MSMEG_3532|M.smegmatis_MC2_155 LAGG---------------------------------------------- MAB_1199|M.abscessus_ATCC_1997 ITHGLRAAGRYLTVRVTVADAPGGLSGLLDVFRASGASVVDVTHWRNSER : Mb1585|M.bovis_AF2122/97 NNRETGEALVGIELGSAADLDGLLARMRATDIHVEALEPGSPAYRYLL- Rv1559|M.tuberculosis_H37Rv NNRETGEALVGIELGSAADLDGLLARMRATDIHVEALEPGSPAYRYLL- MMAR_2374|M.marinum_M NNRETGEALVGVELGSAANLDGLLARMHETEVHVEPLAPGSPAYRYLL- MUL_1550|M.ulcerans_Agy99 NNRETGEALVGVELGSAANLDGLLARMRETEVHVEPLAPGSPAYRYLL- MAV_3217|M.avium_104 NNRETGEALVGIQLGSSADLDGLLARMRATELHVETLKPGSPAYRYLLL MLBr_01209|M.leprae_Br4923 NNRETGEALVGIQLGSAVDLDVLLARMQGTEMHVETLQPGSPAYRYLLL TH_1800|M.thermoresistible__bu NNRETGEALVGIELSSAADLDGLLARMEASDIHVERLEPGSPAYRYLT- Mvan_3022|M.vanbaalenii_PYR-1 ------------------------------------------------- Mflv_3301|M.gilvum_PYR-GCK ------------------------------------------------- MSMEG_3532|M.smegmatis_MC2_155 ------------------------------------------------- MAB_1199|M.abscessus_ATCC_1997 LRLGEVDVLATVETRGPEHRQAVLDAIVAAGLTVQEER-----------