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DLVTLDDISGAAARIAADIVRTPLLAADWGDPRCPLWLKAETLQPIGAFKIRGAFNALGRLDTHTRARGV VAYSSGNHAQAVAYAAAAYGVPAHIVMPEETPAVKVEATRRRGAHVVLCGAGERERTAAELVEKTGAVLI PPFDHPDIIAGQGTIGIEIAEDLPELATVLIPVSGGGLASGIGTAIRALRPKAKIFAVEPELAADTAESL ALGSIVEWPVAKRNRTIADGLRSTPSELTFAHLRQVIDDVITVSEDEIRSAVRELALRARLVAEPSGAVS LAGYRKAALPDGSAVAIVSGGNIEPAQLAAILAGG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3532 | - | - | 100% (316) | serine/threonine dehydratase family protein |
| M. smegmatis MC2 155 | MSMEG_3183 | ilvA | 4e-35 | 32.81% (317) | threonine dehydratase |
| M. smegmatis MC2 155 | MSMEG_4905 | cysM | 4e-08 | 26.11% (180) | cysteine synthase B |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1585 | ilvA | 3e-41 | 36.05% (319) | threonine dehydratase |
| M. gilvum PYR-GCK | Mflv_3301 | - | 1e-119 | 69.65% (313) | pyridoxal-5'-phosphate-dependent enzyme, beta subunit |
| M. tuberculosis H37Rv | Rv1559 | ilvA | 4e-41 | 36.05% (319) | threonine dehydratase |
| M. leprae Br4923 | MLBr_01209 | ilvA | 3e-41 | 35.40% (322) | threonine dehydratase |
| M. abscessus ATCC 19977 | MAB_1199 | - | 2e-59 | 40.80% (326) | threonine dehydratase |
| M. marinum M | MMAR_2374 | ilvA | 9e-39 | 35.65% (317) | threonine dehydratase IlvA |
| M. avium 104 | MAV_3217 | ilvA | 4e-38 | 35.02% (317) | threonine dehydratase |
| M. thermoresistible (build 8) | TH_1800 | ilvA | 2e-38 | 34.15% (325) | Probable threonine dehydratase ilvA |
| M. ulcerans Agy99 | MUL_1550 | ilvA | 6e-39 | 35.65% (317) | threonine dehydratase |
| M. vanbaalenii PYR-1 | Mvan_3022 | - | 1e-121 | 70.44% (318) | pyridoxal-5'-phosphate-dependent enzyme, beta subunit |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1585|M.bovis_AF2122/97 MSAELSQSPSSSPLFSLSGADIDRAAKRIAPVVTPTPLQPSDRLSAITGA
Rv1559|M.tuberculosis_H37Rv MSAELSQSPSSSPLFSLSGADIDRAAKRIAPVVTPTPLQPSDRLSAITGA
MMAR_2374|M.marinum_M MSAELSQTPSRSP---LSAADIDNAAERIAPVITPTPLQLCERLSDITGA
MUL_1550|M.ulcerans_Agy99 MSAELSQTPSRSP---LSAADIDNAAERIAPVITPTPLQLCERLSDITGA
MAV_3217|M.avium_104 MSAELSQSPSVAP---LSAADIDDAAKRIAAVVTPTPLQFSDRLSAITGA
MLBr_01209|M.leprae_Br4923 MSAEPSRNPRTPP---VSAVDIDGAAKRIAPVVTPTPLQLSDRLSAITGA
TH_1800|M.thermoresistible__bu VTADLTHSLRRSDQSPLSAADIDEAAARLAGVVTRTPLQFCDRLSEATGA
Mflv_3301|M.gilvum_PYR-GCK -------------MERVTIDDIRAAAERIRPHVVRTPLLAARWGDAER--
Mvan_3022|M.vanbaalenii_PYR-1 -------------MKLVTIDDVRAAAERIRPNVVRTPLLAARWGDRER--
MSMEG_3532|M.smegmatis_MC2_155 -------------MDLVTLDDISGAAARIAADIVRTPLLAADWGDPRC--
MAB_1199|M.abscessus_ATCC_1997 -----MAMETSGAIGLVTVQEIQEVAERLAPVIRRTPMVAFRALSDRCGH
:: :: .* *: : **: .
Mb1585|M.bovis_AF2122/97 TVYLKREDLQTVRSYKLRGAYNLLVQLSD----EELAAGVVCSSAGNHAQ
Rv1559|M.tuberculosis_H37Rv TVYLKREDLQTVRSYKLRGAYNLLVQLSD----EELAAGVVCSSAGNHAQ
MMAR_2374|M.marinum_M TVYLKREDLQIVRSYKLRGAYNLLVQLTA----EELAAGVVCSSAGNHAQ
MUL_1550|M.ulcerans_Agy99 TVYLKREDLQIVRSYKLRGAYNLLVQLTA----EELAAGVVCSSAGNHAQ
MAV_3217|M.avium_104 QVYLKREDLQIVRSYKLRGAYNLLVQLSE----TELAAGVVCSSAGNHAQ
MLBr_01209|M.leprae_Br4923 AVYLKREDLQTVRSYKLRGAYNLLVQLTD----EEIAAGVVCSSAGNHAQ
TH_1800|M.thermoresistible__bu NIYLKREDLQAVRSYKLRGAYNLLSQLTE----EEKAAGVVCSSAGNHAQ
Mflv_3301|M.gilvum_PYR-GCK PLWVKPESLQPIGAFKMRGAFNAVGTVR------GSTSDVVAYSSGNHAQ
Mvan_3022|M.vanbaalenii_PYR-1 PLWIKPENLQPIGAFKVRGAFNAIGAVRENSDGRDAVTDVVAYSSGNHAQ
MSMEG_3532|M.smegmatis_MC2_155 PLWLKAETLQPIGAFKIRGAFNALGRLDT----HTRARGVVAYSSGNHAQ
MAB_1199|M.abscessus_ATCC_1997 EVRLKCENLQRTGSFKPRGAYNRISQLPG----EQRVNGVVAASAGNHAQ
: :* * ** ::* ***:* : : . .**. *:*****
Mb1585|M.bovis_AF2122/97 GFAYACRCLGVHGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGSTYDLAA
Rv1559|M.tuberculosis_H37Rv GFAYACRCLGVHGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGSTYDLAA
MMAR_2374|M.marinum_M GFAFACKTLGVHGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGETYDLAA
MUL_1550|M.ulcerans_Agy99 GFAFACKTLGVRGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGETYDLAA
MAV_3217|M.avium_104 GFAYACRMLQVHGRVYVPAKTPLQKRDRIRYHGGEFIELIVGGTTYDQAA
MLBr_01209|M.leprae_Br4923 GVAYACRSLGVHGRVYVPAKTPKQKWDRIRYHGGAFIELIVGRSTYDLAA
TH_1800|M.thermoresistible__bu GFALACRMMGIHGRIYIPAKTPKQKRQRIRYHGREFIELIAVGRTYDLAA
Mflv_3301|M.gilvum_PYR-GCK AVAYAAAAFGLRAHIVMPRETPNIKVQATRDLG---ARVVLSEAGQRET-
Mvan_3022|M.vanbaalenii_PYR-1 AVAYAAAAFGLRAHIVMPEETPEVKVAATRGLG---ARVVLCAAGQREA-
MSMEG_3532|M.smegmatis_MC2_155 AVAYAAAAYGVPAHIVMPEETPAVKVEATRRRG---AHVVLCGAGERER-
MAB_1199|M.abscessus_ATCC_1997 GVAWAATTLGIPSTVFMPVGAALPKIVATRAYG---ATVHLTGSTIDDAL
..* *. : . : :* :. * * * :
Mb1585|M.bovis_AF2122/97 AAALEDVERTGATLVPPFDDLRTIAGQGTIAVEVLGQLEDE--------P
Rv1559|M.tuberculosis_H37Rv AAALEDVERTGATLVPPFDDLRTIAGQGTIAVEVLGQLEDE--------P
MMAR_2374|M.marinum_M AAAREDVERTGATLVPPYDDLRTMAGQGTIAVELLAELDAE--------P
MUL_1550|M.ulcerans_Agy99 AAAREDVERTGATLVPPYDDLRTMAGQGTIAVELLAELDAE--------P
MAV_3217|M.avium_104 EAALADVASTGATLVPPYDDLRTIAGQGTIAVELLDQLDTE--------P
MLBr_01209|M.leprae_Br4923 AAAVDDIERTGATLVPPYDDVRVIAGQGTIAVELLEQLNTE--------P
TH_1800|M.thermoresistible__bu AAALADVERTGATLVHPYDDPRTIAGQGTIATEILEQLDAEDGPGGGGEP
Mflv_3301|M.gilvum_PYR-GCK -VAAEVLADTGGVMIPPFDHPDVIAGQGTAGLEIAEDLPSVR--------
Mvan_3022|M.vanbaalenii_PYR-1 -VAEQTAHDTGGVMIPPFDHPDVIAGQGTAGLEIAEDLPSVR--------
MSMEG_3532|M.smegmatis_MC2_155 -TAAELVEKTGAVLIPPFDHPDIIAGQGTIGIEIAEDLPELA--------
MAB_1199|M.abscessus_ATCC_1997 LAATEFAAETGAVLIHPFDHRDVVAGQATVGLEILEQLPEVG--------
.* **..:: *:*. :***.* . *: :*
Mb1585|M.bovis_AF2122/97 DLVVVPVGGGGCIAGITTYLAERTTNTAVLGVEPAGAAAMMAALAAGEPV
Rv1559|M.tuberculosis_H37Rv DLVVVPVGGGGCIAGITTYLAERTTNTAVLGVEPAGAAAMMAALAAGEPV
MMAR_2374|M.marinum_M DLVVVPVGGGGCIAGITSYLAERTTKTAVLGIEPAGAAAMMAALAAGEPV
MUL_1550|M.ulcerans_Agy99 DLVVVPVGGGGCIAGITSYLAERTTKTAVLGIEPAGAAAMMAALAAGEPV
MAV_3217|M.avium_104 DLVVVPVGGGGCIAGITTYLAERTDTTAVLGVEPAGAAAMMAALAAGEPV
MLBr_01209|M.leprae_Br4923 DLVVVPVGGGGCIAGMTTYLAERTANTAVLGVEPAGAAAMMAALAAGEPV
TH_1800|M.thermoresistible__bu DLVIVPVGGGGCIAGITTYLAERTRNTAVLGVEPAGAASMMAALAAGEPV
Mflv_3301|M.gilvum_PYR-GCK -TVLIPVSGGGLASGVGTAIRALCPQARIFGVEPELAGDTAESLRAGRRV
Mvan_3022|M.vanbaalenii_PYR-1 -NVLIPVSGGGLASGIGTAIRALCPAAKIFGVEPELAADTAEGLRLGHRV
MSMEG_3532|M.smegmatis_MC2_155 -TVLIPVSGGGLASGIGTAIRALRPKAKIFAVEPELAADTAESLALGSIV
MAB_1199|M.abscessus_ATCC_1997 -TIVVPAGGGGLVAGVAAVVKAARPAVRIVAVQAAGAAAWPVSLKAGHPV
:::*..*** :*: : : . :..::. *. .* * *
Mb1585|M.bovis_AF2122/97 TLDHVDQFVDGAAVNRAGTLTYAALAAAGDMVS-LTTVDEGAVCTAMLDL
Rv1559|M.tuberculosis_H37Rv TLDHVDQFVDGAAVNRAGTLTYAALAAAGDMVS-LTTVDEGAVCTAMLDL
MMAR_2374|M.marinum_M TLDHVDQFVDGAAVNRAGTLPYAALSAAGDMVS-ITTVDEGAVCTAMLDL
MUL_1550|M.ulcerans_Agy99 TLDHVDQFVDGAAVNRAGALPYAALSAAGDMVS-ITTVDEGAVCTAMLDL
MAV_3217|M.avium_104 TLDHVDQFVDGAAVRRAGDLTYAALAAAGDMVS-ITTVDEGAVCTAMLDL
MLBr_01209|M.leprae_Br4923 TLDYVDQFVDGAAVNRVGTLPYAALTAAGDMVS-ITTVDEGAVCTAMLDL
TH_1800|M.thermoresistible__bu TLDHVDQFVDGAAVNRAGTYTHAALAAAGDMVS-ITTVDEGAVCTAMLDL
Mflv_3301|M.gilvum_PYR-GCK DWSIEDRNRTIADGLRS-QPSELTFAHLQRVLDGVITVTEDEIRSAVREY
Mvan_3022|M.vanbaalenii_PYR-1 DWPVGDRNRTIADGLRS-QPSELTFAHLQQVLDGMITVSEAEIRSAVREL
MSMEG_3532|M.smegmatis_MC2_155 EWPVAKRNRTIADGLRS-TPSELTFAHLRQVIDDVITVSEDEIRSAVREL
MAB_1199|M.abscessus_ATCC_1997 ALESMD---TMADGIAVGKPGAVPFEHVAALVDDVVTVSEEALSRGLLLC
. * .: ::. : ** * : .:
Mb1585|M.bovis_AF2122/97 YQNEGIIAEPAGALSVAGLLEADIEP---GSTVVCLISGGNNDVSRYGEV
Rv1559|M.tuberculosis_H37Rv YQNEGIIAEPAGALSVAGLLEADIEP---GSTVVCLISGGNNDVSRYGEV
MMAR_2374|M.marinum_M YQHEGIIAEPAGALSVAGLLEADIEP---GSTVVCLISGGNNDVSRYGEI
MUL_1550|M.ulcerans_Agy99 YQHEGIIAEPAGALSVAGLLEADIEP---GSTVVCLISGGNNDVSRYGEI
MAV_3217|M.avium_104 YQNEGIIAEPAGALSVTGLLEADIEP---GSTVVCLISGGNNDVSRYGEV
MLBr_01209|M.leprae_Br4923 YQNEGIIAEPAGALSVAGLLETDIEP---GSTVVCLISGGNNDVLRYGEV
TH_1800|M.thermoresistible__bu YQNEGIIAEPAGALAVTGLSEAEIEP---GSTVVCLISGGNNDVSRYNEV
Mflv_3301|M.gilvum_PYR-GCK AYRGRLVAEPSGAVALAGYRQGGTGD----GDTAVILSGGNIEPSTLRQI
Mvan_3022|M.vanbaalenii_PYR-1 VHRAHLVAEPSGAVALAAYRQGVTPP----GDTVLILSGGNVEPQMLRQI
MSMEG_3532|M.smegmatis_MC2_155 ALRARLVAEPSGAVSLAGYRKAALPD----GSAVAIVSGGNIEPAQLAAI
MAB_1199|M.abscessus_ATCC_1997 LERAKLVVEPAGAAAVAALLTLSAEELGLTGPVCAVLSGGNIDPLLLTHV
. ::.**:** :::. . . ::**** : :
Mb1585|M.bovis_AF2122/97 LERSLVHLGLKHYFLVDFPQEPGALRRFLDDVLGPND---DITLFEYVKR
Rv1559|M.tuberculosis_H37Rv LERSLVHLGLKHYFLVDFPQEPGALRRFLDDVLGPND---DITLFEYVKR
MMAR_2374|M.marinum_M LERSLVHLGLKHYFLVDFPQEPGALRRFLDEVLGPND---DITLFEYVKR
MUL_1550|M.ulcerans_Agy99 LERSLVHLGLKHYFLVDFPQEPGALRRFLDEVLGPND---DITLFEYVKR
MAV_3217|M.avium_104 LERSLVHLGLKHYFLVDFPQEPGALRRFLDEVLGPND---DITLFEYVKR
MLBr_01209|M.leprae_Br4923 LERSLIHLGLKHYFLVDFPQKPGALRRFLDEVLGPND---DITLFEYVKR
TH_1800|M.thermoresistible__bu LERSLVHLGLKHYFLVDFPQEPGSLRRFLDEVLGEGD---DITLFEYVKR
Mflv_3301|M.gilvum_PYR-GCK LTEAAPT-------------------------------------------
Mvan_3022|M.vanbaalenii_PYR-1 LAD-----------------------------------------------
MSMEG_3532|M.smegmatis_MC2_155 LAGG----------------------------------------------
MAB_1199|M.abscessus_ATCC_1997 ITHGLRAAGRYLTVRVTVADAPGGLSGLLDVFRASGASVVDVTHWRNSER
:
Mb1585|M.bovis_AF2122/97 NNRETGEALVGIELGSAADLDGLLARMRATDIHVEALEPGSPAYRYLL-
Rv1559|M.tuberculosis_H37Rv NNRETGEALVGIELGSAADLDGLLARMRATDIHVEALEPGSPAYRYLL-
MMAR_2374|M.marinum_M NNRETGEALVGVELGSAANLDGLLARMHETEVHVEPLAPGSPAYRYLL-
MUL_1550|M.ulcerans_Agy99 NNRETGEALVGVELGSAANLDGLLARMRETEVHVEPLAPGSPAYRYLL-
MAV_3217|M.avium_104 NNRETGEALVGIQLGSSADLDGLLARMRATELHVETLKPGSPAYRYLLL
MLBr_01209|M.leprae_Br4923 NNRETGEALVGIQLGSAVDLDVLLARMQGTEMHVETLQPGSPAYRYLLL
TH_1800|M.thermoresistible__bu NNRETGEALVGIELSSAADLDGLLARMEASDIHVERLEPGSPAYRYLT-
Mflv_3301|M.gilvum_PYR-GCK -------------------------------------------------
Mvan_3022|M.vanbaalenii_PYR-1 -------------------------------------------------
MSMEG_3532|M.smegmatis_MC2_155 -------------------------------------------------
MAB_1199|M.abscessus_ATCC_1997 LRLGEVDVLATVETRGPEHRQAVLDAIVAAGLTVQEER-----------