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MAMETSGAIGLVTVQEIQEVAERLAPVIRRTPMVAFRALSDRCGHEVRLKCENLQRTGSFKPRGAYNRIS QLPGEQRVNGVVAASAGNHAQGVAWAATTLGIPSTVFMPVGAALPKIVATRAYGATVHLTGSTIDDALLA ATEFAAETGAVLIHPFDHRDVVAGQATVGLEILEQLPEVGTIVVPAGGGGLVAGVAAVVKAARPAVRIVA VQAAGAAAWPVSLKAGHPVALESMDTMADGIAVGKPGAVPFEHVAALVDDVVTVSEEALSRGLLLCLERA KLVVEPAGAAAVAALLTLSAEELGLTGPVCAVLSGGNIDPLLLTHVITHGLRAAGRYLTVRVTVADAPGG LSGLLDVFRASGASVVDVTHWRNSERLRLGEVDVLATVETRGPEHRQAVLDAIVAAGLTVQEER
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1199 | - | - | 100% (414) | threonine dehydratase |
| M. abscessus ATCC 19977 | MAB_2691c | - | 2e-50 | 34.23% (409) | threonine dehydratase |
| M. abscessus ATCC 19977 | MAB_1436 | - | 2e-18 | 29.69% (320) | threonine synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1585 | ilvA | 5e-52 | 38.33% (347) | threonine dehydratase |
| M. gilvum PYR-GCK | Mflv_3634 | - | 2e-52 | 38.04% (347) | threonine dehydratase |
| M. tuberculosis H37Rv | Rv1559 | ilvA | 5e-52 | 38.33% (347) | threonine dehydratase |
| M. leprae Br4923 | MLBr_01209 | ilvA | 1e-53 | 38.46% (351) | threonine dehydratase |
| M. marinum M | MMAR_2374 | ilvA | 1e-53 | 37.61% (351) | threonine dehydratase IlvA |
| M. avium 104 | MAV_3217 | ilvA | 4e-50 | 35.83% (360) | threonine dehydratase |
| M. smegmatis MC2 155 | MSMEG_3532 | - | 4e-59 | 40.80% (326) | serine/threonine dehydratase family protein |
| M. thermoresistible (build 8) | TH_1800 | ilvA | 5e-52 | 33.57% (414) | Probable threonine dehydratase ilvA |
| M. ulcerans Agy99 | MUL_1550 | ilvA | 3e-54 | 37.89% (351) | threonine dehydratase |
| M. vanbaalenii PYR-1 | Mvan_3022 | - | 3e-54 | 39.33% (328) | pyridoxal-5'-phosphate-dependent enzyme, beta subunit |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1585|M.bovis_AF2122/97 MSAELSQSPSSSPLFSLSGADIDRAAKRIAPVVTPTPLQPSDRLSAITGA
Rv1559|M.tuberculosis_H37Rv MSAELSQSPSSSPLFSLSGADIDRAAKRIAPVVTPTPLQPSDRLSAITGA
MMAR_2374|M.marinum_M MSAELSQTPSRSP---LSAADIDNAAERIAPVITPTPLQLCERLSDITGA
MUL_1550|M.ulcerans_Agy99 MSAELSQTPSRSP---LSAADIDNAAERIAPVITPTPLQLCERLSDITGA
MAV_3217|M.avium_104 MSAELSQSPSVAP---LSAADIDDAAKRIAAVVTPTPLQFSDRLSAITGA
MLBr_01209|M.leprae_Br4923 MSAEPSRNPRTPP---VSAVDIDGAAKRIAPVVTPTPLQLSDRLSAITGA
Mflv_3634|M.gilvum_PYR-GCK MSAELSQSPRIDPATPLRAADIDEAAQRISGLVSRTPLQFCDRLSEITGA
TH_1800|M.thermoresistible__bu VTADLTHSLRRSDQSPLSAADIDEAAARLAGVVTRTPLQFCDRLSEATGA
MSMEG_3532|M.smegmatis_MC2_155 -------------MDLVTLDDISGAAARIAADIVRTPLLAADWGDPRC--
Mvan_3022|M.vanbaalenii_PYR-1 -------------MKLVTIDDVRAAAERIRPNVVRTPLLAARWGDRER--
MAB_1199|M.abscessus_ATCC_1997 -----MAMETSGAIGLVTVQEIQEVAERLAPVIRRTPMVAFRALSDRCGH
: :: .* *: : **: .
Mb1585|M.bovis_AF2122/97 TVYLKREDLQTVRSYKLRGAYNLLVQLSDEELAAG----VVCSSAGNHAQ
Rv1559|M.tuberculosis_H37Rv TVYLKREDLQTVRSYKLRGAYNLLVQLSDEELAAG----VVCSSAGNHAQ
MMAR_2374|M.marinum_M TVYLKREDLQIVRSYKLRGAYNLLVQLTAEELAAG----VVCSSAGNHAQ
MUL_1550|M.ulcerans_Agy99 TVYLKREDLQIVRSYKLRGAYNLLVQLTAEELAAG----VVCSSAGNHAQ
MAV_3217|M.avium_104 QVYLKREDLQIVRSYKLRGAYNLLVQLSETELAAG----VVCSSAGNHAQ
MLBr_01209|M.leprae_Br4923 AVYLKREDLQTVRSYKLRGAYNLLVQLTDEEIAAG----VVCSSAGNHAQ
Mflv_3634|M.gilvum_PYR-GCK TVYLKREDLQAVRSYKLRGAYNLLMQLTPEEKAAG----VVCSSAGNHAQ
TH_1800|M.thermoresistible__bu NIYLKREDLQAVRSYKLRGAYNLLSQLTEEEKAAG----VVCSSAGNHAQ
MSMEG_3532|M.smegmatis_MC2_155 PLWLKAETLQPIGAFKIRGAFNALGRLDTHTRAR----GVVAYSSGNHAQ
Mvan_3022|M.vanbaalenii_PYR-1 PLWIKPENLQPIGAFKVRGAFNAIGAVRENSDGRDAVTDVVAYSSGNHAQ
MAB_1199|M.abscessus_ATCC_1997 EVRLKCENLQRTGSFKPRGAYNRISQLPGEQRVN----GVVAASAGNHAQ
: :* * ** ::* ***:* : : **. *:*****
Mb1585|M.bovis_AF2122/97 GFAYACRCLGVHGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGSTYDLAA
Rv1559|M.tuberculosis_H37Rv GFAYACRCLGVHGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGSTYDLAA
MMAR_2374|M.marinum_M GFAFACKTLGVHGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGETYDLAA
MUL_1550|M.ulcerans_Agy99 GFAFACKTLGVRGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGETYDLAA
MAV_3217|M.avium_104 GFAYACRMLQVHGRVYVPAKTPLQKRDRIRYHGGEFIELIVGGTTYDQAA
MLBr_01209|M.leprae_Br4923 GVAYACRSLGVHGRVYVPAKTPKQKWDRIRYHGGAFIELIVGRSTYDLAA
Mflv_3634|M.gilvum_PYR-GCK GFALACRSMGIHGRVYVPAKTPRQKRDRIRYHGGDFIELIVGGKTYDMAA
TH_1800|M.thermoresistible__bu GFALACRMMGIHGRIYIPAKTPKQKRQRIRYHGREFIELIAVGRTYDLAA
MSMEG_3532|M.smegmatis_MC2_155 AVAYAAAAYGVPAHIVMPEETPAVKVEATRRRG---AHVVLCGAGERER-
Mvan_3022|M.vanbaalenii_PYR-1 AVAYAAAAFGLRAHIVMPEETPEVKVAATRGLG---ARVVLCAAGQREA-
MAB_1199|M.abscessus_ATCC_1997 GVAWAATTLGIPSTVFMPVGAALPKIVATRAYG---ATVHLTGSTIDDAL
..* *. : . : :* :. * * * :
Mb1585|M.bovis_AF2122/97 AAALEDVERTGATLVPPFDDLRTIAGQGTIAVEVLGQLEDE--------P
Rv1559|M.tuberculosis_H37Rv AAALEDVERTGATLVPPFDDLRTIAGQGTIAVEVLGQLEDE--------P
MMAR_2374|M.marinum_M AAAREDVERTGATLVPPYDDLRTMAGQGTIAVELLAELDAE--------P
MUL_1550|M.ulcerans_Agy99 AAAREDVERTGATLVPPYDDLRTMAGQGTIAVELLAELDAE--------P
MAV_3217|M.avium_104 EAALADVASTGATLVPPYDDLRTIAGQGTIAVELLDQLDTE--------P
MLBr_01209|M.leprae_Br4923 AAAVDDIERTGATLVPPYDDVRVIAGQGTIAVELLEQLNTE--------P
Mflv_3634|M.gilvum_PYR-GCK QAALDDVARTGATLVPPYDDLRTMAGQGTIAVEILDELGSE--------P
TH_1800|M.thermoresistible__bu AAALADVERTGATLVHPYDDPRTIAGQGTIATEILEQLDAEDGPGGGGEP
MSMEG_3532|M.smegmatis_MC2_155 -TAAELVEKTGAVLIPPFDHPDIIAGQGTIGIEIAEDLPELA--------
Mvan_3022|M.vanbaalenii_PYR-1 -VAEQTAHDTGGVMIPPFDHPDVIAGQGTAGLEIAEDLPSVR--------
MAB_1199|M.abscessus_ATCC_1997 LAATEFAAETGAVLIHPFDHRDVVAGQATVGLEILEQLPEVG--------
.* **..:: *:*. :***.* . *: :*
Mb1585|M.bovis_AF2122/97 DLVVVPVGGGGCIAGITTYLAERTTNTAVLGVEPAGAAAMMAALAAGEPV
Rv1559|M.tuberculosis_H37Rv DLVVVPVGGGGCIAGITTYLAERTTNTAVLGVEPAGAAAMMAALAAGEPV
MMAR_2374|M.marinum_M DLVVVPVGGGGCIAGITSYLAERTTKTAVLGIEPAGAAAMMAALAAGEPV
MUL_1550|M.ulcerans_Agy99 DLVVVPVGGGGCIAGITSYLAERTTKTAVLGIEPAGAAAMMAALAAGEPV
MAV_3217|M.avium_104 DLVVVPVGGGGCIAGITTYLAERTDTTAVLGVEPAGAAAMMAALAAGEPV
MLBr_01209|M.leprae_Br4923 DLVVVPVGGGGCIAGMTTYLAERTANTAVLGVEPAGAAAMMAALAAGEPV
Mflv_3634|M.gilvum_PYR-GCK DLVVVPVGGGGCISGMTTYLAERTATTSVLGVEPAGAASFVAALANGTPV
TH_1800|M.thermoresistible__bu DLVIVPVGGGGCIAGITTYLAERTRNTAVLGVEPAGAASMMAALAAGEPV
MSMEG_3532|M.smegmatis_MC2_155 -TVLIPVSGGGLASGIGTAIRALRPKAKIFAVEPELAADTAESLALGSIV
Mvan_3022|M.vanbaalenii_PYR-1 -NVLIPVSGGGLASGIGTAIRALCPAAKIFGVEPELAADTAEGLRLGHRV
MAB_1199|M.abscessus_ATCC_1997 -TIVVPAGGGGLVAGVAAVVKAARPAVRIVAVQAAGAAAWPVSLKAGHPV
:::*..*** :*: : : . :..::. ** .* * *
Mb1585|M.bovis_AF2122/97 TLDHVD---QFVDGAAVNRAGTLTYAALAAAGDMVSLTTVDEGAVCTAML
Rv1559|M.tuberculosis_H37Rv TLDHVD---QFVDGAAVNRAGTLTYAALAAAGDMVSLTTVDEGAVCTAML
MMAR_2374|M.marinum_M TLDHVD---QFVDGAAVNRAGTLPYAALSAAGDMVSITTVDEGAVCTAML
MUL_1550|M.ulcerans_Agy99 TLDHVD---QFVDGAAVNRAGALPYAALSAAGDMVSITTVDEGAVCTAML
MAV_3217|M.avium_104 TLDHVD---QFVDGAAVRRAGDLTYAALAAAGDMVSITTVDEGAVCTAML
MLBr_01209|M.leprae_Br4923 TLDYVD---QFVDGAAVNRVGTLPYAALTAAGDMVSITTVDEGAVCTAML
Mflv_3634|M.gilvum_PYR-GCK TLEHVD---QFVDGAAVARAGAKPFEALRAAGDMVSMTTVDEGAVCTAML
TH_1800|M.thermoresistible__bu TLDHVD---QFVDGAAVNRAGTYTHAALAAAGDMVSITTVDEGAVCTAML
MSMEG_3532|M.smegmatis_MC2_155 EWPVAKRNRTIADGLRS-TPSELTFAHLRQV--IDDVITVSEDEIRSAVR
Mvan_3022|M.vanbaalenii_PYR-1 DWPVGDRNRTIADGLRS-QPSELTFAHLQQV--LDGMITVSEAEIRSAVR
MAB_1199|M.abscessus_ATCC_1997 ALESMD---TMADGIAVGKPGAVPFEHVAAL--VDDVVTVSEEALSRGLL
. :.** . .. : : .: **.* : .:
Mb1585|M.bovis_AF2122/97 DLYQNEGIIAEPAGALSVAGLL---EADIEPGSTVVCLISGGNNDVSRYG
Rv1559|M.tuberculosis_H37Rv DLYQNEGIIAEPAGALSVAGLL---EADIEPGSTVVCLISGGNNDVSRYG
MMAR_2374|M.marinum_M DLYQHEGIIAEPAGALSVAGLL---EADIEPGSTVVCLISGGNNDVSRYG
MUL_1550|M.ulcerans_Agy99 DLYQHEGIIAEPAGALSVAGLL---EADIEPGSTVVCLISGGNNDVSRYG
MAV_3217|M.avium_104 DLYQNEGIIAEPAGALSVTGLL---EADIEPGSTVVCLISGGNNDVSRYG
MLBr_01209|M.leprae_Br4923 DLYQNEGIIAEPAGALSVAGLL---ETDIEPGSTVVCLISGGNNDVLRYG
Mflv_3634|M.gilvum_PYR-GCK GLYQNEGIIAEPAGALSVAALL---DADIEPGSTVVCLISGGNNDVSRYG
TH_1800|M.thermoresistible__bu DLYQNEGIIAEPAGALAVTGLS---EAEIEPGSTVVCLISGGNNDVSRYN
MSMEG_3532|M.smegmatis_MC2_155 ELALRARLVAEPSGAVSLAGYR----KAALPDGSAVAIVSGGNIEPAQLA
Mvan_3022|M.vanbaalenii_PYR-1 ELVHRAHLVAEPSGAVALAAYR----QGVTPPGDTVLILSGGNVEPQMLR
MAB_1199|M.abscessus_ATCC_1997 LCLERAKLVVEPAGAAAVAALLTLSAEELGLTGPVCAVLSGGNIDPLLLT
. ::.**:** :::. . . ::**** :
Mb1585|M.bovis_AF2122/97 EVLERSLVHLGLKHYFLVDFPQEPGALRRFLDDVLGPND---DITLFEYV
Rv1559|M.tuberculosis_H37Rv EVLERSLVHLGLKHYFLVDFPQEPGALRRFLDDVLGPND---DITLFEYV
MMAR_2374|M.marinum_M EILERSLVHLGLKHYFLVDFPQEPGALRRFLDEVLGPND---DITLFEYV
MUL_1550|M.ulcerans_Agy99 EILERSLVHLGLKHYFLVDFPQEPGALRRFLDEVLGPND---DITLFEYV
MAV_3217|M.avium_104 EVLERSLVHLGLKHYFLVDFPQEPGALRRFLDEVLGPND---DITLFEYV
MLBr_01209|M.leprae_Br4923 EVLERSLIHLGLKHYFLVDFPQKPGALRRFLDEVLGPND---DITLFEYV
Mflv_3634|M.gilvum_PYR-GCK EVLERSLVHLGLKHYFLVDFPQEPGALRRFLDEVLGPND---DITLFEYV
TH_1800|M.thermoresistible__bu EVLERSLVHLGLKHYFLVDFPQEPGSLRRFLDEVLGEGD---DITLFEYV
MSMEG_3532|M.smegmatis_MC2_155 AILAGG--------------------------------------------
Mvan_3022|M.vanbaalenii_PYR-1 QILAD---------------------------------------------
MAB_1199|M.abscessus_ATCC_1997 HVITHGLRAAGRYLTVRVTVADAPGGLSGLLDVFRASGASVVDVTHWRNS
::
Mb1585|M.bovis_AF2122/97 KRNNRETGEALVGIELGSAADLDGLLARMRATDIHVEALEPGSPAYRYLL
Rv1559|M.tuberculosis_H37Rv KRNNRETGEALVGIELGSAADLDGLLARMRATDIHVEALEPGSPAYRYLL
MMAR_2374|M.marinum_M KRNNRETGEALVGVELGSAANLDGLLARMHETEVHVEPLAPGSPAYRYLL
MUL_1550|M.ulcerans_Agy99 KRNNRETGEALVGVELGSAANLDGLLARMRETEVHVEPLAPGSPAYRYLL
MAV_3217|M.avium_104 KRNNRETGEALVGIQLGSSADLDGLLARMRATELHVETLKPGSPAYRYLL
MLBr_01209|M.leprae_Br4923 KRNNRETGEALVGIQLGSAVDLDVLLARMQGTEMHVETLQPGSPAYRYLL
Mflv_3634|M.gilvum_PYR-GCK KRNNRETGEALVGIEMANASDLDGLLARMQSSECHIELLEPGSPTYRYLT
TH_1800|M.thermoresistible__bu KRNNRETGEALVGIELSSAADLDGLLARMEASDIHVERLEPGSPAYRYLT
MSMEG_3532|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3022|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1199|M.abscessus_ATCC_1997 ERLRLGEVDVLATVETRGPEHRQAVLDAIVAAGLTVQEER----------
Mb1585|M.bovis_AF2122/97 -
Rv1559|M.tuberculosis_H37Rv -
MMAR_2374|M.marinum_M -
MUL_1550|M.ulcerans_Agy99 -
MAV_3217|M.avium_104 L
MLBr_01209|M.leprae_Br4923 L
Mflv_3634|M.gilvum_PYR-GCK -
TH_1800|M.thermoresistible__bu -
MSMEG_3532|M.smegmatis_MC2_155 -
Mvan_3022|M.vanbaalenii_PYR-1 -
MAB_1199|M.abscessus_ATCC_1997 -