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VSTELSQTPRIDPAAPLRAADIDEAARRISGVVSKTPLQFSDRLSAITGAQVYLKREDLQAVRSYKLRGA YNLLMQLSAEEKAAGVVCSSAGNHAQGFALACRSMGVHGRVYVPAKTPKQKRNRIRYHGGDFIELIVGGK TYDLAAEAALDDVARTGATLVPPYDDLRTMAGQGTIAVEILDQLGQEPDLVIVPVGGGGCISGMTTYLAE RTATTSVMGVEPGGAAALVAALATGEPVTLETVDQFVDGAAVARVGALPFAALSAAGDMVSITTVDEGAV CTAMLDLYQNEGIIAEPAGALSVAALLDSDIEPGSTVVCLISGGNNDVSRYGEVLERSLVHLGLKHYFLV DFPQEPGALRRFLDEVLGPNDDITLFEYVKRNNRETGEALVGIEMGSASDLEGLLARMQTSECHVELLEP GSPTYRYLT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2783 | - | - | 100% (429) | threonine dehydratase |
| M. vanbaalenii PYR-1 | Mvan_3022 | - | 2e-32 | 31.69% (325) | pyridoxal-5'-phosphate-dependent enzyme, beta subunit |
| M. vanbaalenii PYR-1 | Mvan_4347 | - | 1e-20 | 31.33% (300) | threonine synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1585 | ilvA | 0.0 | 83.18% (428) | threonine dehydratase |
| M. gilvum PYR-GCK | Mflv_3634 | - | 0.0 | 91.14% (429) | threonine dehydratase |
| M. tuberculosis H37Rv | Rv1559 | ilvA | 0.0 | 83.18% (428) | threonine dehydratase |
| M. leprae Br4923 | MLBr_01209 | ilvA | 0.0 | 82.01% (428) | threonine dehydratase |
| M. abscessus ATCC 19977 | MAB_2691c | - | 1e-175 | 75.18% (411) | threonine dehydratase |
| M. marinum M | MMAR_2374 | ilvA | 0.0 | 82.01% (428) | threonine dehydratase IlvA |
| M. avium 104 | MAV_3217 | ilvA | 0.0 | 84.11% (428) | threonine dehydratase |
| M. smegmatis MC2 155 | MSMEG_3183 | ilvA | 0.0 | 83.72% (430) | threonine dehydratase |
| M. thermoresistible (build 8) | TH_1800 | ilvA | 0.0 | 78.49% (437) | Probable threonine dehydratase ilvA |
| M. ulcerans Agy99 | MUL_1550 | ilvA | 0.0 | 82.01% (428) | threonine dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2783|M.vanbaalenii_PYR-1 MSTELSQTPRIDPA-APLRAADIDEAARRISGVVSKTPLQFSDRLSAITG
Mflv_3634|M.gilvum_PYR-GCK MSAELSQSPRIDPA-TPLRAADIDEAAQRISGLVSRTPLQFCDRLSEITG
Mb1585|M.bovis_AF2122/97 MSAELSQSPSSSPL-FSLSGADIDRAAKRIAPVVTPTPLQPSDRLSAITG
Rv1559|M.tuberculosis_H37Rv MSAELSQSPSSSPL-FSLSGADIDRAAKRIAPVVTPTPLQPSDRLSAITG
MMAR_2374|M.marinum_M MSAELSQTPSRSP----LSAADIDNAAERIAPVITPTPLQLCERLSDITG
MUL_1550|M.ulcerans_Agy99 MSAELSQTPSRSP----LSAADIDNAAERIAPVITPTPLQLCERLSDITG
MLBr_01209|M.leprae_Br4923 MSAEPSRNPRTPP----VSAVDIDGAAKRIAPVVTPTPLQLSDRLSAITG
MAV_3217|M.avium_104 MSAELSQSPSVAP----LSAADIDDAAKRIAAVVTPTPLQFSDRLSAITG
MSMEG_3183|M.smegmatis_MC2_155 MTTELSADSRITALTAPLSAADIDEAARRISGVVTESPLQYCERLSEATG
TH_1800|M.thermoresistible__bu VTADLTHSLRRSDQ-SPLSAADIDEAAARLAGVVTRTPLQFCDRLSEATG
MAB_2691c|M.abscessus_ATCC_199 ----MSTSEVVT-------AADIDAAAKRIDEVVHPTPLQHADRLSALTR
: ..*** ** *: :: :*** .:*** *
Mvan_2783|M.vanbaalenii_PYR-1 AQVYLKREDLQAVRSYKLRGAYNLLMQLSAEEKAAGVVCSSAGNHAQGFA
Mflv_3634|M.gilvum_PYR-GCK ATVYLKREDLQAVRSYKLRGAYNLLMQLTPEEKAAGVVCSSAGNHAQGFA
Mb1585|M.bovis_AF2122/97 ATVYLKREDLQTVRSYKLRGAYNLLVQLSDEELAAGVVCSSAGNHAQGFA
Rv1559|M.tuberculosis_H37Rv ATVYLKREDLQTVRSYKLRGAYNLLVQLSDEELAAGVVCSSAGNHAQGFA
MMAR_2374|M.marinum_M ATVYLKREDLQIVRSYKLRGAYNLLVQLTAEELAAGVVCSSAGNHAQGFA
MUL_1550|M.ulcerans_Agy99 ATVYLKREDLQIVRSYKLRGAYNLLVQLTAEELAAGVVCSSAGNHAQGFA
MLBr_01209|M.leprae_Br4923 AAVYLKREDLQTVRSYKLRGAYNLLVQLTDEEIAAGVVCSSAGNHAQGVA
MAV_3217|M.avium_104 AQVYLKREDLQIVRSYKLRGAYNLLVQLSETELAAGVVCSSAGNHAQGFA
MSMEG_3183|M.smegmatis_MC2_155 ANVYLKREDLQAVRSYKVRGAFNLMAQLSAEELAAGVVCSSAGNHAQGFA
TH_1800|M.thermoresistible__bu ANIYLKREDLQAVRSYKLRGAYNLLSQLTEEEKAAGVVCSSAGNHAQGFA
MAB_2691c|M.abscessus_ATCC_199 AEVYLKREDLQSVRSYKVRGAFNLLMQLSDEEKAAGVVCSSAGNHAQGFA
* :******** *****:***:**: **: * ***************.*
Mvan_2783|M.vanbaalenii_PYR-1 LACRSMGVHGRVYVPAKTPKQKRNRIRYHGGDFIELIVGGKTYDLAAEAA
Mflv_3634|M.gilvum_PYR-GCK LACRSMGIHGRVYVPAKTPRQKRDRIRYHGGDFIELIVGGKTYDMAAQAA
Mb1585|M.bovis_AF2122/97 YACRCLGVHGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGSTYDLAAAAA
Rv1559|M.tuberculosis_H37Rv YACRCLGVHGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGSTYDLAAAAA
MMAR_2374|M.marinum_M FACKTLGVHGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGETYDLAAAAA
MUL_1550|M.ulcerans_Agy99 FACKTLGVRGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGETYDLAAAAA
MLBr_01209|M.leprae_Br4923 YACRSLGVHGRVYVPAKTPKQKWDRIRYHGGAFIELIVGRSTYDLAAAAA
MAV_3217|M.avium_104 YACRMLQVHGRVYVPAKTPLQKRDRIRYHGGEFIELIVGGTTYDQAAEAA
MSMEG_3183|M.smegmatis_MC2_155 MACRTMKTHGRVYVPAKTPKQKRDRIRYHGREFIELIAVGATYDLAAAAA
TH_1800|M.thermoresistible__bu LACRMMGIHGRIYIPAKTPKQKRQRIRYHGREFIELIAVGRTYDLAAAAA
MAB_2691c|M.abscessus_ATCC_199 LACKSMGVHGRVYIPSKTPKQKRQRIIYHGNGFVELIAVGHGYDEAAAAA
**: : :**:*:*:*** ** :** *** *::**. ** ** **
Mvan_2783|M.vanbaalenii_PYR-1 LDDVARTGATLVPPYDDLRTMAGQGTIAVEILDQLGQ--------EPDLV
Mflv_3634|M.gilvum_PYR-GCK LDDVARTGATLVPPYDDLRTMAGQGTIAVEILDELGS--------EPDLV
Mb1585|M.bovis_AF2122/97 LEDVERTGATLVPPFDDLRTIAGQGTIAVEVLGQLED--------EPDLV
Rv1559|M.tuberculosis_H37Rv LEDVERTGATLVPPFDDLRTIAGQGTIAVEVLGQLED--------EPDLV
MMAR_2374|M.marinum_M REDVERTGATLVPPYDDLRTMAGQGTIAVELLAELDA--------EPDLV
MUL_1550|M.ulcerans_Agy99 REDVERTGATLVPPYDDLRTMAGQGTIAVELLAELDA--------EPDLV
MLBr_01209|M.leprae_Br4923 VDDIERTGATLVPPYDDVRVIAGQGTIAVELLEQLNT--------EPDLV
MAV_3217|M.avium_104 LADVASTGATLVPPYDDLRTIAGQGTIAVELLDQLDT--------EPDLV
MSMEG_3183|M.smegmatis_MC2_155 LEDVARTGATLVPPYDDLRTMAGQGTIAAELLDQLDT--------EPDLV
TH_1800|M.thermoresistible__bu LADVERTGATLVHPYDDPRTIAGQGTIATEILEQLDAEDGPGGGGEPDLV
MAB_2691c|M.abscessus_ATCC_199 KADAARTGATLVPAFDDVRTIAGQGTIAAEILDQLDS--------PPDVV
* ****** .:** *.:*******.*:* :* **:*
Mvan_2783|M.vanbaalenii_PYR-1 IVPVGGGGCISGMTTYLAERTATTSVMGVEPGGAAALVAALATGEPVTLE
Mflv_3634|M.gilvum_PYR-GCK VVPVGGGGCISGMTTYLAERTATTSVLGVEPAGAASFVAALANGTPVTLE
Mb1585|M.bovis_AF2122/97 VVPVGGGGCIAGITTYLAERTTNTAVLGVEPAGAAAMMAALAAGEPVTLD
Rv1559|M.tuberculosis_H37Rv VVPVGGGGCIAGITTYLAERTTNTAVLGVEPAGAAAMMAALAAGEPVTLD
MMAR_2374|M.marinum_M VVPVGGGGCIAGITSYLAERTTKTAVLGIEPAGAAAMMAALAAGEPVTLD
MUL_1550|M.ulcerans_Agy99 VVPVGGGGCIAGITSYLAERTTKTAVLGIEPAGAAAMMAALAAGEPVTLD
MLBr_01209|M.leprae_Br4923 VVPVGGGGCIAGMTTYLAERTANTAVLGVEPAGAAAMMAALAAGEPVTLD
MAV_3217|M.avium_104 VVPVGGGGCIAGITTYLAERTDTTAVLGVEPAGAAAMMAALAAGEPVTLD
MSMEG_3183|M.smegmatis_MC2_155 IVPVGGGGCIAGITTYLAARTDNTSVLGVEPAGAASMIAALAAGEPVTLA
TH_1800|M.thermoresistible__bu IVPVGGGGCIAGITTYLAERTRNTAVLGVEPAGAASMMAALAAGEPVTLD
MAB_2691c|M.abscessus_ATCC_199 VVPVGGGGCISGIVTYLRERAPEVRVVGVEPAGAACMAAALRAGGPVPLD
:*********:*:.:** *: . *:*:**.***.: *** * **.*
Mvan_2783|M.vanbaalenii_PYR-1 TVDQFVDGAAVARVGALPFAALSAAGDMVSITTVDEGAVCTAMLDLYQNE
Mflv_3634|M.gilvum_PYR-GCK HVDQFVDGAAVARAGAKPFEALRAAGDMVSMTTVDEGAVCTAMLGLYQNE
Mb1585|M.bovis_AF2122/97 HVDQFVDGAAVNRAGTLTYAALAAAGDMVSLTTVDEGAVCTAMLDLYQNE
Rv1559|M.tuberculosis_H37Rv HVDQFVDGAAVNRAGTLTYAALAAAGDMVSLTTVDEGAVCTAMLDLYQNE
MMAR_2374|M.marinum_M HVDQFVDGAAVNRAGTLPYAALSAAGDMVSITTVDEGAVCTAMLDLYQHE
MUL_1550|M.ulcerans_Agy99 HVDQFVDGAAVNRAGALPYAALSAAGDMVSITTVDEGAVCTAMLDLYQHE
MLBr_01209|M.leprae_Br4923 YVDQFVDGAAVNRVGTLPYAALTAAGDMVSITTVDEGAVCTAMLDLYQNE
MAV_3217|M.avium_104 HVDQFVDGAAVRRAGDLTYAALAAAGDMVSITTVDEGAVCTAMLDLYQNE
MSMEG_3183|M.smegmatis_MC2_155 DVDQFVDGAAVARAGQKPFEALAAAGDMVSLTTVDEGAVCTAMLDLYQNE
TH_1800|M.thermoresistible__bu HVDQFVDGAAVNRAGTYTHAALAAAGDMVSITTVDEGAVCTAMLDLYQNE
MAB_2691c|M.abscessus_ATCC_199 HVDPFVDGCAVQVAGAAPYRVLAAAGEMLTLTTVDEGAACTAMLELYQNE
** ****.** .* .. .* ***:*:::*******.***** ***:*
Mvan_2783|M.vanbaalenii_PYR-1 GIIAEPAGALSVAALLDSDIEPGSTVVCLISGGNNDVSRYGEVLERSLVH
Mflv_3634|M.gilvum_PYR-GCK GIIAEPAGALSVAALLDADIEPGSTVVCLISGGNNDVSRYGEVLERSLVH
Mb1585|M.bovis_AF2122/97 GIIAEPAGALSVAGLLEADIEPGSTVVCLISGGNNDVSRYGEVLERSLVH
Rv1559|M.tuberculosis_H37Rv GIIAEPAGALSVAGLLEADIEPGSTVVCLISGGNNDVSRYGEVLERSLVH
MMAR_2374|M.marinum_M GIIAEPAGALSVAGLLEADIEPGSTVVCLISGGNNDVSRYGEILERSLVH
MUL_1550|M.ulcerans_Agy99 GIIAEPAGALSVAGLLEADIEPGSTVVCLISGGNNDVSRYGEILERSLVH
MLBr_01209|M.leprae_Br4923 GIIAEPAGALSVAGLLETDIEPGSTVVCLISGGNNDVLRYGEVLERSLIH
MAV_3217|M.avium_104 GIIAEPAGALSVTGLLEADIEPGSTVVCLISGGNNDVSRYGEVLERSLVH
MSMEG_3183|M.smegmatis_MC2_155 GIIAEPAGALSVAALLEADIEPGSTVVCLISGGNNDVSRYNEVLERSLVH
TH_1800|M.thermoresistible__bu GIIAEPAGALAVTGLSEAEIEPGSTVVCLISGGNNDVSRYNEVLERSLVH
MAB_2691c|M.abscessus_ATCC_199 GIIAEPAGALSVAALAEMAIEPGATVVCLISGGNNDVSRYGEILERSLVH
**********:*:.* : ****:************* **.*:*****:*
Mvan_2783|M.vanbaalenii_PYR-1 LGLKHYFLVDFPQEPGALRRFLDEVLGPNDDITLFEYVKRNNRETGEALV
Mflv_3634|M.gilvum_PYR-GCK LGLKHYFLVDFPQEPGALRRFLDEVLGPNDDITLFEYVKRNNRETGEALV
Mb1585|M.bovis_AF2122/97 LGLKHYFLVDFPQEPGALRRFLDDVLGPNDDITLFEYVKRNNRETGEALV
Rv1559|M.tuberculosis_H37Rv LGLKHYFLVDFPQEPGALRRFLDDVLGPNDDITLFEYVKRNNRETGEALV
MMAR_2374|M.marinum_M LGLKHYFLVDFPQEPGALRRFLDEVLGPNDDITLFEYVKRNNRETGEALV
MUL_1550|M.ulcerans_Agy99 LGLKHYFLVDFPQEPGALRRFLDEVLGPNDDITLFEYVKRNNRETGEALV
MLBr_01209|M.leprae_Br4923 LGLKHYFLVDFPQKPGALRRFLDEVLGPNDDITLFEYVKRNNRETGEALV
MAV_3217|M.avium_104 LGLKHYFLVDFPQEPGALRRFLDEVLGPNDDITLFEYVKRNNRETGEALV
MSMEG_3183|M.smegmatis_MC2_155 LGLKHYFLVDFPQEPGALRRFLDEVLGPGDDITLFEYVKRNNRETGEALV
TH_1800|M.thermoresistible__bu LGLKHYFLVDFPQEPGSLRRFLDEVLGEGDDITLFEYVKRNNRETGEALV
MAB_2691c|M.abscessus_ATCC_199 LGLKHYFLVDFPQEPGALRRFLGEVLGPNDDITLFEYVKRNNREMGAALV
*************:**:*****.:*** .*************** * ***
Mvan_2783|M.vanbaalenii_PYR-1 GIEMGSASDLEGLLARMQTSECHVELLEPGSPTYRYLT-
Mflv_3634|M.gilvum_PYR-GCK GIEMANASDLDGLLARMQSSECHIELLEPGSPTYRYLT-
Mb1585|M.bovis_AF2122/97 GIELGSAADLDGLLARMRATDIHVEALEPGSPAYRYLL-
Rv1559|M.tuberculosis_H37Rv GIELGSAADLDGLLARMRATDIHVEALEPGSPAYRYLL-
MMAR_2374|M.marinum_M GVELGSAANLDGLLARMHETEVHVEPLAPGSPAYRYLL-
MUL_1550|M.ulcerans_Agy99 GVELGSAANLDGLLARMRETEVHVEPLAPGSPAYRYLL-
MLBr_01209|M.leprae_Br4923 GIQLGSAVDLDVLLARMQGTEMHVETLQPGSPAYRYLLL
MAV_3217|M.avium_104 GIQLGSSADLDGLLARMRATELHVETLKPGSPAYRYLLL
MSMEG_3183|M.smegmatis_MC2_155 GVELSSAADLEGLLARMGQSDIHVELLEPGSPTYRYLT-
TH_1800|M.thermoresistible__bu GIELSSAADLDGLLARMEASDIHVERLEPGSPAYRYLT-
MAB_2691c|M.abscessus_ATCC_199 GIELSYADDLSGLLDRMRFSGLDIERLEPDSPAFRYLT-
*:::. : :*. ** ** : .:* * *.**::***