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TDPQNITVDLLVVGSGTGMAAALAARELGLSTLIVEKTSYVGGSTARSGGAFWMPGNPILTEAGSADSLD KGRTYLDALVGSDAPLERAHAFLENGPATIAMLRRTTPMKFQWAKGYSDYHPEQPGGSAVGRTCECRPFD TAVLGSELSRLRPGVMKSSFPMPVTGADYRWLNLMARAPRKSWPRIMLRAAQGIGGLALRRRYAAGGQAL AAGLFAGVLDAGIPVWTDSPVTTLVTDGARVTGAVVDRNGTEVTVTARRGVVLAAGGFDRLMSWRHKFQS ELLGDHHSLGAEGNTGDGIRMAQDLGAGTGLMDQAWWFPAFAPLPGGDPTVMLAERSLPGCLLVDQKGER FINEATDYMSFGQQLLQREQAGDPVEVMWMIFDQRYRNSYLLAAELFPRMPIPQAWFDAGIAYRSTDLPG LARQIGLETATFVATMDRFNDLADAGVDSDFHRGASAYDRYYGDPTHAPNPNLRPVDSGPFYAVKVVLSD LGTCGGLRADARGRVLREDGSAVDGLYAIGNTAANTFGKTYPGAGATIGQGLVFGYIVAQHAAGRLD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2868 | - | - | 100% (558) | 3-ketosteroid-delta-1-dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5237 | - | e-121 | 42.93% (552) | 3-ketosteroid-delta-1-dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4243 | - | e-111 | 40.91% (572) | 3-ketosteroid-delta-1-dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3567 | - | 1e-121 | 43.35% (556) | 3-ketosteroid-delta-1-dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4567 | - | 0.0 | 70.75% (547) | 3-ketosteroid-delta-1-dehydrogenase |
| M. tuberculosis H37Rv | Rv3537 | - | 1e-121 | 43.35% (556) | 3-ketosteroid-delta-1-dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0081 | - | 0.0 | 66.85% (552) | 3-ketosteroid-delta-1-dehydrogenase |
| M. marinum M | MMAR_5024 | - | 1e-123 | 42.96% (561) | dehydrogenase |
| M. avium 104 | MAV_3039 | - | 0.0 | 67.77% (546) | 3-ketosteroid-delta-1-dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2869 | - | 0.0 | 81.36% (558) | 3-ketosteroid-delta-1-dehydrogenase |
| M. thermoresistible (build 8) | TH_2946 | - | 0.0 | 76.62% (556) | PUTATIVE 3-ketosteroid-delta-1-dehydrogenase |
| M. ulcerans Agy99 | MUL_4098 | - | 1e-122 | 43.14% (561) | 3-ketosteroid-delta-1-dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2868|M.vanbaalenii_PYR-1 ------------MTDPQNITVDLLVVGSG-TGMAAALAARELGLSTLIVE
MSMEG_2869|M.smegmatis_MC2_155 ------------MTDPQNLTVDLLVVGSG-TGMAAALAAHELGLSAMIVE
TH_2946|M.thermoresistible__bu MTARRGGGQNRAVTVAQNIEVDLLVVGSG-TGMAAALAAHELGLTTLIVE
Mflv_4567|M.gilvum_PYR-GCK --MTAASATIPAGLPVSDTTVDLLVVGSG-TGMSAALAAHEAGLSVLIVE
MAV_3039|M.avium_104 --MTTHSATIPAGLPVADTAVDLLVVGSG-TGMAAALAAHELGLSVLIVE
MAB_0081|M.abscessus_ATCC_1997 -MASAPPGLIPAGTVAGDIEIDLLIVGAG-TGMAAALAASELGLSVLIVE
Mb3567|M.bovis_AF2122/97 ---------------MTVQEFDVVVVGSGAAGMVAALVAAHRGLSTVVVE
Rv3537|M.tuberculosis_H37Rv ---------------MTVQEFDVVVVGSGAAGMVAALVAAHRGLSTVVVE
MMAR_5024|M.marinum_M ------------MFYMTSQDYDVVVVGSGGAGMVAALAAAHKGLSTVVIE
MUL_4098|M.ulcerans_Agy99 ---------------MTSQDYDVVVVGSGGAGMVAALAAAHKGLSTVVIE
*:::**:* :** ***.* . **:.:::*
Mvan_2868|M.vanbaalenii_PYR-1 KTSYVGGSTARSGGAFWMPGNPILTEAGSADSLDKGRTYLDALVGS----
MSMEG_2869|M.smegmatis_MC2_155 KTALVGGSTARSGGAFWMPANPILSEEGSDDTLDAGRTYLETLVAD----
TH_2946|M.thermoresistible__bu KTAQVGGSTARSGGAFWMPANPVLTEAGAADTLDAARSYLEAVVED----
Mflv_4567|M.gilvum_PYR-GCK KSEYVGGSTARSGGALWLPASPVLGAAGAGDSVERARTYLDAVVDG----
MAV_3039|M.avium_104 KSSYVGGSTARSGGALWLPASPVLDEANAGDTAERAGTYLDSVVAG----
MAB_0081|M.abscessus_ATCC_1997 KSHQVGGSTARSGGALWLPASPVLRAAGTGDSVERARTYLRSVVAG----
Mb3567|M.bovis_AF2122/97 KAPHYGGSTARSGGGVWIPNNEVLKRRGVRDTPEAARTYLHGIVG----E
Rv3537|M.tuberculosis_H37Rv KAPHYGGSTARSGGGVWIPNNEVLKRRGVRDTPEAARTYLHGIVG----E
MMAR_5024|M.marinum_M KAAHYGGSTARSGGGVWIPNNQILKRARVSDTTEAARTYLHGIIGDSSVS
MUL_4098|M.ulcerans_Agy99 KAAHYGGSTARSGGGVWIPNNQILKRARVSDTTEAARTYLHGIIGDSSVS
*: *********..*:* . :* *: : . :** ::
Mvan_2868|M.vanbaalenii_PYR-1 DAPLERAHAFLENGPATIAMLRRTTPMKFQWAKGYSDYHPEQPGGSAVGR
MSMEG_2869|M.smegmatis_MC2_155 AAPADRAGAFLDHGSATVEMLRRTTPMKFQWAKGYSDYHPERPGGSAVGR
TH_2946|M.thermoresistible__bu SAPADRWQAFLDHGAETVRMLRRTTPMRFQWAKGYSDYHPERPGGAVLGR
Mflv_4567|M.gilvum_PYR-GCK AAPSERSAGFLAHLTGTLDMLRRTTPMKLFWAREYSDYHPEQPGGSAAGR
MAV_3039|M.avium_104 SAPPQRSAAFVAQVSATVEMLRRTTPLRLFWARDYSDYHPEEPGGSAAGR
MAB_0081|M.abscessus_ATCC_1997 SAPDARSDAFLEHEAATVDMLTRLTPMRFTWCRDYADYHPEEPGGSPTGR
Mb3567|M.bovis_AF2122/97 IVEPERIDAYLDRGPEMLSFVLKHTPLKMCWVPGYSDYYPEAPGGRPGGR
Rv3537|M.tuberculosis_H37Rv IVEPERIDAYLDRGPEMLSFVLKHTPLKMCWVPGYSDYYPEAPGGRPGGR
MMAR_5024|M.marinum_M GVEPERIDTYLERGPEMLSFVLEHTPLKMCWVPGYSDYYPEAPGGRSGGR
MUL_4098|M.ulcerans_Agy99 GVEPERIDTYLERGPEMLSFVLEHTPLKMCWVPGYSDYYSEAPGGRSGGR
. * :: . . : :: . **::: * *:**:.* *** **
Mvan_2868|M.vanbaalenii_PYR-1 TCECRPFDTAVLGSELSRLRPGVMKS-SFPMPVTGADYRWLNLMARAPRK
MSMEG_2869|M.smegmatis_MC2_155 TCECRPFDTAVLGRELSRLRPGVMKS-SFPMPVTGADYRWLNLMARVPRK
TH_2946|M.thermoresistible__bu TCECRPFDARILGPELDRLRPGVMKS-SLPVPVTGADYRWLNLMTRMPLK
Mflv_4567|M.gilvum_PYR-GCK TCECRPLDTAVLGEYLPRLRPGVMEV-TIPMPTTGADYRWLNLMTRVPRK
MAV_3039|M.avium_104 TCECRPFDTSLLGEYRTRLEPGLMEV-TVPMPTTGADYRWMNLVARLPRK
MAB_0081|M.abscessus_ATCC_1997 TCECRPFDASVLGEYRTRLQPGVMKPPAVPMPVTSADYRWMNLMARLPRK
Mb3567|M.bovis_AF2122/97 SIEPKPFNARKLGADMAGLEPAYGKV-PLNVVVMQQDYVRLNQLKRHPR-
Rv3537|M.tuberculosis_H37Rv SIEPKPFNARKLGADMAGLEPAYGKV-PLNVVVMQQDYVRLNQLKRHPR-
MMAR_5024|M.marinum_M SIEPKPFDARKLGADMAELEPAYGKI-PLNVVVMQQDYVRLNQLKRHPR-
MUL_4098|M.ulcerans_Agy99 SIEPKPFDARKLGADMAELEPAYGKI-PLNVVVMQQDYVRLNQLKRHPR-
: * :*::: ** *.*. : .. : . ** :* : * *
Mvan_2868|M.vanbaalenii_PYR-1 SWPRIMLRAAQGIGGLALRRRYAAGGQALAAGLFAGVLDAGIPVWTDSPV
MSMEG_2869|M.smegmatis_MC2_155 AVPRIMLRAFQGIGGLALRRRYAAGGQALAAGLYAGVLRAGIPVWTQSPL
TH_2946|M.thermoresistible__bu AIPRIGLRVVQGVGGLALRRRYVAGGQALAAGLFAGVIRAGIPVWTHSPL
Mflv_4567|M.gilvum_PYR-GCK GLPTIAKRLGQGVGGLLLGRRYAAGGQALAAGLFAGVLRAGIPVWTDTAL
MAV_3039|M.avium_104 GIPVYAKRLVQGVGGRMLGRRYAAGGQGLMAGLFTGVLRAGIPIWTGTTL
MAB_0081|M.abscessus_ATCC_1997 ALPLIVKRIAQGVGGAVLGRRYLAGGQALAAGLFAGVLRAGIPIWTGTSL
Mb3567|M.bovis_AF2122/97 GVLRSMKVGARTMWAKATGKNLVGMGRALIGPLRIGLQRAGVPVELNTAF
Rv3537|M.tuberculosis_H37Rv GVLRSMKVGARTMWAKATGKNLVGMGRALIGPLRIGLQRAGVPVELNTAF
MMAR_5024|M.marinum_M GVLRSMKVGARTMWAKATGKNLVGMGRALIGPLRIGLQRKGVPVQLNTAL
MUL_4098|M.ulcerans_Agy99 GVLRSMKVGARTMWAKATGKNLVGMGRALIGPLRIGLQRKGVPVQLNTAL
. : : . :. . *:.* . * *: *:*: :..
Mvan_2868|M.vanbaalenii_PYR-1 TTLVTDGARVTGAVVDRNGTEVT-----VTARRGVVLAAGGFDRLMSWRH
MSMEG_2869|M.smegmatis_MC2_155 VRLLVDGDRVTGAVVNRNGIDVA-----ITARRGVVLATGGFDHQMDWRR
TH_2946|M.thermoresistible__bu TRLLFDGDDVVGAVIDRHGAEVT-----VRTRRGVILATGGFDHLLDWRR
Mflv_4567|M.gilvum_PYR-GCK VELTGDDARVTGAVVSHRGTEIT-----VTARRGVVLAAGGFDHNMDMRW
MAV_3039|M.avium_104 TRLTRRGERVSGAVVEHGGREVT-----ISARRGVVLATGGFDHRMEMRW
MAB_0081|M.abscessus_ATCC_1997 VRLTTAGGRVTGAVVALAGREFT-----VTVSRGVVLAAGGFDHDMEMRH
Mb3567|M.bovis_AF2122/97 TDLFVENGVVSGVYVRDSHEAESAEPQLIRARRGVILACGGFEHNEQMRI
Rv3537|M.tuberculosis_H37Rv TDLFVENGVVSGVYVRDSHEAESAEPQLIRARRGVILACGGFEHNEQMRI
MMAR_5024|M.marinum_M TDLYLEDGMVRGIYVRSTDAQESEEPQLIRARKGVILACGGFDHNEQMRV
MUL_4098|M.ulcerans_Agy99 TDLYLEDGVVRGIYVRSTDAHESEEPQLIRARKGVILACGGFDHNEQMRV
. * . * * : : : . :**:** ***:: . *
Mvan_2868|M.vanbaalenii_PYR-1 KFQSELLGDHHSLGAEGNTGDGIRMAQDLGAGTGLMDQAWWFPAFAPLPG
MSMEG_2869|M.smegmatis_MC2_155 KFQSESMNEDLSLGSEGNTGDGIRIAQDLGADTGLMDQAWWFPAFAPLPG
TH_2946|M.thermoresistible__bu KFQLESLPGDLSLGAEGNTGDGIRIAQEVGAGTGLMDQAWWFPAFAPLPG
Mflv_4567|M.gilvum_PYR-GCK KFQSESLQPGVSLGADTNTGDAIRIAQDRGAAIGLMDQSWWFPAVAPLPG
MAV_3039|M.avium_104 KFQSESLGADLSLGAAGNTGDGIRAGQEIGAAIDLMDQAWWFPAVAPLPG
MAB_0081|M.abscessus_ATCC_1997 KFQSAALGENMSLGADTNTGDALRIGQDCGAAIDSMNQAWWFPAVAPLPG
Mb3567|M.bovis_AF2122/97 KYQRAPITTEWTVGASANTGDGILAAEKLGAALDLMDDAWWGPTVP-LVG
Rv3537|M.tuberculosis_H37Rv KYQRAPITTEWTVGASANTGDGILAAEKLGAALDLMDDAWWGPTVP-LVG
MMAR_5024|M.marinum_M KYQRAPITTDWTVGAKANTGDGIVAAEKLGAALDLMEDAWWGPTVP-LVG
MUL_4098|M.ulcerans_Agy99 KYQRAPITTDWTVGAKANTGDGIVAAEKLGAALDLMEDAWWGPTVP-LVG
*:* : ::*: ****.: .:. ** . *:::** *:.. * *
Mvan_2868|M.vanbaalenii_PYR-1 GDPTVMLAERSLPGCLLVDQKGERFINEATDYMSFGQQLLQREQAGDP--
MSMEG_2869|M.smegmatis_MC2_155 GEPTVMLAERSLPGCLLVDQTGNRFINEATDYMSFGQRVLDRERVGNP--
TH_2946|M.thermoresistible__bu GEPAVMLAERSLPGCLLVDQTGNRFINEATDYMSFGQQLLRRERSGHP--
Mflv_4567|M.gilvum_PYR-GCK KAPAVMLAERSLPGSLIVDQNGRRFANESSDYMSFGQRVLELERTGTP--
MAV_3039|M.avium_104 KAPAVMLAERSLPGCLIVDQHGRRFVNEATDYMSFGQRLLELERSGSP--
MAB_0081|M.abscessus_ATCC_1997 GAPKVMLAERSLPGSFIVDHTGNRFINEATDYMSFGQRVLERERSGDP--
Mb3567|M.bovis_AF2122/97 -KPWFALSERNSPGSIIVNMSGKRFMNESMPYVEACHHMYGGEHGQGPGP
Rv3537|M.tuberculosis_H37Rv -KPWFALSERNSPGSIIVNMSGKRFMNESMPYVEACHHMYGGEHGQGPGP
MMAR_5024|M.marinum_M -RPWFALSERNSPGSIIVNMSGQRFMNESMPYVEACHHMYGGQYGQGPGP
MUL_4098|M.ulcerans_Agy99 -RPWFALSERNSPGSIIVNMSGQRFMNESMPYVEACHHMYGGQYGQGPGP
* . *:**. **.::*: *.** **: *:. ::: : *
Mvan_2868|M.vanbaalenii_PYR-1 --VEVMWMIFDQRYRNSYLLAAELFPRMPIPQAWFDAGIAYRSTDLPGLA
MSMEG_2869|M.smegmatis_MC2_155 --VDVMWMIFDQRYRNSYLLATELFPRMPIPQTWYDAGIAHRSDDLGGLA
TH_2946|M.thermoresistible__bu --VEDMWMVFDQRYRDSYLLAAELFPRMPLPRSWYDAGIAHRSDDIPGLA
Mflv_4567|M.gilvum_PYR-GCK --VESMWIVFDQKYRNSYVFAAELFPRMAIPQSWYDAGIAHRADDFSELA
MAV_3039|M.avium_104 --VESMWIVFDQQYRNSYVFGAELFPRMRIPQAWYDAGIAVRADNLAELG
MAB_0081|M.abscessus_ATCC_1997 --AESMWIIFDQQYRNSYVFAGQLYPRMPVPVSWFEARIAYRADSLADLA
Mb3567|M.bovis_AF2122/97 GENIPAWLVFDQRYRDRYIFAG-LQPGQRIPSRWLDSGVIVQADTLAELA
Rv3537|M.tuberculosis_H37Rv GENIPAWLVFDQRYRDRYIFAG-LQPGQRIPSRWLDSGVIVQADTLAELA
MMAR_5024|M.marinum_M GENIPAWLVFDQRYRDRYIFAG-LQPGQRIPRKWLDSGVIVMADTLEELA
MUL_4098|M.ulcerans_Agy99 GENIPAWLVFDQRYRDRYIFAG-LQPGQRIPRKWLDSGVIVMADTLEELA
*::***:**: *::. * * :* * :: : : : *.
Mvan_2868|M.vanbaalenii_PYR-1 RQIGLETATFVATMDRFNDLADAGVDSDFHRGASAYDRYYGDPTHAPNPN
MSMEG_2869|M.smegmatis_MC2_155 RSIGVDVSVLTATLSRFNALARTGVDSDFGRGDSAYDRYYGDPTVTPNPN
TH_2946|M.thermoresistible__bu RAIGVDASTLDATVERFNRLARAGVDTDFGRGDSAYDRYYGDPTVAPNPN
Mflv_4567|M.gilvum_PYR-GCK GLMGVPPETFGDTMRRFNESAGAGIDSDFHRGESAYDRYYGDPTVTPSPN
MAV_3039|M.avium_104 AGIGVPVPEFVETMTRFNQNAAAGEDPDFGRGRSAYDRYYGDPTVKPNPN
MAB_0081|M.abscessus_ATCC_1997 AMIGIPRDAFLATVCRFNESAAAGDDGDFHRGRSSYDRYYGDPTVTPNPN
Mb3567|M.bovis_AF2122/97 GKAGLPADELTATVQRFNAFARSGVDEDYHRGESAYDRYYGDPSNKPNPN
Rv3537|M.tuberculosis_H37Rv GKAGLPADELTATVQRFNAFARSGVDEDYHRGESAYDRYYGDPSNKPNPN
MMAR_5024|M.marinum_M AKAGLPVDELTSTVSRFNGFARSGVDEDYHRGESAYDRYYGDPTNKPNPN
MUL_4098|M.ulcerans_Agy99 AKAGLPVDELTSTVSRFNGFARSGVDEDYHRGESAYDRYYGDPTNKPNPN
*: : *: *** * :* * *: ** *:********: *.**
Mvan_2868|M.vanbaalenii_PYR-1 LRPVDSGPFYAVKVVLSDLGTCGGLRADARGRVLREDGSAVDGLYAIGNT
MSMEG_2869|M.smegmatis_MC2_155 LRPLDDGPLYAVKVVLSDLGTCGGVRADARGRALREDGSVIEGLYAIGNT
TH_2946|M.thermoresistible__bu LRPLDHGPFYAVRVVLSDLGTCGGVRADHHARVLREDGSVIGGLYAIGNT
Mflv_4567|M.gilvum_PYR-GCK LRPLAKGPFYAVKMVLSDLGTCGGLRADERARVLREDGAAIEGLYAIGNC
MAV_3039|M.avium_104 LRPLVNGPFYAVRMVLSDLGTCGGLKTDERARVLREDGGPIAGLYAIGNT
MAB_0081|M.abscessus_ATCC_1997 LRPLRRGPFYAVRMVLSDLGTCGGLRADERARVLREDGSVIKGLYAIGNT
Mb3567|M.bovis_AF2122/97 LGEVGHPPYYGAKMVPGDLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNV
Rv3537|M.tuberculosis_H37Rv LGEVGHPPYYGAKMVPGDLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNV
MMAR_5024|M.marinum_M LGEINHAPYYAAKMVPGDLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNV
MUL_4098|M.ulcerans_Agy99 LGEINHAPYYAAKMVPGDLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNV
* : * *..::* .**** **:::* ..*.**:**. : **** **
Mvan_2868|M.vanbaalenii_PYR-1 AANTFGKTYPGAGATIGQGLVFGYIVAQHAAGRLD-------------
MSMEG_2869|M.smegmatis_MC2_155 AANTFGASYPGAGATIGQGLVFGYIAARHAAGRLD-------------
TH_2946|M.thermoresistible__bu AANVFGACYPGAGATIGQGLVFGYIAARHAATRAG-------------
Mflv_4567|M.gilvum_PYR-GCK AANAFGATYPGAGATIAQGLVYGYVAALDAARG---------------
MAV_3039|M.avium_104 AANAFGTTYPGAGATIAQGLVYGYIAAQEAARPSAAQEAARPSASQPD
MAB_0081|M.abscessus_ATCC_1997 AANAFGATYPGAGATIAQGLVYGYIAAHDAAAR---------------
Mb3567|M.bovis_AF2122/97 SAPVMGHTYPGPGGTIGPAMTFGYLAALHIADQAGKR-----------
Rv3537|M.tuberculosis_H37Rv SAPVMGHTYPGPGGTIGPAMTFGYLAALHIADQAGKR-----------
MMAR_5024|M.marinum_M SAPVMGHTYPGPGGTIGPAMTFGYLAALHIAGDR--------------
MUL_4098|M.ulcerans_Agy99 SAPVMGHTYPGPGGTIGPAMTFGYLAALHIAGDR--------------
:* .:* ***.*.**. .:.:**:.* . *