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MASAPPGLIPAGTVAGDIEIDLLIVGAGTGMAAALAASELGLSVLIVEKSHQVGGSTARSGGALWLPASP VLRAAGTGDSVERARTYLRSVVAGSAPDARSDAFLEHEAATVDMLTRLTPMRFTWCRDYADYHPEEPGGS PTGRTCECRPFDASVLGEYRTRLQPGVMKPPAVPMPVTSADYRWMNLMARLPRKALPLIVKRIAQGVGGA VLGRRYLAGGQALAAGLFAGVLRAGIPIWTGTSLVRLTTAGGRVTGAVVALAGREFTVTVSRGVVLAAGG FDHDMEMRHKFQSAALGENMSLGADTNTGDALRIGQDCGAAIDSMNQAWWFPAVAPLPGGAPKVMLAERS LPGSFIVDHTGNRFINEATDYMSFGQRVLERERSGDPAESMWIIFDQQYRNSYVFAGQLYPRMPVPVSWF EARIAYRADSLADLAAMIGIPRDAFLATVCRFNESAAAGDDGDFHRGRSSYDRYYGDPTVTPNPNLRPLR RGPFYAVRMVLSDLGTCGGLRADERARVLREDGSVIKGLYAIGNTAANAFGATYPGAGATIAQGLVYGYI AAHDAAAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0081 | - | - | 100% (568) | 3-ketosteroid-delta-1-dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0622c | - | e-117 | 41.31% (564) | 3-ketosteroid-delta-1-dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2389 | - | 2e-28 | 25.44% (566) | hypothetical protein MAB_2389 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3567 | - | 1e-119 | 42.06% (554) | 3-ketosteroid-delta-1-dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4567 | - | 0.0 | 72.52% (564) | 3-ketosteroid-delta-1-dehydrogenase |
| M. tuberculosis H37Rv | Rv3537 | - | 1e-119 | 42.06% (554) | 3-ketosteroid-delta-1-dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_5024 | - | 1e-117 | 41.22% (558) | dehydrogenase |
| M. avium 104 | MAV_3039 | - | 0.0 | 73.66% (558) | 3-ketosteroid-delta-1-dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2869 | - | 0.0 | 66.49% (552) | 3-ketosteroid-delta-1-dehydrogenase |
| M. thermoresistible (build 8) | TH_2946 | - | 0.0 | 66.67% (558) | PUTATIVE 3-ketosteroid-delta-1-dehydrogenase |
| M. ulcerans Agy99 | MUL_4098 | - | 1e-116 | 41.04% (558) | 3-ketosteroid-delta-1-dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2868 | - | 0.0 | 66.85% (552) | 3-ketosteroid-delta-1-dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4567|M.gilvum_PYR-GCK --MTAASATIPAGLPVSDTTVDLLVVGSG-TGMSAALAAHEAGLSVLIVE
MAV_3039|M.avium_104 --MTTHSATIPAGLPVADTAVDLLVVGSG-TGMAAALAAHELGLSVLIVE
MAB_0081|M.abscessus_ATCC_1997 -MASAPPGLIPAGTVAGDIEIDLLIVGAG-TGMAAALAASELGLSVLIVE
MSMEG_2869|M.smegmatis_MC2_155 ------------MTDPQNLTVDLLVVGSG-TGMAAALAAHELGLSAMIVE
Mvan_2868|M.vanbaalenii_PYR-1 ------------MTDPQNITVDLLVVGSG-TGMAAALAARELGLSTLIVE
TH_2946|M.thermoresistible__bu MTARRGGGQNRAVTVAQNIEVDLLVVGSG-TGMAAALAAHELGLTTLIVE
Mb3567|M.bovis_AF2122/97 ---------------MTVQEFDVVVVGSGAAGMVAALVAAHRGLSTVVVE
Rv3537|M.tuberculosis_H37Rv ---------------MTVQEFDVVVVGSGAAGMVAALVAAHRGLSTVVVE
MMAR_5024|M.marinum_M ------------MFYMTSQDYDVVVVGSGGAGMVAALAAAHKGLSTVVIE
MUL_4098|M.ulcerans_Agy99 ---------------MTSQDYDVVVVGSGGAGMVAALAAAHKGLSTVVIE
*:::**:* :** ***.* . **:.:::*
Mflv_4567|M.gilvum_PYR-GCK KSEYVGGSTARSGGALWLPASPVLGAAGAGDSVERARTYLDAVVDG----
MAV_3039|M.avium_104 KSSYVGGSTARSGGALWLPASPVLDEANAGDTAERAGTYLDSVVAG----
MAB_0081|M.abscessus_ATCC_1997 KSHQVGGSTARSGGALWLPASPVLRAAGTGDSVERARTYLRSVVAG----
MSMEG_2869|M.smegmatis_MC2_155 KTALVGGSTARSGGAFWMPANPILSEEGSDDTLDAGRTYLETLVAD----
Mvan_2868|M.vanbaalenii_PYR-1 KTSYVGGSTARSGGAFWMPGNPILTEAGSADSLDKGRTYLDALVGS----
TH_2946|M.thermoresistible__bu KTAQVGGSTARSGGAFWMPANPVLTEAGAADTLDAARSYLEAVVED----
Mb3567|M.bovis_AF2122/97 KAPHYGGSTARSGGGVWIPNNEVLKRRGVRDTPEAARTYLHGIVG----E
Rv3537|M.tuberculosis_H37Rv KAPHYGGSTARSGGGVWIPNNEVLKRRGVRDTPEAARTYLHGIVG----E
MMAR_5024|M.marinum_M KAAHYGGSTARSGGGVWIPNNQILKRARVSDTTEAARTYLHGIIGDSSVS
MUL_4098|M.ulcerans_Agy99 KAAHYGGSTARSGGGVWIPNNQILKRARVSDTTEAARTYLHGIIGDSSVS
*: *********..*:* . :* *: : . :** ::
Mflv_4567|M.gilvum_PYR-GCK AAPSERSAGFLAHLTGTLDMLRRTTPMKLFWAREYSDYHPEQPGGSAAGR
MAV_3039|M.avium_104 SAPPQRSAAFVAQVSATVEMLRRTTPLRLFWARDYSDYHPEEPGGSAAGR
MAB_0081|M.abscessus_ATCC_1997 SAPDARSDAFLEHEAATVDMLTRLTPMRFTWCRDYADYHPEEPGGSPTGR
MSMEG_2869|M.smegmatis_MC2_155 AAPADRAGAFLDHGSATVEMLRRTTPMKFQWAKGYSDYHPERPGGSAVGR
Mvan_2868|M.vanbaalenii_PYR-1 DAPLERAHAFLENGPATIAMLRRTTPMKFQWAKGYSDYHPEQPGGSAVGR
TH_2946|M.thermoresistible__bu SAPADRWQAFLDHGAETVRMLRRTTPMRFQWAKGYSDYHPERPGGAVLGR
Mb3567|M.bovis_AF2122/97 IVEPERIDAYLDRGPEMLSFVLKHTPLKMCWVPGYSDYYPEAPGGRPGGR
Rv3537|M.tuberculosis_H37Rv IVEPERIDAYLDRGPEMLSFVLKHTPLKMCWVPGYSDYYPEAPGGRPGGR
MMAR_5024|M.marinum_M GVEPERIDTYLERGPEMLSFVLEHTPLKMCWVPGYSDYYPEAPGGRSGGR
MUL_4098|M.ulcerans_Agy99 GVEPERIDTYLERGPEMLSFVLEHTPLKMCWVPGYSDYYSEAPGGRSGGR
. * :: . . : :: . **::: * *:**:.* *** **
Mflv_4567|M.gilvum_PYR-GCK TCECRPLDTAVLGEYLPRLRPGVMEV-TIPMPTTGADYRWLNLMTRVPRK
MAV_3039|M.avium_104 TCECRPFDTSLLGEYRTRLEPGLMEV-TVPMPTTGADYRWMNLVARLPRK
MAB_0081|M.abscessus_ATCC_1997 TCECRPFDASVLGEYRTRLQPGVMKPPAVPMPVTSADYRWMNLMARLPRK
MSMEG_2869|M.smegmatis_MC2_155 TCECRPFDTAVLGRELSRLRPGVMKS-SFPMPVTGADYRWLNLMARVPRK
Mvan_2868|M.vanbaalenii_PYR-1 TCECRPFDTAVLGSELSRLRPGVMKS-SFPMPVTGADYRWLNLMARAPRK
TH_2946|M.thermoresistible__bu TCECRPFDARILGPELDRLRPGVMKS-SLPVPVTGADYRWLNLMTRMPLK
Mb3567|M.bovis_AF2122/97 SIEPKPFNARKLGADMAGLEPAYGKV-PLNVVVMQQDYVRLNQLKRHPR-
Rv3537|M.tuberculosis_H37Rv SIEPKPFNARKLGADMAGLEPAYGKV-PLNVVVMQQDYVRLNQLKRHPR-
MMAR_5024|M.marinum_M SIEPKPFDARKLGADMAELEPAYGKI-PLNVVVMQQDYVRLNQLKRHPR-
MUL_4098|M.ulcerans_Agy99 SIEPKPFDARKLGADMAELEPAYGKI-PLNVVVMQQDYVRLNQLKRHPR-
: * :*::: ** *.*. : .. : . ** :* : * *
Mflv_4567|M.gilvum_PYR-GCK GLPTIAKRLGQGVGGLLLGRRYAAGGQALAAGLFAGVLRAGIPVWTDTAL
MAV_3039|M.avium_104 GIPVYAKRLVQGVGGRMLGRRYAAGGQGLMAGLFTGVLRAGIPIWTGTTL
MAB_0081|M.abscessus_ATCC_1997 ALPLIVKRIAQGVGGAVLGRRYLAGGQALAAGLFAGVLRAGIPIWTGTSL
MSMEG_2869|M.smegmatis_MC2_155 AVPRIMLRAFQGIGGLALRRRYAAGGQALAAGLYAGVLRAGIPVWTQSPL
Mvan_2868|M.vanbaalenii_PYR-1 SWPRIMLRAAQGIGGLALRRRYAAGGQALAAGLFAGVLDAGIPVWTDSPV
TH_2946|M.thermoresistible__bu AIPRIGLRVVQGVGGLALRRRYVAGGQALAAGLFAGVIRAGIPVWTHSPL
Mb3567|M.bovis_AF2122/97 GVLRSMKVGARTMWAKATGKNLVGMGRALIGPLRIGLQRAGVPVELNTAF
Rv3537|M.tuberculosis_H37Rv GVLRSMKVGARTMWAKATGKNLVGMGRALIGPLRIGLQRAGVPVELNTAF
MMAR_5024|M.marinum_M GVLRSMKVGARTMWAKATGKNLVGMGRALIGPLRIGLQRKGVPVQLNTAL
MUL_4098|M.ulcerans_Agy99 GVLRSMKVGARTMWAKATGKNLVGMGRALIGPLRIGLQRKGVPVQLNTAL
. : : . :. . *:.* . * *: *:*: :..
Mflv_4567|M.gilvum_PYR-GCK VELTGDDARVTGAVVSHRGTEIT-----VTARRGVVLAAGGFDHNMDMRW
MAV_3039|M.avium_104 TRLTRRGERVSGAVVEHGGREVT-----ISARRGVVLATGGFDHRMEMRW
MAB_0081|M.abscessus_ATCC_1997 VRLTTAGGRVTGAVVALAGREFT-----VTVSRGVVLAAGGFDHDMEMRH
MSMEG_2869|M.smegmatis_MC2_155 VRLLVDGDRVTGAVVNRNGIDVA-----ITARRGVVLATGGFDHQMDWRR
Mvan_2868|M.vanbaalenii_PYR-1 TTLVTDGARVTGAVVDRNGTEVT-----VTARRGVVLAAGGFDRLMSWRH
TH_2946|M.thermoresistible__bu TRLLFDGDDVVGAVIDRHGAEVT-----VRTRRGVILATGGFDHLLDWRR
Mb3567|M.bovis_AF2122/97 TDLFVENGVVSGVYVRDSHEAESAEPQLIRARRGVILACGGFEHNEQMRI
Rv3537|M.tuberculosis_H37Rv TDLFVENGVVSGVYVRDSHEAESAEPQLIRARRGVILACGGFEHNEQMRI
MMAR_5024|M.marinum_M TDLYLEDGMVRGIYVRSTDAQESEEPQLIRARKGVILACGGFDHNEQMRV
MUL_4098|M.ulcerans_Agy99 TDLYLEDGVVRGIYVRSTDAHESEEPQLIRARKGVILACGGFDHNEQMRV
. * . * * : : : . :**:** ***:: . *
Mflv_4567|M.gilvum_PYR-GCK KFQSESLQPGVSLGADTNTGDAIRIAQDRGAAIGLMDQSWWFPAVAPLPG
MAV_3039|M.avium_104 KFQSESLGADLSLGAAGNTGDGIRAGQEIGAAIDLMDQAWWFPAVAPLPG
MAB_0081|M.abscessus_ATCC_1997 KFQSAALGENMSLGADTNTGDALRIGQDCGAAIDSMNQAWWFPAVAPLPG
MSMEG_2869|M.smegmatis_MC2_155 KFQSESMNEDLSLGSEGNTGDGIRIAQDLGADTGLMDQAWWFPAFAPLPG
Mvan_2868|M.vanbaalenii_PYR-1 KFQSELLGDHHSLGAEGNTGDGIRMAQDLGAGTGLMDQAWWFPAFAPLPG
TH_2946|M.thermoresistible__bu KFQLESLPGDLSLGAEGNTGDGIRIAQEVGAGTGLMDQAWWFPAFAPLPG
Mb3567|M.bovis_AF2122/97 KYQRAPITTEWTVGASANTGDGILAAEKLGAALDLMDDAWWGPTVP-LVG
Rv3537|M.tuberculosis_H37Rv KYQRAPITTEWTVGASANTGDGILAAEKLGAALDLMDDAWWGPTVP-LVG
MMAR_5024|M.marinum_M KYQRAPITTDWTVGAKANTGDGIVAAEKLGAALDLMEDAWWGPTVP-LVG
MUL_4098|M.ulcerans_Agy99 KYQRAPITTDWTVGAKANTGDGIVAAEKLGAALDLMEDAWWGPTVP-LVG
*:* : ::*: ****.: .:. ** . *:::** *:.. * *
Mflv_4567|M.gilvum_PYR-GCK KAPAVMLAERSLPGSLIVDQNGRRFANESSDYMSFGQRVLELERTGTP--
MAV_3039|M.avium_104 KAPAVMLAERSLPGCLIVDQHGRRFVNEATDYMSFGQRLLELERSGSP--
MAB_0081|M.abscessus_ATCC_1997 GAPKVMLAERSLPGSFIVDHTGNRFINEATDYMSFGQRVLERERSGDP--
MSMEG_2869|M.smegmatis_MC2_155 GEPTVMLAERSLPGCLLVDQTGNRFINEATDYMSFGQRVLDRERVGNP--
Mvan_2868|M.vanbaalenii_PYR-1 GDPTVMLAERSLPGCLLVDQKGERFINEATDYMSFGQQLLQREQAGDP--
TH_2946|M.thermoresistible__bu GEPAVMLAERSLPGCLLVDQTGNRFINEATDYMSFGQQLLRRERSGHP--
Mb3567|M.bovis_AF2122/97 -KPWFALSERNSPGSIIVNMSGKRFMNESMPYVEACHHMYGGEHGQGPGP
Rv3537|M.tuberculosis_H37Rv -KPWFALSERNSPGSIIVNMSGKRFMNESMPYVEACHHMYGGEHGQGPGP
MMAR_5024|M.marinum_M -RPWFALSERNSPGSIIVNMSGQRFMNESMPYVEACHHMYGGQYGQGPGP
MUL_4098|M.ulcerans_Agy99 -RPWFALSERNSPGSIIVNMSGQRFMNESMPYVEACHHMYGGQYGQGPGP
* . *:**. **.::*: *.** **: *:. ::: : *
Mflv_4567|M.gilvum_PYR-GCK --VESMWIVFDQKYRNSYVFAAELFPRMAIPQSWYDAGIAHRADDFSELA
MAV_3039|M.avium_104 --VESMWIVFDQQYRNSYVFGAELFPRMRIPQAWYDAGIAVRADNLAELG
MAB_0081|M.abscessus_ATCC_1997 --AESMWIIFDQQYRNSYVFAGQLYPRMPVPVSWFEARIAYRADSLADLA
MSMEG_2869|M.smegmatis_MC2_155 --VDVMWMIFDQRYRNSYLLATELFPRMPIPQTWYDAGIAHRSDDLGGLA
Mvan_2868|M.vanbaalenii_PYR-1 --VEVMWMIFDQRYRNSYLLAAELFPRMPIPQAWFDAGIAYRSTDLPGLA
TH_2946|M.thermoresistible__bu --VEDMWMVFDQRYRDSYLLAAELFPRMPLPRSWYDAGIAHRSDDIPGLA
Mb3567|M.bovis_AF2122/97 GENIPAWLVFDQRYRDRYIFAG-LQPGQRIPSRWLDSGVIVQADTLAELA
Rv3537|M.tuberculosis_H37Rv GENIPAWLVFDQRYRDRYIFAG-LQPGQRIPSRWLDSGVIVQADTLAELA
MMAR_5024|M.marinum_M GENIPAWLVFDQRYRDRYIFAG-LQPGQRIPRKWLDSGVIVMADTLEELA
MUL_4098|M.ulcerans_Agy99 GENIPAWLVFDQRYRDRYIFAG-LQPGQRIPRKWLDSGVIVMADTLEELA
*::***:**: *::. * * :* * :: : : : *.
Mflv_4567|M.gilvum_PYR-GCK GLMGVPPETFGDTMRRFNESAGAGIDSDFHRGESAYDRYYGDPTVTPSPN
MAV_3039|M.avium_104 AGIGVPVPEFVETMTRFNQNAAAGEDPDFGRGRSAYDRYYGDPTVKPNPN
MAB_0081|M.abscessus_ATCC_1997 AMIGIPRDAFLATVCRFNESAAAGDDGDFHRGRSSYDRYYGDPTVTPNPN
MSMEG_2869|M.smegmatis_MC2_155 RSIGVDVSVLTATLSRFNALARTGVDSDFGRGDSAYDRYYGDPTVTPNPN
Mvan_2868|M.vanbaalenii_PYR-1 RQIGLETATFVATMDRFNDLADAGVDSDFHRGASAYDRYYGDPTHAPNPN
TH_2946|M.thermoresistible__bu RAIGVDASTLDATVERFNRLARAGVDTDFGRGDSAYDRYYGDPTVAPNPN
Mb3567|M.bovis_AF2122/97 GKAGLPADELTATVQRFNAFARSGVDEDYHRGESAYDRYYGDPSNKPNPN
Rv3537|M.tuberculosis_H37Rv GKAGLPADELTATVQRFNAFARSGVDEDYHRGESAYDRYYGDPSNKPNPN
MMAR_5024|M.marinum_M AKAGLPVDELTSTVSRFNGFARSGVDEDYHRGESAYDRYYGDPTNKPNPN
MUL_4098|M.ulcerans_Agy99 AKAGLPVDELTSTVSRFNGFARSGVDEDYHRGESAYDRYYGDPTNKPNPN
*: : *: *** * :* * *: ** *:********: *.**
Mflv_4567|M.gilvum_PYR-GCK LRPLAKGPFYAVKMVLSDLGTCGGLRADERARVLREDGAAIEGLYAIGNC
MAV_3039|M.avium_104 LRPLVNGPFYAVRMVLSDLGTCGGLKTDERARVLREDGGPIAGLYAIGNT
MAB_0081|M.abscessus_ATCC_1997 LRPLRRGPFYAVRMVLSDLGTCGGLRADERARVLREDGSVIKGLYAIGNT
MSMEG_2869|M.smegmatis_MC2_155 LRPLDDGPLYAVKVVLSDLGTCGGVRADARGRALREDGSVIEGLYAIGNT
Mvan_2868|M.vanbaalenii_PYR-1 LRPVDSGPFYAVKVVLSDLGTCGGLRADARGRVLREDGSAVDGLYAIGNT
TH_2946|M.thermoresistible__bu LRPLDHGPFYAVRVVLSDLGTCGGVRADHHARVLREDGSVIGGLYAIGNT
Mb3567|M.bovis_AF2122/97 LGEVGHPPYYGAKMVPGDLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNV
Rv3537|M.tuberculosis_H37Rv LGEVGHPPYYGAKMVPGDLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNV
MMAR_5024|M.marinum_M LGEINHAPYYAAKMVPGDLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNV
MUL_4098|M.ulcerans_Agy99 LGEINHAPYYAAKMVPGDLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNV
* : * *..::* .**** **:::* ..*.**:**. : **** **
Mflv_4567|M.gilvum_PYR-GCK AANAFGATYPGAGATIAQGLVYGYVAALDAARG---------------
MAV_3039|M.avium_104 AANAFGTTYPGAGATIAQGLVYGYIAAQEAARPSAAQEAARPSASQPD
MAB_0081|M.abscessus_ATCC_1997 AANAFGATYPGAGATIAQGLVYGYIAAHDAAAR---------------
MSMEG_2869|M.smegmatis_MC2_155 AANTFGASYPGAGATIGQGLVFGYIAARHAAGRLD-------------
Mvan_2868|M.vanbaalenii_PYR-1 AANTFGKTYPGAGATIGQGLVFGYIVAQHAAGRLD-------------
TH_2946|M.thermoresistible__bu AANVFGACYPGAGATIGQGLVFGYIAARHAATRAG-------------
Mb3567|M.bovis_AF2122/97 SAPVMGHTYPGPGGTIGPAMTFGYLAALHIADQAGKR-----------
Rv3537|M.tuberculosis_H37Rv SAPVMGHTYPGPGGTIGPAMTFGYLAALHIADQAGKR-----------
MMAR_5024|M.marinum_M SAPVMGHTYPGPGGTIGPAMTFGYLAALHIAGDR--------------
MUL_4098|M.ulcerans_Agy99 SAPVMGHTYPGPGGTIGPAMTFGYLAALHIAGDR--------------
:* .:* ***.*.**. .:.:**:.* . *