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MRRPHWSLARTWLLQPDLPGFPEATTGAADVVVLDLEDGLPTAEKAAGRAAVTEWLLDGHRAWVRISAAA TSDWAADLDALRPASGLDGVMLAKTESADELSDTAARLPAGVPLVGLIESALGMESALEIARRCSRIAFG LGDFRSDTGMSDDPTVLAYPRARLVIASRAAGLPAPIDGPTLRDRVRHLVRDTEVAKAAGMTGRLCLDAG HAKTINAVLSPSASEIDEARITLARLDAPTGPYDGSVGPTRARAAAVLDLAAKLGVT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2654 | - | - | 100% (267) | HpcH/HpaI aldolase |
| M. vanbaalenii PYR-1 | Mvan_2378 | - | 5e-53 | 45.83% (264) | HpcH/HpaI aldolase |
| M. vanbaalenii PYR-1 | Mvan_4087 | - | 8e-18 | 31.97% (269) | HpcH/HpaI aldolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3102c | - | 2e-51 | 45.08% (264) | hypothetical protein Mb3102c |
| M. gilvum PYR-GCK | Mflv_4009 | - | 2e-51 | 45.08% (264) | HpcH/HpaI aldolase |
| M. tuberculosis H37Rv | Rv3075c | - | 2e-51 | 45.08% (264) | hypothetical protein Rv3075c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4737 | - | 5e-48 | 43.40% (265) | putative citrate lyase/aldolase |
| M. marinum M | MMAR_1583 | citE_2 | 6e-51 | 43.94% (264) | citrate lyase beta subunit, CitE_2 |
| M. avium 104 | MAV_3981 | - | 3e-50 | 44.36% (266) | HpcH/HpaI aldolase/citrate lyase family protein, putative |
| M. smegmatis MC2 155 | MSMEG_2667 | - | 3e-51 | 43.94% (264) | HpcH/HpaI aldolase/citrate lyase family protein, putative |
| M. thermoresistible (build 8) | TH_0719 | - | 1e-17 | 30.86% (269) | HpcH/HpaI aldolase/citrate lyase family protein |
| M. ulcerans Agy99 | MUL_3451 | citE_2 | 2e-50 | 43.56% (264) | citrate lyase beta subunit, CitE_2 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4009|M.gilvum_PYR-GCK ------MYDQSFGEAAFGEQ-GQRIDPVLARSWLLVNGAHYERFQAAAHS
MSMEG_2667|M.smegmatis_MC2_155 ------MYDQPIHDPDPSASPGFRIDPVLARSWLLVNGAQYERFAPASRS
Mb3102c|M.bovis_AF2122/97 ---MTSMYEQVDTNTADPV-AGSRIDPVLARSWLLVNGAHGDRFESAAHS
Rv3075c|M.tuberculosis_H37Rv ---MTSMYEQVDTNTADPV-AGSRIDPVLARSWLLVNGAHGDRFESAAHS
MMAR_1583|M.marinum_M MAAEQAMYEQVNSYVVDPADVGSRIDPVLARSWLLVNGTHADRFQAASHS
MUL_3451|M.ulcerans_Agy99 MAAEQAMYEQVNSYVVDPADVGSRIDPVLARSWLLVNGTHADRFQAASHS
MAV_3981|M.avium_104 ------MYEQVNSSAAEPDDIGSRIDPVLARSWLLVNGTHPDRFQSAVDS
MAB_4737|M.abscessus_ATCC_1997 ------------------------MNSKVSRSWLLMNPSREASLEAAIAS
Mvan_2654|M.vanbaalenii_PYR-1 ---------------------MRRPHWSLARTWLLQP--DLPGFPEATTG
TH_0719|M.thermoresistible__bu -----------------------MDLSAVGPAWLFCPADRPERFEKAAAA
:. :**: : * .
Mflv_4009|M.gilvum_PYR-GCK R-ADIVVLDIEDAVAPKDKAAARANVVRWLGEGHADWVRVNGFGTEWWAG
MSMEG_2667|M.smegmatis_MC2_155 R-ADIVILDIEDAVAPKDKAAARDNVVRWLSEGNTDWVRVNGFGTPWWAD
Mb3102c|M.bovis_AF2122/97 R-ADIVVLDIEDAVAPKDKHAARDNAVRWFGDGNADWVRINGFGTPWWAD
Rv3075c|M.tuberculosis_H37Rv R-ADIVVLDIEDAVAPKDKHAARDNAVRWFGDGNADWVRINGFGTPWWAD
MMAR_1583|M.marinum_M R-ADIVVLDIEDAVAPKDKGSARDNVVHWLGDGNADWVRINGFGTPWWAD
MUL_3451|M.ulcerans_Agy99 R-ADIVVVDIEDAVAPKDKGSARDNVVHWLGDGNADWVRINGFGTPWWAD
MAV_3981|M.avium_104 R-ADIVVFDIEDAVAPKDKNAARDNVVSWLRAGNVDWVRINGFGTPWWAD
MAB_4737|M.abscessus_ATCC_1997 TNADEVILDLEDAVAPNEKEPARGRVLEYLNSGGNAWVRVNDASSDFWSA
Mvan_2654|M.vanbaalenii_PYR-1 A-ADVVVLDLEDGLPTAEKAAGRAAVTEWLLDGHRAWVRISAAATSDWAA
TH_0719|M.thermoresistible__bu A--DVVILDLEDGVAAKDRPAAREALLSTPLDPARTVVRVNPAGTADHRL
* *:.*:**.:.. :: ..* **:. .:
Mflv_4009|M.gilvum_PYR-GCK DLEMLAGTS-VGGVMLAMVESVDHVTETAKRLP-GVPIVALVETARGLER
MSMEG_2667|M.smegmatis_MC2_155 DLDTLKGTS-VGGIMLAMVESVDHVTETANRLP-DVPIVALVETARGLER
Mb3102c|M.bovis_AF2122/97 DLAMLADSP-VGGVMLAMVESVDHVTETAKRLP-NVPIVALVETARGLER
Rv3075c|M.tuberculosis_H37Rv DLAMLADSP-VGGVMLAMVESVDHVTETAKRLP-NVPIVALVETARGLER
MMAR_1583|M.marinum_M DIAILAGSS-VGGVMLAMVESVDHVTETARRLP-NVPIVALVETARGLER
MUL_3451|M.ulcerans_Agy99 DIAILAGSS-VGGVMLAMVESVDHVTETARRLP-NVPIVALVETARGLER
MAV_3981|M.avium_104 DLTALAGTP-VGGVMLAMVESVDHVTETAKRLP-DVPIVALVETARGLER
MAB_4737|M.abscessus_ATCC_1997 DCRALADARGLKGVVLAKTEGGNHMWDTSNRLGGETPVIALIETARGLSR
Mvan_2654|M.vanbaalenii_PYR-1 DLDALRPASGLDGVMLAKTESADELSDTAARLPAGVPLVGLIESALGMES
TH_0719|M.thermoresistible__bu DLDALTRTP-YRTVMLAKTDAAEQVRALA-----PLQVVVLIETPLGALN
* * : ::** .:. :.: : :: *:*:. *
Mflv_4009|M.gilvum_PYR-GCK ITEIAAAKGTFRLAFGIGDFRRDTGFGGDA-------LTLAYTRSRFTIA
MSMEG_2667|M.smegmatis_MC2_155 ITEIAATKGTFRLAFGIGDFRRDTGFGENP-------ATLAYARSRFTIA
Mb3102c|M.bovis_AF2122/97 INEIAAAKGTFRLAFGIGDFRRDTGFGEDP-------ATLAYARSRFTIA
Rv3075c|M.tuberculosis_H37Rv INEIAAAKGTFRLAFGIGDFRRDTGFGEDP-------ATLAYARSRFTIA
MMAR_1583|M.marinum_M ITEIASAKGTFRLAFGIGDFRRDTGFGEDA-------TTLAYARSRFTIA
MUL_3451|M.ulcerans_Agy99 ITEIASAKGTFRLAFGIGDFRRDTGFGKDA-------TTLAYARSRFTIA
MAV_3981|M.avium_104 ITEIAATKGTFRLAFGIGDFRRDTGFGEDP-------ATLAYTRSRFTIA
MAB_4737|M.abscessus_ATCC_1997 VHDIAAARPCFRIAFGVNDYTLDIGVDQDP-------LALAYSRSQLVVA
Mvan_2654|M.vanbaalenii_PYR-1 ALEIARR--CSRIAFGLGDFRSDTGMSDDP-------TVLAYPRARLVIA
TH_0719|M.thermoresistible__bu VVESARADNAVAVMWGAEDLFAVTGGTDNRNPDGSYRDVARHVRSQSLLA
: * : :* * * : . : *:: :*
Mflv_4009|M.gilvum_PYR-GCK AKAAHLPSAIDGPTVGSSALKLSEATAVSAEFGMTGKICLTPEQCLTVNE
MSMEG_2667|M.smegmatis_MC2_155 AKAAHLPSAIDGPTVGSSPLKLAEATAVSAEFGMTGKICLTPDQCPTVNE
Mb3102c|M.bovis_AF2122/97 ARAAGLPSAIDGPTIGSNALKLIEATAVSAEFGMTGKICLSPDQCPVVNE
Rv3075c|M.tuberculosis_H37Rv ARAAGLPSAIDGPTIGSNALKLIEATAVSAEFGMTGKICLSPDQCPVVNE
MMAR_1583|M.marinum_M AKAAGLPSAIDGPTIGSNPLKLIEASAVSVEFGMTGKICLSPEQCAVVNE
MUL_3451|M.ulcerans_Agy99 AKAAGLPSAIDGPTIGSNPLKLIEASAVSVEFGMTGKICLSPEQCAVVNE
MAV_3981|M.avium_104 SKAADLPSAIDGPTIGSNPLKLIEATAVSTQFGMTGKICLTPDQCSVVNE
MAB_4737|M.abscessus_ATCC_1997 SRAAHIPGPIDGPTR--DPAELPEAVSLTRRMGMTGKLALRSSDADTINT
Mvan_2654|M.vanbaalenii_PYR-1 SRAAGLPAPIDGPTLRDRVRHLVRDTEVAKAAGMTGRLCLDAGHAKTINA
TH_0719|M.thermoresistible__bu AKAHGRLALDSVYLDIKDLDGLRAEVDDAVAVGFDAKVAIHPTQVAVIRE
::* . . * : *: .::.: . . .:.
Mflv_4009|M.gilvum_PYR-GCK GLSPSAEEIAWAKEFFVEFERDGGEIRNG---SDLPRIARANKILELARA
MSMEG_2667|M.smegmatis_MC2_155 GLSPSQDEISWAKEFFAEFQRDGGEIRNG---SDLPRIARANKILDLARA
Mb3102c|M.bovis_AF2122/97 GLSPSQDEIVWAKEFFAEFARDGGEIRNG---SDLPRIARATKILDLARA
Rv3075c|M.tuberculosis_H37Rv GLSPSQDEIVWAKEFFAEFARDGGEIRNG---SDLPRIARATKILDLARA
MMAR_1583|M.marinum_M GLSPSQDEIGWAKEFFAEFERDGGEIRNG---SDLPRIARATKILDLARA
MUL_3451|M.ulcerans_Agy99 GLSPSQDEIGWAKEFFAEFERDGGEIRNG---SDLPRIARATKILDLARA
MAV_3981|M.avium_104 GLSPSQDEIAWAKEFFAEFERDGGEIRNG---SDLPRIARATKILELARA
MAB_4737|M.abscessus_ATCC_1997 GLSPSDEDVSWAQDFVDRFNSQGGKPKDG---SDLPRLNRARIILERARM
Mvan_2654|M.vanbaalenii_PYR-1 VLSPSASEIDEARITLARLDAPTG-PYDG---SVGPTRARAAAVLDLAAK
TH_0719|M.thermoresistible__bu GYTPTPDQVRWARHVLAAARDERGVFQFEGIMVDAPVLRRAERIVQLAPD
:*: .:: *: . * * ** ::: *
Mflv_4009|M.gilvum_PYR-GCK YGIEPSEFDDVDEPTHIPAPSDTYHY
MSMEG_2667|M.smegmatis_MC2_155 YGIHEPEYSN-DDPDHVPAPSDTYHY
Mb3102c|M.bovis_AF2122/97 YGIEVSDFED-EP-VHMPAPTDTYHY
Rv3075c|M.tuberculosis_H37Rv YGIEVSDFED-EP-VHMPAPTDTYHY
MMAR_1583|M.marinum_M YGIEASDFED-EP-VHSPAPTDTYHY
MUL_3451|M.ulcerans_Agy99 YGIEASDFED-EP-VHSPAPTDTYHY
MAV_3981|M.avium_104 YGIEALDIDE-EERDHSPAPSDTYHY
MAB_4737|M.abscessus_ATCC_1997 LGLITP--------------------
Mvan_2654|M.vanbaalenii_PYR-1 LGVT----------------------
TH_0719|M.thermoresistible__bu PGR-----------------------
*