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ANPQSAHGDDPARVEMRRADGSPIHVLVVDDEPVLAELVSMALRYEGWEISTAGDGATAIAIARDNPPDV VVLDVMLPDMSGLEVLRKLREQIPGLPLLLLTAKDSVEDRIAGLTAGGDDYVTKPFSIEEVVLRLRALLR RTGVSTDTSGAKIVVGDLVLDEDSHEVTRGGDPITLTATEFELLRFMMRNAKRVLSKTQILDRVWSYDFG GRSNIVELYVSYLRKKIDSGREPMIHTLRGAGYVLKPAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4429 | - | - | 100% (250) | two component transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_2296 | - | 5e-83 | 63.68% (234) | two component transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_5175 | - | 3e-67 | 54.67% (225) | two component transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3791c | - | 1e-112 | 85.04% (234) | putative two component transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_2266 | - | 1e-124 | 91.20% (250) | two component transcriptional regulator |
| M. tuberculosis H37Rv | Rv3765c | - | 1e-112 | 85.04% (234) | two component transcriptional regulatory protein |
| M. leprae Br4923 | MLBr_00174 | - | 6e-54 | 45.09% (224) | putative two-component response regulator |
| M. abscessus ATCC 19977 | MAB_2581 | - | 1e-108 | 80.33% (239) | putative two component transcriptional regulatory protein |
| M. marinum M | MMAR_5317 | tcrX | 1e-111 | 85.47% (234) | two-component transcriptional regulatory protein TcrX |
| M. avium 104 | MAV_0304 | - | 1e-112 | 85.65% (237) | DNA-binding response regulator |
| M. smegmatis MC2 155 | MSMEG_4990 | - | 1e-121 | 90.00% (240) | DNA-binding response regulator |
| M. thermoresistible (build 8) | TH_1732 | phoP | 2e-57 | 47.77% (224) | DNA-binding response regulator PhoP |
| M. ulcerans Agy99 | MUL_4391 | tcrX | 1e-110 | 84.19% (234) | two component transcriptional regulatory protein TcrX |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4429|M.vanbaalenii_PYR-1 MANPQSAHGDDPARVEMRRADGSPIHVLVVDDEPVLAELVSMALRYEGWE
Mflv_2266|M.gilvum_PYR-GCK MAHPQSDP-EDPARVVMRRADGSPIRVLVVDDEAVLAELMSMALRYEGWD
MSMEG_4990|M.smegmatis_MC2_155 MG-TANGTEIETGRAVMRRADGNPIRVLVVDDEPVLAELVSMALRYEGWD
MMAR_5317|M.marinum_M ---------------MMCRADGQPVSVLVVDDEPVLAEMVSMALRYEGWN
MUL_4391|M.ulcerans_Agy99 ----------------MCRADGQPVSVLVVDDEPVLADMVSMALRYEGWN
MAV_0304|M.avium_104 ----MSQPRASAERVVMCRADGNPINVLVVDDEAVLAEMVSMALRYEGWN
Mb3791c|M.bovis_AF2122/97 ----------------MRRADGQPVTVLVVDDEPVLAEMVSMALRYEGWN
Rv3765c|M.tuberculosis_H37Rv ----------------MRRADGQPVTVLVVDDEPVLAEMVSMALRYEGWN
MAB_2581|M.abscessus_ATCC_1997 -MSDAASVSSEKARSSLRRPDGSPVRVLVVDDERSLAELISMALRYEGWE
MLBr_00174|M.leprae_Br4923 ------------------------MRILAVDDDRAVRESLRRSLSFNGYS
TH_1732|M.thermoresistible__bu ----------------------VAVRILVVDDDRAVRESLRRSLSFNGYS
: :*.***: : : : :* ::*:.
Mvan_4429|M.vanbaalenii_PYR-1 ISTAGDGATAIAIARDNPPDVVVLDVMLPDMSGLEVLRKLREQIPGLPLL
Mflv_2266|M.gilvum_PYR-GCK ISTAGDGATAIALARQNPPDVVVLDVMLPDMSGLEVLRTLREQIPGLPLL
MSMEG_4990|M.smegmatis_MC2_155 ITTAGDGASAIAAARETPPDVVVLDVMLPDMSGLDVLRKLREQIPGLPLL
MMAR_5317|M.marinum_M IATASDGASAIASARAERPDVVVLDVMLPDMSGLEVLHRLRKENPALPVL
MUL_4391|M.ulcerans_Agy99 IATASDGASAIASARAERPDVVVLDVMLPDMSGLEVLHRLRKENPRLPVL
MAV_0304|M.avium_104 IATASDGASAIAAARNQRPDVVVLDVMLPDMSGLDVLHKLREENPQLPVL
Mb3791c|M.bovis_AF2122/97 ITTAGDGSSAIAAARRQRPDVVVLDVMLPDMSGLDVLHKLRSENPGLPVL
Rv3765c|M.tuberculosis_H37Rv ITTAGDGSSAIAAARRQRPDVVVLDVMLPDMSGLDVLHKLRSENPGLPVL
MAB_2581|M.abscessus_ATCC_1997 IHVAGDGMSAVKLARQVHPDIVVLDVMLPDVSGLEVLRQLRDLYPGLPLL
MLBr_00174|M.leprae_Br4923 VELANDGVEALEMVARDRPDALVLDVMMPRLDGLEVCRQLRSTGDDLPIL
TH_1732|M.thermoresistible__bu VELAEDGVEALDLIANDRPDAVVLDVMMPRLDGLEVCRQLRSTGDDLPIL
: * ** *: ** :*****:* :.**:* : **. **:*
Mvan_4429|M.vanbaalenii_PYR-1 LLTAKDSVEDRIAGLTAGGDDYVTKPFSIEEVVLRLRALLRRTGVSTDTS
Mflv_2266|M.gilvum_PYR-GCK LLTAKDSVEDRIAGLTAGGDDYVTKPFSIEEVVLRLRALLRRTGVATATG
MSMEG_4990|M.smegmatis_MC2_155 LLTAKDSVEDRIAGLTAGGDDYVTKPFSLEEVVLRLRALLRRTGVTSEDG
MMAR_5317|M.marinum_M LLTAKDAVEDRIAGLTAGGDDYVTKPFSIEEVVLRLRALLRRTGVTTVDS
MUL_4391|M.ulcerans_Agy99 LLTAKDAVEDRIAGLTAGGDDYVTKPFSIEEIVLRLRALLRRTGVTTVDS
MAV_0304|M.avium_104 LLTAKDAVEDRIAGLTAGGDDYVTKPFSIEEVVLRLRALLRRTGVTTVDS
Mb3791c|M.bovis_AF2122/97 LLTAKDAVEDRIAGLTAGGDDYVTKPFSIEEVVLRLRALLRRTGVTTVDS
Rv3765c|M.tuberculosis_H37Rv LLTAKDAVEDRIAGLTAGGDDYVTKPFSIEEVVLRLRALLRRTGVTTVDS
MAB_2581|M.abscessus_ATCC_1997 LLTAKDSLEDRIAGLTAGGDDYVTKPFSLEEVVLRLRALLRRTGIAGDSG
MLBr_00174|M.leprae_Br4923 VLTARDSVSERVAGLDAGADDYLPKPFALEELLARIRALLRRTKPDDAAE
TH_1732|M.thermoresistible__bu VLTARDSVSERVAGLDAGADDYLPKPFALEELLARLRALLRRTTPDDAAD
:***:*::.:*:*** **.***:.***::**:: *:*******
Mvan_4429|M.vanbaalenii_PYR-1 GAKIVVGDLVLDEDSHEVTRGGDPITLTATEFELLRFMMRNAKRVLSKTQ
Mflv_2266|M.gilvum_PYR-GCK GAKLVVGDLVLDEDSHEVTRGGDLITLTATEFELLRFMMRNARCVLSKAQ
MSMEG_4990|M.smegmatis_MC2_155 GAKIVVGDLVLDEDSHEVTRGGDPIALTATEFELLRFMMRNAKRVLSKAQ
MMAR_5317|M.marinum_M GAQLVVGDLVLDEDSHEVTRAGEPISLTSTEFELLRFMMRNSKRVLSKAQ
MUL_4391|M.ulcerans_Agy99 GAQLVVGDLVLDEDSHEVTRAGEPISLTSTEFELLRFMMRNSKRVLSNAQ
MAV_0304|M.avium_104 GAQLVVGDLVLDEDSHEVTRAGEPISLTSTEFELLRFMMRNSKRVLSKAQ
Mb3791c|M.bovis_AF2122/97 GAQLVVGDLVLDEDSHEVMRAGEPVSLTSTEFELLRFMMHNSKRVLSKAQ
Rv3765c|M.tuberculosis_H37Rv GAQLVVGDLVLDEDSHEVMRAGEPVSLTSTEFELLRFMMHNSKRVLSKAQ
MAB_2581|M.abscessus_ATCC_1997 DARLIVGDLVLDEDSHEVTRDGELINLTATEFELLRFMMRNNKRVLSKHQ
MLBr_00174|M.leprae_Br4923 SVAMSFSDLTLDPVTREVARGQRWISLTRTEFALLEMLIANPRRVLTRSR
TH_1732|M.thermoresistible__bu SQKLTFADLTLDPVTREVTRGNRQISLTRTEFALLELLIANPRRVLSRSR
. : ..**.** ::** * : ** *** **.::: * : **:. :
Mvan_4429|M.vanbaalenii_PYR-1 ILDRVWSYDFGGRSNIVELYVSYLRKKIDSGREP-MIHTLRGAGYVLKPA
Mflv_2266|M.gilvum_PYR-GCK ILDRVWSYDFGGRSNIVELYVSYLRKKIDSGREP-MIHTLRGAGYVLKPA
MSMEG_4990|M.smegmatis_MC2_155 ILDRVWSYDFGGRSNIVELYVSYLRKKIDSGREP-MIHTLRGAGYVLRPP
MMAR_5317|M.marinum_M ILDRVWSYDFGGRSNIVELYISYLRKKIDNGREP-MIHTLRGAGYVLKPA
MUL_4391|M.ulcerans_Agy99 ILDRVWSYDFGGRSNIVELYISYLRKKIDNGREP-MIHTLRGAGYVLKPA
MAV_0304|M.avium_104 ILDRVWSYDFGGRSNIVELYISYLRKKIDNGREP-MIHTLRGAGYVLKPA
Mb3791c|M.bovis_AF2122/97 ILDRVWSYDFGGRSNIVELYISYLRKKIDNGREP-MIHTLRGAGYVLKPA
Rv3765c|M.tuberculosis_H37Rv ILDRVWSYDFGGRSNIVELYISYLRKKIDNGREP-MIHTLRGAGYVLKPA
MAB_2581|M.abscessus_ATCC_1997 ILDRVWSYDFGGRSNVVELYISYLRKKIDTGREP-MIHTLRGAGYVLKPA
MLBr_00174|M.leprae_Br4923 ILEEVWGFDFPTSGNALEVYVGYLRRKTEADGESRLIHTVRGVGYVLRET
TH_1732|M.thermoresistible__bu ILEEVWGFDFPTSGNALEVYIGYLRRKTEAEGEPRLIHTVRGVGYVLRET
**:.**.:** .* :*:*:.***:* : *. :***:**.****: .
Mvan_4429|M.vanbaalenii_PYR-1 R-
Mflv_2266|M.gilvum_PYR-GCK R-
MSMEG_4990|M.smegmatis_MC2_155 R-
MMAR_5317|M.marinum_M R-
MUL_4391|M.ulcerans_Agy99 R-
MAV_0304|M.avium_104 R-
Mb3791c|M.bovis_AF2122/97 R-
Rv3765c|M.tuberculosis_H37Rv R-
MAB_2581|M.abscessus_ATCC_1997 H-
MLBr_00174|M.leprae_Br4923 PP
TH_1732|M.thermoresistible__bu PP