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MTRIQDLVFRVLQHPLRMLSLRSIVILSQLGVIILVLTLGVWVWVGVTNDQYDQLDRRLDSLSSLGDVNT LLRSAQDGVGPEPTEGGLVRTARIGGITVSTPAEVVLPELPNGYADATIEGVEYRVRTITTGTASIALGA PLADTQARIDGLHWRVFWICAGVILSTLLIGWVIGLIMVNPFRLLARQARAINAQSNPDEVQVRGVWEAV EISEAVEGMLARIGDEQQRTRAALETARDFASVASHELRTPLTAMRTNLEVLSTLDLAPEQRQEVIGDVI RTQSRIEATLTALERLAQGQLTTVEDFVPVDIAELLDRAAHDAMRNYPGVDVSLASSTTVLMLGMPAGLR LVIDNAIANAVKHGGATQIRLSVVSSQSGVEIAVDDNGSGVPEEERAAVFERFHRGTTASRSGSGLGLAL VAQQAEIHGGTASLEVSPQGGTRLMLRLPGHGPE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2118 | - | - | 100% (454) | integral membrane sensor signal transduction histidine kinase |
| M. vanbaalenii PYR-1 | Mvan_5010 | - | e-132 | 57.08% (438) | integral membrane sensor signal transduction histidine kinase |
| M. vanbaalenii PYR-1 | Mvan_0192 | - | 2e-67 | 37.61% (436) | integral membrane sensor signal transduction histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0926c | prrB | 1e-131 | 57.08% (438) | two component sensor histidine kinase PRRB |
| M. gilvum PYR-GCK | Mflv_4243 | - | 0.0 | 90.73% (453) | integral membrane sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv0902c | prrB | 1e-131 | 57.08% (438) | two component sensor histidine kinase PRRB |
| M. leprae Br4923 | MLBr_02124 | - | 1e-133 | 57.34% (436) | sensor histidine kinase |
| M. abscessus ATCC 19977 | MAB_0955c | - | 1e-171 | 67.56% (450) | sensor histidine kinase PrrB |
| M. marinum M | MMAR_4634 | prrB | 1e-131 | 57.76% (438) | two-component sensor histidine kinase PrrB |
| M. avium 104 | MAV_0147 | - | 0.0 | 75.11% (438) | sensor-type histidine kinase PrrB |
| M. smegmatis MC2 155 | MSMEG_2793 | - | 0.0 | 76.27% (451) | sensor-type histidine kinase PrrB |
| M. thermoresistible (build 8) | TH_0454 | - | 1e-136 | 59.59% (438) | sensor-type histidine kinase PrrB |
| M. ulcerans Agy99 | MUL_0249 | prrB | 1e-131 | 57.53% (438) | two component sensor histidine kinase PrrB |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4634|M.marinum_M -------------------MTVMNILSRIFA---RTPSLRTRVVVATAIG
MUL_0249|M.ulcerans_Agy99 ----------------------MNILSRIFA---RTPSLRTRVVVATAIG
Mb0926c|M.bovis_AF2122/97 ----------------------MNILSRIFA---RTPSLRTRVVVATAIG
Rv0902c|M.tuberculosis_H37Rv ----------------------MNILSRIFA---RTPSLRTRVVVATAIG
MLBr_02124|M.leprae_Br4923 ----------------------MNILSRIFA---RTPSLRTRVVVATAIG
TH_0454|M.thermoresistible__bu ----------------------MNLVTRLFR---RTPSLRTRVAFATAIA
Mvan_2118|M.vanbaalenii_PYR-1 ------------------MTRIQDLVFRVLQHPLRMLSLRS-IVILSQLG
Mflv_4243|M.gilvum_PYR-GCK ------------------MTRIQDLVYRVLDHPLRWLSLRS-IVILSQLG
MAV_0147|M.avium_104 ---------------------------------MRVLSLRT-IVIVAAIS
MSMEG_2793|M.smegmatis_MC2_155 ---------------MTFEERMIRLLRPVLRPVMRVLSLRT-IVIVAALS
MAB_0955c|M.abscessus_ATCC_199 MSTSHENPPVMGRPSKHRSQRITDLSYRLLEKPMRIFSLRT-LVAIAALG
* ***: :. : :.
MMAR_4634|M.marinum_M AAIPVLIVGTVVWVGITNDRKERLDRRLDEAAGFAIPFVPRGLDEIPRS-
MUL_0249|M.ulcerans_Agy99 AAIPVLIVGTVVWVGITNDRKERLDRRLDEAAGFAIPFVPRGLDEIPRS-
Mb0926c|M.bovis_AF2122/97 AAIPVLIVGTVVWVGITNDRKERLDRRLDEAAGFAIPFVPRGLDEIPRS-
Rv0902c|M.tuberculosis_H37Rv AAIPVLIVGTVVWVGITNDRKERLDRRLDEAAGFAIPFVPRGLDEIPRS-
MLBr_02124|M.leprae_Br4923 AAIPVLIVGTVVWVGITNDRKERLDRKLDEAAGFAIPFVPRGLDEIPRS-
TH_0454|M.thermoresistible__bu AAIVVGIVGVVVWVGITNDRKERLDRRLDEAAGFALPFVPRGLEQIPPS-
Mvan_2118|M.vanbaalenii_PYR-1 VIILVLTLGVWVWVGVTNDQYDQLDRRLDSLS--SLGDVNTLLRSAQDG-
Mflv_4243|M.gilvum_PYR-GCK VTILVLTLGVWVWVGVTNDQYDQLDRRLDSLS--SLGDVNTLLRSAQEG-
MAV_0147|M.avium_104 VMTLVVLLGTWVWVGVTNDQYNQLDRRLDSVS--SLGDISSLLTNPQHNS
MSMEG_2793|M.smegmatis_MC2_155 VVVLVLTLGTWVWIGVTNDQYAQLDRRLDSLS--SLGDVSTLLNSTRETD
MAB_0955c|M.abscessus_ATCC_199 VMVLVVTLGTWVWLGVEEDQYSQLDRRLDSVS--SLGAVSNLLNSVISS-
. * :*. **:*: :*: :***:**. : :: : * .
MMAR_4634|M.marinum_M -----PNDQDALITVRRGDLVKSN-SDITLPKLQKDYADTYIRGVRYRVR
MUL_0249|M.ulcerans_Agy99 -----PNDQDALITVRRGDLVKSN-SDITLPKLQEDYADTYIRGVRYRVR
Mb0926c|M.bovis_AF2122/97 -----PNDQDALITVRRGNVIKSN-SDITLPKLQDDYADTYVRGVRYRVR
Rv0902c|M.tuberculosis_H37Rv -----PNDQDALITVRRGNVIKSN-SDITLPKLQDDYADTYVRGVRYRVR
MLBr_02124|M.leprae_Br4923 -----PNDQDAIITVRRGNLVKSN-FDITLPKLTNDYADTYLRGVRYRVR
TH_0454|M.thermoresistible__bu -----PNDQDVVITVRRGDEVRSN-SEVVLPELDADYADTYIDGVRYRVR
Mvan_2118|M.vanbaalenii_PYR-1 -VGPEPTEGGLVRTARIGGITVSTPAEVVLPELPNGYADATIEGVEYRVR
Mflv_4243|M.gilvum_PYR-GCK -VGPEPTEGGLVRTARWAGSTVSIPADIVLPDLDSGYADATIDGVEYRVR
MAV_0147|M.avium_104 PDRATQD-GNLVRTARIGGVTVSVPSNIVLPQLPDGYANTTINGVQYRVR
MSMEG_2793|M.smegmatis_MC2_155 ADNAGHDDGGLVRTAYIGGVTVSVPSDIVLPHLENGYANTTIDGVEYRVR
MAB_0955c|M.abscessus_ATCC_199 -DKKLDTPDGLVLTARVAGLTKSIPTDTELPLLEPGYANTKINGVEYRVR
. : *. .. * : ** * .**:: : **.****
MMAR_4634|M.marinum_M TVEIPGPEPTSVAVGATYDATIAETNNLHRRVLLICTFAIGAATVFAWLL
MUL_0249|M.ulcerans_Agy99 TVEIPGPEPTSVAVGATYDATIAETNNLHRRVLLICTFAIGAATVFAWLL
Mb0926c|M.bovis_AF2122/97 TVEIPGPEPTSVAVGATYDATVAETNNLHRRVLLICTFAIGAAAVFAWLL
Rv0902c|M.tuberculosis_H37Rv TVEIPGPEPTSVAVGATYDATVAETNNLHRRVLLICTFAIGAAAVFAWLL
MLBr_02124|M.leprae_Br4923 TVEIPAPEPTSIAVGATYDATVAETNNLHRRVLLICGFAIAAAAVFAWLL
TH_0454|M.thermoresistible__bu TVQTPYPIRTTLAVGATYDDTIADTANLHRRVILICTLAIGAATIAGWLL
Mvan_2118|M.vanbaalenii_PYR-1 TITT---GTASIALGAPLADTQARIDGLHWRVFWICAGVILSTLLIGWVI
Mflv_4243|M.gilvum_PYR-GCK TIKT---GNASIALGAPMAETQARIDSLHWRVFWICSGVILTTMLVGWVI
MAV_0147|M.avium_104 TFTA---GPASIALAAPLAEAQHRINELHLRVLLICASVIGGTVVVGWVI
MSMEG_2793|M.smegmatis_MC2_155 TFTA---GPATIALGAPLAETQRRIDELHLRVVLICAGVIAGTVVVGWVI
MAB_0955c|M.abscessus_ATCC_199 SFIAP--GNIPVAVGAPVAETQRQIDRYHMRILAICGGVLIGTVIVGWVI
:. .:*:.*. : * *:. ** .: : : .*::
MMAR_4634|M.marinum_M AVFAVRPFKQLAEQTRSIDAGDEAPRVEVHGASEAIEIAEAMRGMLQRIW
MUL_0249|M.ulcerans_Agy99 AVFAVRPFKQLAEQTRSIDAGDEAPRVEVHGASEAIEIAEGMRGMLQRIW
Mb0926c|M.bovis_AF2122/97 AAFAVRPFKQLAEQTRSIDAGDEAPRVEVHGASEAIEIAEAMRGMLQRIW
Rv0902c|M.tuberculosis_H37Rv AAFAVRPFKQLAEQTRSIDAGDEAPRVEVHGASEAIEIAEAMRGMLQRIW
MLBr_02124|M.leprae_Br4923 AAFAVRPFKQLAQQTRSVDAGGEAPRVEVHGATEAVEIAEAMRGMLQRIW
TH_0454|M.thermoresistible__bu AAFAVRPFKQLAAQARSIDAGDEVPDVEIRGATEAVEIADAVKGMLQRIW
Mvan_2118|M.vanbaalenii_PYR-1 GLIMVNPFRLLARQARAINAQSNPDEVQVRGVWEAVEISEAVEGMLARIG
Mflv_4243|M.gilvum_PYR-GCK GLIMVNPFRLLAQQARAINAQSNPDEVQVRGVWEAVEISEAVEGMLARIG
MAV_0147|M.avium_104 SLIMVNPFLLLAQQARAINAQSSPDEVQVRGVREAVEIAEAVEGMLARIG
MSMEG_2793|M.smegmatis_MC2_155 SLVMINPFRLLAQQARAINAQSNPEEVKVRGVREAVEIAEAVEGMLARIG
MAB_0955c|M.abscessus_ATCC_199 SLIVVSPFRLLAQQARLINAQSNPDDVNVRGVREAVEISEAVEGMLERIN
. . : ** ** *:* ::* .. *:::*. **:**::.:.*** **
MMAR_4634|M.marinum_M NEQIRTKEALASARDFAAVSSHELRTPLTAMRTNLEVLSTLDLPDDQRKE
MUL_0249|M.ulcerans_Agy99 NEQIRTKEALASARDFAAVSSHELRTPLTAMRTNLEVLSTLDLPDDQRKE
Mb0926c|M.bovis_AF2122/97 NEQNRTKEALASARDFAAVSSHELRTPLTAMRTNLEVLSTLDLPDDQRKE
Rv0902c|M.tuberculosis_H37Rv NEQNRTKEALASARDFAAVSSHELRTPLTAMRTNLEVLSTLDLPDDQRKE
MLBr_02124|M.leprae_Br4923 NEQNRTKEALASARDFAAVSSHELRTPLTAMRTNLEVLATLDLADDQRKE
TH_0454|M.thermoresistible__bu KEQDRTKAALASARDFASAAAHELRTPLTAMRTNLEVLSTLDMPEEQRKE
Mvan_2118|M.vanbaalenii_PYR-1 DEQQRTRAALETARDFASVASHELRTPLTAMRTNLEVLSTLDLAPEQRQE
Mflv_4243|M.gilvum_PYR-GCK DEQQRTRAALESARDFAAVASHELRTPLTAMRTNLEVLATLDLGAEQRQE
MAV_0147|M.avium_104 KEQQRTKAALESARDFAAVASHELRTPLTAMRTNLEVLSTLDLPHEQRQE
MSMEG_2793|M.smegmatis_MC2_155 SEQERTKAALESARDFAAVASHELRTPLTAMRTNLEVLSTLDMTPEQRQE
MAB_0955c|M.abscessus_ATCC_199 TEQEKTKAALESARDFAAVASHELRTPLTAMRTNLEVLSTLNLSDDQREE
** :*: ** :*****:.::*****************:**:: :**:*
MMAR_4634|M.marinum_M VLNDVIRTQSRIEATLGALERLAQGELSTSEDHVPVDITELLDRAAHDAM
MUL_0249|M.ulcerans_Agy99 VLNDVIRTQSRIEATLGALERLAQGELSTSEDHVPVDITELLDRAAHDAM
Mb0926c|M.bovis_AF2122/97 VLNDVIRTQSRIEATLSALERLAQGELSTSDDHVPVDITDLLDRAAHDAA
Rv0902c|M.tuberculosis_H37Rv VLNDVIRTQSRIEATLSALERLAQGELSTSDDHVPVDITDLLDRAAHDAA
MLBr_02124|M.leprae_Br4923 VLGDVIRTQSRIEATLSALERLAQGELSTSDDHVPVDITELLDRAAHDAT
TH_0454|M.thermoresistible__bu VLADVIRTQSRIEATLSALERLAQGELSTSDDHVPVDITELLDRAAHEAM
Mvan_2118|M.vanbaalenii_PYR-1 VIGDVIRTQSRIEATLTALERLAQGQLTTVEDFVPVDIAELLDRAAHDAM
Mflv_4243|M.gilvum_PYR-GCK VLGDVIRTQSRIEATLTALERLAQGELTTVDDFVPVDVAELLDRAAHDAM
MAV_0147|M.avium_104 VIGDVIRTQSRIEATLTALERLAQGELTTVDDFVPFDITELLDRAAHDAL
MSMEG_2793|M.smegmatis_MC2_155 VIGDVMRTQSRIEATLTALERLAQGELTTVEDFVPMDVTELLDRAAHDAQ
MAB_0955c|M.abscessus_ATCC_199 IIEETIRTQSRVEATLSALERLAQGQLTTEDDHVPVDITELLDRAAHDAD
:: :.:*****:**** ********:*:* :*.**.*:::*******:*
MMAR_4634|M.marinum_M RIYPDLDVSLVPSPTCIIVGLPAGLRLAVDNAIANAVKHGGSTRVQLSAV
MUL_0249|M.ulcerans_Agy99 RIYPDLDVSLVPSPTCIIVGLPAGLRLAVDNAIANAVKHGGSTRVQLSAV
Mb0926c|M.bovis_AF2122/97 RIYPDLDVSLVPSPTCIIVGLPAGLRLAVDNAIANAVKHGGATLVQLSAV
Rv0902c|M.tuberculosis_H37Rv RIYPDLDVSLVPSPTCIIVGLPAGLRLAVDNAIANAVKHGGATLVQLSAV
MLBr_02124|M.leprae_Br4923 RSYPELKVSLVPSPTCIIVGLPAGLRLAVDNAVANAVKHGGATRVQLSAV
TH_0454|M.thermoresistible__bu RIYPDLEVSLVPAPTVIIVGLPAGLRLAVDNAIANAVKHGGATRVQLSAV
Mvan_2118|M.vanbaalenii_PYR-1 RNYPGVDVSLASSTTVLMLGMPAGLRLVIDNAIANAVKHGGATQIRLSVV
Mflv_4243|M.gilvum_PYR-GCK HNYPGVEVTLASSTTVLMLGMPAGLRLVIDNAIANAVKHGGATQIRLSVV
MAV_0147|M.avium_104 RVYPDVEVSLVPSPTVLMIGLPTGLRLVIDNAIANAVKHGNAGKIQLTVS
MSMEG_2793|M.smegmatis_MC2_155 HTYPGLKVTLMPSPTVLMLGMPAGLRLVIDNAIANAVKHGGATEIRLSAV
MAB_0955c|M.abscessus_ATCC_199 RSYPNLEISLVPSSTILMLGLPAGLRLVIDNAIKNAVKHGGASKIQLSAT
: ** :.::* .:.* :::*:*:****.:***: ******.: ::*:.
MMAR_4634|M.marinum_M SSRAGVEIAVDDNGSGVPEAERQMVFERFSRGSTASHSGSGLGLALVAQQ
MUL_0249|M.ulcerans_Agy99 SSRAGVEIAVDDNGSGVPEAERQMVFERFSRGSTASHSGSGLGLALVAQQ
Mb0926c|M.bovis_AF2122/97 SSRAGVEIAIDDNGSGVPEGERQVVFERFSRGSTASHSGSGLGLALVAQQ
Rv0902c|M.tuberculosis_H37Rv SSRAGVEIAIDDNGSGVPEGERQVVFERFSRGSTASHSGSGLGLALVAQQ
MLBr_02124|M.leprae_Br4923 SSRAGVEIAVDDNGSGVPEDERQVVFERFSRGSTASHSGSGLGLALVAQQ
TH_0454|M.thermoresistible__bu SSREGVEIAIDDNGTGVPEEERERVFDRFTRGSTASHSGSGLGLALVAQQ
Mvan_2118|M.vanbaalenii_PYR-1 SSQSGVEIAVDDNGSGVPEEERAAVFERFHRGTTASRSGSGLGLALVAQQ
Mflv_4243|M.gilvum_PYR-GCK SSHTGVEIAVDDNGSGVPEEERAEVFARFHRGTTASRSGSGLGLALVAQQ
MAV_0147|M.avium_104 SSGEGVEIAIDDDGSGIPESERATVFERFARGSTASRSGSGLGLALVAQQ
MSMEG_2793|M.smegmatis_MC2_155 SSADDVEIAVDDNGSGVPEAERAEVFERFARGSTASRSGSGLGLALVAQQ
MAB_0955c|M.abscessus_ATCC_199 STVHGVEIAVDDNGSGIPEAERVQVFERFSRGSTASHSGSGLGLALVAQQ
*: .****:**:*:*:** ** ** ** **:***:*************
MMAR_4634|M.marinum_M AHLHGGTASLQNSPLGGARLLLKLPGPS--------
MUL_0249|M.ulcerans_Agy99 AHLHGGTASLQNSPLGGARLLLKLPGPS--------
Mb0926c|M.bovis_AF2122/97 AQLHGGTASLENSPLGGARLVLRLPGPS--------
Rv0902c|M.tuberculosis_H37Rv AQLHGGTASLENSPLGGARLVLRLPGPS--------
MLBr_02124|M.leprae_Br4923 AQLHGGTASLETSPLGGARLLLRISAPS--------
TH_0454|M.thermoresistible__bu AEIHGGTASLEASPLGGARLVLRLPGPR--------
Mvan_2118|M.vanbaalenii_PYR-1 AEIHGGTASLEVSPQGGTRLMLRLPGH---GPE---
Mflv_4243|M.gilvum_PYR-GCK AEIHGGTASLEVSPQGGTRLMLRLPGS---GPS---
MAV_0147|M.avium_104 AELHGGTAELQNSPLGGTRLLLRLAGD-GRGPA---
MSMEG_2793|M.smegmatis_MC2_155 AELHGGKAALEESPLGGARLLLRLPINRSRGDDASF
MAB_0955c|M.abscessus_ATCC_199 AELHGGTAALESSPLGGARLVLRLPGH---------
*.:***.* *: ** **:**:*::.