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TQRYDVVIAGGGPSGSAAAWQAAQTGAKVVVLDKAQFPRAKPCGDGLTARAVSYLQKMGLADEVATYHRV NRVTVFSPSRWELSFPKRPGMPDHGHTVSREHLDTVLLKHAESAGAEVRQGAEVAGPEFDASGRVIGVVL KGGEKVYGDAVIAADGAYSPIKRALKIDSEYNGYSAIAIRSEMPANRPDTDSLDIYLKLLFQGDQLPGYG WVFPMGNGIFNIGLGYVNSYKNWQSINATQFLGDFLRTLPREWDLPPIEELKKNKSVRAWRLPMGFTAWP PWRPGVLFTGDSLGAGKPASGAGISKALESGLAAGECAVAALMNGGPDDFTNYAQRMEAAWGREYRRGRY MHKLIGQPRLAAAGVKLIDNAAFRDRMLKALYKKAQGPQHSF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2055 | - | - | 100% (393) | geranylgeranyl reductase |
| M. vanbaalenii PYR-1 | Mvan_0991 | - | 4e-40 | 32.99% (385) | geranylgeranyl reductase |
| M. vanbaalenii PYR-1 | Mvan_2422 | - | 4e-10 | 25.00% (164) | hypothetical protein Mvan_2422 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0576c | - | 2e-42 | 35.56% (315) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_4291 | - | 0.0 | 96.44% (393) | geranylgeranyl reductase |
| M. tuberculosis H37Rv | Rv0561c | - | 2e-42 | 35.56% (315) | oxidoreductase |
| M. leprae Br4923 | MLBr_02276 | - | 3e-41 | 35.56% (315) | putative FAD-linked oxidoreductase |
| M. abscessus ATCC 19977 | MAB_3406 | - | 1e-162 | 69.72% (393) | geranylgeranyl reductase |
| M. marinum M | MMAR_0910 | - | 1e-40 | 32.40% (358) | FAD-linked oxidoreductase |
| M. avium 104 | MAV_4582 | - | 5e-39 | 32.58% (353) | FAD dependent oxidoreductase, putative |
| M. smegmatis MC2 155 | MSMEG_2308 | - | 0.0 | 94.88% (391) | geranylgeranyl reductase |
| M. thermoresistible (build 8) | TH_4610 | - | 3e-34 | 82.05% (78) | PUTATIVE geranylgeranyl reductase |
| M. ulcerans Agy99 | MUL_0663 | - | 2e-40 | 32.12% (358) | FAD-linked oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0910|M.marinum_M METRVPRALGADLVVVGAGPAGSAAAAWAARAGRDVLVIDSAGFPRDKAC
MUL_0663|M.ulcerans_Agy99 METRVPRALGADLVVVGAGPAGSAAAAWAARAGRDVLVIDSAGFPRDKAC
Mb0576c|M.bovis_AF2122/97 ----MSVDDSADVVVVGAGPAGSAAAAWAARAGRDVLVIDTATFPRDKPC
Rv0561c|M.tuberculosis_H37Rv ----MSVDDSADVVVVGAGPAGSAAAAWAARAGRDVLVIDTATFPRDKPC
MLBr_02276|M.leprae_Br4923 ----MRVETSADVVVVGAGPAGSAAATWAARAGNDVIVIDSVCFPRDKAC
MAV_4582|M.avium_104 -MCMTTAATRADLVVVGAGPAGSAAAAWAARAGHDVLVVDAARFPRDKAC
Mvan_2055|M.vanbaalenii_PYR-1 ------MTQRYDVVIAGGGPSGSAAAWQAAQTGAKVVVLDKAQFPRAKPC
Mflv_4291|M.gilvum_PYR-GCK ------MTQRYDVVIAGGGPSGSAAAWQAAQTGAKVVVLDKAQFPRAKPC
MSMEG_2308|M.smegmatis_MC2_155 ------MTQRYDLVIAGGGPSGSAAAWQAAQTGAKVVVLDKAEFPRDKPC
TH_4610|M.thermoresistible__bu --------------------------------------------------
MAB_3406|M.abscessus_ATCC_1997 -----MSEKHYDIAVVGGGPAGSSAAWQAARTGARVVLVDKAEFPRDKPC
MMAR_0910|M.marinum_M GDGLTPRAIAELQQLGLGEWLAGRIQHRGLRMSGFGGEVEIGWPGPSFPA
MUL_0663|M.ulcerans_Agy99 GDGLTPRAIAELQQLGLGEWLAGRIQHRGLRMSGFGGEVEIGWPGPSFPA
Mb0576c|M.bovis_AF2122/97 GDGLTPRAVAELHQLGLGKWLADHIRHRGLRMSGFGGEVEVDWPGPSFPS
Rv0561c|M.tuberculosis_H37Rv GDGLTPRAVAELHQLGLGKWLADHIRHRGLRMSGFGGEVEVDWPGPSFPS
MLBr_02276|M.leprae_Br4923 GDGLTPRAVAELKRLGLDDWLNTRIRHRGLRMSGFGGEVEVDWPGPSFPS
MAV_4582|M.avium_104 GDGLTPRAVAECERLGLGGWLDSRIRHRGLRMSGFGAQVQVDWPGPSFPS
Mvan_2055|M.vanbaalenii_PYR-1 GDGLTARAVSYLQKMGLADEVATYHRVNRVTVFSPSRWELSFPKRPGMPD
Mflv_4291|M.gilvum_PYR-GCK GDGLTARAVSYLQKMGLADEVATYHRVNRVTVFSPSRWELSFPKRPGMPD
MSMEG_2308|M.smegmatis_MC2_155 GDGLTARAVSYLQKMGLADEVATYHRVNRVTVFSPSEWELSFPRRPGMPD
TH_4610|M.thermoresistible__bu --------------------------------------------------
MAB_3406|M.abscessus_ATCC_1997 GDGLTARAVSYLQKMGLAQEVAQFHRVDGVRVDSGSIWELTFPKRPGMPD
MMAR_0910|M.marinum_M YSSAVARLELDDRIRKVAEESGARMLLGTKAVAAHHD---SSRRVVSLTL
MUL_0663|M.ulcerans_Agy99 YSSAVARLELDDRIRKVAEESGARMLLGTKAVAAHHD---SSRRVVSLTL
Mb0576c|M.bovis_AF2122/97 YGSAVARLELDDRIRKVAEDTGARMLLGAKAVAVHHD---SSRRVVSLTL
Rv0561c|M.tuberculosis_H37Rv YGSAVARLELDDRIRKVAEDTGARMLLGAKAVAVHHD---SSRRVVSLTL
MLBr_02276|M.leprae_Br4923 TSSAVPRLELDDRIRKVAENSGARMLLGTKAVSVYHD---SSRRAASVTL
MAV_4582|M.avium_104 TGSAVARTELDDRIRRVAEDSGARMLLGTKAVGVQRD---SSAAVTSLML
Mvan_2055|M.vanbaalenii_PYR-1 HGHTVSREHLDTVLLKHAESAGAEVRQGAEVAGPEFD---ASGRVIGVVL
Mflv_4291|M.gilvum_PYR-GCK HGHTVSREHLDTVLLKHAESAGAEIRQGAEVAGPEFD---ASGRVVGVIL
MSMEG_2308|M.smegmatis_MC2_155 HGHTVSRTHLDTVLLKHAESAGAEVRQGAEVAGPEFD---ANGRVIGVVL
TH_4610|M.thermoresistible__bu --------------------------------------------------
MAB_3406|M.abscessus_ATCC_1997 HGHVVRRPELDTLLLKHAESAGVEVRQSTEAVGPVGDGDLVKGVEVKTAN
MMAR_0910|M.marinum_M ADRTEVACRQLIVADGARSSLGRKLGRRWHQETVYGVAARGYLTTARSED
MUL_0663|M.ulcerans_Agy99 ADRTEVACRQLIVADGARSSLGRKLGRRWHQETVYGVAARGYLTTARSED
Mb0576c|M.bovis_AF2122/97 ADGTEVGCRQLIVADGARSPLGRKLGRRWHRETVYGVAVRGYLSTAYSDD
Rv0561c|M.tuberculosis_H37Rv ADGTEVGCRQLIVADGARSPLGRKLGRRWHRETVYGVAVRGYLSTAYSDD
MLBr_02276|M.leprae_Br4923 ADGTEVGCRQLIIADGARSPLGRKLGRSWHQKTVYGVAARGYLTTPRSDD
MAV_4582|M.avium_104 ADGTGVQCRQLIVADGARSSLGRTLGRRWHQETVYGVAARGYLSTPRADD
Mvan_2055|M.vanbaalenii_PYR-1 KGGEKVYGDAVIAADGAYSPIKRALKIDSEYNGYSAIAIRSEMPANRPDT
Mflv_4291|M.gilvum_PYR-GCK KSGEKVLGDAVIAADGAYSPIKRALKIDSEYNGYSAIAIRSEMPANRPDT
MSMEG_2308|M.smegmatis_MC2_155 KSGEKVYGDAVIAADGAYSPIKRALKIDSEYNGYSAIAIRSEMHANRPDS
TH_4610|M.thermoresistible__bu --------------------------------------------------
MAB_3406|M.abscessus_ATCC_1997 GSRETISADAVIVADGAYSPFKRAMNIDSEYKGYSAIAIRAEMTANREDS
MMAR_0910|M.marinum_M PWLTSHLELRSPDGA---VLPGYGWIFPLGNGEVNIGVGALSTTKRPADL
MUL_0663|M.ulcerans_Agy99 PWLTSHLELRSPDGA---VLPGYGWIFPLGNGEVNIGVGGLSTTKRPADL
Mb0576c|M.bovis_AF2122/97 PWLTSHLELRSPDGA---VLPGYGWIFPLGNGEVNIGVGALSTSRRPADL
Rv0561c|M.tuberculosis_H37Rv PWLTSHLELRSPDGA---VLPGYGWIFPLGNGEVNIGVGALSTSRRPADL
MLBr_02276|M.leprae_Br4923 LWLTSHLELRSPDGA---VLPGYGWIFPLGNGEVNIGVGALSTSKRPADL
MAV_4582|M.avium_104 PWLTSHLELRGPDGARDKVLPGYGWIFPLGNGEVNIGVGALSTSRRPAEL
Mvan_2055|M.vanbaalenii_PYR-1 DSLDIYLKLLFQGDQ----LPGYGWVFPMGNGIFNIGLGYVNSYKNWQSI
Mflv_4291|M.gilvum_PYR-GCK DSLDIYLKLLFEGDQ----LPGYGWVFPMGDGIFNIGLGYVNSYKNWQSI
MSMEG_2308|M.smegmatis_MC2_155 DSLDIYLKLVFQGDQ----LPGYGWVFPMGNGMFNIGLGYVNSYKNWQSI
TH_4610|M.thermoresistible__bu --------------------------------------------------
MAB_3406|M.abscessus_ATCC_1997 NMLDIDLRIHHKQDA----LPGYGWVFPLGGGRINIGIGYVNSYRRWQDV
MMAR_0910|M.marinum_M ALRPLMSYYTDLRRDEWGFT-----GQPRAVASALLPMGGAVSGVAGPNW
MUL_0663|M.ulcerans_Agy99 ALRPLMSYYTDLRRDEWGFT-----GQPRAVASALLPMGGAVSGVAGPNW
Mb0576c|M.bovis_AF2122/97 ALRPLISYYTDLRRDEWGFT-----GQPRAVSSALLPMGGAVSGVAGSNW
Rv0561c|M.tuberculosis_H37Rv ALRPLISYYTDLRRDEWGFT-----GQPRAVSSALLPMGGAVSGVAGSNW
MLBr_02276|M.leprae_Br4923 ALRSLISYYTDLRRHEWGFS-----GQPRAVSSALLPMGGAVSGVAGPNW
MAV_4582|M.avium_104 ALRPLIDHYTDLRRDEWGFV-----GRPRAVASALLPMGGAVSGVAGPNW
Mvan_2055|M.vanbaalenii_PYR-1 NATQFLGDFLRTLPREWDLPPIEELKKNKSVRAWRLPMGFTAWPPWRPGV
Mflv_4291|M.gilvum_PYR-GCK NATQFLGEFLRTLPREWELPPIEELKKNKSVRAWRLPMGFTAWPPWRPGV
MSMEG_2308|M.smegmatis_MC2_155 NATQFLGEFLRSLPREWELPPIEELKKNKSVRAWRLPMGFTAWPPWRPGV
TH_4610|M.thermoresistible__bu --------------------------------------------------
MAB_3406|M.abscessus_ATCC_1997 NAAQVLDTYMNKLPKEWELPNLAELRKNKGVRAWRLPMGFTAWPPWRPGV
MMAR_0910|M.marinum_M MLIGDAAACVNPLNGEGIDYGLETG------RLAAELLDSPDLSQLWPSL
MUL_0663|M.ulcerans_Agy99 MLIGDAAACVNPLNGEGIDYGLDTG------RLAAELLDSPDLSQLWPSL
Mb0576c|M.bovis_AF2122/97 MLIGDAAACVNPLNGEGIDYGLETG------RLAAELLDSRDLARLWPSL
Rv0561c|M.tuberculosis_H37Rv MLIGDAAACVNPLNGEGIDYGLETG------RLAAELLDSRDLARLWPSL
MLBr_02276|M.leprae_Br4923 MLIGDAAACVNPLNGEGIDYGLETG------RLAAELLDLRDLSYVWPSL
MAV_4582|M.avium_104 MLIGDAAACVNPLNGEGIDYGMETG------RLAAGLLGCPDLSQEWPAL
Mvan_2055|M.vanbaalenii_PYR-1 LFTGDSLGAGKPASGAGISKALESGLAAGECAVAALMNGGPDDFTNYAQR
Mflv_4291|M.gilvum_PYR-GCK LFTGDSLGAGKPASGAGISKALESGLAAGECAVAALTNGGPDDFTNYALR
MSMEG_2308|M.smegmatis_MC2_155 LFTGDSLGAGKPASGAGISKALESGLAAGECAIAALQNGGPDDFTNYAQR
TH_4610|M.thermoresistible__bu -MATATLXX-----------------XAGECAIAALLNGGPDDFTNYAQR
MAB_3406|M.abscessus_ATCC_1997 LFAGDSLGAGKPASGAGISKALESGLAAGECAVAALQNAGPQDFINYEQR
: : :** : :
MMAR_0910|M.marinum_M LQAHYGRGFSVARRLALLLTYQRFLPTTGPVAMRSTALMKVAVRVMANLV
MUL_0663|M.ulcerans_Agy99 LQAHYGRGFSVARRLALLLTYQRFLPTTGPVAMRSTALMKVAMRVMANLV
Mb0576c|M.bovis_AF2122/97 LADRYGRGFSVARRLALLLTFPRFLPTTGPITMRSTALMNIAVRVMSNLV
Rv0561c|M.tuberculosis_H37Rv LADRYGRGFSVARRLALLLTFPRFLPTTGPITMRSTALMNIAVRVMSNLV
MLBr_02276|M.leprae_Br4923 LQQHYGRGFSVARRLALLLTFKRCLPAIGPSAMRSTSLITIAVRVMANLV
MAV_4582|M.avium_104 LREHYARGFSVARRLALLLTYQRFLPATGPVAMRSTTLMRIAVRVMANLV
Mvan_2055|M.vanbaalenii_PYR-1 MEAAWGREYRRGRYMHKLIGQPRLAAAG--------------VKLIDNAA
Mflv_4291|M.gilvum_PYR-GCK MEAAWGREYRRGRIMHKLIGQPKLAEAG--------------VKLIDNAA
MSMEG_2308|M.smegmatis_MC2_155 MEAAWGREYRRGRYMHKLIGKPKLAEAG--------------VKLIDNAA
TH_4610|M.thermoresistible__bu MEAAWGKEYRRGRYMHKLIGYPKIAEAG--------------VRLIDNRA
MAB_3406|M.abscessus_ATCC_1997 MNEAWGKEYKRGRLMHRAIGNPWLCAQG--------------IKLIDNDL
: :.: : .* : : :::: *
MMAR_0910|M.marinum_M TEEDSDWVARLWRGGGRASRLIDRRPPFH
MUL_0663|M.ulcerans_Agy99 TEEDSDWVARLWRGGGRASRLIDRRPPFH
Mb0576c|M.bovis_AF2122/97 TDDDRDWVARVWRGGGQLSRLVDRRPPFS
Rv0561c|M.tuberculosis_H37Rv TDDDRDWVARVWRGGGQLSRLVDRRPPFS
MLBr_02276|M.leprae_Br4923 TDDDADWVARVWRSGGWASWLVDRRPPFS
MAV_4582|M.avium_104 TDDDADWVARAWRGAGRLSRLIDRRAPFS
Mvan_2055|M.vanbaalenii_PYR-1 FRDR--MLKALYKKAQGPQHSF-------
Mflv_4291|M.gilvum_PYR-GCK FRDR--MLKALYKKAQGPQHSF-------
MSMEG_2308|M.smegmatis_MC2_155 FRDR--MLKALYKKAQGPQHVIKK-----
TH_4610|M.thermoresistible__bu FRDR--MLRALYKKH-GPRHTVK------
MAB_3406|M.abscessus_ATCC_1997 FRDR--MLKVLYKRAQGPGHKTSH-----
: : ::