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TSAAGRSAATGDSTAVDVVVVGAGPAGSSAAAWAARAGRDVLVIDSAQFPRDKACGDGLTPRAIAELRRL GLQSWLDGRIAHRGLRMSGFGADVEVAWPGPSFPSISSAVPRTELDERIRLVAVDDGAKMKLGVKAVSVE RGSGGRVTGVVLDTGEVVRCRDLIVADGARSTLGRALGREWHKETVYGVAIRGYIATPRSDEPWITSHLE LRSPAGEVLPGYGWIFPLGNGEVNIGVGALATAKRPADAALRPLMNYYAGLRRDEWGFSGDPRAGLSALL PMGGAVSGVAGPNWMLIGDAAACVNPLNGEGIDYGLETGRLAASLLGSGSYSAAWPALLHGHYARGFSIA RRLALLLTFPRFLPAAGPLAMRSSALMKTAVRVMGNFVTDEDEDAVARVWRGAGTLSRRMDARRPFT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0991 | - | - | 100% (418) | geranylgeranyl reductase |
| M. vanbaalenii PYR-1 | Mvan_2055 | - | 5e-40 | 32.99% (385) | geranylgeranyl reductase |
| M. vanbaalenii PYR-1 | Mvan_1194 | - | 4e-16 | 27.63% (333) | FAD dependent oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0576c | - | 1e-174 | 74.19% (403) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_5254 | - | 0.0 | 88.86% (404) | geranylgeranyl reductase |
| M. tuberculosis H37Rv | Rv0561c | - | 1e-174 | 74.19% (403) | oxidoreductase |
| M. leprae Br4923 | MLBr_02276 | - | 1e-172 | 73.76% (404) | putative FAD-linked oxidoreductase |
| M. abscessus ATCC 19977 | MAB_3929 | - | 1e-160 | 67.89% (408) | oxidoreductase |
| M. marinum M | MMAR_0910 | - | 1e-176 | 75.50% (400) | FAD-linked oxidoreductase |
| M. avium 104 | MAV_4582 | - | 1e-178 | 73.97% (411) | FAD dependent oxidoreductase, putative |
| M. smegmatis MC2 155 | MSMEG_1132 | - | 0.0 | 79.41% (408) | FAD binding domain-containing protein |
| M. thermoresistible (build 8) | TH_0132 | - | 1e-146 | 77.95% (322) | POSSIBLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_0663 | - | 1e-175 | 74.75% (400) | FAD-linked oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0576c|M.bovis_AF2122/97 ----------MSVDDSADVVVVGAGPAGSAAAAWAARAGRDVLVIDTATF
Rv0561c|M.tuberculosis_H37Rv ----------MSVDDSADVVVVGAGPAGSAAAAWAARAGRDVLVIDTATF
MMAR_0910|M.marinum_M ------METRVPRALGADLVVVGAGPAGSAAAAWAARAGRDVLVIDSAGF
MUL_0663|M.ulcerans_Agy99 ------METRVPRALGADLVVVGAGPAGSAAAAWAARAGRDVLVIDSAGF
MLBr_02276|M.leprae_Br4923 ----------MRVETSADVVVVGAGPAGSAAATWAARAGNDVIVIDSVCF
MAV_4582|M.avium_104 -------MCMTTAATRADLVVVGAGPAGSAAAAWAARAGHDVLVVDAARF
Mvan_0991|M.vanbaalenii_PYR-1 MTSAAGRSAATGDSTAVDVVVVGAGPAGSSAAAWAARAGRDVLVIDSAQF
Mflv_5254|M.gilvum_PYR-GCK MDTPA--VGAIRGSSGADVVVIGAGPAGSSAAAWAARSGRDVLVIDSAQF
MSMEG_1132|M.smegmatis_MC2_155 ------------MNTRADVVVVGAGPAGSAAAAWAARAGRDVVVVDAAQF
TH_0132|M.thermoresistible__bu --------------------------------------------------
MAB_3929|M.abscessus_ATCC_1997 ------------MQTSADLVVVGAGPAGSAAAAWAARSGREVVLVDSAVF
Mb0576c|M.bovis_AF2122/97 PRDKPCGDGLTPRAVAELHQLGLGKWLADHIRHRGLRMSGFGGEVEVDWP
Rv0561c|M.tuberculosis_H37Rv PRDKPCGDGLTPRAVAELHQLGLGKWLADHIRHRGLRMSGFGGEVEVDWP
MMAR_0910|M.marinum_M PRDKACGDGLTPRAIAELQQLGLGEWLAGRIQHRGLRMSGFGGEVEIGWP
MUL_0663|M.ulcerans_Agy99 PRDKACGDGLTPRAIAELQQLGLGEWLAGRIQHRGLRMSGFGGEVEIGWP
MLBr_02276|M.leprae_Br4923 PRDKACGDGLTPRAVAELKRLGLDDWLNTRIRHRGLRMSGFGGEVEVDWP
MAV_4582|M.avium_104 PRDKACGDGLTPRAVAECERLGLGGWLDSRIRHRGLRMSGFGAQVQVDWP
Mvan_0991|M.vanbaalenii_PYR-1 PRDKACGDGLTPRAIAELRRLGLQSWLDGRIAHRGLRMSGFGADVEVAWP
Mflv_5254|M.gilvum_PYR-GCK PRDKACGDGLTPRAVAELDRLGLRSWLDGRIAHRGLRMSGFGSDVEVPWP
MSMEG_1132|M.smegmatis_MC2_155 PRDKACGDGLTPRAVAELQRLGMASWLDTRIRHHGLRMSGFGADVEIPWP
TH_0132|M.thermoresistible__bu ----------------------------------------------VPWP
MAB_3929|M.abscessus_ATCC_1997 PRDKTCGDGLTPRAVEQLELLGLRPWLDEHIRYRGLRLHGFGGNLEVPWP
: **
Mb0576c|M.bovis_AF2122/97 GPSFPSYGSAVARLELDDRIRKVAEDTGARMLLGAKAVAVHHDSSRRVVS
Rv0561c|M.tuberculosis_H37Rv GPSFPSYGSAVARLELDDRIRKVAEDTGARMLLGAKAVAVHHDSSRRVVS
MMAR_0910|M.marinum_M GPSFPAYSSAVARLELDDRIRKVAEESGARMLLGTKAVAAHHDSSRRVVS
MUL_0663|M.ulcerans_Agy99 GPSFPAYSSAVARLELDDRIRKVAEESGARMLLGTKAVAAHHDSSRRVVS
MLBr_02276|M.leprae_Br4923 GPSFPSTSSAVPRLELDDRIRKVAENSGARMLLGTKAVSVYHDSSRRAAS
MAV_4582|M.avium_104 GPSFPSTGSAVARTELDDRIRRVAEDSGARMLLGTKAVGVQRDSSAAVTS
Mvan_0991|M.vanbaalenii_PYR-1 GPSFPSISSAVPRTELDERIRLVAVDDGAKMKLGVKAVSVERGSGGRVTG
Mflv_5254|M.gilvum_PYR-GCK GPSFPPTSSAVPRTELDERIRLVAVDDGAKMKLGVKAVDVERDSTGRVTG
MSMEG_1132|M.smegmatis_MC2_155 GPSFPATSSAVPRTELDDRIRSVAADDGAKMMLGTKVVDVTHDSSGRVDA
TH_0132|M.thermoresistible__bu GPSFPSTGSAGPRTELDDRIRMVAVDDGAKMMLGVKAAGVTHDSSGRVAS
MAB_3929|M.abscessus_ATCC_1997 GTSFGGTGSAVRRTELDDKIRQVAVDSGAKMAESTKAVDVERDSAGRITS
*.** .** * ***::** ** : **:* ..*.. . :.* .
Mb0576c|M.bovis_AF2122/97 LTLADGT---EVGCRQLIVADGARSPLGRKLGRRWHRETVYGVAVRGYLS
Rv0561c|M.tuberculosis_H37Rv LTLADGT---EVGCRQLIVADGARSPLGRKLGRRWHRETVYGVAVRGYLS
MMAR_0910|M.marinum_M LTLADRT---EVACRQLIVADGARSSLGRKLGRRWHQETVYGVAARGYLT
MUL_0663|M.ulcerans_Agy99 LTLADRT---EVACRQLIVADGARSSLGRKLGRRWHQETVYGVAARGYLT
MLBr_02276|M.leprae_Br4923 VTLADGT---EVGCRQLIIADGARSPLGRKLGRSWHQKTVYGVAARGYLT
MAV_4582|M.avium_104 LMLADGT---GVQCRQLIVADGARSSLGRTLGRRWHQETVYGVAARGYLS
Mvan_0991|M.vanbaalenii_PYR-1 VVLDTGE---VVRCRDLIVADGARSTLGRALGREWHKETVYGVAIRGYIA
Mflv_5254|M.gilvum_PYR-GCK VVLDSGE---LVRCSSLIVADGARSTLGRTLGRQWHKETVYGVAIRGYIG
MSMEG_1132|M.smegmatis_MC2_155 VVLDDGN---TVGCAQLIVADGARSTLGRVLGRTWHRETVYGVAIRGYIA
TH_0132|M.thermoresistible__bu VQLDNGT---EIRCTELIVADGARSTLGRALGRQWHQQTVYGIAIRAYAE
MAB_3929|M.abscessus_ATCC_1997 VRVLDDNGPGEIACKAVIVADGVRSTLGKILGREWHKDTVYAVAGRAYIE
: : : * :*:***.**.**: *** **:.***.:* *.*
Mb0576c|M.bovis_AF2122/97 TAYSDDPWLTSHLELRSPDGA---VLPGYGWIFPLGNGEVNIGVGALSTS
Rv0561c|M.tuberculosis_H37Rv TAYSDDPWLTSHLELRSPDGA---VLPGYGWIFPLGNGEVNIGVGALSTS
MMAR_0910|M.marinum_M TARSEDPWLTSHLELRSPDGA---VLPGYGWIFPLGNGEVNIGVGALSTT
MUL_0663|M.ulcerans_Agy99 TARSEDPWLTSHLELRSPDGA---VLPGYGWIFPLGNGEVNIGVGGLSTT
MLBr_02276|M.leprae_Br4923 TPRSDDLWLTSHLELRSPDGA---VLPGYGWIFPLGNGEVNIGVGALSTS
MAV_4582|M.avium_104 TPRADDPWLTSHLELRGPDGARDKVLPGYGWIFPLGNGEVNIGVGALSTS
Mvan_0991|M.vanbaalenii_PYR-1 TPRSDEPWITSHLELRSPAGE---VLPGYGWIFPLGNGEVNIGVGALATA
Mflv_5254|M.gilvum_PYR-GCK TPRSDEEWITSHLELRSPAGE---VLPGYGWIFPLGNGEVNIGVGALATS
MSMEG_1132|M.smegmatis_MC2_155 SPRASEPWITSHLELRSPEGK---VLPGYGWMFPLGNGEVNIGVGALATA
TH_0132|M.thermoresistible__bu SPRHDEPWITSHLELRSAEGE---LLPGYGWIFPLGNGEVNIGVGALSTA
MAB_3929|M.abscessus_ATCC_1997 SARGDEEWMTSHLELRSPEGD---VLPGYGWIFPLGGGQINIGVGALATS
:. .: *:*******.. * :******:****.*::*****.*:*:
Mb0576c|M.bovis_AF2122/97 RRPADLALRPLISYYTDLRRDEWGFTGQPRAVSSALLPMGGAVSGVAGSN
Rv0561c|M.tuberculosis_H37Rv RRPADLALRPLISYYTDLRRDEWGFTGQPRAVSSALLPMGGAVSGVAGSN
MMAR_0910|M.marinum_M KRPADLALRPLMSYYTDLRRDEWGFTGQPRAVASALLPMGGAVSGVAGPN
MUL_0663|M.ulcerans_Agy99 KRPADLALRPLMSYYTDLRRDEWGFTGQPRAVASALLPMGGAVSGVAGPN
MLBr_02276|M.leprae_Br4923 KRPADLALRSLISYYTDLRRHEWGFSGQPRAVSSALLPMGGAVSGVAGPN
MAV_4582|M.avium_104 RRPAELALRPLIDHYTDLRRDEWGFVGRPRAVASALLPMGGAVSGVAGPN
Mvan_0991|M.vanbaalenii_PYR-1 KRPADAALRPLMNYYAGLRRDEWGFSGDPRAGLSALLPMGGAVSGVAGPN
Mflv_5254|M.gilvum_PYR-GCK KRPADAALRPLLNYYTGLRRAEWGFEGDPRAPLSALLPMGGAVSRVAGPN
MSMEG_1132|M.smegmatis_MC2_155 KRPADAALRPLMSYYADLRREEWGLVGEPRAGLSALLPMGGAVSGVAGPN
TH_0132|M.thermoresistible__bu KRPADAALRPLLSFYTGLRRDEWGFPGPPRAALSALLPMGGAVSGVAGPN
MAB_3929|M.abscessus_ATCC_1997 KRPADAALRPLIEYYTELRREDFGLTGRLQSIASALLPMGGAVSGVAGPN
:***: ***.*:..*: *** ::*: * :: *********** ***.*
Mb0576c|M.bovis_AF2122/97 WMLIGDAAACVNPLNGEGIDYGLETGRLAAELLDSR---DLARLWPSLLA
Rv0561c|M.tuberculosis_H37Rv WMLIGDAAACVNPLNGEGIDYGLETGRLAAELLDSR---DLARLWPSLLA
MMAR_0910|M.marinum_M WMLIGDAAACVNPLNGEGIDYGLETGRLAAELLDSP---DLSQLWPSLLQ
MUL_0663|M.ulcerans_Agy99 WMLIGDAAACVNPLNGEGIDYGLDTGRLAAELLDSP---DLSQLWPSLLQ
MLBr_02276|M.leprae_Br4923 WMLIGDAAACVNPLNGEGIDYGLETGRLAAELLDLR---DLSYVWPSLLQ
MAV_4582|M.avium_104 WMLIGDAAACVNPLNGEGIDYGMETGRLAAGLLGCP---DLSQEWPALLR
Mvan_0991|M.vanbaalenii_PYR-1 WMLIGDAAACVNPLNGEGIDYGLETGRLAASLLGSG---SYSAAWPALLH
Mflv_5254|M.gilvum_PYR-GCK WMLIGDAAACVNPLNGEGIDYGLETGRLAVSLLGTG---SFEASWPALLH
MSMEG_1132|M.smegmatis_MC2_155 WMLIGDAAACVNPLNGEGIDYGLETGRLAAELMTSGGVTDYSSAWPTLLQ
TH_0132|M.thermoresistible__bu WMLIGDAAACVNPLNGEGIDYGLETGRFAAGLLGSG---DLSQAWPALLQ
MAB_3929|M.abscessus_ATCC_1997 WMLIGDAAACVNPLNGEGIDYGLETGHLAAEVLDAG---DYSQLWPQLLR
**********************::**::*. :: . ** **
Mb0576c|M.bovis_AF2122/97 DRYGRGFSVARRLALLLTFPRFLPTTGPITMRSTALMNIAVRVMSNLVTD
Rv0561c|M.tuberculosis_H37Rv DRYGRGFSVARRLALLLTFPRFLPTTGPITMRSTALMNIAVRVMSNLVTD
MMAR_0910|M.marinum_M AHYGRGFSVARRLALLLTYQRFLPTTGPVAMRSTALMKVAVRVMANLVTE
MUL_0663|M.ulcerans_Agy99 AHYGRGFSVARRLALLLTYQRFLPTTGPVAMRSTALMKVAMRVMANLVTE
MLBr_02276|M.leprae_Br4923 QHYGRGFSVARRLALLLTFKRCLPAIGPSAMRSTSLITIAVRVMANLVTD
MAV_4582|M.avium_104 EHYARGFSVARRLALLLTYQRFLPATGPVAMRSTTLMRIAVRVMANLVTD
Mvan_0991|M.vanbaalenii_PYR-1 GHYARGFSIARRLALLLTFPRFLPAAGPLAMRSSALMKTAVRVMGNFVTD
Mflv_5254|M.gilvum_PYR-GCK EHYARGFSVARRLALLLTFPRFLPVAGPVAMRSSTLMKIAVRVMGNFVTD
MSMEG_1132|M.smegmatis_MC2_155 EHYARGFSVARRLALLLTLPRFLQVTGPVAMRSATLMTIAVRVMGNLVTD
TH_0132|M.thermoresistible__bu RHYGHGFSVARRLASLLTRPRFLPLTGPVAMRSTKLMNIAVRVMGNLVTD
MAB_3929|M.abscessus_ATCC_1997 DRYGRSFSIARRLAALLTLPRFLPVMGPVGMHSAVLMRIAVRLMGNLVTD
:*.:.**:***** *** * * ** *:*: *: *:*:*.*:**:
Mb0576c|M.bovis_AF2122/97 DDRDWVARVWRGGGQLSRLVDRRPPFS
Rv0561c|M.tuberculosis_H37Rv DDRDWVARVWRGGGQLSRLVDRRPPFS
MMAR_0910|M.marinum_M EDSDWVARLWRGGGRASRLIDRRPPFH
MUL_0663|M.ulcerans_Agy99 EDSDWVARLWRGGGRASRLIDRRPPFH
MLBr_02276|M.leprae_Br4923 DDADWVARVWRSGGWASWLVDRRPPFS
MAV_4582|M.avium_104 DDADWVARAWRGAGRLSRLIDRRAPFS
Mvan_0991|M.vanbaalenii_PYR-1 EDEDAVARVWRGAGTLSRRMDARRPFT
Mflv_5254|M.gilvum_PYR-GCK EDEDAVARVWRGAGRLSGRIDERRPFV
MSMEG_1132|M.smegmatis_MC2_155 EDADWIARVWRTAGLASRRIDQRVPFS
TH_0132|M.thermoresistible__bu EDSDWVARVWRTAGAGSRRLDERPPFS
MAB_3929|M.abscessus_ATCC_1997 DDQDMIARAWRVAGGGSRRLDSRPPFS
:* * :** ** .* * :* * **