For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MAASMRGTAITARVGVALGVAIAVCLVTGLISHLIQHPQPWFDWPTRPVWLYRFTQGLHVASGIAAIPLV VVKLWSVWPKLFDRPVIGGPVRALERMSILVLVASVLFQLSTGLLNIAQWYVFGFFFTTAHYAMAYVAVG AVVVHIGVKLPVIRRALGEPLDDVARSGSLGPSRRTVLRGTWLAVGLATLVTAGQTVPLLRRVSVLAPRT GEGPQGVPVNRTAVAAGVLGSARSADYRLTVINGDRAQEFTVDELRAMPQATRRLPIVCVEGWSAEGQWS GVVLAHLVALVGASPDSDVRMISLEPPGPYSRTVLPARHARDDMTLVALDLNGEPLDLDHGYPCRLIAPS RPGVLQTKWLSRIEVVP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0889 | - | - | 100% (367) | oxidoreductase, molybdopterin binding |
| M. vanbaalenii PYR-1 | Mvan_2026 | - | 5e-11 | 31.16% (138) | oxidoreductase, molybdopterin binding |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0224 | - | 2e-70 | 39.55% (397) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_4320 | - | 5e-10 | 29.92% (127) | oxidoreductase, molybdopterin binding |
| M. tuberculosis H37Rv | Rv0218 | - | 3e-71 | 39.80% (397) | transmembrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4441 | - | 4e-08 | 30.71% (127) | putative oxidoreductase |
| M. marinum M | MMAR_0461 | - | 7e-67 | 39.29% (397) | hypothetical protein MMAR_0461 |
| M. avium 104 | MAV_2997 | - | 2e-65 | 39.00% (400) | oxidoreductase, molybdopterin binding |
| M. smegmatis MC2 155 | MSMEG_0998 | - | 1e-167 | 77.63% (371) | oxidoreductase, molybdopterin binding |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_1110 | - | 6e-67 | 39.45% (398) | hypothetical protein MUL_1110 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0889|M.vanbaalenii_PYR-1 ---------------------------------------------MAASM
MSMEG_0998|M.smegmatis_MC2_155 -------------------------------------------------M
Mb0224|M.bovis_AF2122/97 --------MSDPARGAEAEDAYGFPAGLWRWLQRHPPPALHRLTRFRSPL
Rv0218|M.tuberculosis_H37Rv --------MSDPARGAEAEDAYGFPAGLWRWLQRHPPPALHRLTRFRSPL
MMAR_0461|M.marinum_M ---MNCPAEDDPERELEPEPAHGFPARLWRTLERHPPPGVRRLAAFRSPL
MUL_1110|M.ulcerans_Agy99 ---MNCPAEDDPERELEPEPAHGFPARLWRTLERHPPPGVRRLAAFRSPL
MAV_2997|M.avium_104 ---------MKPTR----TTGRSFPERLWR-----------------SPL
Mflv_4320|M.gilvum_PYR-GCK MTTPGVRAAGGVAAAAVAVGVASLVGAAFGPEADVRTAVGSSVIDLTPGP
MAB_4441|M.abscessus_ATCC_1997 MEHAARRIIAGLIAAAAALAVGQLAAAAVAPDSAPFYAVGNTVVDHTPAA
Mvan_0889|M.vanbaalenii_PYR-1 RGTAITARVGVALGVAIAVCLVTGLISHLIQHPQ--------------PW
MSMEG_0998|M.smegmatis_MC2_155 RGTAITARVGLALGVAVAVCFVTGLISHFIQHPQ--------------PW
Mb0224|M.bovis_AF2122/97 RGPWLTSVFGLVLLVALPFVIITGLLSYIAYAPQLGQAIPGDVGWLRLPA
Rv0218|M.tuberculosis_H37Rv RGPWLTSVFGLVLLVALPFVIITGLLSYIAYAPQLGQAIPGDVGWLRLPA
MMAR_0461|M.marinum_M RGPWLTSVFGLVLLVAMPIVILTGLLSYIAYAPQFGQAIPADVGWLRLPG
MUL_1110|M.ulcerans_Agy99 RGPWLTSVFGLVLLVAMPIVILTGLLSYIAYAPQFGQAIPADVGWLRLPG
MAV_2997|M.avium_104 RGPWLTSVFGSILLVTLPVVIVTGLLSYIAYGPRFGQAVPAEVGWLRLPV
Mflv_4320|M.gilvum_PYR-GCK VKEWAIATFGTADKLALAVMVLLTIAAIAAVAGLAETRRRPVCSIAIVIA
MAB_4441|M.abscessus_ATCC_1997 VREWVIGIFGTSDKAVLFACLTVIIALLAALAGLVEGERR-YGTVLIGLL
. .* .: . :
Mvan_0889|M.vanbaalenii_PYR-1 FDWPTRPVWLYRFTQGLHVASGIAAIPLVVVKLWSVWPKLFDRPVIGGPV
MSMEG_0998|M.smegmatis_MC2_155 FFWPTRPVWLYRLTQGLHVISGIAAIPLIVVKLWSVWPKLFERPVIGGFV
Mb0224|M.bovis_AF2122/97 FTWPTRPSWLYRLTQGLHVGLGLVIIPVVLAKLWSVIPRLFVWPPARSIA
Rv0218|M.tuberculosis_H37Rv FTWPTRPSWLYRLTQGLHVGLGLVIIPVVLAKLWSVIPRLFVWPPARSIA
MMAR_0461|M.marinum_M FDWPAHPSWLYRLTQGLHVGLGLVLIPVVLAKLWSVIPKLFVWPPARSIA
MUL_1110|M.ulcerans_Agy99 FDWPAHPSWLYRLTQGLHVGLGLVLIPVVVAKLWSVIPKLFVWPPARSIA
MAV_2997|M.avium_104 FDWPTDPSWLYRATQGLHVGLGLVLIPVVLAKLWSVIPRLFAWPPARSIA
Mflv_4320|M.gilvum_PYR-GCK GGIGCAAVLSRAGSTGADIIPTLIGTACGVAVLRILQSDRLDGPSSETGT
MAB_4441|M.abscessus_ATCC_1997 GVFGAVAAVTRPAGTFAWIWPSVIAAVAGALVLGTLVHR------AQSQA
. : : * : .
Mvan_0889|M.vanbaalenii_PYR-1 RALERMSILVLVASVLFQLSTGLLNIAQWYVFGFFFTTAHYAMAYVAVGA
MSMEG_0998|M.smegmatis_MC2_155 RQLERASILVLVGAMLFQLSTGIMNIAQWYAFEFFFTTSHYAMAYVAAGA
Mb0224|M.bovis_AF2122/97 QVLERLSVLMLVGGILFQIVTGVLNIQYDYIFGFSFYTGHYFGAWVFIAG
Rv0218|M.tuberculosis_H37Rv QVLERLSVLMLVGGILFQIVTGVLNIQYDYIFGFSFYTGHYFGAWVFIAG
MMAR_0461|M.marinum_M TLLERLSLLMLVGGVLFEIVTGVLNIQYDYIFGFSFYDGHYFGAWVFIAG
MUL_1110|M.ulcerans_Agy99 TLLERLSLLMLVGGVLFEIVTGVLNIQYDYIFGFSFYDGHYFGAWVFIAG
MAV_2997|M.avium_104 QLLERVSVLMLVGGILFEMVTGVLNIQYDYIFGFSFYTAHYFGAWVFVIG
Mflv_4320|M.gilvum_PYR-GCK DPGRRRSLLTIGLLAAGAVSGVAGVVISRLASSVAGDRDAFALPRIDTPA
MAB_4441|M.abscessus_ATCC_1997 VPDRRRFFGTAAVFALGSAGLYWLGTRWSKGTVVAAERREATVPAPVAPA
.* . . . .
Mvan_0889|M.vanbaalenii_PYR-1 VVVHIGVKLP---------VIRRALGEPLDDVAR------------SGSL
MSMEG_0998|M.smegmatis_MC2_155 VLVHIAVKLP---------VIRRALGEPLEQPSGE------LPGVPGLSR
Mb0224|M.bovis_AF2122/97 FLLHIVVKIPHMVTGLRSIPMREVLGTNVADTRAQPCDPDGLVSVNPGEA
Rv0218|M.tuberculosis_H37Rv FLLHIVVKIPHMVTGLRSIPMREVLGTNVADTRAQPCDPDGLVSVNPGEA
MMAR_0461|M.marinum_M FLMHIAVKMPKMITGLRSFSIREVLRTNVTDTRPEPPDASGLVSEDPAEP
MUL_1110|M.ulcerans_Agy99 FLMHIAVKMPKMITGLRSFSIREVLRTNVTNTRPEPPDASGLVSADPAEP
MAV_2997|M.avium_104 FLMHVTIKGRRMWAGLRSMSMRAVLRTPAADTEPEPWRPGGLAAAEPGPA
Mflv_4320|M.gilvum_PYR-GCK APIPESVQPKGVELPSWVTGNDDFYRIDTALSVPQLSRSEWRLRIHGMVD
MAB_4441|M.abscessus_ATCC_1997 PPLPEGIDVKGAVP--YITSNTDFYRIDTALRVPQVSTAEWQLNIHGMVD
: :.
Mvan_0889|M.vanbaalenii_PYR-1 G--PSRRTVLRGTWLAVGLATLVTAGQTVP-LLRRVSVLAPRTG---EGP
MSMEG_0998|M.smegmatis_MC2_155 G--LTRRTVLRGTWLAVAVATVATAGQTVP-LLRKVSVLAPRTG---QGP
Mb0224|M.bovis_AF2122/97 T--LSRRGALGLVGAGVLLIGVLTVGQTLGGFTRKAALLLPRGR-VVSPG
Rv0218|M.tuberculosis_H37Rv T--LSRRGALGLVGAGVLLIGVLTVGQTLGGFTRKAALLLPRGR-VVSPG
MMAR_0461|M.marinum_M T--VSRRGALALVGSGVLLLGVLTVGQTLGGPLRNIALLLPRGR-PAQGN
MUL_1110|M.ulcerans_Agy99 T--VSRRGALALVGSGVLLLGVLTVGQTLGGPLRNIALLLPRGR-PAQGN
MAV_2997|M.avium_104 T--MSRRGALALVGGGALFLALITAGQTLGGRTRPAALLLPHGRGRGSGA
Mflv_4320|M.gilvum_PYR-GCK REVTFTYEDLDRFEVVEKVITLTCVSNPVGGELISNAVWTGYRVKDLLAE
MAB_4441|M.abscessus_ATCC_1997 RPRTLMWADLNAMAATQRAVTLTCVSNEIGGNLIGNAVWTGFPIKPILES
* : ..: : ::
Mvan_0889|M.vanbaalenii_PYR-1 QGVPVNRTAVAAGVLGSARSADYRLTVINGDRAQEFTVDELRAMPQAT--
MSMEG_0998|M.smegmatis_MC2_155 QGVPVNRSAIAAGVLRTARSPQYRLTVTDGAVSRAFTLEDLQAMPQVT--
Mb0224|M.bovis_AF2122/97 -DFPVNKTAAAAGITAEAIGPDWRLVLRGGPAEVVLDRATLAGLPQRT--
Rv0218|M.tuberculosis_H37Rv -DFPVNKTAAAAGITAEAIGPDWRLVLCGGPAEVVLDRATLAGLPQRT--
MMAR_0461|M.marinum_M REFPVNKTAAVAGITPEAVGPAWRLVLRGGPNEVVLDRAALAGLPQHT--
MUL_1110|M.ulcerans_Agy99 REFPVNKTAAVAGITPEAVGPAWRLVLRGGPNEVVLDRAALAGLPQHT--
MAV_2997|M.avium_104 NDFDVNRTAAAAGIAAADIGARWRLTLGGGARPVVLDRASLLAMPQHT--
Mflv_4320|M.gilvum_PYR-GCK AGVRSGADMVLSMSVDGWTAGTPVEALT-GDDALLAIGMNGEPLPIEHGY
MAB_4441|M.abscessus_ATCC_1997 VGVHPDADMLLSKSVDGWTAGTPLQVLTDGRDAILAIAMNGTPLPVEHGY
. . : . .: * :*
Mvan_0889|M.vanbaalenii_PYR-1 -RRLPIVCVEGWSAEGQWSG-------VVLAHLVALVGASPDSDVRMISL
MSMEG_0998|M.smegmatis_MC2_155 -HRLPIACVEGWSVDAEWTG-------AVLADLLATVGASPDSDVRMISL
Mb0224|M.bovis_AF2122/97 -ARLPLACVEGWSAVRTWSG-------VPLAELALLAGVPAARSARVTSL
Rv0218|M.tuberculosis_H37Rv -ARLPLACVEGWSAVRTWSG-------VPLAELALLAGVPAARSARVTSL
MMAR_0461|M.marinum_M -ARLPIACVEGWSTVQTWTG-------VRLSELARRAGVAAPRSARVTSL
MUL_1110|M.ulcerans_Agy99 -ARLPIACVEGWSTVQTWTG-------VRLSELARRAGVAAPRSARVTSL
MAV_2997|M.avium_104 -AVLPIACVEGWSTTQAWTG-------VRLADLARLAGVPAPRSARVSSV
Mflv_4320|M.gilvum_PYR-GCK PARLVVPGLYGYVSATKWVTALELTRFDRAQAYWTRLGWSARGPIKTASR
MAB_4441|M.abscessus_ATCC_1997 PVRQVVPGLYGYVSATKWVVDWEITRFDKADAYWTIRGWSARGPIKTGCR
: : *: * * .. : .
Mvan_0889|M.vanbaalenii_PYR-1 EPPGPYSRTVLPARHARDDMTLVALD-LNGEPLDLDHG-YPCRLIAPSRP
MSMEG_0998|M.smegmatis_MC2_155 EPPGPYSRTTLPARHVRDSQTLIALR-LNGEALDLDHG-YPCRLIAPTRP
Mb0224|M.bovis_AF2122/97 QRGGAFGEAKLAANQIADPDALLALR-VDGADLSLNHG-YPARIIVPALP
Rv0218|M.tuberculosis_H37Rv QRGGAFGEAKLAANQIADPDALLALR-VDGADLSLDHG-YPARIIVPALP
MMAR_0461|M.marinum_M QRGGAFGEATLQGNQVGAPDALLALR-VNGEDLPLDHG-YPARIIVPALP
MUL_1110|M.ulcerans_Agy99 QRGGAFGEATLQGNQVGASDALLALR-GNGEDLPLDHG-YPARIIVPALP
MAV_2997|M.avium_104 ERVGAFNAATLHGSQVLHPDALLALR-VNGAELSVDHG-FPARIVVPALP
Mflv_4320|M.gilvum_PYR-GCK VDVPRSGQDVALGPVTFGGVAWAQNRGVRSVEVQMDDGPWEQATLGDSYS
MAB_4441|M.abscessus_ATCC_1997 IDTPRTGDRLGTGTQIVAGTAWAQHRGIATVEVQIDDGPWLPARLAPEYS
. . : : ::.* : : .
Mvan_0889|M.vanbaalenii_PYR-1 GVLQTKWLSRIEVVP-----------------------------------
MSMEG_0998|M.smegmatis_MC2_155 GVLQTKWLSRIEVVP-----------------------------------
Mb0224|M.bovis_AF2122/97 GVHNTKWVAGIEFHKR----------------------------------
Rv0218|M.tuberculosis_H37Rv GVHNTKWVAGIEFHKR----------------------------------
MMAR_0461|M.marinum_M GVHNTKWVASINFEAG----------------------------------
MUL_1110|M.ulcerans_Agy99 GVHNTKWVASINFEAG----------------------------------
MAV_2997|M.avium_104 GVHNTKWVGAIDFRAGSDA-------------------------------
Mflv_4320|M.gilvum_PYR-GCK GDTWRMWSYAWEARDTGFHTITVRATDDSGYTQTPDRADPVPDGATGWHS
MAB_4441|M.abscessus_ATCC_1997 VDTWRQWWFAWQA-TAGEHIITARATDGTGAVQTDQIASPVPDGATGYPK
* :
Mvan_0889|M.vanbaalenii_PYR-1 -------
MSMEG_0998|M.smegmatis_MC2_155 -------
Mb0224|M.bovis_AF2122/97 -------
Rv0218|M.tuberculosis_H37Rv -------
MMAR_0461|M.marinum_M -------
MUL_1110|M.ulcerans_Agy99 -------
MAV_2997|M.avium_104 -------
Mflv_4320|M.gilvum_PYR-GCK ITFAVK-
MAB_4441|M.abscessus_ATCC_1997 RLVTVAA