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MTVLPGGMTASRREPMAEFLERQRTAFIADGPPDAALRRNRIDRLMALVLDNADDFVDAMAADYGTRPRA GTLFTEVMGMISVIEHTRTHVRQWMKPVKLMRPARPLGLRAEVQPSPLGVVGIIGPWNFPLNLVVLPAAA AFAAGNRVMIKMSEVTPRTAELMQSVAPTYFDATELAVITGDAEVAADFAALPFDHLFFTGSPGVGALVQ QAAAANLVPVTLELGGKNPVVVAPGADLGRAAARIAQGRMINGGQVCVCPDYVFVPADRMEKFVAVARDT LRGMFGSIVDNADYCSSVNEANFDRVVGLIEDAREKGARVESVAPPSETLPDRKSRKIAPTILLDVDDSM RIADEETFGPVLTVRPYERLADVVDYVNARPAPLVAYWFGPDDTDFRSFVEHTRSGGVARNDFAAQMIPS AAPFGGVGRSGMGAYHGKAGFDAFSHYRTVVGSDLPFTITGRAAPPFPRSMQMTTTLALRLARRRTRRRL RNR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2009 | - | - | 100% (493) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0105 | - | 3e-71 | 35.27% (465) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0771 | - | 1e-42 | 33.33% (414) | aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0152 | - | 5e-69 | 33.47% (481) | aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4336 | - | 0.0 | 82.19% (483) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0147 | - | 5e-69 | 33.47% (481) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02639 | - | 3e-70 | 33.91% (466) | aldehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4605c | - | 1e-65 | 35.66% (415) | aldehyde dehydrogenase |
| M. marinum M | MMAR_0359 | - | 1e-72 | 34.97% (489) | aldehyde dehydrogenase (NAD+) dependent |
| M. avium 104 | MAV_5095 | - | 3e-70 | 38.62% (435) | fatty aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2242 | - | 0.0 | 72.97% (481) | coniferyl aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_4463 | - | 0.0 | 71.73% (481) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_4760 | - | 4e-72 | 36.20% (453) | aldehyde dehydrogenase (NAD+) dependent |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0359|M.marinum_M ---------------MMTTESVAAKAQERGANGAGGVRAPSDDSKPTDVG
MUL_4760|M.ulcerans_Agy99 ---------------MMTTESVAAKAQERGANGAGGVRAPSDDSKPTDVG
Mb0152|M.bovis_AF2122/97 MSDRVKAVAPPDGRTMMTTESVARKTQ-KSETEAPREPAPVSDEKQTDVA
Rv0147|M.tuberculosis_H37Rv MSDRVKAVAPPDGRTMMTTESVARKTQ-KSETEAPREPAPVSDEKQTDVA
MLBr_02639|M.leprae_Br4923 MLSRRAVGSCGKEEALMITESVAQKTA------VSKSGVPPHTPPGVNSE
MAB_4605c|M.abscessus_ATCC_199 ----------------MTTEISTPADQ-------------HAASEPSRIP
MAV_5095|M.avium_104 ----------------MT----------------------IHAAEATGSA
Mvan_2009|M.vanbaalenii_PYR-1 ----------------MTVLPG-GMTAS----------------RREPMA
Mflv_4336|M.gilvum_PYR-GCK ----------------MTTT---EQVTV----------------TAESMS
MSMEG_2242|M.smegmatis_MC2_155 ----------------MSTIDQRAEKHS----------------RQGGAA
TH_4463|M.thermoresistible__bu ----------------MSTVDERIDSPPD---------------ERSVLR
*
MMAR_0359|M.marinum_M ATVARLRQTFASGRTRNVQWRKQQLLQLQRLMEENEDAITKALVEDLD-R
MUL_4760|M.ulcerans_Agy99 ATVARLRQTLASGRTRNVQWRKQQLLQLQRLMEENEDAITKALVEDLD-R
Mb0152|M.bovis_AF2122/97 KTVARLRKTFASGRTRSVEWRKQQLRALQKLMDENEDAIAAALAEDLD-R
Rv0147|M.tuberculosis_H37Rv KTVARLRKTFASGRTRSVEWRKQQLRALQKLMDENEDAIAAALAEDLD-R
MLBr_02639|M.leprae_Br4923 ATVVRLRQTFASGRTRSVDWRTQQLRALQALMVENEGAIAQALADDLD-R
MAB_4605c|M.abscessus_ATCC_199 GIVRGLRETFATGRTREYQWRKAQLVGLERLFKENEAAIAKALNDDLG-R
MAV_5095|M.avium_104 SVITDLRRVFSTGRTGDLHWRLGQLRGIERFVDERETEIAAALADDLG-R
Mvan_2009|M.vanbaalenii_PYR-1 EFLERQRTAFIADGPPDAALRRNRIDRLMALVLDNADDFVDAMAADYGTR
Mflv_4336|M.gilvum_PYR-GCK SMLERQRAAFVADGPPDVALRRNRIDRLMALVLDNVDDFVDAMGRDFGTR
MSMEG_2242|M.smegmatis_MC2_155 DVLAAQRRSFLDDGPPDIALRRNRIDRLLAMVLDNAEDFVTATASDYGTR
TH_4463|M.thermoresistible__bu TVLDRQRRAFEAEGPPSAAVRRDRIDRLMALLLENTDAFVDAMAADYGTR
: * : . . * :: : :. :. :. * * . *
MMAR_0359|M.marinum_M NPVEAFIADIATTIAEAKYAAKKVRKWMRRKHVL-LEAPQLPGRGWVQYE
MUL_4760|M.ulcerans_Agy99 NPVEAFIADIATTIAEAKYAAKKVRKWMRRKHVL-LEAPQLPGRGWVQYE
Mb0152|M.bovis_AF2122/97 NPFEAYLADIATTSAEAKYAAKRVRRWMRRRYLL-LEVPQLPGRGWVEYE
Rv0147|M.tuberculosis_H37Rv NPFEAYLADIATTSAEAKYAAKRVRRWMRRRYLL-LEVPQLPGRGWVEYE
MLBr_02639|M.leprae_Br4923 NPVEAFIVDIAATVSEAKYAAKKVRKWMRRKYRF-LEVSQLPGRGWVEYE
MAB_4605c|M.abscessus_ATCC_199 SSAEAWIADVVGTVVEITYARKHLKRWMRRKRVRGLPMAQQPAKAYVQSE
MAV_5095|M.avium_104 SPAEAWLGDVASTKGEAVYARKHLKKWMRRRRQS-LPLAQLPGRAWVQYD
Mvan_2009|M.vanbaalenii_PYR-1 PRAGTLFTEVMGMISVIEHTRTHVRQWMKPVKLM-RPARPLGLRAEVQPS
Mflv_4336|M.gilvum_PYR-GCK PKQGSLFTEIMGMISVIEHTRSHVPQWMKPNRMM-RPARMFGLRAEVEPT
MSMEG_2242|M.smegmatis_MC2_155 SRSAAFFAEILGMISVIEHTRSNLPRWMRSTRLM-RAARLAGLRAEVVPS
TH_4463|M.thermoresistible__bu SKAGSLFTEVLGVVPVVEHTRRHVAQWMRTTPLL-RAARLVGLRAEVQPT
: : :: :: .: :**: :. *
MMAR_0359|M.marinum_M PYGTVLIIGAWNYPFYLTLGPAVGAIAAGNTVVLKPSEIAEASSRLMAEL
MUL_4760|M.ulcerans_Agy99 PYGTVLIIGAWNYPFYLTLGPAVGAIAAGNTVVLKPSEIAEASSRLMAEL
Mb0152|M.bovis_AF2122/97 PYGTVLIIGAWNYPFYLTLGPAVGAIAAGNAVVLKPSEIAAASAHLMTEL
Rv0147|M.tuberculosis_H37Rv PYGTVLIIGAWNYPFYLTLGPAVGAIAAGNAVVLKPSEIAAASAHLMTEL
MLBr_02639|M.leprae_Br4923 PYGTVLIIGAWNYPFYLTLVPAVGAIAAGNTMVLKPSEVAAASAHLMAEL
MAB_4605c|M.abscessus_ATCC_199 PYGTTLIIGAWNFPFYLTIGPLVGAVAAGNTVALKPSELAPACSALMAKL
MAV_5095|M.avium_104 PLGVVLIIGPWNYPLYLSLAPLVAAVAAGNCAVIKPSELAPATSALLARW
Mvan_2009|M.vanbaalenii_PYR-1 PLGVVGIIGPWNFPLNLVVLPAAAAFAAGNRVMIKMSEVTPRTAELMQSV
Mflv_4336|M.gilvum_PYR-GCK PLGVVGVIGPWNFPLNLVVLPAVAAFAAGNRVMIKMSEVTPRTAELMRRL
MSMEG_2242|M.smegmatis_MC2_155 PVGVVGVIGPWNFPVQLTVLPAAAAFAAGNRVMIKMSEVTPRTAEAMADL
TH_4463|M.thermoresistible__bu PLGVVGIIGPWNFPVNLVVLPAAAAFAAGNRVMIKMSEITGRTAELMKTL
* *.. :**.**:*. * : * ..*.**** :* **:: : :
MMAR_0359|M.marinum_M VPRYLDRDAIAVIEGDGAVSQELIGQGLDRVMFTGGTEIGRKVYEGAAPH
MUL_4760|M.ulcerans_Agy99 VPRYLDPDAIAVIEGDGAVSQELIGQGLDRVMFTGGTEIGRKVYEGAAPH
Mb0152|M.bovis_AF2122/97 VYRYLDTEAIAVVQGDGAVSQELIAQGFDRVMFTGGTEIGRKVYEGAAPH
Rv0147|M.tuberculosis_H37Rv VYRYLDTEAIAVVQGDGAVSQELIAQGFDRVMFTGGTEIGRKVYEGAAPH
MLBr_02639|M.leprae_Br4923 VPRYLDNDAIAVIEGGGAVSQELIAQGLDRVMFTGGTEIGRKVYEGAASH
MAB_4605c|M.abscessus_ATCC_199 LPQYLDPHAVVVVEGDGYVTQELLAQGFDKAMFTGGTEIGKRILEGAAPH
MAV_5095|M.avium_104 LPQYVDPEAVRVVEGDADVTQQLLATGFDHVLFTGGTEVGKKIMAAAAPT
Mvan_2009|M.vanbaalenii_PYR-1 APTYFDATELAVITGDAEVAADFAALPFDHLFFTGSPGVGALVQQAAAAN
Mflv_4336|M.gilvum_PYR-GCK SAEYFEPTELCVVTGGADVAAEFAALPFDHLFFTGSPSVGVLVQRAAAAN
MSMEG_2242|M.smegmatis_MC2_155 APRYFDQRELAVITGGPELAAEFSALPFDHLFFTGSPAIGAVVGRAAAAN
TH_4463|M.thermoresistible__bu APTYFTPDELTVATGGPDVAAEFASLPFDHLFFTGSPTVGGLVQRAAADN
*. : * *. :: :: . :*: :***.. :* : .**
MMAR_0359|M.marinum_M LTPVTLELGGKSPVIVAADADIDVAAKRIAWIKLLNGGQTCVAPDYVLAD
MUL_4760|M.ulcerans_Agy99 LTPVTLELGGKSPVIVAADADIDVAAKRIAWIKLLNGGQTCVAPDYVLAD
Mb0152|M.bovis_AF2122/97 LTPVTLELGGKSPVIVAADADVDVAAKRIAWIKLLNAGQTCVAPDYVLAD
Rv0147|M.tuberculosis_H37Rv LTPVTLELGGKSPVIVAADADVDVAAKRIAWIKLLNAGQTCVAPDYVLAD
MLBr_02639|M.leprae_Br4923 LTPVTLELGGKSPVIVAVDADIDVAAKRIAWIKILNAGQTCVAPDYVLAA
MAB_4605c|M.abscessus_ATCC_199 LTPVALELGGKSPVYVASDANIEVAARRIGYMKGLNSGQVCLAPDYVIAD
MAV_5095|M.avium_104 LTPVTLELGGKSPVIVTADADIDVAARRIAWVKLLNSGQTCIAPDYVLAD
Mvan_2009|M.vanbaalenii_PYR-1 LVPVTLELGGKNPVVVAPGADLGRAAARIAQGRMINGGQVCVCPDYVFVP
Mflv_4336|M.gilvum_PYR-GCK LVPVTLELGGKNPVVVGPGADMRRAATRIAQGRMINGGQVCVCPDYVFVP
MSMEG_2242|M.smegmatis_MC2_155 LVPVTLELGGKNPVVVAPGADITRAATRIAQARMVNGGQVCVCPDYVFVP
TH_4463|M.thermoresistible__bu LVPVTLELGGKNPVVVAPNADIGRSATRLAQARMVNGGQVCVCPDYVLVP
*.**:******.** * .*:: :* *:. : :*.**.*:.****:.
MMAR_0359|M.marinum_M ATIRDELVGKIGAAVTKFRSQDDPDG--LRIVNRRQFDRLSGYIAAAESE
MUL_4760|M.ulcerans_Agy99 ATIRDELVGKIGAAVTKFRSQDDPDG--LRIVNRRQFDRLSGYIAAAESE
Mb0152|M.bovis_AF2122/97 ATVRDELVSKITAALTKFRSG-APQG--MRIVNQRQFDRLSGYLAAAKTD
Rv0147|M.tuberculosis_H37Rv ATVRDELVSKITAALTKFRSG-APQG--MRIVNQRQFDRLSGYLAAAKTD
MLBr_02639|M.leprae_Br4923 APIRDELVNKIGFAIAKFRSQDDPSG--MRIVNQRQFDRLCGYLAGVQS-
MAB_4605c|M.abscessus_ATCC_199 ASIRDELVEKIKESWEQFQADREDKG--LRVLNQRQFDRLVGYLAATEG-
MAV_5095|M.avium_104 HRVVKELVGKLVANMRDFRADQRNPA--LPIVNQRQFDRLVSLIDVTDG-
Mvan_2009|M.vanbaalenii_PYR-1 ADRMEKFVAVARDTLRGMFGSIVDNADYCSSVNEANFDRVVGLIEDAREK
Mflv_4336|M.gilvum_PYR-GCK AARIDAFVAVARETLQAMFPTIVANDDFCSSVNEANFERVVGLIEDARAK
MSMEG_2242|M.smegmatis_MC2_155 DRHVDEFVEVARGTLRRMFPTITDNPDYCSSVNRSNFDRVVGLIADARAR
TH_4463|M.thermoresistible__bu EQRVQAFVDGLLSQWRTMFPTIIDNGDYCSAVNDANFDRVLSLIEDARER
. :* : :* :*:*: . : .
MMAR_0359|M.marinum_M AKAGGKCKVEVGGKCTAESLRIQPTVVVDPDPSGPVMTNEIFGPILPVLT
MUL_4760|M.ulcerans_Agy99 AKAGGKCKVEVGGKCTAESLRIQPTVVVDPDPSGPVMTNEIFGPILPVLT
Mb0152|M.bovis_AF2122/97 AAADG-GGVVVGGDCDASNLRIQPTVVVDPDPDGPLMSNEIFGPILPVVT
Rv0147|M.tuberculosis_H37Rv AAADG-GGVVVGGDCDASNLRIQPTVVVDPDPDGPLMSNEIFGPILPVVT
MLBr_02639|M.leprae_Br4923 -AAGGKGVVVVGGKCDASTLRIQPTVIVDPDPEGPLMTKEIFGPILPVLT
MAB_4605c|M.abscessus_ATCC_199 -------QVAVGGASDAESLTIEPTIVVDPDADEPLMQEEIFGPILPIVT
MAV_5095|M.avium_104 -------KVVAGGRADATTLRIEPTVIVDPPPNDPVMAEEIFGPILPVLS
Mvan_2009|M.vanbaalenii_PYR-1 GARVESVAPPSETLPDRKSRKIAPTILLDVDDSMRIADEETFGPVLTVRP
Mflv_4336|M.gilvum_PYR-GCK GARVESVAPAGESLPDPGTRKIAPTILRDVDDSMLIASEETFGPVLTVRP
MSMEG_2242|M.smegmatis_MC2_155 GARVESIVPVGEVLPDPVTRKIPPTIIRDVDDRMRINDEEVFGPVLAVRG
TH_4463|M.thermoresistible__bu GATVQQAVPDGESLPDRATRKIPPTVIRDVDDDMRIAAEEVFGPVLTVRG
. * **:: * : :* ***:*.:
MMAR_0359|M.marinum_M VKSLDEAIGFVNSRPKPLSAYLFTKSREIRERVINEVPAGGMMVNHLAFQ
MUL_4760|M.ulcerans_Agy99 VKSLDEAIGFVNSRPKPLSAYLFTKSREIRERVINEVPAGGMMVNHLAFQ
Mb0152|M.bovis_AF2122/97 VKSLDDAIRFVNSRPKPLSAYLFTKSRAVRERVIREVPAGGMMVNHLAFQ
Rv0147|M.tuberculosis_H37Rv VKSLDDAIRFVNSRPKPLSAYLFTKSRAVRERVIREVPAGGMMVNHLAFQ
MLBr_02639|M.leprae_Br4923 VQSLDEAIGFINARPKPLAAYLFTKSRKTRDRVIKEVSAGGMLVNHLAIQ
MAB_4605c|M.abscessus_ATCC_199 AETLDAAIDFINSRPKPLAAYAFTESKYTANRYAAEVPAGGMVINHLLYH
MAV_5095|M.avium_104 VESLDDAVRFVNARPKSLALYIFATGKVGRD-LVDRIPSGGAVINHVAMH
Mvan_2009|M.vanbaalenii_PYR-1 YERLADVVDYVNARPAPLVAYWFGPDDTDFRSFVEHTRSGGVARNDFAAQ
Mflv_4336|M.gilvum_PYR-GCK YEKLADVVEYVNARPAPLVTYWFGPDDHDFRSFVRQTRSGGVARNDFAAQ
MSMEG_2242|M.smegmatis_MC2_155 YSSLASTIDYINSRPSPLVAYWFGPDDADFRHFVDHTRSGGVARNDFAAH
TH_4463|M.thermoresistible__bu YRRLDDAIAYVNARPSPLVAYWFGPDDADFRTFVRRTRSGGVARNDFAAQ
* .: ::*:** .* * * . . :** *.. :
MMAR_0359|M.marinum_M VSTAKLPFGGVGASGMGAYHGKWGFDEFSHRKSVLTKPTRPDLSNIIYPP
MUL_4760|M.ulcerans_Agy99 VSTAKLPFGGVGASGMGAYHGKWGFDEFSHRKSVLTKPTRPDLSNIIYPP
Mb0152|M.bovis_AF2122/97 VSTAKLPFGGVGASGMGAYHGRWGFEEFSHRKSVLTKPTRPDLSSFIYPP
Rv0147|M.tuberculosis_H37Rv VSTAKLPFGGVGASGMGAYHGRWGFEEFSHRKSVLTKPTRPDLSSFIYPP
MLBr_02639|M.leprae_Br4923 VLTAKLPFGGVGESGIGAYHGKWGFDEFSHRKSVLTKPTRPDLSSFIYPP
MAB_4605c|M.abscessus_ATCC_199 AVIPKLPFGGVGASGMGAYHGKAGFDEFSHRKSTLYKSTALDLK-LPYPP
MAV_5095|M.avium_104 CLVPALPFGGVGASGMGAYHGKWGFETLSHRRAVLSKSPRPDPR-LVYPP
Mvan_2009|M.vanbaalenii_PYR-1 MIPSAAPFGGVGRSGMGAYHGKAGFDAFSHYRTVVGSDLPFTITGRAAPP
Mflv_4336|M.gilvum_PYR-GCK MIPSAAPFGGVGRSGMGAYHGKAGFDAFSHYRTVVGSDLPFTITGRAAPP
MSMEG_2242|M.smegmatis_MC2_155 MIPSSAPFGGVGRSGMGAYHGKAGFDAFSHHRTVVGTDLPFSITGRAALP
TH_4463|M.thermoresistible__bu MIPSDAPFGGVGRSGMGAYHGKAGFDTFSHHRTIVGSDLPFSITASAAPP
. ****** **:*****: **: :** :: : . *
MMAR_0359|M.marinum_M Y-------TERAFKLARRLF----------
MUL_4760|M.ulcerans_Agy99 Y-------TERAFKLARRLF----------
Mb0152|M.bovis_AF2122/97 Y-------TERAIKVARRLF----------
Rv0147|M.tuberculosis_H37Rv Y-------TERAIKVARRLF----------
MLBr_02639|M.leprae_Br4923 Y-------TERSFRLAHRLF----------
MAB_4605c|M.abscessus_ATCC_199 Y-------TEKNLKLMQRLM----------
MAV_5095|M.avium_104 Y-------SQRALGVMRKLF----------
Mvan_2009|M.vanbaalenii_PYR-1 FPRSMQMTTTLALRLARRRTRR---RLRNR
Mflv_4336|M.gilvum_PYR-GCK FPLTMRATTALALRIAHRRTHRRLSRLRNR
MSMEG_2242|M.smegmatis_MC2_155 FTGSMRVSADLALWRARSRTKNRLRKFR--
TH_4463|M.thermoresistible__bu FGAAMRRGAEFRLRMARNRTRRRIQRRRR-
: : : :