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MSDRVKAVAPPDGRTMMTTESVARKTQKSETEAPREPAPVSDEKQTDVAKTVARLRKTFASGRTRSVEWR KQQLRALQKLMDENEDAIAAALAEDLDRNPFEAYLADIATTSAEAKYAAKRVRRWMRRRYLLLEVPQLPG RGWVEYEPYGTVLIIGAWNYPFYLTLGPAVGAIAAGNAVVLKPSEIAAASAHLMTELVYRYLDTEAIAVV QGDGAVSQELIAQGFDRVMFTGGTEIGRKVYEGAAPHLTPVTLELGGKSPVIVAADADVDVAAKRIAWIK LLNAGQTCVAPDYVLADATVRDELVSKITAALTKFRSGAPQGMRIVNQRQFDRLSGYLAAAKTDAAADGG GVVVGGDCDASNLRIQPTVVVDPDPDGPLMSNEIFGPILPVVTVKSLDDAIRFVNSRPKPLSAYLFTKSR AVRERVIREVPAGGMMVNHLAFQVSTAKLPFGGVGASGMGAYHGRWGFEEFSHRKSVLTKPTRPDLSSFI YPPYTERAIKVARRLF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0147 | - | - | 100% (506) | PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT |
| M. tuberculosis H37Rv | Rv1731 | gabD2 | 6e-49 | 30.20% (447) | succinic semialdehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0223c | - | 6e-42 | 30.34% (445) | aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0152 | - | 0.0 | 100.00% (506) | aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0742 | - | 0.0 | 69.18% (490) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02639 | - | 0.0 | 76.83% (492) | aldehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4605c | - | 1e-156 | 57.23% (491) | aldehyde dehydrogenase |
| M. marinum M | MMAR_0359 | - | 0.0 | 81.38% (494) | aldehyde dehydrogenase (NAD+) dependent |
| M. avium 104 | MAV_5147 | - | 0.0 | 79.39% (490) | fatty aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2242 | - | 5e-71 | 36.59% (440) | coniferyl aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_4611 | - | 1e-167 | 71.07% (401) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_4760 | - | 0.0 | 81.17% (494) | aldehyde dehydrogenase (NAD+) dependent |
| M. vanbaalenii PYR-1 | Mvan_0105 | - | 0.0 | 69.18% (490) | aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0742|M.gilvum_PYR-GCK ----------------MTTESVAP--------------VQAA--EGADIP
Mvan_0105|M.vanbaalenii_PYR-1 ----------------MTTESVVP--------------AQAANVGGTDIP
TH_4611|M.thermoresistible__bu --------------------------------------------------
Rv0147|M.tuberculosis_H37Rv MSDRVKAVAPPDGRTMMTTESVARKTQKSETE-APREPAPVSDEKQTDVA
Mb0152|M.bovis_AF2122/97 MSDRVKAVAPPDGRTMMTTESVARKTQKSETE-APREPAPVSDEKQTDVA
MAV_5147|M.avium_104 ----------------MTTESVASKTTTS-----------ANGTASADIA
MMAR_0359|M.marinum_M ---------------MMTTESVAAKAQERGANGAGGVRAPSDDSKPTDVG
MUL_4760|M.ulcerans_Agy99 ---------------MMTTESVAAKAQERGANGAGGVRAPSDDSKPTDVG
MLBr_02639|M.leprae_Br4923 MLSRRAVGSCGKEEALMITESVAQKTAVSKSG------VPPHTPPGVNSE
MAB_4605c|M.abscessus_ATCC_199 ----------------MTTEISTP-------------ADQHAASEPSRIP
MSMEG_2242|M.smegmatis_MC2_155 ----------------MSTIDQRA----------------EKHSRQGGAA
Mflv_0742|M.gilvum_PYR-GCK AIVQRLRRTYATGRTRSVQWRKEQLHALERLMTENEGVITEALEKDLG-R
Mvan_0105|M.vanbaalenii_PYR-1 AVVRKLRQTFATGRTRSVQWRKEQLHALERLMTENEGAIAEALEKDLG-R
TH_4611|M.thermoresistible__bu --------------------------------------------------
Rv0147|M.tuberculosis_H37Rv KTVARLRKTFASGRTRSVEWRKQQLRALQKLMDENEDAIAAALAEDLD-R
Mb0152|M.bovis_AF2122/97 KTVARLRKTFASGRTRSVEWRKQQLRALQKLMDENEDAIAAALAEDLD-R
MAV_5147|M.avium_104 GTVARLRQTFATGRTRDVEWRKRQLLQLQKLMEENEAAIAAALAEDLD-R
MMAR_0359|M.marinum_M ATVARLRQTFASGRTRNVQWRKQQLLQLQRLMEENEDAITKALVEDLD-R
MUL_4760|M.ulcerans_Agy99 ATVARLRQTLASGRTRNVQWRKQQLLQLQRLMEENEDAITKALVEDLD-R
MLBr_02639|M.leprae_Br4923 ATVVRLRQTFASGRTRSVDWRTQQLRALQALMVENEGAIAQALADDLD-R
MAB_4605c|M.abscessus_ATCC_199 GIVRGLRETFATGRTREYQWRKAQLVGLERLFKENEAAIAKALNDDLG-R
MSMEG_2242|M.smegmatis_MC2_155 DVLAAQRRSFLDDGPPDIALRRNRIDRLLAMVLDNAEDFVTATASDYGTR
Mflv_0742|M.gilvum_PYR-GCK APFEAWLADIASTAGEAAYAAKNVGKWMKR-RYRLLEMSQLPGR-GWVEY
Mvan_0105|M.vanbaalenii_PYR-1 GPFEAWLADVASTVGEAAYAAKNVGKWMKR-RYRLLEMSQLPGR-GWVEY
TH_4611|M.thermoresistible__bu ------XADVASTAAEAKTAAKNVRKWARR-RYKMLEFSQLPGL-GWIEY
Rv0147|M.tuberculosis_H37Rv NPFEAYLADIATTSAEAKYAAKRVRRWMRR-RYLLLEVPQLPGR-GWVEY
Mb0152|M.bovis_AF2122/97 NPFEAYLADIATTSAEAKYAAKRVRRWMRR-RYLLLEVPQLPGR-GWVEY
MAV_5147|M.avium_104 GPFEAYIADIATTAGEAKYAAKRVRKWTRR-RYQLLELPQLPGR-GWVEY
MMAR_0359|M.marinum_M NPVEAFIADIATTIAEAKYAAKKVRKWMRR-KHVLLEAPQLPGR-GWVQY
MUL_4760|M.ulcerans_Agy99 NPVEAFIADIATTIAEAKYAAKKVRKWMRR-KHVLLEAPQLPGR-GWVQY
MLBr_02639|M.leprae_Br4923 NPVEAFIVDIAATVSEAKYAAKKVRKWMRR-KYRFLEVSQLPGR-GWVEY
MAB_4605c|M.abscessus_ATCC_199 SSAEAWIADVVGTVVEITYARKHLKRWMRRKRVRGLPMAQQPAK-AYVQS
MSMEG_2242|M.smegmatis_MC2_155 SRSAAFFAEILGMISVIEHTRSNLPRWMRS--TRLMRAARLAGLRAEVVP
.:: : ..: :* : : .: .. . :
Mflv_0742|M.gilvum_PYR-GCK EPYGTVLVIGAWNFPFALTLGPAVGAIAAGNTVVLKPSEVAPASSAVMAE
Mvan_0105|M.vanbaalenii_PYR-1 EPYGTVLIIGAWNFPFALTLGPAVGAIAAGNTVVLKPSEVAPASSALMAE
TH_4611|M.thermoresistible__bu EPYGTVLIIGAWNFPFALTLGPAVGAIAAGNVVVLKPSEVSPASSALMAE
Rv0147|M.tuberculosis_H37Rv EPYGTVLIIGAWNYPFYLTLGPAVGAIAAGNAVVLKPSEIAAASAHLMTE
Mb0152|M.bovis_AF2122/97 EPYGTVLIIGAWNYPFYLTLGPAVGAIAAGNAVVLKPSEIAAASAHLMTE
MAV_5147|M.avium_104 EPYGTVLIIGAWNYPFYLTLGPAVGAIAAGNAVILKPSEIAAASSRVMAE
MMAR_0359|M.marinum_M EPYGTVLIIGAWNYPFYLTLGPAVGAIAAGNTVVLKPSEIAEASSRLMAE
MUL_4760|M.ulcerans_Agy99 EPYGTVLIIGAWNYPFYLTLGPAVGAIAAGNTVVLKPSEIAEASSRLMAE
MLBr_02639|M.leprae_Br4923 EPYGTVLIIGAWNYPFYLTLVPAVGAIAAGNTMVLKPSEVAAASAHLMAE
MAB_4605c|M.abscessus_ATCC_199 EPYGTTLIIGAWNFPFYLTIGPLVGAVAAGNTVALKPSELAPACSALMAK
MSMEG_2242|M.smegmatis_MC2_155 SPVGVVGVIGPWNFPVQLTVLPAAAAFAAGNRVMIKMSEVTPRTAEAMAD
.* *.. :**.**:*. **: * ..*.**** : :* **:: : *:.
Mflv_0742|M.gilvum_PYR-GCK LVPRYLDNDAIAVIEGDGAVSQELIAQGFDHLIFTGGTEVGRKVYESAAT
Mvan_0105|M.vanbaalenii_PYR-1 LVPRYMDNDAIAVVEGDGAVSQELIAQGFDHLIFTGGTEVGRRVYEAAAT
TH_4611|M.thermoresistible__bu LVPKYLDNDAIVVIEGDAAVSQELIAQGFDKICFTGGTDIGRKVYESAAP
Rv0147|M.tuberculosis_H37Rv LVYRYLDTEAIAVVQGDGAVSQELIAQGFDRVMFTGGTEIGRKVYEGAAP
Mb0152|M.bovis_AF2122/97 LVYRYLDTEAIAVVQGDGAVSQELIAQGFDRVMFTGGTEIGRKVYEGAAP
MAV_5147|M.avium_104 LVPKYLDNDAIAVIEGDGATSQELIAQGLDRVMFTGGTEIGRKVYEGAAP
MMAR_0359|M.marinum_M LVPRYLDRDAIAVIEGDGAVSQELIGQGLDRVMFTGGTEIGRKVYEGAAP
MUL_4760|M.ulcerans_Agy99 LVPRYLDPDAIAVIEGDGAVSQELIGQGLDRVMFTGGTEIGRKVYEGAAP
MLBr_02639|M.leprae_Br4923 LVPRYLDNDAIAVIEGGGAVSQELIAQGLDRVMFTGGTEIGRKVYEGAAS
MAB_4605c|M.abscessus_ATCC_199 LLPQYLDPHAVVVVEGDGYVTQELLAQGFDKAMFTGGTEIGKRILEGAAP
MSMEG_2242|M.smegmatis_MC2_155 LAPRYFDQRELAVITGGPELAAEFSALPFDHLFFTGSPAIGAVVGRAAAA
* :*:* :.*: *. : *: . :*: ***.. :* : ..**.
Mflv_0742|M.gilvum_PYR-GCK HLTPVTLELGGKSPVIVAKDADIEVAAKRIAWTKLINSGQICIAPDYVLV
Mvan_0105|M.vanbaalenii_PYR-1 HLTPVTLELGGKSPVIVAADADIEVAAKRIAWTKLINSGQICIAPDYVLA
TH_4611|M.thermoresistible__bu HLTPVTLELGGKSPVIVAADADIDVAAKRIAWTKLINSGQICIAPDYVLA
Rv0147|M.tuberculosis_H37Rv HLTPVTLELGGKSPVIVAADADVDVAAKRIAWIKLLNAGQTCVAPDYVLA
Mb0152|M.bovis_AF2122/97 HLTPVTLELGGKSPVIVAADADVDVAAKRIAWIKLLNAGQTCVAPDYVLA
MAV_5147|M.avium_104 HLTPCTLELGGKSPVIVAADADVEVAAKRIAWMKLLNAGQTCVAPDYVLA
MMAR_0359|M.marinum_M HLTPVTLELGGKSPVIVAADADIDVAAKRIAWIKLLNGGQTCVAPDYVLA
MUL_4760|M.ulcerans_Agy99 HLTPVTLELGGKSPVIVAADADIDVAAKRIAWIKLLNGGQTCVAPDYVLA
MLBr_02639|M.leprae_Br4923 HLTPVTLELGGKSPVIVAVDADIDVAAKRIAWIKILNAGQTCVAPDYVLA
MAB_4605c|M.abscessus_ATCC_199 HLTPVALELGGKSPVYVASDANIEVAARRIGYMKGLNSGQVCLAPDYVIA
MSMEG_2242|M.smegmatis_MC2_155 NLVPVTLELGGKNPVVVAPGADITRAATRIAQARMVNGGQVCVCPDYVFV
:*.* :******.** ** .*:: ** **. : :*.** *:.****:.
Mflv_0742|M.gilvum_PYR-GCK EAPIRDKLVDSIRSAIDTFEA---GNAPGKKIVNERHFNRLSNALAATK-
Mvan_0105|M.vanbaalenii_PYR-1 EAPIRDKLVEAIRKAIDTFEA---GNAAGKKIVNERHFNRLANALAATK-
TH_4611|M.thermoresistible__bu DASIRDQLVDRIAEAVRSFE----GESGGKPIVNKRHFDRLTAALAATK-
Rv0147|M.tuberculosis_H37Rv DATVRDELVSKITAALTKFRS---GAPQGMRIVNQRQFDRLSGYLAAAKT
Mb0152|M.bovis_AF2122/97 DATVRDELVSKITAALTKFRS---GAPQGMRIVNQRQFDRLSGYLAAAKT
MAV_5147|M.avium_104 DAKIRDELVDKIGAAITKFTA---DKPEGMRVVNQRQFDRISSYLSGSD-
MMAR_0359|M.marinum_M DATIRDELVGKIGAAVTKFRSQ--DDPDGLRIVNRRQFDRLSGYIAAAES
MUL_4760|M.ulcerans_Agy99 DATIRDELVGKIGAAVTKFRSQ--DDPDGLRIVNRRQFDRLSGYIAAAES
MLBr_02639|M.leprae_Br4923 AAPIRDELVNKIGFAIAKFRSQ--DDPSGMRIVNQRQFDRLCGYLAGVQS
MAB_4605c|M.abscessus_ATCC_199 DASIRDELVEKIKESWEQFQAD--REDKGLRVLNQRQFDRLVGYLAATE-
MSMEG_2242|M.smegmatis_MC2_155 PDRHVDEFVEVARGTLRRMFPTITDNPDYCSSVNRSNFDRVVGLIADARA
*::* : : :*. :*:*: ::
Mflv_0742|M.gilvum_PYR-GCK -------GTVAVGGDSDAVNLKISPTVVVDPDPAEPLMTDEIFGPILPVL
Mvan_0105|M.vanbaalenii_PYR-1 -------GKVAIGGGSDAVAMKIQPTVVVDPDPAEPLMTDEIFGPILPVV
TH_4611|M.thermoresistible__bu -------GKVVLGGGSDPSTLKIEPTIVVDPALDEPLMTDEIFGPILPIV
Rv0147|M.tuberculosis_H37Rv DAAAD-GGGVVVGGDCDASNLRIQPTVVVDPDPDGPLMSNEIFGPILPVV
Mb0152|M.bovis_AF2122/97 DAAAD-GGGVVVGGDCDASNLRIQPTVVVDPDPDGPLMSNEIFGPILPVV
MAV_5147|M.avium_104 -------GKVTVGGACDPSTLRIQPAVVVDPDPDGPLMRNEIFGPVLPVI
MMAR_0359|M.marinum_M EAKAGGKCKVEVGGKCTAESLRIQPTVVVDPDPSGPVMTNEIFGPILPVL
MUL_4760|M.ulcerans_Agy99 EAKAGGKCKVEVGGKCTAESLRIQPTVVVDPDPSGPVMTNEIFGPILPVL
MLBr_02639|M.leprae_Br4923 AAGGK--GVVVVGGKCDASTLRIQPTVIVDPDPEGPLMTKEIFGPILPVL
MAB_4605c|M.abscessus_ATCC_199 -------GQVAVGGASDAESLTIEPTIVVDPDADEPLMQEEIFGPILPIV
MSMEG_2242|M.smegmatis_MC2_155 RGARVESIVPVGEVLPDPVTRKIPPTIIRDVDDRMRINDEEVFGPVLAVR
. * *::: * : .*:***:*.:
Mflv_0742|M.gilvum_PYR-GCK TVQNLDEAISFVNSRPKPLAAYLFTKAKAVRERVIKEVPAGGMVVNHLIF
Mvan_0105|M.vanbaalenii_PYR-1 TVQNLDEAISFVNSRPKPLAAYLFTKAKAVRERVIKEVPAGGMVVNHLIF
TH_4611|M.thermoresistible__bu TVRSIDDAIEFVNARPKPLAAYLFTKTKAIRERVVREVPAGGMVINQLLF
Rv0147|M.tuberculosis_H37Rv TVKSLDDAIRFVNSRPKPLSAYLFTKSRAVRERVIREVPAGGMMVNHLAF
Mb0152|M.bovis_AF2122/97 TVKSLDDAIRFVNSRPKPLSAYLFTKSRAVRERVIREVPAGGMMVNHLAF
MAV_5147|M.avium_104 TVQNLDEAIRFVNSRPKPLSAYLFTKTRETRERVIKEVPAGGMLINHLAF
MMAR_0359|M.marinum_M TVKSLDEAIGFVNSRPKPLSAYLFTKSREIRERVINEVPAGGMMVNHLAF
MUL_4760|M.ulcerans_Agy99 TVKSLDEAIGFVNSRPKPLSAYLFTKSREIRERVINEVPAGGMMVNHLAF
MLBr_02639|M.leprae_Br4923 TVQSLDEAIGFINARPKPLAAYLFTKSRKTRDRVIKEVSAGGMLVNHLAI
MAB_4605c|M.abscessus_ATCC_199 TAETLDAAIDFINSRPKPLAAYAFTESKYTANRYAAEVPAGGMVINHLLY
MSMEG_2242|M.smegmatis_MC2_155 GYSSLASTIDYINSRPSPLVAYWFGPDDADFRHFVDHTRSGGVARNDFAA
.: :* ::*:**.** ** * : .. :**: *.:
Mflv_0742|M.gilvum_PYR-GCK HFATHKLPFGGVGPSGLGAYHGKFGFEEFSHRKSVLTKPTRPDLGSMIYP
Mvan_0105|M.vanbaalenii_PYR-1 HFATHKLPFGGVGPSGLGAYHGKFGFEEFSHRKSVLTKPTRPDLGAMIYP
TH_4611|M.thermoresistible__bu HFATAKLPFGGVGPSGTGAYHGRYGFEEFSHRKTVMTKPTRPDVVQMLYP
Rv0147|M.tuberculosis_H37Rv QVSTAKLPFGGVGASGMGAYHGRWGFEEFSHRKSVLTKPTRPDLSSFIYP
Mb0152|M.bovis_AF2122/97 QVSTAKLPFGGVGASGMGAYHGRWGFEEFSHRKSVLTKPTRPDLSSFIYP
MAV_5147|M.avium_104 QVSTAKLPFGGVGASGMGAYHGRYGFEEFSHRKSVLTKPTRPDLSSFIYP
MMAR_0359|M.marinum_M QVSTAKLPFGGVGASGMGAYHGKWGFDEFSHRKSVLTKPTRPDLSNIIYP
MUL_4760|M.ulcerans_Agy99 QVSTAKLPFGGVGASGMGAYHGKWGFDEFSHRKSVLTKPTRPDLSNIIYP
MLBr_02639|M.leprae_Br4923 QVLTAKLPFGGVGESGIGAYHGKWGFDEFSHRKSVLTKPTRPDLSSFIYP
MAB_4605c|M.abscessus_ATCC_199 HAVIPKLPFGGVGASGMGAYHGKAGFDEFSHRKSTLYKSTALDLK-LPYP
MSMEG_2242|M.smegmatis_MC2_155 HMIPSSAPFGGVGRSGMGAYHGKAGFDAFSHHRTVVGTDLPFSITGRAAL
: . ****** ** *****: **: ***:::.: . .:
Mflv_0742|M.gilvum_PYR-GCK PYTEKAFKLARKLF---------------
Mvan_0105|M.vanbaalenii_PYR-1 PYTEKAWKLARKLF---------------
TH_4611|M.thermoresistible__bu PYTEKAWKLARKLF---------------
Rv0147|M.tuberculosis_H37Rv PYTERAIKVARRLF---------------
Mb0152|M.bovis_AF2122/97 PYTERAIKVARRLF---------------
MAV_5147|M.avium_104 PYTERAFKMARKMF---------------
MMAR_0359|M.marinum_M PYTERAFKLARRLF---------------
MUL_4760|M.ulcerans_Agy99 PYTERAFKLARRLF---------------
MLBr_02639|M.leprae_Br4923 PYTERSFRLAHRLF---------------
MAB_4605c|M.abscessus_ATCC_199 PYTEKNLKLMQRLM---------------
MSMEG_2242|M.smegmatis_MC2_155 PFTGSMRVSADLALWRARSRTKNRLRKFR
*:* :