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TTEISTPADQHAASEPSRIPGIVRGLRETFATGRTREYQWRKAQLVGLERLFKENEAAIAKALNDDLGRS SAEAWIADVVGTVVEITYARKHLKRWMRRKRVRGLPMAQQPAKAYVQSEPYGTTLIIGAWNFPFYLTIGP LVGAVAAGNTVALKPSELAPACSALMAKLLPQYLDPHAVVVVEGDGYVTQELLAQGFDKAMFTGGTEIGK RILEGAAPHLTPVALELGGKSPVYVASDANIEVAARRIGYMKGLNSGQVCLAPDYVIADASIRDELVEKI KESWEQFQADREDKGLRVLNQRQFDRLVGYLAATEGQVAVGGASDAESLTIEPTIVVDPDADEPLMQEEI FGPILPIVTAETLDAAIDFINSRPKPLAAYAFTESKYTANRYAAEVPAGGMVINHLLYHAVIPKLPFGGV GASGMGAYHGKAGFDEFSHRKSTLYKSTALDLKLPYPPYTEKNLKLMQRLM*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4605c | - | - | 100% (472) | aldehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4484 | - | 4e-40 | 29.65% (462) | aldehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4136c | - | 5e-39 | 28.84% (423) | putative aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0152 | - | 1e-156 | 57.23% (491) | aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0742 | - | 1e-163 | 60.59% (472) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0147 | - | 1e-156 | 57.23% (491) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02639 | - | 1e-153 | 58.67% (467) | aldehyde dehydrogenase |
| M. marinum M | MMAR_0359 | - | 1e-161 | 60.08% (476) | aldehyde dehydrogenase (NAD+) dependent |
| M. avium 104 | MAV_5147 | - | 1e-160 | 58.91% (477) | fatty aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2242 | - | 6e-69 | 36.42% (453) | coniferyl aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_2652 | - | 1e-157 | 59.33% (445) | PUTATIVE fatty aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_4760 | - | 1e-162 | 60.08% (476) | aldehyde dehydrogenase (NAD+) dependent |
| M. vanbaalenii PYR-1 | Mvan_0105 | - | 1e-167 | 62.71% (472) | aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0152|M.bovis_AF2122/97 MSDRVKAVAPPDGRTMMTTESVARKTQKSETE-APREPAPVSDEKQTDVA
Rv0147|M.tuberculosis_H37Rv MSDRVKAVAPPDGRTMMTTESVARKTQKSETE-APREPAPVSDEKQTDVA
MAV_5147|M.avium_104 ----------------MTTESVASKTTTS-----------ANGTASADIA
MMAR_0359|M.marinum_M ---------------MMTTESVAAKAQERGANGAGGVRAPSDDSKPTDVG
MUL_4760|M.ulcerans_Agy99 ---------------MMTTESVAAKAQERGANGAGGVRAPSDDSKPTDVG
MLBr_02639|M.leprae_Br4923 MLSRRAVGSCGKEEALMITESVAQKTAVSKSG------VPPHTPPGVNSE
Mflv_0742|M.gilvum_PYR-GCK ----------------MTTESVAPVQAA----------------EGADIP
Mvan_0105|M.vanbaalenii_PYR-1 ----------------MTTESVVPAQAAN--------------VGGTDIP
MAB_4605c|M.abscessus_ATCC_199 ----------------MTTEISTPADQHAAS-------------EPSRIP
TH_2652|M.thermoresistible__bu --------------------------------------------------
MSMEG_2242|M.smegmatis_MC2_155 ----------------MSTIDQRAEKHSR----------------QGGAA
Mb0152|M.bovis_AF2122/97 KTVARLRKTFASGRTRSVEWRKQQLRALQKLMDENEDAIAAALAEDLD-R
Rv0147|M.tuberculosis_H37Rv KTVARLRKTFASGRTRSVEWRKQQLRALQKLMDENEDAIAAALAEDLD-R
MAV_5147|M.avium_104 GTVARLRQTFATGRTRDVEWRKRQLLQLQKLMEENEAAIAAALAEDLD-R
MMAR_0359|M.marinum_M ATVARLRQTFASGRTRNVQWRKQQLLQLQRLMEENEDAITKALVEDLD-R
MUL_4760|M.ulcerans_Agy99 ATVARLRQTLASGRTRNVQWRKQQLLQLQRLMEENEDAITKALVEDLD-R
MLBr_02639|M.leprae_Br4923 ATVVRLRQTFASGRTRSVDWRTQQLRALQALMVENEGAIAQALADDLD-R
Mflv_0742|M.gilvum_PYR-GCK AIVQRLRRTYATGRTRSVQWRKEQLHALERLMTENEGVITEALEKDLG-R
Mvan_0105|M.vanbaalenii_PYR-1 AVVRKLRQTFATGRTRSVQWRKEQLHALERLMTENEGAIAEALEKDLG-R
MAB_4605c|M.abscessus_ATCC_199 GIVRGLRETFATGRTREYQWRKAQLVGLERLFKENEAAIAKALNDDLG-R
TH_2652|M.thermoresistible__bu -VRDQLHEVFATGRTKPLRWRLAQLAGIERLCREQEAAIAEALEHDLG-R
MSMEG_2242|M.smegmatis_MC2_155 DVLAAQRRSFLDDGPPDIALRRNRIDRLLAMVLDNAEDFVTATASDYGTR
:. . . * :: : : :: :. * * . *
Mb0152|M.bovis_AF2122/97 NPFEAYLADIATTSAEAKYAAKRVRRWMRR-RYLLLEVPQLPGRGWVEYE
Rv0147|M.tuberculosis_H37Rv NPFEAYLADIATTSAEAKYAAKRVRRWMRR-RYLLLEVPQLPGRGWVEYE
MAV_5147|M.avium_104 GPFEAYIADIATTAGEAKYAAKRVRKWTRR-RYQLLELPQLPGRGWVEYE
MMAR_0359|M.marinum_M NPVEAFIADIATTIAEAKYAAKKVRKWMRR-KHVLLEAPQLPGRGWVQYE
MUL_4760|M.ulcerans_Agy99 NPVEAFIADIATTIAEAKYAAKKVRKWMRR-KHVLLEAPQLPGRGWVQYE
MLBr_02639|M.leprae_Br4923 NPVEAFIVDIAATVSEAKYAAKKVRKWMRR-KYRFLEVSQLPGRGWVEYE
Mflv_0742|M.gilvum_PYR-GCK APFEAWLADIASTAGEAAYAAKNVGKWMKR-RYRLLEMSQLPGRGWVEYE
Mvan_0105|M.vanbaalenii_PYR-1 GPFEAWLADVASTVGEAAYAAKNVGKWMKR-RYRLLEMSQLPGRGWVEYE
MAB_4605c|M.abscessus_ATCC_199 SSAEAWIADVVGTVVEITYARKHLKRWMRRKRVRGLPMAQQPAKAYVQSE
TH_2652|M.thermoresistible__bu SAVEAWLGDIASTVAEAGYARRHLKKWMRR-KRVSLPLAQRPGRGWVQYD
MSMEG_2242|M.smegmatis_MC2_155 SRSAAFFAEILGMISVIEHTRSNLPRWMRS-TRLMRAARLAGLRAEVVPS
*:: :: :: .: :* : :. * .
Mb0152|M.bovis_AF2122/97 PYGTVLIIGAWNYPFYLTLGPAVGAIAAGNAVVLKPSEIAAASAHLMTEL
Rv0147|M.tuberculosis_H37Rv PYGTVLIIGAWNYPFYLTLGPAVGAIAAGNAVVLKPSEIAAASAHLMTEL
MAV_5147|M.avium_104 PYGTVLIIGAWNYPFYLTLGPAVGAIAAGNAVILKPSEIAAASSRVMAEL
MMAR_0359|M.marinum_M PYGTVLIIGAWNYPFYLTLGPAVGAIAAGNTVVLKPSEIAEASSRLMAEL
MUL_4760|M.ulcerans_Agy99 PYGTVLIIGAWNYPFYLTLGPAVGAIAAGNTVVLKPSEIAEASSRLMAEL
MLBr_02639|M.leprae_Br4923 PYGTVLIIGAWNYPFYLTLVPAVGAIAAGNTMVLKPSEVAAASAHLMAEL
Mflv_0742|M.gilvum_PYR-GCK PYGTVLVIGAWNFPFALTLGPAVGAIAAGNTVVLKPSEVAPASSAVMAEL
Mvan_0105|M.vanbaalenii_PYR-1 PYGTVLIIGAWNFPFALTLGPAVGAIAAGNTVVLKPSEVAPASSALMAEL
MAB_4605c|M.abscessus_ATCC_199 PYGTTLIIGAWNFPFYLTIGPLVGAVAAGNTVALKPSELAPACSALMAKL
TH_2652|M.thermoresistible__bu PLGVVLIIGPWNYPLYLSLGPLVAAVAAGNCAVIKPSELAPATSALLARL
MSMEG_2242|M.smegmatis_MC2_155 PVGVVGVIGPWNFPVQLTVLPAAAAFAAGNRVMIKMSEVTPRTAEAMADL
* *.. :**.**:*. *:: * ..*.**** :* **:: : :: *
Mb0152|M.bovis_AF2122/97 VYRYLDTEAIAVVQGDGAVSQELIAQGFDRVMFTGGTEIGRKVYEGAAPH
Rv0147|M.tuberculosis_H37Rv VYRYLDTEAIAVVQGDGAVSQELIAQGFDRVMFTGGTEIGRKVYEGAAPH
MAV_5147|M.avium_104 VPKYLDNDAIAVIEGDGATSQELIAQGLDRVMFTGGTEIGRKVYEGAAPH
MMAR_0359|M.marinum_M VPRYLDRDAIAVIEGDGAVSQELIGQGLDRVMFTGGTEIGRKVYEGAAPH
MUL_4760|M.ulcerans_Agy99 VPRYLDPDAIAVIEGDGAVSQELIGQGLDRVMFTGGTEIGRKVYEGAAPH
MLBr_02639|M.leprae_Br4923 VPRYLDNDAIAVIEGGGAVSQELIAQGLDRVMFTGGTEIGRKVYEGAASH
Mflv_0742|M.gilvum_PYR-GCK VPRYLDNDAIAVIEGDGAVSQELIAQGFDHLIFTGGTEVGRKVYESAATH
Mvan_0105|M.vanbaalenii_PYR-1 VPRYMDNDAIAVVEGDGAVSQELIAQGFDHLIFTGGTEVGRRVYEAAATH
MAB_4605c|M.abscessus_ATCC_199 LPQYLDPHAVVVVEGDGYVTQELLAQGFDKAMFTGGTEIGKRILEGAAPH
TH_2652|M.thermoresistible__bu VPRYLDGDAIKVVEGDAQTTQDLLAQGFDHALFTGGTEVGRKIMAAAAPT
MSMEG_2242|M.smegmatis_MC2_155 APRYFDQRELAVITGGPELAAEFSALPFDHLFFTGSPAIGAVVGRAAAAN
:*:* : *: *. : :: . :*: :***.. :* : .**.
Mb0152|M.bovis_AF2122/97 LTPVTLELGGKSPVIVAADADVDVAAKRIAWIKLLNAGQTCVAPDYVLAD
Rv0147|M.tuberculosis_H37Rv LTPVTLELGGKSPVIVAADADVDVAAKRIAWIKLLNAGQTCVAPDYVLAD
MAV_5147|M.avium_104 LTPCTLELGGKSPVIVAADADVEVAAKRIAWMKLLNAGQTCVAPDYVLAD
MMAR_0359|M.marinum_M LTPVTLELGGKSPVIVAADADIDVAAKRIAWIKLLNGGQTCVAPDYVLAD
MUL_4760|M.ulcerans_Agy99 LTPVTLELGGKSPVIVAADADIDVAAKRIAWIKLLNGGQTCVAPDYVLAD
MLBr_02639|M.leprae_Br4923 LTPVTLELGGKSPVIVAVDADIDVAAKRIAWIKILNAGQTCVAPDYVLAA
Mflv_0742|M.gilvum_PYR-GCK LTPVTLELGGKSPVIVAKDADIEVAAKRIAWTKLINSGQICIAPDYVLVE
Mvan_0105|M.vanbaalenii_PYR-1 LTPVTLELGGKSPVIVAADADIEVAAKRIAWTKLINSGQICIAPDYVLAE
MAB_4605c|M.abscessus_ATCC_199 LTPVALELGGKSPVYVASDANIEVAARRIGYMKGLNSGQVCLAPDYVIAD
TH_2652|M.thermoresistible__bu LTPVTLELGGKSPVIVTADADLDVAARRIAWVKLMNSGQTCIAPDYVLVD
MSMEG_2242|M.smegmatis_MC2_155 LVPVTLELGGKNPVVVAPGADITRAATRIAQARMVNGGQVCVCPDYVFVP
*.* :******.** *: .*:: ** **. : :*.** *:.****:.
Mb0152|M.bovis_AF2122/97 ATVRDELVSKITAALTKFRS---GAPQGMRIVNQRQFDRLSGYLAAAKTD
Rv0147|M.tuberculosis_H37Rv ATVRDELVSKITAALTKFRS---GAPQGMRIVNQRQFDRLSGYLAAAKTD
MAV_5147|M.avium_104 AKIRDELVDKIGAAITKFTA---DKPEGMRVVNQRQFDRISSYLSGSD--
MMAR_0359|M.marinum_M ATIRDELVGKIGAAVTKFRSQ--DDPDGLRIVNRRQFDRLSGYIAAAESE
MUL_4760|M.ulcerans_Agy99 ATIRDELVGKIGAAVTKFRSQ--DDPDGLRIVNRRQFDRLSGYIAAAESE
MLBr_02639|M.leprae_Br4923 APIRDELVNKIGFAIAKFRSQ--DDPSGMRIVNQRQFDRLCGYLAGVQSA
Mflv_0742|M.gilvum_PYR-GCK APIRDKLVDSIRSAIDTFEA---GNAPGKKIVNERHFNRLSNALAATK--
Mvan_0105|M.vanbaalenii_PYR-1 APIRDKLVEAIRKAIDTFEA---GNAAGKKIVNERHFNRLANALAATK--
MAB_4605c|M.abscessus_ATCC_199 ASIRDELVEKIKESWEQFQAD--REDKGLRVLNQRQFDRLVGYLAATE--
TH_2652|M.thermoresistible__bu RSVRDALVTKIVDTVKAFRA---GESPSLRIVNERQFDRLASLIATTS--
MSMEG_2242|M.smegmatis_MC2_155 DRHVDEFVEVARGTLRRMFPTITDNPDYCSSVNRSNFDRVVGLIADARAR
* :* : : . :*. :*:*: . ::
Mb0152|M.bovis_AF2122/97 AAAD-GGGVVVGGDCDASNLRIQPTVVVDPDPDGPLMSNEIFGPILPVVT
Rv0147|M.tuberculosis_H37Rv AAAD-GGGVVVGGDCDASNLRIQPTVVVDPDPDGPLMSNEIFGPILPVVT
MAV_5147|M.avium_104 ------GKVTVGGACDPSTLRIQPAVVVDPDPDGPLMRNEIFGPVLPVIT
MMAR_0359|M.marinum_M AKAGGKCKVEVGGKCTAESLRIQPTVVVDPDPSGPVMTNEIFGPILPVLT
MUL_4760|M.ulcerans_Agy99 AKAGGKCKVEVGGKCTAESLRIQPTVVVDPDPSGPVMTNEIFGPILPVLT
MLBr_02639|M.leprae_Br4923 AGGK--GVVVVGGKCDASTLRIQPTVIVDPDPEGPLMTKEIFGPILPVLT
Mflv_0742|M.gilvum_PYR-GCK ------GTVAVGGDSDAVNLKISPTVVVDPDPAEPLMTDEIFGPILPVLT
Mvan_0105|M.vanbaalenii_PYR-1 ------GKVAIGGGSDAVAMKIQPTVVVDPDPAEPLMTDEIFGPILPVVT
MAB_4605c|M.abscessus_ATCC_199 ------GQVAVGGASDAESLTIEPTIVVDPDADEPLMQEEIFGPILPIVT
TH_2652|M.thermoresistible__bu ------GRIVSGGGTDRARLRIEPTVIVDPVPTDPVMAEEIFGPILPVLT
MSMEG_2242|M.smegmatis_MC2_155 GARVESIVPVGEVLPDPVTRKIPPTIIRDVDDRMRINDEEVFGPVLAVRG
* *::: * : .*:***:*.:
Mb0152|M.bovis_AF2122/97 VKSLDDAIRFVNSRPKPLSAYLFTKSRAVRERVIREVPAGGMMVNHLAFQ
Rv0147|M.tuberculosis_H37Rv VKSLDDAIRFVNSRPKPLSAYLFTKSRAVRERVIREVPAGGMMVNHLAFQ
MAV_5147|M.avium_104 VQNLDEAIRFVNSRPKPLSAYLFTKTRETRERVIKEVPAGGMLINHLAFQ
MMAR_0359|M.marinum_M VKSLDEAIGFVNSRPKPLSAYLFTKSREIRERVINEVPAGGMMVNHLAFQ
MUL_4760|M.ulcerans_Agy99 VKSLDEAIGFVNSRPKPLSAYLFTKSREIRERVINEVPAGGMMVNHLAFQ
MLBr_02639|M.leprae_Br4923 VQSLDEAIGFINARPKPLAAYLFTKSRKTRDRVIKEVSAGGMLVNHLAIQ
Mflv_0742|M.gilvum_PYR-GCK VQNLDEAISFVNSRPKPLAAYLFTKAKAVRERVIKEVPAGGMVVNHLIFH
Mvan_0105|M.vanbaalenii_PYR-1 VQNLDEAISFVNSRPKPLAAYLFTKAKAVRERVIKEVPAGGMVVNHLIFH
MAB_4605c|M.abscessus_ATCC_199 AETLDAAIDFINSRPKPLAAYAFTESKYTANRYAAEVPAGGMVINHLLYH
TH_2652|M.thermoresistible__bu IESADAAVKFVNDRPKPLAMYVFTKSTQTGRRLIDAIPSGGAVINHLAMH
MSMEG_2242|M.smegmatis_MC2_155 YSSLASTIDYINSRPSPLVAYWFGPDDADFRHFVDHTRSGGVARNDFAAH
.. :: ::* **.** * * : :** *.: :
Mb0152|M.bovis_AF2122/97 VSTAKLPFGGVGASGMGAYHGRWGFEEFSHRKSVLTKPTRPDLSSFIYPP
Rv0147|M.tuberculosis_H37Rv VSTAKLPFGGVGASGMGAYHGRWGFEEFSHRKSVLTKPTRPDLSSFIYPP
MAV_5147|M.avium_104 VSTAKLPFGGVGASGMGAYHGRYGFEEFSHRKSVLTKPTRPDLSSFIYPP
MMAR_0359|M.marinum_M VSTAKLPFGGVGASGMGAYHGKWGFDEFSHRKSVLTKPTRPDLSNIIYPP
MUL_4760|M.ulcerans_Agy99 VSTAKLPFGGVGASGMGAYHGKWGFDEFSHRKSVLTKPTRPDLSNIIYPP
MLBr_02639|M.leprae_Br4923 VLTAKLPFGGVGESGIGAYHGKWGFDEFSHRKSVLTKPTRPDLSSFIYPP
Mflv_0742|M.gilvum_PYR-GCK FATHKLPFGGVGPSGLGAYHGKFGFEEFSHRKSVLTKPTRPDLGSMIYPP
Mvan_0105|M.vanbaalenii_PYR-1 FATHKLPFGGVGPSGLGAYHGKFGFEEFSHRKSVLTKPTRPDLGAMIYPP
MAB_4605c|M.abscessus_ATCC_199 AVIPKLPFGGVGASGMGAYHGKAGFDEFSHRKSTLYKSTALDLK-LPYPP
TH_2652|M.thermoresistible__bu CLVPQLPFGGVGDSGMGAYHGRWGFEALSHRRAVLAKPSRPDPS-LVYPP
MSMEG_2242|M.smegmatis_MC2_155 MIPSSAPFGGVGRSGMGAYHGKAGFDAFSHHRTVVGTDLPFSITGRAALP
. ****** **:*****: **: :**:::.: . . *
Mb0152|M.bovis_AF2122/97 YTERAIKVARRLF---------------
Rv0147|M.tuberculosis_H37Rv YTERAIKVARRLF---------------
MAV_5147|M.avium_104 YTERAFKMARKMF---------------
MMAR_0359|M.marinum_M YTERAFKLARRLF---------------
MUL_4760|M.ulcerans_Agy99 YTERAFKLARRLF---------------
MLBr_02639|M.leprae_Br4923 YTERSFRLAHRLF---------------
Mflv_0742|M.gilvum_PYR-GCK YTEKAFKLARKLF---------------
Mvan_0105|M.vanbaalenii_PYR-1 YTEKAWKLARKLF---------------
MAB_4605c|M.abscessus_ATCC_199 YTEKNLKLMQRLM---------------
TH_2652|M.thermoresistible__bu YTERALKLMRRMF---------------
MSMEG_2242|M.smegmatis_MC2_155 FTGSMRVSADLALWRARSRTKNRLRKFR
:* :