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TIHAAEATGSASVITDLRRVFSTGRTGDLHWRLGQLRGIERFVDERETEIAAALADDLGRSPAEAWLGDV ASTKGEAVYARKHLKKWMRRRRQSLPLAQLPGRAWVQYDPLGVVLIIGPWNYPLYLSLAPLVAAVAAGNC AVIKPSELAPATSALLARWLPQYVDPEAVRVVEGDADVTQQLLATGFDHVLFTGGTEVGKKIMAAAAPTL TPVTLELGGKSPVIVTADADIDVAARRIAWVKLLNSGQTCIAPDYVLADHRVVKELVGKLVANMRDFRAD QRNPALPIVNQRQFDRLVSLIDVTDGKVVAGGRADATTLRIEPTVIVDPPPNDPVMAEEIFGPILPVLSV ESLDDAVRFVNARPKSLALYIFATGKVGRDLVDRIPSGGAVINHVAMHCLVPALPFGGVGASGMGAYHGK WGFETLSHRRAVLSKSPRPDPRLVYPPYSQRALGVMRKLF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5095 | - | - | 100% (461) | fatty aldehyde dehydrogenase |
| M. avium 104 | MAV_5147 | - | e-152 | 54.84% (465) | fatty aldehyde dehydrogenase |
| M. avium 104 | MAV_1643 | - | 1e-41 | 30.40% (454) | aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0152 | - | 1e-151 | 56.93% (462) | aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0742 | - | 1e-148 | 54.23% (461) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0147 | - | 1e-151 | 56.93% (462) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02639 | - | 1e-145 | 53.43% (466) | aldehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4605c | - | 1e-150 | 56.55% (458) | aldehyde dehydrogenase |
| M. marinum M | MMAR_0359 | - | 1e-148 | 54.29% (466) | aldehyde dehydrogenase (NAD+) dependent |
| M. smegmatis MC2 155 | MSMEG_2242 | - | 2e-72 | 38.36% (438) | coniferyl aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_2652 | - | 0.0 | 74.83% (445) | PUTATIVE fatty aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_4760 | - | 1e-148 | 54.29% (466) | aldehyde dehydrogenase (NAD+) dependent |
| M. vanbaalenii PYR-1 | Mvan_0105 | - | 1e-148 | 55.82% (455) | aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_5095|M.avium_104 --------------------------------------MTIHAAEATGSA
TH_2652|M.thermoresistible__bu --------------------------------------------------
MMAR_0359|M.marinum_M ---------------MMTTESVAAKAQERGANGAGGVRAPSDDSKPTDVG
MUL_4760|M.ulcerans_Agy99 ---------------MMTTESVAAKAQERGANGAGGVRAPSDDSKPTDVG
Mb0152|M.bovis_AF2122/97 MSDRVKAVAPPDGRTMMTTESVARKTQ-KSETEAPREPAPVSDEKQTDVA
Rv0147|M.tuberculosis_H37Rv MSDRVKAVAPPDGRTMMTTESVARKTQ-KSETEAPREPAPVSDEKQTDVA
MLBr_02639|M.leprae_Br4923 MLSRRAVGSCGKEEALMITESVAQKTA------VSKSGVPPHTPPGVNSE
Mflv_0742|M.gilvum_PYR-GCK ----------------MTTESVA--------------PVQAA--EGADIP
Mvan_0105|M.vanbaalenii_PYR-1 ----------------MTTESVV--------------PAQAANVGGTDIP
MAB_4605c|M.abscessus_ATCC_199 ----------------MTTEISTP-------------ADQHAASEPSRIP
MSMEG_2242|M.smegmatis_MC2_155 --------------------------------MSTIDQRAEKHSRQGGAA
MAV_5095|M.avium_104 SVITDLRRVFSTGRTGDLHWRLGQLRGIERFVDERETEIAAALADDLG-R
TH_2652|M.thermoresistible__bu -VRDQLHEVFATGRTKPLRWRLAQLAGIERLCREQEAAIAEALEHDLG-R
MMAR_0359|M.marinum_M ATVARLRQTFASGRTRNVQWRKQQLLQLQRLMEENEDAITKALVEDLD-R
MUL_4760|M.ulcerans_Agy99 ATVARLRQTLASGRTRNVQWRKQQLLQLQRLMEENEDAITKALVEDLD-R
Mb0152|M.bovis_AF2122/97 KTVARLRKTFASGRTRSVEWRKQQLRALQKLMDENEDAIAAALAEDLD-R
Rv0147|M.tuberculosis_H37Rv KTVARLRKTFASGRTRSVEWRKQQLRALQKLMDENEDAIAAALAEDLD-R
MLBr_02639|M.leprae_Br4923 ATVVRLRQTFASGRTRSVDWRTQQLRALQALMVENEGAIAQALADDLD-R
Mflv_0742|M.gilvum_PYR-GCK AIVQRLRRTYATGRTRSVQWRKEQLHALERLMTENEGVITEALEKDLG-R
Mvan_0105|M.vanbaalenii_PYR-1 AVVRKLRQTFATGRTRSVQWRKEQLHALERLMTENEGAIAEALEKDLG-R
MAB_4605c|M.abscessus_ATCC_199 GIVRGLRETFATGRTREYQWRKAQLVGLERLFKENEAAIAKALNDDLG-R
MSMEG_2242|M.smegmatis_MC2_155 DVLAAQRRSFLDDGPPDIALRRNRIDRLLAMVLDNAEDFVTATASDYGTR
:. . . * :: : : :. :. * * . *
MAV_5095|M.avium_104 SPAEAWLGDVASTKGEAVYARKHLKKWMRR-RRQSLPLAQLPGRAWVQYD
TH_2652|M.thermoresistible__bu SAVEAWLGDIASTVAEAGYARRHLKKWMRR-KRVSLPLAQRPGRGWVQYD
MMAR_0359|M.marinum_M NPVEAFIADIATTIAEAKYAAKKVRKWMRR-KHVLLEAPQLPGRGWVQYE
MUL_4760|M.ulcerans_Agy99 NPVEAFIADIATTIAEAKYAAKKVRKWMRR-KHVLLEAPQLPGRGWVQYE
Mb0152|M.bovis_AF2122/97 NPFEAYLADIATTSAEAKYAAKRVRRWMRR-RYLLLEVPQLPGRGWVEYE
Rv0147|M.tuberculosis_H37Rv NPFEAYLADIATTSAEAKYAAKRVRRWMRR-RYLLLEVPQLPGRGWVEYE
MLBr_02639|M.leprae_Br4923 NPVEAFIVDIAATVSEAKYAAKKVRKWMRR-KYRFLEVSQLPGRGWVEYE
Mflv_0742|M.gilvum_PYR-GCK APFEAWLADIASTAGEAAYAAKNVGKWMKR-RYRLLEMSQLPGRGWVEYE
Mvan_0105|M.vanbaalenii_PYR-1 GPFEAWLADVASTVGEAAYAAKNVGKWMKR-RYRLLEMSQLPGRGWVEYE
MAB_4605c|M.abscessus_ATCC_199 SSAEAWIADVVGTVVEITYARKHLKRWMRRKRVRGLPMAQQPAKAYVQSE
MSMEG_2242|M.smegmatis_MC2_155 SRSAAFFAEILGMISVIEHTRSNLPRWMRS-TRLMRAARLAGLRAEVVPS
*:: :: :: .: :**: :. * .
MAV_5095|M.avium_104 PLGVVLIIGPWNYPLYLSLAPLVAAVAAGNCAVIKPSELAPATSALLARW
TH_2652|M.thermoresistible__bu PLGVVLIIGPWNYPLYLSLGPLVAAVAAGNCAVIKPSELAPATSALLARL
MMAR_0359|M.marinum_M PYGTVLIIGAWNYPFYLTLGPAVGAIAAGNTVVLKPSEIAEASSRLMAEL
MUL_4760|M.ulcerans_Agy99 PYGTVLIIGAWNYPFYLTLGPAVGAIAAGNTVVLKPSEIAEASSRLMAEL
Mb0152|M.bovis_AF2122/97 PYGTVLIIGAWNYPFYLTLGPAVGAIAAGNAVVLKPSEIAAASAHLMTEL
Rv0147|M.tuberculosis_H37Rv PYGTVLIIGAWNYPFYLTLGPAVGAIAAGNAVVLKPSEIAAASAHLMTEL
MLBr_02639|M.leprae_Br4923 PYGTVLIIGAWNYPFYLTLVPAVGAIAAGNTMVLKPSEVAAASAHLMAEL
Mflv_0742|M.gilvum_PYR-GCK PYGTVLVIGAWNFPFALTLGPAVGAIAAGNTVVLKPSEVAPASSAVMAEL
Mvan_0105|M.vanbaalenii_PYR-1 PYGTVLIIGAWNFPFALTLGPAVGAIAAGNTVVLKPSEVAPASSALMAEL
MAB_4605c|M.abscessus_ATCC_199 PYGTTLIIGAWNFPFYLTIGPLVGAVAAGNTVALKPSELAPACSALMAKL
MSMEG_2242|M.smegmatis_MC2_155 PVGVVGVIGPWNFPVQLTVLPAAAAFAAGNRVMIKMSEVTPRTAEAMADL
* *.. :**.**:*. *:: * ..*.**** :* **:: : ::
MAV_5095|M.avium_104 LPQYVDPEAVRVVEGDADVTQQLLATGFDHVLFTGGTEVGKKIMAAAAPT
TH_2652|M.thermoresistible__bu VPRYLDGDAIKVVEGDAQTTQDLLAQGFDHALFTGGTEVGRKIMAAAAPT
MMAR_0359|M.marinum_M VPRYLDRDAIAVIEGDGAVSQELIGQGLDRVMFTGGTEIGRKVYEGAAPH
MUL_4760|M.ulcerans_Agy99 VPRYLDPDAIAVIEGDGAVSQELIGQGLDRVMFTGGTEIGRKVYEGAAPH
Mb0152|M.bovis_AF2122/97 VYRYLDTEAIAVVQGDGAVSQELIAQGFDRVMFTGGTEIGRKVYEGAAPH
Rv0147|M.tuberculosis_H37Rv VYRYLDTEAIAVVQGDGAVSQELIAQGFDRVMFTGGTEIGRKVYEGAAPH
MLBr_02639|M.leprae_Br4923 VPRYLDNDAIAVIEGGGAVSQELIAQGLDRVMFTGGTEIGRKVYEGAASH
Mflv_0742|M.gilvum_PYR-GCK VPRYLDNDAIAVIEGDGAVSQELIAQGFDHLIFTGGTEVGRKVYESAATH
Mvan_0105|M.vanbaalenii_PYR-1 VPRYMDNDAIAVVEGDGAVSQELIAQGFDHLIFTGGTEVGRRVYEAAATH
MAB_4605c|M.abscessus_ATCC_199 LPQYLDPHAVVVVEGDGYVTQELLAQGFDKAMFTGGTEIGKRILEGAAPH
MSMEG_2242|M.smegmatis_MC2_155 APRYFDQRELAVITGGPELAAEFSALPFDHLFFTGSPAIGAVVGRAAAAN
:*.* : *: *. : :: . :*: :***.. :* : .**.
MAV_5095|M.avium_104 LTPVTLELGGKSPVIVTADADIDVAARRIAWVKLLNSGQTCIAPDYVLAD
TH_2652|M.thermoresistible__bu LTPVTLELGGKSPVIVTADADLDVAARRIAWVKLMNSGQTCIAPDYVLVD
MMAR_0359|M.marinum_M LTPVTLELGGKSPVIVAADADIDVAAKRIAWIKLLNGGQTCVAPDYVLAD
MUL_4760|M.ulcerans_Agy99 LTPVTLELGGKSPVIVAADADIDVAAKRIAWIKLLNGGQTCVAPDYVLAD
Mb0152|M.bovis_AF2122/97 LTPVTLELGGKSPVIVAADADVDVAAKRIAWIKLLNAGQTCVAPDYVLAD
Rv0147|M.tuberculosis_H37Rv LTPVTLELGGKSPVIVAADADVDVAAKRIAWIKLLNAGQTCVAPDYVLAD
MLBr_02639|M.leprae_Br4923 LTPVTLELGGKSPVIVAVDADIDVAAKRIAWIKILNAGQTCVAPDYVLAA
Mflv_0742|M.gilvum_PYR-GCK LTPVTLELGGKSPVIVAKDADIEVAAKRIAWTKLINSGQICIAPDYVLVE
Mvan_0105|M.vanbaalenii_PYR-1 LTPVTLELGGKSPVIVAADADIEVAAKRIAWTKLINSGQICIAPDYVLAE
MAB_4605c|M.abscessus_ATCC_199 LTPVALELGGKSPVYVASDANIEVAARRIGYMKGLNSGQVCLAPDYVIAD
MSMEG_2242|M.smegmatis_MC2_155 LVPVTLELGGKNPVVVAPGADITRAATRIAQARMVNGGQVCVCPDYVFVP
*.**:******.** *: .*:: ** **. : :*.** *:.****:.
MAV_5095|M.avium_104 HRVVKELVGKLVANMRDFRADQ--RNPALPIVNQRQFDRLVSLIDVTDG-
TH_2652|M.thermoresistible__bu RSVRDALVTKIVDTVKAFRAGE---SPSLRIVNERQFDRLASLIATTSG-
MMAR_0359|M.marinum_M ATIRDELVGKIGAAVTKFRSQD--DPDGLRIVNRRQFDRLSGYIAAAESE
MUL_4760|M.ulcerans_Agy99 ATIRDELVGKIGAAVTKFRSQD--DPDGLRIVNRRQFDRLSGYIAAAESE
Mb0152|M.bovis_AF2122/97 ATVRDELVSKITAALTKFRSG---APQGMRIVNQRQFDRLSGYLAAAKTD
Rv0147|M.tuberculosis_H37Rv ATVRDELVSKITAALTKFRSG---APQGMRIVNQRQFDRLSGYLAAAKTD
MLBr_02639|M.leprae_Br4923 APIRDELVNKIGFAIAKFRSQD--DPSGMRIVNQRQFDRLCGYLAGVQS-
Mflv_0742|M.gilvum_PYR-GCK APIRDKLVDSIRSAIDTFEAG---NAPGKKIVNERHFNRLSNALAATKG-
Mvan_0105|M.vanbaalenii_PYR-1 APIRDKLVEAIRKAIDTFEAG---NAAGKKIVNERHFNRLANALAATKG-
MAB_4605c|M.abscessus_ATCC_199 ASIRDELVEKIKESWEQFQADR--EDKGLRVLNQRQFDRLVGYLAATEG-
MSMEG_2242|M.smegmatis_MC2_155 DRHVDEFVEVARGTLRRMFPTITDNPDYCSSVNRSNFDRVVGLIADARAR
. :* : . :*. :*:*: . : .
MAV_5095|M.avium_104 -------KVVAGGRADATTLRIEPTVIVDPPPNDPVMAEEIFGPILPVLS
TH_2652|M.thermoresistible__bu -------RIVSGGGTDRARLRIEPTVIVDPVPTDPVMAEEIFGPILPVLT
MMAR_0359|M.marinum_M AKAGGKCKVEVGGKCTAESLRIQPTVVVDPDPSGPVMTNEIFGPILPVLT
MUL_4760|M.ulcerans_Agy99 AKAGGKCKVEVGGKCTAESLRIQPTVVVDPDPSGPVMTNEIFGPILPVLT
Mb0152|M.bovis_AF2122/97 AAADG-GGVVVGGDCDASNLRIQPTVVVDPDPDGPLMSNEIFGPILPVVT
Rv0147|M.tuberculosis_H37Rv AAADG-GGVVVGGDCDASNLRIQPTVVVDPDPDGPLMSNEIFGPILPVVT
MLBr_02639|M.leprae_Br4923 -AAGGKGVVVVGGKCDASTLRIQPTVIVDPDPEGPLMTKEIFGPILPVLT
Mflv_0742|M.gilvum_PYR-GCK -------TVAVGGDSDAVNLKISPTVVVDPDPAEPLMTDEIFGPILPVLT
Mvan_0105|M.vanbaalenii_PYR-1 -------KVAIGGGSDAVAMKIQPTVVVDPDPAEPLMTDEIFGPILPVVT
MAB_4605c|M.abscessus_ATCC_199 -------QVAVGGASDAESLTIEPTIVVDPDADEPLMQEEIFGPILPIVT
MSMEG_2242|M.smegmatis_MC2_155 GARVESIVPVGEVLPDPVTRKIPPTIIRDVDDRMRINDEEVFGPVLAVRG
* **:: * : .*:***:*.:
MAV_5095|M.avium_104 VESLDDAVRFVNARPKSLALYIFATG-KVGRDLVDRIPSGGAVINHVAMH
TH_2652|M.thermoresistible__bu IESADAAVKFVNDRPKPLAMYVFTKSTQTGRRLIDAIPSGGAVINHLAMH
MMAR_0359|M.marinum_M VKSLDEAIGFVNSRPKPLSAYLFTKSREIRERVINEVPAGGMMVNHLAFQ
MUL_4760|M.ulcerans_Agy99 VKSLDEAIGFVNSRPKPLSAYLFTKSREIRERVINEVPAGGMMVNHLAFQ
Mb0152|M.bovis_AF2122/97 VKSLDDAIRFVNSRPKPLSAYLFTKSRAVRERVIREVPAGGMMVNHLAFQ
Rv0147|M.tuberculosis_H37Rv VKSLDDAIRFVNSRPKPLSAYLFTKSRAVRERVIREVPAGGMMVNHLAFQ
MLBr_02639|M.leprae_Br4923 VQSLDEAIGFINARPKPLAAYLFTKSRKTRDRVIKEVSAGGMLVNHLAIQ
Mflv_0742|M.gilvum_PYR-GCK VQNLDEAISFVNSRPKPLAAYLFTKAKAVRERVIKEVPAGGMVVNHLIFH
Mvan_0105|M.vanbaalenii_PYR-1 VQNLDEAISFVNSRPKPLAAYLFTKAKAVRERVIKEVPAGGMVVNHLIFH
MAB_4605c|M.abscessus_ATCC_199 AETLDAAIDFINSRPKPLAAYAFTESKYTANRYAAEVPAGGMVINHLLYH
MSMEG_2242|M.smegmatis_MC2_155 YSSLASTIDYINSRPSPLVAYWFGPDDADFRHFVDHTRSGGVARNDFAAH
.. :: ::* **..* * * :** *.. :
MAV_5095|M.avium_104 CLVPALPFGGVGASGMGAYHGKWGFETLSHRRAVLSKSPRPDPR-LVYPP
TH_2652|M.thermoresistible__bu CLVPQLPFGGVGDSGMGAYHGRWGFEALSHRRAVLAKPSRPDPS-LVYPP
MMAR_0359|M.marinum_M VSTAKLPFGGVGASGMGAYHGKWGFDEFSHRKSVLTKPTRPDLSNIIYPP
MUL_4760|M.ulcerans_Agy99 VSTAKLPFGGVGASGMGAYHGKWGFDEFSHRKSVLTKPTRPDLSNIIYPP
Mb0152|M.bovis_AF2122/97 VSTAKLPFGGVGASGMGAYHGRWGFEEFSHRKSVLTKPTRPDLSSFIYPP
Rv0147|M.tuberculosis_H37Rv VSTAKLPFGGVGASGMGAYHGRWGFEEFSHRKSVLTKPTRPDLSSFIYPP
MLBr_02639|M.leprae_Br4923 VLTAKLPFGGVGESGIGAYHGKWGFDEFSHRKSVLTKPTRPDLSSFIYPP
Mflv_0742|M.gilvum_PYR-GCK FATHKLPFGGVGPSGLGAYHGKFGFEEFSHRKSVLTKPTRPDLGSMIYPP
Mvan_0105|M.vanbaalenii_PYR-1 FATHKLPFGGVGPSGLGAYHGKFGFEEFSHRKSVLTKPTRPDLGAMIYPP
MAB_4605c|M.abscessus_ATCC_199 AVIPKLPFGGVGASGMGAYHGKAGFDEFSHRKSTLYKSTALDLK-LPYPP
MSMEG_2242|M.smegmatis_MC2_155 MIPSSAPFGGVGRSGMGAYHGKAGFDAFSHHRTVVGTDLPFSITGRAALP
****** **:*****: **: :**:::.: . . *
MAV_5095|M.avium_104 YSQRALGVMRKLF---------------
TH_2652|M.thermoresistible__bu YTERALKLMRRMF---------------
MMAR_0359|M.marinum_M YTERAFKLARRLF---------------
MUL_4760|M.ulcerans_Agy99 YTERAFKLARRLF---------------
Mb0152|M.bovis_AF2122/97 YTERAIKVARRLF---------------
Rv0147|M.tuberculosis_H37Rv YTERAIKVARRLF---------------
MLBr_02639|M.leprae_Br4923 YTERSFRLAHRLF---------------
Mflv_0742|M.gilvum_PYR-GCK YTEKAFKLARKLF---------------
Mvan_0105|M.vanbaalenii_PYR-1 YTEKAWKLARKLF---------------
MAB_4605c|M.abscessus_ATCC_199 YTEKNLKLMQRLM---------------
MSMEG_2242|M.smegmatis_MC2_155 FTGSMRVSADLALWRARSRTKNRLRKFR
:: :