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MPLHASVRPEADAETDRLGPDDVHHVLARSILADGLDLVLDIDRSHGSHLVDARTGRSYLDMFTFFASSA LGMNHPGLAGDPEFRAELAAAALNKPSNSDVYSVPMARFVDTFARVLGDPDLLHLFFVDGGALAVENALK VAFDWKSRLNEARGLDPALGTKVLHLKGAFHGRSGYTLSLTNTDPNKVARFPKFDWPRIDAPVCSAGMDN EAVDALEAESLRQARAAFEANPHDIACFIAEPIQGEGGDRHFRPQFFAAMRQLCDEFDSLLIFDEVQTGC GITGTPWAYQQLGVRPDVVAFGKKTQVCGVMAGGRVDEVPANVFHTSSRINSTWGGNLADMVRARRILEV IEVDGLFDRAAESGRYLRDGLDGLAADFPVLVRDVRGRGLMCAFSMPSAAQRDALIAGLWDCGVIMLGSG PDSVRFRPALTVSTAELDAALDAVRAVLRTM
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1652 | - | - | 100% (451) | L-lysine aminotransferase |
| M. vanbaalenii PYR-1 | Mvan_3146 | - | 2e-30 | 30.64% (408) | aminotransferase class-III |
| M. vanbaalenii PYR-1 | Mvan_3311 | argD | 1e-26 | 28.57% (399) | acetylornithine aminotransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3318c | lat | 0.0 | 76.46% (429) | L-lysine aminotransferase |
| M. gilvum PYR-GCK | Mflv_4796 | - | 0.0 | 84.95% (432) | L-lysine aminotransferase |
| M. tuberculosis H37Rv | Rv3290c | lat | 0.0 | 76.46% (429) | L-lysine aminotransferase |
| M. leprae Br4923 | MLBr_01409 | argD | 7e-28 | 28.82% (399) | acetylornithine aminotransferase |
| M. abscessus ATCC 19977 | MAB_3646c | - | 0.0 | 74.42% (434) | L-lysine aminotransferase |
| M. marinum M | MMAR_1243 | lat | 0.0 | 74.27% (447) | L-lysine-epsilon aminotransferase Lat |
| M. avium 104 | MAV_4262 | - | 0.0 | 78.29% (433) | L-lysine aminotransferase |
| M. smegmatis MC2 155 | MSMEG_1764 | - | 0.0 | 78.75% (447) | L-lysine aminotransferase |
| M. thermoresistible (build 8) | TH_3529 | - | 9e-33 | 32.27% (406) | PUTATIVE aminotransferase |
| M. ulcerans Agy99 | MUL_2644 | lat | 0.0 | 73.83% (447) | L-lysine aminotransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3318c|M.bovis_AF2122/97 ---------MAAVVKSVAL-AGRPTTPDRVHEVLGRSMLVDGLDIVLDLT
Rv3290c|M.tuberculosis_H37Rv ---------MAAVVKSVAL-AGRPTTPDRVHEVLGRSMLVDGLDIVLDLT
MMAR_1243|M.marinum_M ---------MTAAVRSTVP-ACQQIEADDVQEVLGRSMLVDGFDLVLDLS
MUL_2644|M.ulcerans_Agy99 ---------MTAAVRSTVP-ACQQIEADDIQEVLGRSMLVDGFDLVLDLS
MAV_4262|M.avium_104 ---------MTAALERLAR-ARSCTGPDRVHEVLSRSILTDGFDFVLDLD
Mvan_1652|M.vanbaalenii_PYR-1 ------MPLHASVRPEADA-ETDRLGPDDVHHVLARSILADGLDLVLDID
Mflv_4796|M.gilvum_PYR-GCK ---------MTAVLSRAD--RTAVIVPADVRTVLSRSILADGLDLVLDLE
MSMEG_1764|M.smegmatis_MC2_155 ----MTALLNTPVSGSSSPGASPELAPELVRETLARSILADGFDFVLDLE
MAB_3646c|M.abscessus_ATCC_199 MTALIFPGFQAGPTHGDQATRPDPVTPDRVHDVLRRSILADGMDLVLDLE
MLBr_01409|M.leprae_Br4923 -------------------MTPTQTNTATMQQRWETVMMNNYGTPPIVLA
TH_3529|M.thermoresistible__bu --------------------VSGSKGRHTLLDRWQGVMMNNYGTPPLALV
: :: : : :
Mb3318c|M.bovis_AF2122/97 RSGGSYLVDAITGRRYLDMFTFVASSALGMNPPALVDDREFHAELMQAAL
Rv3290c|M.tuberculosis_H37Rv RSGGSYLVDAITGRRYLDMFTFVASSALGMNPPALVDDREFHAELMQAAL
MMAR_1243|M.marinum_M QSAGSYLVDARTGRRYLDMFTFFASSALGMNHPGLAEDEQFRAELLEAAL
MUL_2644|M.ulcerans_Agy99 QSAGSYLVDARTGRRYLDMFTFFASSALGMNHPGLAEDEQFRAELLEAAL
MAV_4262|M.avium_104 RSRGSVLYDARDGRRYLDMFTFFASSALGMNHPALARDAEFRAELTAAAL
Mvan_1652|M.vanbaalenii_PYR-1 RSHGSHLVDARTGRSYLDMFTFFASSALGMNHPGLAGDPEFRAELAAAAL
Mflv_4796|M.gilvum_PYR-GCK RSHGSYLVDARTGRGYLDMFTFFASSALGMNHPALADDPDFRAELAAAAV
MSMEG_1764|M.smegmatis_MC2_155 ESRGSHLVDARTGERFLDMFTFFASSALGMNHSALADDPEFRAELAQAAL
MAB_3646c|M.abscessus_ATCC_199 RSHGAHLVDARDGTDYLDMFTFFASSALGMNHPMLAEDDEFRAELATAAI
MLBr_01409|M.leprae_Br4923 SGNGAVVTDVD-SNTYLDLLGGIAVNVLGHRHPAVIEAVTHQITTLGHTS
TH_3529|M.thermoresistible__bu SGDGAVVTDAD-GKSYLDLLGGIAVNILGHRHPAVIEAVTRQLNTLGHTS
. *: : *. . :**:: .* . ** . . : : :
Mb3318c|M.bovis_AF2122/97 NKPSNSDVYSVAMARFVETFARVLGDPALPHLFFVEGGALAVENALKAAF
Rv3290c|M.tuberculosis_H37Rv NKPSNSDVYSVAMARFVETFARVLGDPALPHLFFVEGGALAVENALKAAF
MMAR_1243|M.marinum_M NKPSNADVYSVPMARFVQTFVRVLGDPALPHLFFVDGGALAVENALKVAF
MUL_2644|M.ulcerans_Agy99 NKPSNADVYSVPMARFVQTFVRVLGDPALPHLFFVDGGALAVENALKVAF
MAV_4262|M.avium_104 NKPSNSDVYSVPMARFVETFVRVLGDPALPHLFFVDGGALAVENALKVAF
Mvan_1652|M.vanbaalenii_PYR-1 NKPSNSDVYSVPMARFVDTFARVLGDPDLLHLFFVDGGALAVENALKVAF
Mflv_4796|M.gilvum_PYR-GCK NKPSNSDVYSVPMARFVDTFSRVLGDPALPHLFFVDGGALAVENALKVAF
MSMEG_1764|M.smegmatis_MC2_155 NKPSNSDIYSVPMARFVDTFRRVLGDPALPHLFFVDGGALAVENALKVAF
MAB_3646c|M.abscessus_ATCC_199 NKPSNSDIYTVEMARFVDTFARVLGDPALPHLFFVDGGALAVENALKVAF
MLBr_01409|M.leprae_Br4923 N-----LYATEPSITLAEELVALLGADTQTRVFFCNSGTEANELAFKLSR
TH_3529|M.thermoresistible__bu N-----LYATEPGVALAEALVGHLGAP--ARVFFCNSGAEANEVAFKISR
* : :.: : ** ::** :.*: * * *:* :
Mb3318c|M.bovis_AF2122/97 DWKSRHNQAHGIDPALGTQVLHLRGAFHGRSGYTLSLTNTKPTITARFPK
Rv3290c|M.tuberculosis_H37Rv DWKSRHNQAHGIDPALGTQVLHLRGAFHGRSGYTLSLTNTKPTITARFPK
MMAR_1243|M.marinum_M DWKSRHNQALGIDAGLGTKVLHLRGAFHGRSGYTLSLTNTKPVNVARFPT
MUL_2644|M.ulcerans_Agy99 DWKSRHNQALGIDAGLGTKVLHLRGAFHGRSGYTLSLTNTKPVNVARFPT
MAV_4262|M.avium_104 DWKNRHNERRGVDPALGTRVLHLRGAFHGRSGYTLSLTNTKPVTVARFPR
Mvan_1652|M.vanbaalenii_PYR-1 DWKSRLNEARGLDPALGTKVLHLKGAFHGRSGYTLSLTNTDPNKVARFPK
Mflv_4796|M.gilvum_PYR-GCK DWKSRLNEAQGRSPDLGTKVLHLRGAFHGRSGYTMSLTNTDPNKVARFPK
MSMEG_1764|M.smegmatis_MC2_155 DWKSRHNEAHGIDPELGTKVLHLRGAFHGRSGYTLSLTNTDPVKVARFPK
MAB_3646c|M.abscessus_ATCC_199 DWKSRWNEAHGIDASLGTKVLHLREAFHGRSGYTMSLTNTDPNKVARFPK
MLBr_01409|M.leprae_Br4923 LTG-------------RTKLVAAQAAFHGRTMGSLALTGQ-PAKQAAFEP
TH_3529|M.thermoresistible__bu LTG-------------RTKVVAAEGGFHGRTMGALALTGQ-PSKREPFEP
*::: . .****: :::**. * *
Mb3318c|M.bovis_AF2122/97 FDWPRIDAPYMRPGLDEPAMAALEAEALRQARAAFETRPHDIACFVAEPI
Rv3290c|M.tuberculosis_H37Rv FDWPRIDAPYMRPGLDEPAMAALEAEALRQARAAFETRPHDIACFVAEPI
MMAR_1243|M.marinum_M FDWPRIDAPYIRP---DADMDAVEAESLAQARAAFEAHPHDIACFIAEPI
MUL_2644|M.ulcerans_Agy99 FDWPRIDAPYIRP---DADMDAVEAESLAQARAAFEAHPHDIACFIAEPI
MAV_4262|M.avium_104 FDWPRIDAPHLRCG---ADIDALEAESLRQARAAFAAHPHDIACFIAEPI
Mvan_1652|M.vanbaalenii_PYR-1 FDWPRIDAPVCSAGMDNEAVDALEAESLRQARAAFEANPHDIACFIAEPI
Mflv_4796|M.gilvum_PYR-GCK FDWPRIDAPSVRSGAN---IEALEAESLRQARAAFEAHPHDIACFIAEPI
MSMEG_1764|M.smegmatis_MC2_155 FDWPRIDAPYVRPGLDDDAMAALEAESLRQARAAFEAHPHDIACFIAEPI
MAB_3646c|M.abscessus_ATCC_199 FDWPRIDAPYLRPG---ADIEALEASALAQARRAFAENPHDIACFIAEPI
MLBr_01409|M.leprae_Br4923 LPGHVTHVPYGQVD------------------ALAAAVDNDTAAVFLEPI
TH_3529|M.thermoresistible__bu LPGDVIHVPYGDAG------------------ALERAVDDTTAAVFLEPI
: ..* . *... ***
Mb3318c|M.bovis_AF2122/97 QGEGGDRHFRPEFFAAMRELCDEFDALLIFDEVQTGCGLTGTAWAYQQLD
Rv3290c|M.tuberculosis_H37Rv QGEGGDRHFRPEFFAAMRELCDEFDALLIFDEVQTGCGLTGTAWAYQQLD
MMAR_1243|M.marinum_M QGEGGDRHFRPEFFAAMRRLCDEHDALLIFDEVQTGCAMTGTPWAYQQLG
MUL_2644|M.ulcerans_Agy99 QGEGGDRHFRPEFFAAMRRLCDEHDALLIFDEVQTGCAMTGTPWAYQQLG
MAV_4262|M.avium_104 QGEGGDRHFRPEFFAAMRRLCDEHDALLIFDEVQTGCGLTGTAWAYQQFG
Mvan_1652|M.vanbaalenii_PYR-1 QGEGGDRHFRPQFFAAMRQLCDEFDSLLIFDEVQTGCGITGTPWAYQQLG
Mflv_4796|M.gilvum_PYR-GCK QGEGGDRHLRPEFFAAMRELCDEFDALLIFDEVQTGCGITGTAWAYQQLG
MSMEG_1764|M.smegmatis_MC2_155 QGEGGDRHFRPEFFAAMRELCDEFDALLIFDEVQTGCGITGTAWAYQQLG
MAB_3646c|M.abscessus_ATCC_199 QGEGGDHHFRPEFFHAMRALCHENDALFIFDEVQTGCGLTGTAWAFQQLG
MLBr_01409|M.leprae_Br4923 MGESGVIVPPEGYLAAARDITTRHGALLVIDEVQTGIGRTGAFFAHQHDS
TH_3529|M.thermoresistible__bu MGEGGVVVPPAGYLAAAREVTARHGALLVLDEVQTGIGRTGTFFAHQHDG
**.* :: * * : . .:*:::****** . **: :*.*: .
Mb3318c|M.bovis_AF2122/97 VAPDIVAFGKKTQVCGVMAGRRVDEVADNVFAVPSRLNSTWGGNLTDMVR
Rv3290c|M.tuberculosis_H37Rv VAPDIVAFGKKTQVCGVMAGRRVDEVADNVFAVPSRLNSTWGGNLTDMVR
MMAR_1243|M.marinum_M VKPDVVAFGKKTQVCGVMAGGRVDEIVDNVFAVSSRLNSTWGGNLTDMVR
MUL_2644|M.ulcerans_Agy99 VKPDVVAFGKKTQVCGVMAGGRVDEIVDNVFAVSSRLNSTWGGNLTDMVR
MAV_4262|M.avium_104 VQPDVVAFGKKTQVCGIMAGRRVDEVADNVFAVSSRLNSTWGGNLADMVR
Mvan_1652|M.vanbaalenii_PYR-1 VRPDVVAFGKKTQVCGVMAGGRVDEVPANVFHTSSRINSTWGGNLADMVR
Mflv_4796|M.gilvum_PYR-GCK VLPDVVAFGKKTQVCGVMAGTRVDEVPDNVFRTSSRINSTWGGNLVDMVR
MSMEG_1764|M.smegmatis_MC2_155 VMPDVVSFGKKTQVCGVMAGRRVDEVADNVFAVSSRINSTWGGNLVDMVR
MAB_3646c|M.abscessus_ATCC_199 VIPDVVAFGKKTQVCGVMAGGRVDEVDDNVFAVSSRINSTWGGNLVDMVR
MLBr_01409|M.leprae_Br4923 ITPDVVTLAKG-LGGGLPIGAFLATGPAAELLTLGLHGSTFGGNPVCTAA
TH_3529|M.thermoresistible__bu ITPDVVTLAKG-LGGGLPIGACLAVGPAGDLLTPGMHGSTFGGNPVCTAA
: **:*::.* *: * : : . . .**:*** . .
Mb3318c|M.bovis_AF2122/97 ARRILEVIEAEGLFERAVQHGKYLRARLDELAADFPAVVLDPRGRGLMCA
Rv3290c|M.tuberculosis_H37Rv ARRILEVIEAEGLFERAVQHGKYLRARLDELAADFPAVVLDPRGRGLMCA
MMAR_1243|M.marinum_M ARRILEVIEAEGLVDNAAEQGRYLRAQFDELAKDLPAVVLHPRGRGLMCA
MUL_2644|M.ulcerans_Agy99 SRRILEVIEAEGLVDNAAEQGRYLRAQFDELAKDLPAVVLHPRGRGLMCA
MAV_4262|M.avium_104 ARRILEVIEADELFEHAARQGAYLLRGLHDLAREFPGLVLDVRGRGLMCA
Mvan_1652|M.vanbaalenii_PYR-1 ARRILEVIEVDGLFDRAAESGRYLRDGLDGLAADFPVLVRDVRGRGLMCA
Mflv_4796|M.gilvum_PYR-GCK ARRILEVIERDGLFDNAAQRGRHLRDGLAGLAVEFPGLVRDVRGRGLMCA
MSMEG_1764|M.smegmatis_MC2_155 SRRILEVIERDGLLDNARDMGAYLLDELRVLATRFPGVVVDPRGRGLMCA
MAB_3646c|M.abscessus_ATCC_199 SRRILEVVEAQRLFANAMRMGEYLLERLQTLAVRHDAVG-DVRGRGLMCA
MLBr_01409|M.leprae_Br4923 ALAVLRVLATQGLVRRAEVLGDSMRIGIESLS---HPLIDQVRGRGLLLG
TH_3529|M.thermoresistible__bu AVAVLGALAEGDLINRADVLGKKLSHGIEELR---HPLVDHVRGRGLLCG
: :* .: *. .* * : : * : . *****: .
Mb3318c|M.bovis_AF2122/97 FSLPTTADRDELIRQLWQRA-VIVLPAGADTVRFRPPLTVSTAEIDAAIA
Rv3290c|M.tuberculosis_H37Rv FSLPTTADRDELIRQLWQRA-VIVLPAGADTVRFRPPLTVSTAEIDAAIA
MMAR_1243|M.marinum_M FDLPTTADRDELIQRLWQRA-VIALPAGKVSVRFRPALTVGRDEIDLAIA
MUL_2644|M.ulcerans_Agy99 FDLPTTADRDELIQRLWQRA-VIALPAGKVSVRFRPALTVGRDEIDLAIA
MAV_4262|M.avium_104 FSLPTTADRDELIGRLWRGG-VIVLPTGDDGVRFRPALTVSRGEIDAAIG
Mvan_1652|M.vanbaalenii_PYR-1 FSMPSAAQRDALIAGLWDCG-VIMLGSGPDSVRFRPALTVSTAELDAALD
Mflv_4796|M.gilvum_PYR-GCK FSMPSARQRDELLARLWECG-VIMLGCGTDSVRFRPALTVNDDEIDAALT
MSMEG_1764|M.smegmatis_MC2_155 FSMPTPEDRDALIRKLWDRH-VIMLPSGADSVRFRPALPVTRAEIDACLD
MAB_3646c|M.abscessus_ATCC_199 FSLPTAEERDHLVQRLWADERVILLPSGENSVRFRPPLIVSAEEIDAAVA
MLBr_01409|M.leprae_Br4923 IVLTAPRAKD--IEKAARDAGFLVNATAPEVIRLAPPLIITESQIDSFIT
TH_3529|M.thermoresistible__bu VVLNAPQAKA--AEAAARDAGFLVNAAAPEVIRLAPPLIITETQIDEFLA
. : :. : .: . :*: *.* : ::* :
Mb3318c|M.bovis_AF2122/97 AVRSALPVVT-------
Rv3290c|M.tuberculosis_H37Rv AVRSALPVVT-------
MMAR_1243|M.marinum_M AVRSALSAMT-------
MUL_2644|M.ulcerans_Agy99 AVRSALSAMT-------
MAV_4262|M.avium_104 AVRDALPTLG-------
Mvan_1652|M.vanbaalenii_PYR-1 AVRAVLRTM--------
Mflv_4796|M.gilvum_PYR-GCK AVAAVLRTMAVPQAG--
MSMEG_1764|M.smegmatis_MC2_155 AVRAVLSER--------
MAB_3646c|M.abscessus_ATCC_199 AVSRVLALR--------
MLBr_01409|M.leprae_Br4923 ALPGILDASIAELGKKA
TH_3529|M.thermoresistible__bu ALPGVLDTAKEAS----
*: *