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VIEFAMPALGSDMDEGMLNEWLVKPGDTVSRGQVVAVVETTKAAVEIECWHDGTVHELLVPVGQTVSVGT PLATLLESGEVAAEHPAVSPKQPAAAPSEQPAAVSSEQPAAVAPGRPAAVSSGRPAAVSSGRPAAVSSGR PAAVSSGRPAAVPSGHRRWVSPAARRLASSLHVDLDAVTGTGPQGAVTITDVEHAAAEAAGSAAETARPA AETAGPAAAKPAESRGAMMRRSIAAAMGRSKREIPHYYLANEILLDASSQWLAERNAQRSITERVLPAAL LLKAVGVAAQRFQELNGFWRDDGFVPADAVHVGVGISLRGGGLVAPAIHDVPGKKLDEVMSELTDLVARA RAGSLRSSEMSDPTITVTNLGDQGVDTVFGIIYPPQVALVGFGKPAQRVCAVDGGIRIATTVHATLAADH RASDGHRGAMFLAAIDQLLQQPDQLEK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1410 | - | - | 100% (447) | branched-chain alpha-keto acid dehydrogenase subunit E2 |
| M. vanbaalenii PYR-1 | Mvan_4084 | - | 1e-40 | 29.75% (447) | branched-chain alpha-keto acid dehydrogenase subunit E2 |
| M. vanbaalenii PYR-1 | Mvan_3579 | - | 8e-36 | 28.98% (459) | dihydrolipoamide acetyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2238 | dlaT | 6e-35 | 30.07% (459) | dihydrolipoamide acetyltransferase |
| M. gilvum PYR-GCK | Mflv_2935 | - | 6e-37 | 27.77% (461) | dihydrolipoamide acetyltransferase |
| M. tuberculosis H37Rv | Rv2215 | dlaT | 6e-35 | 30.07% (459) | dihydrolipoamide acetyltransferase |
| M. leprae Br4923 | MLBr_00861 | - | 2e-31 | 26.49% (521) | dihydrolipoamide acetyltransferase |
| M. abscessus ATCC 19977 | MAB_4916c | - | 1e-43 | 31.54% (447) | putative dihydrolipoamide acyltransferase component |
| M. marinum M | MMAR_3491 | - | 1e-163 | 67.99% (453) | pyruvate dehydrogenase (E2 component) |
| M. avium 104 | MAV_2273 | sucB | 2e-39 | 27.96% (465) | dihydrolipoamide acetyltransferase |
| M. smegmatis MC2 155 | MSMEG_4710 | - | 3e-42 | 29.53% (447) | branched-chain alpha-keto acid dehydrogenase subunit E2 |
| M. thermoresistible (build 8) | TH_0716 | pdhC | 5e-42 | 31.54% (447) | PROBABLE DIHYDROLIPOAMIDE S-ACETYLTRANSFERASE E2 COMPONENT |
| M. ulcerans Agy99 | MUL_3575 | sucB | 2e-38 | 29.87% (462) | dihydrolipoamide acetyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_00861|M.leprae_Br4923 ---MACSVQMPALGESVTEGTVTRWLKQEGDTVELDEPLVEVSTDKVDTE
MAV_2273|M.avium_104 ---MAFSVQMPALGESVTEGTVTRWLKQEGDTVELDEPLVEVSTDKVDTE
Mb2238|M.bovis_AF2122/97 ---MAFSVQMPALGESVTEGTVTRWLKQEGDTVELDEPLVEVSTDKVDTE
Rv2215|M.tuberculosis_H37Rv ---MAFSVQMPALGESVTEGTVTRWLKQEGDTVELDEPLVEVSTDKVDTE
MUL_3575|M.ulcerans_Agy99 ---MAFSVQMPALGESVTEGTVTRWLKQEGDTVEIDEPLVEVSTDKVDTE
Mflv_2935|M.gilvum_PYR-GCK ---MAISVQMPALGESVTEGTVTRWLKQEGDTVEEDEPLLEVSTDKVDTE
MSMEG_4710|M.smegmatis_MC2_155 --MSTRDFLVPDLGEGLQDATITSWNVDVGDTVELNQTLCTVETNKAEVE
TH_0716|M.thermoresistible__bu MNGSIREFLLPDLGEGLEDATITDWSVTVGDEVELNQPLCTVETNKAEVE
MAB_4916c|M.abscessus_ATCC_199 --MAVKQFLLPDLGEGLTEADLISWKVRVGDEVKLNQVLADVETAKAMVE
Mvan_1410|M.vanbaalenii_PYR-1 ----MIEFAMPALGSDMDEGMLNEWLVKPGDTVSRGQVVAVVETTKAAVE
MMAR_3491|M.marinum_M ----MIEFKMPALGSDMDEGTLNEWLVKPGDKVSRGQIVAIVETTKAAVE
.. :* **..: :. : * ** *. .: : *.* *. .*
MLBr_00861|M.leprae_Br4923 IPSPAAGVLTKIIAQEDDTVEVGGELAVIGAPSE----------AAAA--
MAV_2273|M.avium_104 IPSPAAGVLTKIIAQEDDTVEVGGELAVIGDAAD----------DAAAGG
Mb2238|M.bovis_AF2122/97 IPSPAAGVLTKIIAQEDDTVEVGGELAVIGDAKD----------AGEA--
Rv2215|M.tuberculosis_H37Rv IPSPAAGVLTKIIAQEDDTVEVGGELAVIGDAKD----------AGEA--
MUL_3575|M.ulcerans_Agy99 IPSPAAGVLTKIVAKEDDTVEVGGELAIIGDAAE----------SGGG--
Mflv_2935|M.gilvum_PYR-GCK IPSPASGVLKKIVAQEDDTVEVGGELAVIGDADDSDSDDSDSDDAGDSDD
MSMEG_4710|M.smegmatis_MC2_155 IPSPYAGKVEALGGAAGDTLAVGSLLVRIATSSDEP--------------
TH_0716|M.thermoresistible__bu IPSPYAGRIVELGGAAGETLPVGAVLVRIETSSAG---------------
MAB_4916c|M.abscessus_ATCC_199 LPSPFEGTVVALQAAENSTVAVGAPLISIEVAGAE---------------
Mvan_1410|M.vanbaalenii_PYR-1 IECWHDGTVHELLVPVGQTVSVGTPLATLLESGEVA--------------
MMAR_3491|M.marinum_M IECWQEGTVDELVVPVGDTVEVGTVLATLLEPG-----------------
: . * : : ..*: ** * : .
MLBr_00861|M.leprae_Br4923 -APAP----------RPEPKAQPEPAASSQPAAPAQ-----QPSGAATAT
MAV_2273|M.avium_104 GAQAPSQPSQPQAPAQPEPQAQAQPEAPAQPQAPAQPAP--QESGGGAAT
Mb2238|M.bovis_AF2122/97 AAPAP----------EKVPAAQPESKPAPEP-PPVQPTS--GAPAGGDAK
Rv2215|M.tuberculosis_H37Rv AAPAP----------EKVPAAQPESKPAPEP-PPVQPTS--GAPAGGDAK
MUL_3575|M.ulcerans_Agy99 DAPSQPEPE-----AEPAAAAQPEPEAEPEPQPEAKPQSGGSSTAGGDVT
Mflv_2935|M.gilvum_PYR-GCK SEAEDSGDEAEPAAEESEPEPEPEPEDEDEPEPEPKKKSSGGSGSSGSGT
MSMEG_4710|M.smegmatis_MC2_155 --------------------------------------------------
TH_0716|M.thermoresistible__bu --------------------------------------------------
MAB_4916c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_1410|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3491|M.marinum_M --------------------------------------------------
MLBr_00861|M.leprae_Br4923 PVLMPELGESVTEGTVTRWLKKIGDSVQADEPLVEVSTDKVDTEIPSPVA
MAV_2273|M.avium_104 PVLMPELGESVTEGTVTRWLKKVGDSVQVDDALVEVSTDKVDTEIPSPVA
Mb2238|M.bovis_AF2122/97 PVLMPELGESVTEGTVIRWLKKIGDSVQVDEPLVEVSTDKVDTEIPSPVA
Rv2215|M.tuberculosis_H37Rv PVLMPELGESVTEGTVIRWLKKIGDSVQVDEPLVEVSTDKVDTEIPSPVA
MUL_3575|M.ulcerans_Agy99 PVLMPELGESVAEGTVTRWLKKVGDSVQVDEALVEVSTDKVDTEIPSPVA
Mflv_2935|M.gilvum_PYR-GCK SVTMPELGESVTEGTVTRWLKEVGDTVEVDEPLVEVSTDKVDTEIPSPVA
MSMEG_4710|M.smegmatis_MC2_155 ------------------------------------VEAQPMNGEVPQRK
TH_0716|M.thermoresistible__bu ----------------------------------------------ADRD
MAB_4916c|M.abscessus_ATCC_199 ----------------------------------------------PDAP
Mvan_1410|M.vanbaalenii_PYR-1 -------------------------------------------AEHPAVS
MMAR_3491|M.marinum_M --------------------------------------------ASPQRS
.
MLBr_00861|M.leprae_Br4923 GVLVSITTNEDTTVPVGGELARIG-VTLDS--------------------
MAV_2273|M.avium_104 GVLISITAEEDSTVPVGGELARIG-TGAQAPAPAAPQPPPAPKPEPKPEP
Mb2238|M.bovis_AF2122/97 GVLVSISADEDATVPVGGELARIG-VAADIG-------------------
Rv2215|M.tuberculosis_H37Rv GVLVSISADEDATVPVGGELARIG-VAADIG-------------------
MUL_3575|M.ulcerans_Agy99 GVLLSITAEEDDVVQVGGELARIG-SGSAAAAPPESKPAPAPEAAPETKA
Mflv_2935|M.gilvum_PYR-GCK GTLLSITAEEDDTVEVGGELAKIGDAGAEEESEPEPEPEPEPEPEPEPEP
MSMEG_4710|M.smegmatis_MC2_155 SVLVGYGADDSMDASRRR--------------------------------
TH_0716|M.thermoresistible__bu PVLVGYGADDAMDTSRRT--------------------------------
MAB_4916c|M.abscessus_ATCC_199 ANLVGYGPSDSAGQTRRRRRSGAG--------------------------
Mvan_1410|M.vanbaalenii_PYR-1 PKQPAAAPSEQPAAVSSEQPAAVA--------------------------
MMAR_3491|M.marinum_M PRQ-----------------------------------------------
MLBr_00861|M.leprae_Br4923 -----------------------IATPAPAPRAESVPSRPTPARKEANG-
MAV_2273|M.avium_104 A-------PQPQAQPAPQPQPQPQAQPAPEPKAQPAQAQPAQAQPAAGGE
Mb2238|M.bovis_AF2122/97 ------------AAPAPKPAPKPVPEPAPTPKAEPAPS-PPAAQPAGAAE
Rv2215|M.tuberculosis_H37Rv ------------AAPAPKPAPKPVPEPAPTPKAEPAPS-PPAAQPAGAAE
MUL_3575|M.ulcerans_Agy99 A-------PEPKAAPEPKAAPEPKAAPEPKP-APAATPQPAAAPAPSAGD
Mflv_2935|M.gilvum_PYR-GCK KQTKPESKPSEEAAPEPKSESKPEAESKPEPKPKPEPEPKRESKPEAESS
MSMEG_4710|M.smegmatis_MC2_155 ----------------------------------------------THGP
TH_0716|M.thermoresistible__bu ----------------------------------------------PHRA
MAB_4916c|M.abscessus_ATCC_199 -----------------------AAALALVEQTTEPEPAVAAPAAQAESV
Mvan_1410|M.vanbaalenii_PYR-1 ---------PGRPAAVSSGRPAAVSSGRPAAVSSGRPAAVSSGRPAAVPS
MMAR_3491|M.marinum_M -------------------RPRKRATPAPTVAAS---APAPAHGATAAPR
MLBr_00861|M.leprae_Br4923 --APYVTPLVRKLATENNIDLAKVI-GTGVGGRIRKQDVLAAAEQRKQQQ
MAV_2273|M.avium_104 G-TPYVTPLVRKLAAENNIDLSSIT-GTGVGGRIRKQDVLAAAEQKQRQQ
Mb2238|M.bovis_AF2122/97 G-APYVTPLVRKLASENNIDLAGVT-GTGVGGRIRKQDVLAAAEQKKRAK
Rv2215|M.tuberculosis_H37Rv G-APYVTPLVRKLASENNIDLAGVT-GTGVGGRIRKQDVLAAAEQKKRAK
MUL_3575|M.ulcerans_Agy99 G-TPYVTPLVRKLAEENNIDLDSVT-GTGVGGRIRKQDVLAAAEKKKERP
Mflv_2935|M.gilvum_PYR-GCK GDSPYVTPLVRKLAGEHGVDLASVK-GTGVGGRIRKQDVLAAAEKSKAPK
MSMEG_4710|M.smegmatis_MC2_155 --RARAKPPVRKLAAELNVDLGALDPGSGPDGIITRDDVLAAAGRSPAAQ
TH_0716|M.thermoresistible__bu TGRPRAKPPVRRLAADLGVDLTAVAPGSGPDGVITRQDVLAAAGADGADA
MAB_4916c|M.abscessus_ATCC_199 PSRAAAKPSVRKLAAELGVALELIN-GTGIGGSITRQDVEAYTRSLTARA
Mvan_1410|M.vanbaalenii_PYR-1 GHRRWVSPAARRLASSLHVDLDAVT-GTGPQGAVTITDVEHAAAEAAGSA
MMAR_3491|M.marinum_M -HRRWVSPAARRLAQSLHVDLDAVS-GTGPQGAVTISDVEHAAASAVPAK
..* .*:** . : * : *:* * : ** :
MLBr_00861|M.leprae_Br4923 APTSAPSAA------------APTPTPVLAHLRGTTQKVSRIRQITAKKT
MAV_2273|M.avium_104 QAAAQPSAAPAPAAAEARKPAAPTPAPALAHLRGTTQKASRIRQITAAKT
Mb2238|M.bovis_AF2122/97 APAPAAQAAAAPAP-----KAPPAPAPALAHLRGTTQKASRIRQITANKT
Rv2215|M.tuberculosis_H37Rv APAPAAQAAAAPAP-----KAPPAPAPALAHLRGTTQKASRIRQITANKT
MUL_3575|M.ulcerans_Agy99 EAKPAAAQASAPASPS--KAAVPAAAAALAHLRGTKQKASRIRQITAIKT
Mflv_2935|M.gilvum_PYR-GCK EDAPKAEPAAEAPG---KTTQAPAPEGALAHLRGTTQKANRIRQITAKKT
MSMEG_4710|M.smegmatis_MC2_155 SAGTPQPSQ--------------------------TRDVRGVQAEMARRM
TH_0716|M.thermoresistible__bu PAAPADAAD--------------------------VVEVGAVQAAMARRM
MAB_4916c|M.abscessus_ATCC_199 PQGAPAEEEPVAGV-------------AVQPGGETRIPIAGVRKHTAAAM
Mvan_1410|M.vanbaalenii_PYR-1 AETARPAAETAGPAA-----------AKPAES-----RGAMMRRSIAAAM
MMAR_3491|M.marinum_M RPAATAASTSAKSIG-----------AKSTAQNKIAERAAQMRKSIAAAM
. :: *
MLBr_00861|M.leprae_Br4923 RESLQATAQLTQTHEVDMAKIVGLRAKAKAAFAEREGVNLTFLPFIAKAA
MAV_2273|M.avium_104 RESLLATAQLTQTHEVDMTRLVGLRARAKAAFAEREGVNLTFLPFIARAV
Mb2238|M.bovis_AF2122/97 RESLQATAQLTQTHEVDMTKIVGLRARAKAAFAEREGVNLTFLPFFAKAV
Rv2215|M.tuberculosis_H37Rv RESLQATAQLTQTHEVDMTKIVGLRARAKAAFAEREGVNLTFLPFFAKAV
MUL_3575|M.ulcerans_Agy99 RESLQATAQLTQTHEVDMTRIVALRARAKGSFAEREGVNLTFLPFIARAV
Mflv_2935|M.gilvum_PYR-GCK RESLQTTAQLTQVHEVDMTRIVALRAKAKAGFAEREGVNLTYLPFIARAV
MSMEG_4710|M.smegmatis_MC2_155 ALSRREIPDAHARVDVDCTALLRLRDRIRSAET---ELPITPFVLTLRLL
TH_0716|M.thermoresistible__bu TQSRREIPDAHGRVEVDCRALLELCAQLG-------ERTVTPFVLTLRLL
MAB_4916c|M.abscessus_ATCC_199 VRSAFTAPHVTEFLTVDMTSTMGLLAELKAKSP---DLKLTPMTLVARMV
Mvan_1410|M.vanbaalenii_PYR-1 GRSKREIPHYYLANEILLDASSQWLAERNAQRS--ITERVLPAALLLKAV
MMAR_3491|M.marinum_M SRSKREIPHYYLADEILMEKSLNWLTTRNAQRS--ITERVLPAVLLLKAV
* .. : : : :
MLBr_00861|M.leprae_Br4923 IDALKIHPNINASYNEDTK--EITYYDAEHLGFAIDTDKG-LLSPVIHYA
MAV_2273|M.avium_104 IDALKIHPNINASYNEETK--EITYYDAEHLGFAVDTEQG-LLSPVVHNA
Mb2238|M.bovis_AF2122/97 IDALKIHPNINASYNEDTK--EITYYDAEHLGFAVDTEQG-LLSPVIHDA
Rv2215|M.tuberculosis_H37Rv IDALKIHPNINASYNEDTK--EITYYDAEHLGFAVDTEQG-LLSPVIHDA
MUL_3575|M.ulcerans_Agy99 IDALKIHPNINASYNEETK--EITYYDAEHLGFAVDTDQG-LLSPVIHNA
Mflv_2935|M.gilvum_PYR-GCK IDALKLHPNVNASYNEESK--EITYHEAEHLGIAVDTEQG-LLSPVIHNA
MSMEG_4710|M.smegmatis_MC2_155 TVALRRHVVLNATWMETTGGPQIHQHSAVHLGIGVAAPRG-LLVPVVRDA
TH_0716|M.thermoresistible__bu GIALQHHPNLNATWRDTDDGPRIHRHRAVHLGIAVSAPRG-LLVPVVADA
MAB_4916c|M.abscessus_ATCC_199 LLALRSHPSLNSAWDEQAG--EIIVKHYVNLGIAAATERG-LVVPNVKGA
Mvan_1410|M.vanbaalenii_PYR-1 GVAAQRFQELNGFWRDDGF----VPADAVHVGVGISLRGGGLVAPAIHDV
MMAR_3491|M.marinum_M GLAAQRFGEFNGFWRDDGF----QAATGVHVGVGISLRGGGLVAPAIHDV
* : . .*. : : ::*.. * *: * : .
MLBr_00861|M.leprae_Br4923 GDLSLAGLARAIVDIAARARSGNLKPEELSGGTFTITNIGSQGALFDTPI
MAV_2273|M.avium_104 GDLSLAGLARAIADIAARARSGNLKPDELSGGTFTITNIGSQGALFDTPI
Mb2238|M.bovis_AF2122/97 GDLSLAGLARAIADIAARARSGNLKPDELSGGTFTITNIGSQGALFDTPI
Rv2215|M.tuberculosis_H37Rv GDLSLAGLARAIADIAARARSGNLKPDELSGGTFTITNIGSQGALFDTPI
MUL_3575|M.ulcerans_Agy99 GDLSLAGLARAIADIAARARSGNLKPDELSGGTFTITNIGSQGALFDTPI
Mflv_2935|M.gilvum_PYR-GCK GDLSLGGLARAISDIAGRARSGNLKPDELSGGTFTITNIGSQGALFDTPI
MSMEG_4710|M.smegmatis_MC2_155 QGMTTRQLAVTVARLVESARAGTLSPAELTGSTFTVSNFGALGVDDGVPV
TH_0716|M.thermoresistible__bu HRMTLPQLGAAVERLVDRARAGTLTPAELTGSTFTVSNFGALGLDDGVPV
MAB_4916c|M.abscessus_ATCC_199 DAMSLGELATAIAQLVSTARAGKTAPTDMSGGTFTLTNIGVFGVDAGTPI
Mvan_1410|M.vanbaalenii_PYR-1 PGKKLDEVMSELTDLVARARAGSLRSSEMSDPTITVTNLGDQGVDTVFGI
MMAR_3491|M.marinum_M ADKKLDELMGDLTDLVARARAGSLRSSEMSDPTITVTNLGDQGVDTVFGV
. : : :. **:*. . :::. *:*::*:* * :
MLBr_00861|M.leprae_Br4923 LVPPQAAMLGIGAIVKRPRVVIDASGNESIGVRAICYLPLTYDHRLIDGA
MAV_2273|M.avium_104 LVPPQAAMLGTGAIVKRPRVIVDEFGNESIGVRSVCYLPLTYDHRLIDGA
Mb2238|M.bovis_AF2122/97 LVPPQAAMLGTGAIVKRPRVVVDASGNESIGVRSVCYLPLTYDHRLIDGA
Rv2215|M.tuberculosis_H37Rv LVPPQAAMLGTGAIVKRPRVVVDASGNESIGVRSVCYLPLTYDHRLIDGA
MUL_3575|M.ulcerans_Agy99 LVPPQAAMLGTGAIVKRPRVVVDDTGNESIGVRSVCYLPLTYDHRLVDGA
Mflv_2935|M.gilvum_PYR-GCK LVPPQAAMLGTGAIVKRPRIIIDEFGNESIGVRSVSYLPLTYDHRLIDGA
MSMEG_4710|M.smegmatis_MC2_155 INYPEAAILGMGSLRERPVVVDG-----AVVARPTMSLTCVFDHRIADGA
TH_0716|M.thermoresistible__bu INYPEAAILGMGMIKPRPVVIDD-----AVVARPTMTLTCAFDHRVADGA
MAB_4916c|M.abscessus_ATCC_199 INPGEAAILALGSVAKRPWVVNG-----ELAVRDVTTLALSFDHRLVDGE
Mvan_1410|M.vanbaalenii_PYR-1 IYPPQVALVGFGKPAQRVCAVDG-----GIRIATTVHATLAADHRASDGH
MMAR_3491|M.marinum_M IYPPQVAIVGFGKPAQRVCVIDG-----GIRVVTTVQGTLAADHRASDGH
: :.*::. * * : . : . *** **
MLBr_00861|M.leprae_Br4923 DAGRFLTTIKHRLEEGAFEADLGL
MAV_2273|M.avium_104 DAGRFLTTIKHRLEEGAFEADLGL
Mb2238|M.bovis_AF2122/97 DAGRFLTTIKHRLEEGAFEADLGL
Rv2215|M.tuberculosis_H37Rv DAGRFLTTIKHRLEEGAFEADLGL
MUL_3575|M.ulcerans_Agy99 DAGRFLTTIKHRLEKGAFEADLGL
Mflv_2935|M.gilvum_PYR-GCK DAGRFVTTIKRRLEEGAFEADLGL
MSMEG_4710|M.smegmatis_MC2_155 QAAAFLGELRGLIEEPDLALLDL-
TH_0716|M.thermoresistible__bu QVAAFLDELRGLIESPSRALLFLR
MAB_4916c|M.abscessus_ATCC_199 QGSKFLADLGAMLTDPRMALVV--
Mvan_1410|M.vanbaalenii_PYR-1 RGAMFLAAIDQLLQQPDQLEK---
MMAR_3491|M.marinum_M RGALFLAAINELLQQPDLLEK---
. *: : : .