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AVKQFLLPDLGEGLTEADLISWKVRVGDEVKLNQVLADVETAKAMVELPSPFEGTVVALQAAENSTVAVG APLISIEVAGAEPDAPANLVGYGPSDSAGQTRRRRRSGAGAAALALVEQTTEPEPAVAAPAAQAESVPSR AAAKPSVRKLAAELGVALELINGTGIGGSITRQDVEAYTRSLTARAPQGAPAEEEPVAGVAVQPGGETRI PIAGVRKHTAAAMVRSAFTAPHVTEFLTVDMTSTMGLLAELKAKSPDLKLTPMTLVARMVLLALRSHPSL NSAWDEQAGEIIVKHYVNLGIAAATERGLVVPNVKGADAMSLGELATAIAQLVSTARAGKTAPTDMSGGT FTLTNIGVFGVDAGTPIINPGEAAILALGSVAKRPWVVNGELAVRDVTTLALSFDHRLVDGEQGSKFLAD LGAMLTDPRMALVV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4916c | - | - | 100% (435) | putative dihydrolipoamide acyltransferase component |
| M. abscessus ATCC 19977 | MAB_0895c | - | 3e-73 | 39.16% (452) | branched-chain alpha-keto acid dehydrogenase subunit E2 |
| M. abscessus ATCC 19977 | MAB_1945c | - | 2e-64 | 36.41% (434) | dihydrolipoamide succinyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2523c | pdhC | 2e-66 | 37.56% (442) | branched-chain alpha-keto acid dehydrogenase subunit E2 |
| M. gilvum PYR-GCK | Mflv_2935 | - | 1e-63 | 35.14% (461) | dihydrolipoamide acetyltransferase |
| M. tuberculosis H37Rv | Rv2495c | pdhC | 1e-66 | 37.78% (442) | branched-chain alpha-keto acid dehydrogenase subunit E2 |
| M. leprae Br4923 | MLBr_00861 | - | 6e-57 | 33.03% (436) | dihydrolipoamide acetyltransferase |
| M. marinum M | MMAR_3842 | pdhC | 3e-63 | 37.92% (443) | dihydrolipoamide S-acetyltransferase E2 component PdhC |
| M. avium 104 | MAV_1677 | - | 1e-67 | 37.81% (439) | branched-chain alpha-keto acid dehydrogenase subunit E2 |
| M. smegmatis MC2 155 | MSMEG_4710 | - | 5e-73 | 39.06% (448) | branched-chain alpha-keto acid dehydrogenase subunit E2 |
| M. thermoresistible (build 8) | TH_0716 | pdhC | 6e-72 | 38.76% (436) | PROBABLE DIHYDROLIPOAMIDE S-ACETYLTRANSFERASE E2 COMPONENT |
| M. ulcerans Agy99 | MUL_3773 | pdhC | 9e-65 | 38.37% (443) | branched-chain alpha-keto acid dehydrogenase subunit E2 |
| M. vanbaalenii PYR-1 | Mvan_3579 | - | 2e-67 | 37.13% (439) | dihydrolipoamide acetyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2523c|M.bovis_AF2122/97 --------------------------------------------------
Rv2495c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3842|M.marinum_M --------------------------------------------------
MUL_3773|M.ulcerans_Agy99 --------------------------------------------------
MAV_1677|M.avium_104 --------------------------------------------------
MSMEG_4710|M.smegmatis_MC2_155 --------------------------------------------------
TH_0716|M.thermoresistible__bu --------------------------------------------------
MAB_4916c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_2935|M.gilvum_PYR-GCK MAISVQMPALGESVTEGTVTRWLKQEGDTVEEDEPLLEVSTDKVDTEIPS
Mvan_3579|M.vanbaalenii_PYR-1 MAISVQMPALGESVTEGTVTRWLKQEGDTVEEDEPLLEVSTDKVDTEIPS
MLBr_00861|M.leprae_Br4923 MACSVQMPALGESVTEGTVTRWLKQEGDTVELDEPLVEVSTDKVDTEIPS
Mb2523c|M.bovis_AF2122/97 --------------------------------------------------
Rv2495c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3842|M.marinum_M --------------------------------------------------
MUL_3773|M.ulcerans_Agy99 --------------------------------------------------
MAV_1677|M.avium_104 --------------------------------------------------
MSMEG_4710|M.smegmatis_MC2_155 --------------------------------------------------
TH_0716|M.thermoresistible__bu --------------------------------------------------
MAB_4916c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_2935|M.gilvum_PYR-GCK PASGVLKKIVAQEDDTVEVGGELAVIGDADDSDSDDSDSDDAGDSDDSEA
Mvan_3579|M.vanbaalenii_PYR-1 PAAGVLKKIVAQEDDTVEVGGELAVIGDADDSD--------AGGDEKPEP
MLBr_00861|M.leprae_Br4923 PAAGVLTKIIAQEDDTVEVGGELAVIGAP------------------SEA
Mb2523c|M.bovis_AF2122/97 ---------------------------------------MSGEDSIRSFP
Rv2495c|M.tuberculosis_H37Rv ---------------------------------------MSGEDSIRSFP
MMAR_3842|M.marinum_M ---------------------------------------MSTGDRLKCFQ
MUL_3773|M.ulcerans_Agy99 ---------------------------------------MSTGDRLKCFQ
MAV_1677|M.avium_104 ---------------------------------------MS-DERVKPFL
MSMEG_4710|M.smegmatis_MC2_155 -------------------------------------------MSTRDFL
TH_0716|M.thermoresistible__bu -----------------------------------------MNGSIREFL
MAB_4916c|M.abscessus_ATCC_199 -------------------------------------------MAVKQFL
Mflv_2935|M.gilvum_PYR-GCK EDSGDEAEPAAEESEPEPEPEPEDEDEPEPEPKKKSSGGSGSSGSGTSVT
Mvan_3579|M.vanbaalenii_PYR-1 E---PEPEP---EAEAEPEPAPEPEPEPEAKPKAKPAQ---SSGSATPVL
MLBr_00861|M.leprae_Br4923 AAAAPAPRP---EPKAQPEPAASSQP---AAPAQQPSG----AATATPVL
.
Mb2523c|M.bovis_AF2122/97 VPDLGEGLQEVTVTCWSVAVGDDVEINQTLCSVETAKAEVEIPSPYAGRI
Rv2495c|M.tuberculosis_H37Rv VPDLGEGLQEVTVTCWSVAVGDDVEINQTLCSVETAKAEVEIPSPYAGRI
MMAR_3842|M.marinum_M VPDLGEGLEEVTVTSWAVAVGDDVELNQVLCSVETAKAEVEIPSPYAGRI
MUL_3773|M.ulcerans_Agy99 VPDLGEGLEEVTVTSWAVAVGDDVELNQVLCSVETAKAEVEIPSPYAGRI
MAV_1677|M.avium_104 VPDLGEGLEEVTVTHWNVAVGDDVELNQVLCTVETAKAEVELPSPYAGRI
MSMEG_4710|M.smegmatis_MC2_155 VPDLGEGLQDATITSWNVDVGDTVELNQTLCTVETNKAEVEIPSPYAGKV
TH_0716|M.thermoresistible__bu LPDLGEGLEDATITDWSVTVGDEVELNQPLCTVETNKAEVEIPSPYAGRI
MAB_4916c|M.abscessus_ATCC_199 LPDLGEGLTEADLISWKVRVGDEVKLNQVLADVETAKAMVELPSPFEGTV
Mflv_2935|M.gilvum_PYR-GCK MPELGESVTEGTVTRWLKEVGDTVEVDEPLVEVSTDKVDTEIPSPVAGTL
Mvan_3579|M.vanbaalenii_PYR-1 MPELGESVTEGTVTRWLKKVGDSVDVDEPLVEVSTDKVDTEIPSPVAGTL
MLBr_00861|M.leprae_Br4923 MPELGESVTEGTVTRWLKKIGDSVQADEPLVEVSTDKVDTEIPSPVAGVL
:*:***.: : : * :** *. :: * *.* *. .*:*** * :
Mb2523c|M.bovis_AF2122/97 VELGGAEGDVLKVGAELVRIDTGPTAVAQP-----NGEGAVPTLVGYGAD
Rv2495c|M.tuberculosis_H37Rv VELGGAEGDVLKVGAELVRIDTGPTAVAQP-----NGEGAVPTLVGYGAD
MMAR_3842|M.marinum_M VELGGAEGDVIKVGAALVRIDTAPELPAPT-----NGEIAVPTLVGYGAD
MUL_3773|M.ulcerans_Agy99 VELGGAEGDVIKVGAALVRIDTAPELSAPT-----NGEIAVPTLVGYGAD
MAV_1677|M.avium_104 VEMNGAEGDVLKVGAVLVRLDTAPESAEPP-----AAE-TAPTLVGYGAD
MSMEG_4710|M.smegmatis_MC2_155 EALGGAAGDTLAVGSLLVRIATSSDEPVEAQPMNGEVPQRKSVLVGYGAD
TH_0716|M.thermoresistible__bu VELGGAAGETLPVGAVLVRIETSSAG-----------ADRDPVLVGYGAD
MAB_4916c|M.abscessus_ATCC_199 VALQAAENSTVAVGAPLISIEVAGAEPDAP-----------ANLVGYGPS
Mflv_2935|M.gilvum_PYR-GCK LSITAEEDDTVEVGGELAKIGDAGAEEESEPEPE---PEPEPEPEPEPEP
Mvan_3579|M.vanbaalenii_PYR-1 LSITAEEDDTVEVGGELAKIGDAGA----EAAPE---PEPEPEPQPEPEP
MLBr_00861|M.leprae_Br4923 VSITTNEDTTVPVGGELARIG-------VTLDSI---ATPAPAPRAESVP
: . .: **. * : .
Mb2523c|M.bovis_AF2122/97 AAIETSRRT-----------------------------------------
Rv2495c|M.tuberculosis_H37Rv TAIETSRRT-----------------------------------------
MMAR_3842|M.marinum_M AAIDTSRRP-----------------------------------------
MUL_3773|M.ulcerans_Agy99 AAIDTSRRP-----------------------------------------
MAV_1677|M.avium_104 AGIDTSRRT-----------------------------------------
MSMEG_4710|M.smegmatis_MC2_155 DSMDASRRRTHGP-------------------------------------
TH_0716|M.thermoresistible__bu DAMDTSRRTPHRAT------------------------------------
MAB_4916c|M.abscessus_ATCC_199 DSAGQTRRRRRSGAGAAALA---------LVEQTTEPEPAVAAPAAQAES
Mflv_2935|M.gilvum_PYR-GCK KQTKPESKPSEEAAPEPKSESKPEAESKPEPKPKPEPEPKRESKPEAESS
Mvan_3579|M.vanbaalenii_PYR-1 KTTTPSAKPAEEAAPEPKPE--------PTPQPKPEPAP----AAAAESS
MLBr_00861|M.leprae_Br4923 SRPTPARKEAN---------------------------------------
:
Mb2523c|M.bovis_AF2122/97 --SRPLAAPVVRKLAKELAVDLAALQRGSGAGGVITRADVLAAARGG---
Rv2495c|M.tuberculosis_H37Rv --SRPLAAPVVRKLAKELAVDLAALQRGSGAGGVITRADVLAAARGG---
MMAR_3842|M.marinum_M --GRPRAAPPVRKLAKELMVDLASLQRGS---TVITRADVLAAAKG----
MUL_3773|M.ulcerans_Agy99 --GRPRAAPPVRKLAKELMVDLASLQRGS---TVITRADVLAAAKG----
MAV_1677|M.avium_104 --ARPLAAPPVRKLAKELMVDLGSLRPRSG--AVITREDVLSAAHG----
MSMEG_4710|M.smegmatis_MC2_155 ---RARAKPPVRKLAAELNVDLGALDPGSGPDGIITRDDVLAAAGRSPAA
TH_0716|M.thermoresistible__bu --GRPRAKPPVRRLAADLGVDLTAVAPGSGPDGVITRQDVLAAAGADGAD
MAB_4916c|M.abscessus_ATCC_199 VPSRAAAKPSVRKLAAELGVALELIN-GTGIGGSITRQDVEAYTRSLTAR
Mflv_2935|M.gilvum_PYR-GCK GDS-PYVTPLVRKLAGEHGVDLASVK-GTGVGGRIRKQDVLAAAEKSKAP
Mvan_3579|M.vanbaalenii_PYR-1 GDSSPYVTPLVRKLAGEHSVDLASVK-GTGVGGRIRKQDVLAAAEASKAP
MLBr_00861|M.leprae_Br4923 --GAPYVTPLVRKLATENNIDLAKVI-GTGVGGRIRKQDVLAAAEQRKQQ
. . * **:** : : * : : * : ** : :
Mb2523c|M.bovis_AF2122/97 ----VGAGPD-----------------------VRPVHGVHARMAEKMTL
Rv2495c|M.tuberculosis_H37Rv ----VGAGPD-----------------------VRPVHGVHARMAEKMTL
MMAR_3842|M.marinum_M ----AGASAR-----------------------VREVRGVQAHMAEKMSL
MUL_3773|M.ulcerans_Agy99 ----AGASAR-----------------------VREVRGVQAHMAEKMSL
MAV_1677|M.avium_104 ----TGNGAE-----------------------VRPVQGVQARMADKMTL
MSMEG_4710|M.smegmatis_MC2_155 QSAGTPQPSQ-----------------------TRDVRGVQAEMARRMAL
TH_0716|M.thermoresistible__bu APAAPADAAD-----------------------VVEVGAVQAAMARRMTQ
MAB_4916c|M.abscessus_ATCC_199 APQGAPAEEEPVAGVAVQ----------PGGETRIPIAGVRKHTAAAMVR
Mflv_2935|M.gilvum_PYR-GCK KEDAPKAEPAAEAPGKTTQAPAPEGALAHLRGTTQKANRIRQITAKKTRE
Mvan_3579|M.vanbaalenii_PYR-1 K-EAPKAAPAAEAPAKVP-TPAPEGALAHLRGTTQKANRIRQITAKKTRE
MLBr_00861|M.leprae_Br4923 Q--APTSAPSAAAPTPTP-------VLAHLRGTTQKVSRIRQITAKKTRE
:: *
Mb2523c|M.bovis_AF2122/97 SHKEIPTAKASVEVICAELLRLRDWFVS-----AAPEITPFALTLRLLVI
Rv2495c|M.tuberculosis_H37Rv SHKEIPTAKASVEVICAELLRLRDRFVS-----AAPEITPFALTLRLLVI
MMAR_3842|M.marinum_M SHQEIPAAKASVEVDCTELLRLSEQFRA-----AVPPATPFALALRMLVI
MUL_3773|M.ulcerans_Agy99 SHQEIPAAKASVEVDCTELLGLSEQFRA-----VVPPATPFALALRMLVI
MAV_1677|M.avium_104 SHKEIPAATVSVQVDCTALVRLSERLGP-----AEQRITPFVLTLRLLVI
MSMEG_4710|M.smegmatis_MC2_155 SRREIPDAHARVDVDCTALLRLRDRIRSAE---TELPITPFVLTLRLLTV
TH_0716|M.thermoresistible__bu SRREIPDAHGRVEVDCRALLELCAQLG-------ERTVTPFVLTLRLLGI
MAB_4916c|M.abscessus_ATCC_199 SAFTAPHVTEFLTVDMTSTMGLLAELKAKS---PDLKLTPMTLVARMVLL
Mflv_2935|M.gilvum_PYR-GCK SLQTTAQLTQVHEVDMTRIVALRAKAKAGFAEREGVNLTYLPFIARAVID
Mvan_3579|M.vanbaalenii_PYR-1 SLQTTAQLTQVHEVDMTKIVALRAKAKAKFAEREGVNLTYLPFIARAVID
MLBr_00861|M.leprae_Br4923 SLQATAQLTQTHEVDMAKIVGLRAKAKAAFAEREGVNLTFLPFIAKAAID
* . * : * * : : :
Mb2523c|M.bovis_AF2122/97 ALKHNVILNSTWVDSGEGPQVHVHRGVHLGFGAATERGLLVPVVTDAQDK
Rv2495c|M.tuberculosis_H37Rv ALKHNVILNSTWVDSGEGPQVHVHRGVHLGFGAATERGLLVPVVTDAQDK
MMAR_3842|M.marinum_M ALKNNEILNSTWVDSPGGPQVHLHPGVHLGFGVATERGLLVPVIADAHRM
MUL_3773|M.ulcerans_Agy99 ALKNNEILNSTWVDSPGGPQVHLHPGVHLGFGVATERGLLVPVIADAHRM
MAV_1677|M.avium_104 ALRRNEIMNSTWVDTPQGPQVRIEHRVHLGVAVATERGLLVPVIADAHTK
MSMEG_4710|M.smegmatis_MC2_155 ALRRHVVLNATWMETTGGPQIHQHSAVHLGIGVAAPRGLLVPVVRDAQGM
TH_0716|M.thermoresistible__bu ALQHHPNLNATWRDTDDGPRIHRHRAVHLGIAVSAPRGLLVPVVADAHRM
MAB_4916c|M.abscessus_ATCC_199 ALRSHPSLNSAWDEQAG--EIIVKHYVNLGIAAATERGLVVPNVKGADAM
Mflv_2935|M.gilvum_PYR-GCK ALKLHPNVNASYNEESK--EITYHEAEHLGIAVDTEQGLLSPVIHNAGDL
Mvan_3579|M.vanbaalenii_PYR-1 ALKIHPNVNASYNEDSK--EITYYDAEHLGVAVDTEQGLLSPVIHNAGDL
MLBr_00861|M.leprae_Br4923 ALKIHPNINASYNEDTK--EITYYDAEHLGFAIDTDKGLLSPVIHYAGDL
**: : :*::: : .: :**.. : :**: * : *
Mb2523c|M.bovis_AF2122/97 NTRELASRVAELITGAREGTLTPAELRGSTFTVSNFGALGVDDGVPVINH
Rv2495c|M.tuberculosis_H37Rv NTRELASRVAELITGAREGTLTPAELRGSTFTVSNFGALGVDDGVPVINH
MMAR_3842|M.marinum_M TTRELVCRAAELITGAREGTLAPGQLRGSTFTVSNYGALGVDDGVPVINH
MUL_3773|M.ulcerans_Agy99 TTRELVCRAAELITGAREGTLAPGQLRGWTFTVSNYGALGVDDGVPVINH
MAV_1677|M.avium_104 TTRELASRAAELISGARAGSLTPGELRGSTFTVSNFGALGVDDGVPVINH
MSMEG_4710|M.smegmatis_MC2_155 TTRQLAVTVARLVESARAGTLSPAELTGSTFTVSNFGALGVDDGVPVINY
TH_0716|M.thermoresistible__bu TLPQLGAAVERLVDRARAGTLTPAELTGSTFTVSNFGALGLDDGVPVINY
MAB_4916c|M.abscessus_ATCC_199 SLGELATAIAQLVSTARAGKTAPTDMSGGTFTLTNIGVFGVDAGTPIINP
Mflv_2935|M.gilvum_PYR-GCK SLGGLARAISDIAGRARSGNLKPDELSGGTFTITNIGSQGALFDTPILVP
Mvan_3579|M.vanbaalenii_PYR-1 SLGGLARAISDIAARARSGDLKPDELSGGTFTITNIGSQGALFDTPILVP
MLBr_00861|M.leprae_Br4923 SLAGLARAIVDIAARARSGNLKPEELSGGTFTITNIGSQGALFDTPILVP
. * : ** * * :: * ***::* * * ..*::
Mb2523c|M.bovis_AF2122/97 PEAAILGLGAIKPRPVVVGGE-----VVARPTMTLTCVFDHRVVDGAQVA
Rv2495c|M.tuberculosis_H37Rv PEAAILGLGAIKPRPVVVGGE-----VVARPTMTLTCVFDHRVVDGAQVA
MMAR_3842|M.marinum_M PEAAILGMGSIKPRPVVRGDA-----VVVRPTMSLTCVFDHRVADGAQVA
MUL_3773|M.ulcerans_Agy99 PDAAILGMGSIKPRPVVRGDE-----VVVRPTMSLTCVFDHRVADGAQVA
MAV_1677|M.avium_104 PEAAILGMGAIKPRPVAVGTE-----VVVRPTMSLSAVFDHRIADGAQAA
MSMEG_4710|M.smegmatis_MC2_155 PEAAILGMGSLRERPVVVDGA-----VVARPTMSLTCVFDHRIADGAQAA
TH_0716|M.thermoresistible__bu PEAAILGMGMIKPRPVVIDDA-----VVARPTMTLTCAFDHRVADGAQVA
MAB_4916c|M.abscessus_ATCC_199 GEAAILALGSVAKRPWVVNGE-----LAVRDVTTLALSFDHRLVDGEQGS
Mflv_2935|M.gilvum_PYR-GCK PQAAMLGTGAIVKRPRIIIDEFGNESIGVRSVSYLPLTYDHRLIDGADAG
Mvan_3579|M.vanbaalenii_PYR-1 PQAAMLGTGAIVKRPRVIVDDYGNESIGVRSVSYLPLTYDHRLIDGADAG
MLBr_00861|M.leprae_Br4923 PQAAMLGIGAIVKRPRVVIDASGNESIGVRAICYLPLTYDHRLIDGADAG
:**:*. * : ** : .* *. :***: ** : .
Mb2523c|M.bovis_AF2122/97 QFMCELRDLIES-PETALLDL-
Rv2495c|M.tuberculosis_H37Rv QFMCELRDLIES-PETALLDL-
MMAR_3842|M.marinum_M RFICELRGLIEA-PETVLLDL-
MUL_3773|M.ulcerans_Agy99 RFICELRGLIEA-PETALLDL-
MAV_1677|M.avium_104 RFVCELRDLIES-PETALLDL-
MSMEG_4710|M.smegmatis_MC2_155 AFLGELRGLIEE-PDLALLDL-
TH_0716|M.thermoresistible__bu AFLDELRGLIES-PSRALLFLR
MAB_4916c|M.abscessus_ATCC_199 KFLADLGAMLTD-PRMALVV--
Mflv_2935|M.gilvum_PYR-GCK RFVTTIKRRLEEGAFEADLGL-
Mvan_3579|M.vanbaalenii_PYR-1 RFVTTIKRRLEEGAFEADLGL-
MLBr_00861|M.leprae_Br4923 RFLTTIKHRLEEGAFEADLGL-
*: : : . . :