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STVREFLVPDLGEGLEEATVTAWQVAIGDVVTLNQTLCTVETNKAEVEIPSPFAGRIAELGGAAGQTLPV GSVLVRIDLGNDTENDRAGDTDSDGDSATDAEKDAPRRPVLVGYGADHTMDGSRRRARAKPRVRKLAADL DVDLSRIDGSGPDGIVTRDDVLAVTDGGTSQDSVVSGVRLAMARRMSLSRSEIPDAHASVEVDGSELLRL RDRLAAAGADGVTPFVLVLRLLVVALRRHPVLNATWVDTVDGPRVHVHPAVHLGVGVAAPRGLLVPVVTD AQERSTRRLADEVARLVAAARAGTLKPGELQGSTFTVSNYGALGLDDGVPVINHPEAAIVGVGSLKPRAV VVGGAVVARPTMRLTCAFDHRVADGAQVAAFLAELRSLIELPELALLDL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4084 | - | - | 100% (400) | branched-chain alpha-keto acid dehydrogenase subunit E2 |
| M. vanbaalenii PYR-1 | Mvan_3579 | - | 4e-42 | 28.22% (443) | dihydrolipoamide acetyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1410 | - | 9e-41 | 29.75% (447) | branched-chain alpha-keto acid dehydrogenase subunit E2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2523c | pdhC | 1e-127 | 60.64% (404) | branched-chain alpha-keto acid dehydrogenase subunit E2 |
| M. gilvum PYR-GCK | Mflv_2935 | - | 1e-40 | 26.97% (456) | dihydrolipoamide acetyltransferase |
| M. tuberculosis H37Rv | Rv2495c | pdhC | 1e-128 | 60.89% (404) | branched-chain alpha-keto acid dehydrogenase subunit E2 |
| M. leprae Br4923 | MLBr_00861 | - | 4e-45 | 29.88% (425) | dihydrolipoamide acetyltransferase |
| M. abscessus ATCC 19977 | MAB_0895c | - | 3e-75 | 40.92% (413) | branched-chain alpha-keto acid dehydrogenase subunit E2 |
| M. marinum M | MMAR_3842 | pdhC | 1e-121 | 59.55% (398) | dihydrolipoamide S-acetyltransferase E2 component PdhC |
| M. avium 104 | MAV_1677 | - | 1e-118 | 57.36% (401) | branched-chain alpha-keto acid dehydrogenase subunit E2 |
| M. smegmatis MC2 155 | MSMEG_4710 | - | 1e-141 | 65.62% (416) | branched-chain alpha-keto acid dehydrogenase subunit E2 |
| M. thermoresistible (build 8) | TH_0716 | pdhC | 1e-131 | 63.22% (416) | PROBABLE DIHYDROLIPOAMIDE S-ACETYLTRANSFERASE E2 COMPONENT |
| M. ulcerans Agy99 | MUL_3773 | pdhC | 1e-119 | 58.54% (398) | branched-chain alpha-keto acid dehydrogenase subunit E2 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2523c|M.bovis_AF2122/97 MSGEDSIRSFPVPDLGEGLQEVTVTCWSVAVGDDVEINQTLCSVETAKAE
Rv2495c|M.tuberculosis_H37Rv MSGEDSIRSFPVPDLGEGLQEVTVTCWSVAVGDDVEINQTLCSVETAKAE
MMAR_3842|M.marinum_M MSTGDRLKCFQVPDLGEGLEEVTVTSWAVAVGDDVELNQVLCSVETAKAE
MUL_3773|M.ulcerans_Agy99 MSTGDRLKCFQVPDLGEGLEEVTVTSWAVAVGDDVELNQVLCSVETAKAE
MAV_1677|M.avium_104 MS-DERVKPFLVPDLGEGLEEVTVTHWNVAVGDDVELNQVLCTVETAKAE
MSMEG_4710|M.smegmatis_MC2_155 ----MSTRDFLVPDLGEGLQDATITSWNVDVGDTVELNQTLCTVETNKAE
TH_0716|M.thermoresistible__bu --MNGSIREFLLPDLGEGLEDATITDWSVTVGDEVELNQPLCTVETNKAE
Mvan_4084|M.vanbaalenii_PYR-1 ---MSTVREFLVPDLGEGLEEATVTAWQVAIGDVVTLNQTLCTVETNKAE
MAB_0895c|M.abscessus_ATCC_199 ----MTAQTFNLPDLGEGLTEAIIIKWLVSVGDTVVIDQPVVEVETAKAS
Mflv_2935|M.gilvum_PYR-GCK -----MAISVQMPALGESVTEGTVTRWLKQEGDTVEEDEPLLEVSTDKVD
MLBr_00861|M.leprae_Br4923 -----MACSVQMPALGESVTEGTVTRWLKQEGDTVELDEPLVEVSTDKVD
. :* ***.: : : * ** * :: : *.* *..
Mb2523c|M.bovis_AF2122/97 VEIPSPYAGRIVELGGAEGDVLKVGAELVRIDTGP---------------
Rv2495c|M.tuberculosis_H37Rv VEIPSPYAGRIVELGGAEGDVLKVGAELVRIDTGP---------------
MMAR_3842|M.marinum_M VEIPSPYAGRIVELGGAEGDVIKVGAALVRIDTAP---------------
MUL_3773|M.ulcerans_Agy99 VEIPSPYAGRIVELGGAEGDVIKVGAALVRIDTAP---------------
MAV_1677|M.avium_104 VELPSPYAGRIVEMNGAEGDVLKVGAVLVRLDTAP---------------
MSMEG_4710|M.smegmatis_MC2_155 VEIPSPYAGKVEALGGAAGDTLAVGSLLVRIATS----------------
TH_0716|M.thermoresistible__bu VEIPSPYAGRIVELGGAAGETLPVGAVLVRIETS----------------
Mvan_4084|M.vanbaalenii_PYR-1 VEIPSPFAGRIAELGGAAGQTLPVGSVLVRIDLGND--------------
MAB_0895c|M.abscessus_ATCC_199 VEVPVPFAGTIVELHGDPGAAMPVGSPLITVRGNDS--------------
Mflv_2935|M.gilvum_PYR-GCK TEIPSPASGVLKKIVAQEDDTVEVGGELAVIGDADDSDSDDSDSDDAGDS
MLBr_00861|M.leprae_Br4923 TEIPSPAAGVLTKIIAQEDDTVEVGGELAVIGAP----------------
.*:* * :* : : . . .: **. * :
Mb2523c|M.bovis_AF2122/97 --------------------------------------------------
Rv2495c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3842|M.marinum_M --------------------------------------------------
MUL_3773|M.ulcerans_Agy99 --------------------------------------------------
MAV_1677|M.avium_104 --------------------------------------------------
MSMEG_4710|M.smegmatis_MC2_155 --------------------------------------------------
TH_0716|M.thermoresistible__bu --------------------------------------------------
Mvan_4084|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0895c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_2935|M.gilvum_PYR-GCK DDSEAEDSGDEAEPAAEESEPEPEPEPEDEDEPEPEPKKKSSGGSGSSGS
MLBr_00861|M.leprae_Br4923 ---------SEAAAAAPAPRPEPKAQPEPAASSQPAAPAQQPSG---AAT
Mb2523c|M.bovis_AF2122/97 ----------------------------------------TAVAQPNGEG
Rv2495c|M.tuberculosis_H37Rv ----------------------------------------TAVAQPNGEG
MMAR_3842|M.marinum_M ----------------------------------------ELPAPTNGEI
MUL_3773|M.ulcerans_Agy99 ----------------------------------------ELSAPTNGEI
MAV_1677|M.avium_104 ----------------------------------------ESAEPPAAE-
MSMEG_4710|M.smegmatis_MC2_155 ----------------------------------SDEPVEAQPMNGEVPQ
TH_0716|M.thermoresistible__bu ----------------------------------SAG-----------AD
Mvan_4084|M.vanbaalenii_PYR-1 --------------------------TENDRAGDTDSDGDSATDAEKDAP
MAB_0895c|M.abscessus_ATCC_199 --------------------------TD--PGDSPSADAFAQHREEERAG
Mflv_2935|M.gilvum_PYR-GCK GTSVTMPELGESVTEGTVTRWLKEVGDTVEVDEPLVEVSTDKVDTEIPSP
MLBr_00861|M.leprae_Br4923 ATPVLMPELGESVTEGTVTRWLKKIGDSVQADEPLVEVSTDKVDTEIPSP
Mb2523c|M.bovis_AF2122/97 AVPTLVGYGADAAIETSRRTS-----------------------------
Rv2495c|M.tuberculosis_H37Rv AVPTLVGYGADTAIETSRRTS-----------------------------
MMAR_3842|M.marinum_M AVPTLVGYGADAAIDTSRRPG-----------------------------
MUL_3773|M.ulcerans_Agy99 AVPTLVGYGADAAIDTSRRPG-----------------------------
MAV_1677|M.avium_104 TAPTLVGYGADAGIDTSRRTA-----------------------------
MSMEG_4710|M.smegmatis_MC2_155 RKSVLVGYGADDSMDASRRRTHGP--------------------------
TH_0716|M.thermoresistible__bu RDPVLVGYGADDAMDTSRRTPHRAT-------------------------
Mvan_4084|M.vanbaalenii_PYR-1 RRPVLVGYGADHTMDGSRR-------------------------------
MAB_0895c|M.abscessus_ATCC_199 SGNVLIGYGTSTDEGPTRRRKRTHEP------------------------
Mflv_2935|M.gilvum_PYR-GCK VAGTLLSITAEEDDTVEVGGELAKIGDAGAEEESEPEPEPEPEPEPEPEP
MLBr_00861|M.leprae_Br4923 VAGVLVSITTNEDTTVPVGGELARIG---VTLDSIATP------------
.*:. :.
Mb2523c|M.bovis_AF2122/97 --------------------------------------------------
Rv2495c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3842|M.marinum_M --------------------------------------------------
MUL_3773|M.ulcerans_Agy99 --------------------------------------------------
MAV_1677|M.avium_104 --------------------------------------------------
MSMEG_4710|M.smegmatis_MC2_155 --------------------------------------------------
TH_0716|M.thermoresistible__bu --------------------------------------------------
Mvan_4084|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0895c|M.abscessus_ATCC_199 -------------------------------------------------A
Mflv_2935|M.gilvum_PYR-GCK EPKQTKPESKPSEEAAPEPKSESKPEAESKPEPKPKPEPEPKRESKPEAE
MLBr_00861|M.leprae_Br4923 ---------------APAPRAESVP---SRPTPARK-------------E
Mb2523c|M.bovis_AF2122/97 ----RPLAAPVVRKLAKELAVDLAALQRGSGAGGVITRADVLAAARGG--
Rv2495c|M.tuberculosis_H37Rv ----RPLAAPVVRKLAKELAVDLAALQRGSGAGGVITRADVLAAARGG--
MMAR_3842|M.marinum_M ----RPRAAPPVRKLAKELMVDLASLQRGS---TVITRADVLAAAKG---
MUL_3773|M.ulcerans_Agy99 ----RPRAAPPVRKLAKELMVDLASLQRGS---TVITRADVLAAAKG---
MAV_1677|M.avium_104 ----RPLAAPPVRKLAKELMVDLGSLRPRSG--AVITREDVLSAAHG---
MSMEG_4710|M.smegmatis_MC2_155 ----RARAKPPVRKLAAELNVDLGALDPGSGPDGIITRDDVLAAAGRSPA
TH_0716|M.thermoresistible__bu ---GRPRAKPPVRRLAADLGVDLTAVAPGSGPDGVITRQDVLAAAGADGA
Mvan_4084|M.vanbaalenii_PYR-1 ----RARAKPRVRKLAADLDVDLSRID-GSGPDGIVTRDDVLAVTDGG--
MAB_0895c|M.abscessus_ATCC_199 VGTVTKVISPLVRKLAADKGINLAQAS-GTGAGGVITRSDVERLVSTN--
Mflv_2935|M.gilvum_PYR-GCK SSGDSPYVTPLVRKLAGEHGVDLASVK-GTGVGGRIRKQDVLAAAEKSKA
MLBr_00861|M.leprae_Br4923 ANG-APYVTPLVRKLATENNIDLAKVI-GTGVGGRIRKQDVLAAAEQRKQ
* **:** : ::* : : : ** .
Mb2523c|M.bovis_AF2122/97 -----VGAGPDVR-----------------------PVHGVHARMAEKMT
Rv2495c|M.tuberculosis_H37Rv -----VGAGPDVR-----------------------PVHGVHARMAEKMT
MMAR_3842|M.marinum_M -----AGASARVR-----------------------EVRGVQAHMAEKMS
MUL_3773|M.ulcerans_Agy99 -----AGASARVR-----------------------EVRGVQAHMAEKMS
MAV_1677|M.avium_104 -----TGNGAEVR-----------------------PVQGVQARMADKMT
MSMEG_4710|M.smegmatis_MC2_155 AQSAGTPQPSQTR-----------------------DVRGVQAEMARRMA
TH_0716|M.thermoresistible__bu DAPAAPADAADVV-----------------------EVGAVQAAMARRMT
Mvan_4084|M.vanbaalenii_PYR-1 --------TSQDS-----------------------VVSGVRLAMARRMS
MAB_0895c|M.abscessus_ATCC_199 ----PPAGAGNVTRI---------------------PVTGIRKVIADKLS
Mflv_2935|M.gilvum_PYR-GCK PKEDAPKAEPAAEAPGKTTQAPAPEGALAHLRGTTQKANRIRQITAKKTR
MLBr_00861|M.leprae_Br4923 --QQAPTSAPSAAAP-------TPTPVLAHLRGTTQKVSRIRQITAKKTR
. :: * :
Mb2523c|M.bovis_AF2122/97 LSHKEIPTAKASVEVICAELLRLRDWFVSA-----APEITPFALTLRLLV
Rv2495c|M.tuberculosis_H37Rv LSHKEIPTAKASVEVICAELLRLRDRFVSA-----APEITPFALTLRLLV
MMAR_3842|M.marinum_M LSHQEIPAAKASVEVDCTELLRLSEQFRAA-----VPPATPFALALRMLV
MUL_3773|M.ulcerans_Agy99 LSHQEIPAAKASVEVDCTELLGLSEQFRAV-----VPPATPFALALRMLV
MAV_1677|M.avium_104 LSHKEIPAATVSVQVDCTALVRLSERLGPA-----EQRITPFVLTLRLLV
MSMEG_4710|M.smegmatis_MC2_155 LSRREIPDAHARVDVDCTALLRLRDRIRSAET---ELPITPFVLTLRLLT
TH_0716|M.thermoresistible__bu QSRREIPDAHGRVEVDCRALLELCAQLG-------ERTVTPFVLTLRLLG
Mvan_4084|M.vanbaalenii_PYR-1 LSRSEIPDAHASVEVDGSELLRLRDRLAAAG----ADGVTPFVLVLRLLV
MAB_0895c|M.abscessus_ATCC_199 ISRREIPEATVWVDVDATELLAAKRLLSQT------QSISLLALLARLTV
Mflv_2935|M.gilvum_PYR-GCK ESLQTTAQLTQVHEVDMTRIVALRAKAKAGFAEREGVNLTYLPFIARAVI
MLBr_00861|M.leprae_Br4923 ESLQATAQLTQTHEVDMAKIVGLRAKAKAAFAEREGVNLTFLPFIAKAAI
* . :* :: : : : :
Mb2523c|M.bovis_AF2122/97 IALKHNVILNSTWVDSGEGPQVHVHRGVHLGFGAATERGLLVPVVTDAQD
Rv2495c|M.tuberculosis_H37Rv IALKHNVILNSTWVDSGEGPQVHVHRGVHLGFGAATERGLLVPVVTDAQD
MMAR_3842|M.marinum_M IALKNNEILNSTWVDSPGGPQVHLHPGVHLGFGVATERGLLVPVIADAHR
MUL_3773|M.ulcerans_Agy99 IALKNNEILNSTWVDSPGGPQVHLHPGVHLGFGVATERGLLVPVIADAHR
MAV_1677|M.avium_104 IALRRNEIMNSTWVDTPQGPQVRIEHRVHLGVAVATERGLLVPVIADAHT
MSMEG_4710|M.smegmatis_MC2_155 VALRRHVVLNATWMETTGGPQIHQHSAVHLGIGVAAPRGLLVPVVRDAQG
TH_0716|M.thermoresistible__bu IALQHHPNLNATWRDTDDGPRIHRHRAVHLGIAVSAPRGLLVPVVADAHR
Mvan_4084|M.vanbaalenii_PYR-1 VALRRHPVLNATWVDTVDGPRVHVHPAVHLGVGVAAPRGLLVPVVTDAQE
MAB_0895c|M.abscessus_ATCC_199 AALKQFPELNATFDTGRQ--EILQYSDIHLGVAVQAPYGLVVPVISQADT
Mflv_2935|M.gilvum_PYR-GCK DALKLHPNVNASYN--EESKEITYHEAEHLGIAVDTEQGLLSPVIHNAGD
MLBr_00861|M.leprae_Br4923 DALKIHPNINASYN--EDTKEITYYDAEHLGFAIDTDKGLLSPVIHYAGD
**: :*::: .: ***.. : **: **: *
Mb2523c|M.bovis_AF2122/97 KNTRELASRVAELITGAREGTLTPAELRGSTFTVSNFGALGVDDGVPVIN
Rv2495c|M.tuberculosis_H37Rv KNTRELASRVAELITGAREGTLTPAELRGSTFTVSNFGALGVDDGVPVIN
MMAR_3842|M.marinum_M MTTRELVCRAAELITGAREGTLAPGQLRGSTFTVSNYGALGVDDGVPVIN
MUL_3773|M.ulcerans_Agy99 MTTRELVCRAAELITGAREGTLAPGQLRGWTFTVSNYGALGVDDGVPVIN
MAV_1677|M.avium_104 KTTRELASRAAELISGARAGSLTPGELRGSTFTVSNFGALGVDDGVPVIN
MSMEG_4710|M.smegmatis_MC2_155 MTTRQLAVTVARLVESARAGTLSPAELTGSTFTVSNFGALGVDDGVPVIN
TH_0716|M.thermoresistible__bu MTLPQLGAAVERLVDRARAGTLTPAELTGSTFTVSNFGALGLDDGVPVIN
Mvan_4084|M.vanbaalenii_PYR-1 RSTRRLADEVARLVAAARAGTLKPGELQGSTFTVSNYGALGLDDGVPVIN
MAB_0895c|M.abscessus_ATCC_199 LDTVALSDALAEVIALARDSKLPPAKMSGGTVTLNNYGVFGVDGSAAIIN
Mflv_2935|M.gilvum_PYR-GCK LSLGGLARAISDIAGRARSGNLKPDELSGGTFTITNIGSQGALFDTPILV
MLBr_00861|M.leprae_Br4923 LSLAGLARAIVDIAARARSGNLKPEELSGGTFTITNIGSQGALFDTPILV
* : ** ..* * :: * *.*:.* * * ...::
Mb2523c|M.bovis_AF2122/97 HPEAAILGLGAIKPRPVVVGGE-----VVARPTMTLTCVFDHRVVDGAQV
Rv2495c|M.tuberculosis_H37Rv HPEAAILGLGAIKPRPVVVGGE-----VVARPTMTLTCVFDHRVVDGAQV
MMAR_3842|M.marinum_M HPEAAILGMGSIKPRPVVRGDA-----VVVRPTMSLTCVFDHRVADGAQV
MUL_3773|M.ulcerans_Agy99 HPDAAILGMGSIKPRPVVRGDE-----VVVRPTMSLTCVFDHRVADGAQV
MAV_1677|M.avium_104 HPEAAILGMGAIKPRPVAVGTE-----VVVRPTMSLSAVFDHRIADGAQA
MSMEG_4710|M.smegmatis_MC2_155 YPEAAILGMGSLRERPVVVDGA-----VVARPTMSLTCVFDHRIADGAQA
TH_0716|M.thermoresistible__bu YPEAAILGMGMIKPRPVVIDDA-----VVARPTMTLTCAFDHRVADGAQV
Mvan_4084|M.vanbaalenii_PYR-1 HPEAAIVGVGSLKPRAVVVGGA-----VVARPTMRLTCAFDHRVADGAQV
MAB_0895c|M.abscessus_ATCC_199 HPEAAILGVGRIIDRPWVVDGQ-----LTVRKTMELTLSFDHRVCDGGSA
Mflv_2935|M.gilvum_PYR-GCK PPQAAMLGTGAIVKRPRIIIDEFGNESIGVRSVSYLPLTYDHRLIDGADA
MLBr_00861|M.leprae_Br4923 PPQAAMLGIGAIVKRPRVVIDASGNESIGVRAICYLPLTYDHRLIDGADA
*:**::* * : *. : .* *. :***: **...
Mb2523c|M.bovis_AF2122/97 AQFMCELRDLIES-PETALLDL-
Rv2495c|M.tuberculosis_H37Rv AQFMCELRDLIES-PETALLDL-
MMAR_3842|M.marinum_M ARFICELRGLIEA-PETVLLDL-
MUL_3773|M.ulcerans_Agy99 ARFICELRGLIEA-PETALLDL-
MAV_1677|M.avium_104 ARFVCELRDLIES-PETALLDL-
MSMEG_4710|M.smegmatis_MC2_155 AAFLGELRGLIEE-PDLALLDL-
TH_0716|M.thermoresistible__bu AAFLDELRGLIES-PSRALLFLR
Mvan_4084|M.vanbaalenii_PYR-1 AAFLAELRSLIEL-PELALLDL-
MAB_0895c|M.abscessus_ATCC_199 AGFLRLFADYVEN-PVAALGRL-
Mflv_2935|M.gilvum_PYR-GCK GRFVTTIKRRLEEGAFEADLGL-
MLBr_00861|M.leprae_Br4923 GRFLTTIKHRLEEGAFEADLGL-
. *: : :* . . *