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M. marinum M MMAR_3491 (-)

annotation: pyruvate dehydrogenase (E2 component)
coordinates: 4297706 - 4298947
length: 413

MIEFKMPALGSDMDEGTLNEWLVKPGDKVSRGQIVAIVETTKAAVEIECWQEGTVDELVVPVGDTVEVGT
VLATLLEPGASPQRSPRQRPRKRATPAPTVAASAPAPAHGATAAPRHRRWVSPAARRLAQSLHVDLDAVS
GTGPQGAVTISDVEHAAASAVPAKRPAATAASTSAKSIGAKSTAQNKIAERAAQMRKSIAAAMSRSKREI
PHYYLADEILMEKSLNWLTTRNAQRSITERVLPAVLLLKAVGLAAQRFGEFNGFWRDDGFQAATGVHVGV
GISLRGGGLVAPAIHDVADKKLDELMGDLTDLVARARAGSLRSSEMSDPTITVTNLGDQGVDTVFGVIYP
PQVAIVGFGKPAQRVCVIDGGIRVVTTVQGTLAADHRASDGHRGALFLAAINELLQQPDLLEK
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. marinum MMMAR_3491--100% (413)pyruvate dehydrogenase (E2 component)
M. marinum MMMAR_3260sucB1e-3429.27% (451) pyruvate dehydrogenase (E2 component) SucB
M. marinum MMMAR_3842pdhC1e-3028.47% (411) dihydrolipoamide S-acetyltransferase E2 component PdhC

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2238dlaT1e-3629.29% (420) dihydrolipoamide acetyltransferase
M. gilvum PYR-GCKMflv_2935-1e-3026.42% (458) dihydrolipoamide acetyltransferase
M. tuberculosis H37RvRv2215dlaT1e-3629.29% (420) dihydrolipoamide acetyltransferase
M. leprae Br4923MLBr_00861-9e-3229.22% (421) dihydrolipoamide acetyltransferase
M. abscessus ATCC 19977MAB_4916c-2e-4331.54% (428) putative dihydrolipoamide acyltransferase component
M. avium 104MAV_2273sucB2e-3328.16% (451) dihydrolipoamide acetyltransferase
M. smegmatis MC2 155MSMEG_4710-5e-4330.53% (416) branched-chain alpha-keto acid dehydrogenase subunit E2
M. thermoresistible (build 8)TH_0716pdhC2e-4735.28% (411) PROBABLE DIHYDROLIPOAMIDE S-ACETYLTRANSFERASE E2 COMPONENT
M. ulcerans Agy99MUL_3575sucB2e-3529.05% (451) dihydrolipoamide acetyltransferase
M. vanbaalenii PYR-1Mvan_1410-1e-16367.99% (453) branched-chain alpha-keto acid dehydrogenase subunit E2

CLUSTAL 2.0.9 multiple sequence alignment


MLBr_00861|M.leprae_Br4923          ---MACSVQMPALGESVTEGTVTRWLKQEGDTVELDEPLVEVSTDKVDTE
MAV_2273|M.avium_104                ---MAFSVQMPALGESVTEGTVTRWLKQEGDTVELDEPLVEVSTDKVDTE
Mb2238|M.bovis_AF2122/97            ---MAFSVQMPALGESVTEGTVTRWLKQEGDTVELDEPLVEVSTDKVDTE
Rv2215|M.tuberculosis_H37Rv         ---MAFSVQMPALGESVTEGTVTRWLKQEGDTVELDEPLVEVSTDKVDTE
MUL_3575|M.ulcerans_Agy99           ---MAFSVQMPALGESVTEGTVTRWLKQEGDTVEIDEPLVEVSTDKVDTE
Mflv_2935|M.gilvum_PYR-GCK          ---MAISVQMPALGESVTEGTVTRWLKQEGDTVEEDEPLLEVSTDKVDTE
MSMEG_4710|M.smegmatis_MC2_155      --MSTRDFLVPDLGEGLQDATITSWNVDVGDTVELNQTLCTVETNKAEVE
TH_0716|M.thermoresistible__bu      MNGSIREFLLPDLGEGLEDATITDWSVTVGDEVELNQPLCTVETNKAEVE
MAB_4916c|M.abscessus_ATCC_199      --MAVKQFLLPDLGEGLTEADLISWKVRVGDEVKLNQVLADVETAKAMVE
MMAR_3491|M.marinum_M               ----MIEFKMPALGSDMDEGTLNEWLVKPGDKVSRGQIVAIVETTKAAVE
Mvan_1410|M.vanbaalenii_PYR-1       ----MIEFAMPALGSDMDEGMLNEWLVKPGDTVSRGQVVAVVETTKAAVE
                                          .. :* **..: :. :  *    ** *. .: :  *.* *. .*

MLBr_00861|M.leprae_Br4923          IPSPAAGVLTKIIAQEDDTVEVGGELAVIGAPSE----------AAAA--
MAV_2273|M.avium_104                IPSPAAGVLTKIIAQEDDTVEVGGELAVIGDAAD----------DAAAGG
Mb2238|M.bovis_AF2122/97            IPSPAAGVLTKIIAQEDDTVEVGGELAVIGDAKD----------AGEA--
Rv2215|M.tuberculosis_H37Rv         IPSPAAGVLTKIIAQEDDTVEVGGELAVIGDAKD----------AGEA--
MUL_3575|M.ulcerans_Agy99           IPSPAAGVLTKIVAKEDDTVEVGGELAIIGDAAE----------SGGG--
Mflv_2935|M.gilvum_PYR-GCK          IPSPASGVLKKIVAQEDDTVEVGGELAVIGDADDSDSDDSDSDDAGDSDD
MSMEG_4710|M.smegmatis_MC2_155      IPSPYAGKVEALGGAAGDTLAVGSLLVRIATSSDEP--------------
TH_0716|M.thermoresistible__bu      IPSPYAGRIVELGGAAGETLPVGAVLVRIETSSAG---------------
MAB_4916c|M.abscessus_ATCC_199      LPSPFEGTVVALQAAENSTVAVGAPLISIEVAGAE---------------
MMAR_3491|M.marinum_M               IECWQEGTVDELVVPVGDTVEVGTVLATLLEPG-----------------
Mvan_1410|M.vanbaalenii_PYR-1       IECWHDGTVHELLVPVGQTVSVGTPLATLLESGEVA--------------
                                    : .   * :  :    ..*: **  *  :  .                  

MLBr_00861|M.leprae_Br4923          -APAP----------RPEPKAQPEPAASSQPAAPAQ-----QPSGAATAT
MAV_2273|M.avium_104                GAQAPSQPSQPQAPAQPEPQAQAQPEAPAQPQAPAQPAP--QESGGGAAT
Mb2238|M.bovis_AF2122/97            AAPAP----------EKVPAAQPESKPAPEP-PPVQPTS--GAPAGGDAK
Rv2215|M.tuberculosis_H37Rv         AAPAP----------EKVPAAQPESKPAPEP-PPVQPTS--GAPAGGDAK
MUL_3575|M.ulcerans_Agy99           DAPSQPEPE-----AEPAAAAQPEPEAEPEPQPEAKPQSGGSSTAGGDVT
Mflv_2935|M.gilvum_PYR-GCK          SEAEDSGDEAEPAAEESEPEPEPEPEDEDEPEPEPKKKSSGGSGSSGSGT
MSMEG_4710|M.smegmatis_MC2_155      --------------------------------------------------
TH_0716|M.thermoresistible__bu      --------------------------------------------------
MAB_4916c|M.abscessus_ATCC_199      --------------------------------------------------
MMAR_3491|M.marinum_M               --------------------------------------------------
Mvan_1410|M.vanbaalenii_PYR-1       --------------------------------------------------
                                                                                      

MLBr_00861|M.leprae_Br4923          PVLMPELGESVTEGTVTRWLKKIGDSVQADEPLVEVSTDKVDTEIPSPVA
MAV_2273|M.avium_104                PVLMPELGESVTEGTVTRWLKKVGDSVQVDDALVEVSTDKVDTEIPSPVA
Mb2238|M.bovis_AF2122/97            PVLMPELGESVTEGTVIRWLKKIGDSVQVDEPLVEVSTDKVDTEIPSPVA
Rv2215|M.tuberculosis_H37Rv         PVLMPELGESVTEGTVIRWLKKIGDSVQVDEPLVEVSTDKVDTEIPSPVA
MUL_3575|M.ulcerans_Agy99           PVLMPELGESVAEGTVTRWLKKVGDSVQVDEALVEVSTDKVDTEIPSPVA
Mflv_2935|M.gilvum_PYR-GCK          SVTMPELGESVTEGTVTRWLKEVGDTVEVDEPLVEVSTDKVDTEIPSPVA
MSMEG_4710|M.smegmatis_MC2_155      ------------------------------------VEAQPMNGEVPQRK
TH_0716|M.thermoresistible__bu      ----------------------------------------------ADRD
MAB_4916c|M.abscessus_ATCC_199      ----------------------------------------------PDAP
MMAR_3491|M.marinum_M               --------------------ASPQRSPRQ---------------------
Mvan_1410|M.vanbaalenii_PYR-1       -------------------AEHPAVSPKQPAAAPSEQPAAVSSEQPAAVA
                                                                                      

MLBr_00861|M.leprae_Br4923          GVLVSITTNEDTTVPVGGELARIG-VTLDS--------------------
MAV_2273|M.avium_104                GVLISITAEEDSTVPVGGELARIG-TGAQAPAPAAPQPPPAPKPEPKPEP
Mb2238|M.bovis_AF2122/97            GVLVSISADEDATVPVGGELARIG-VAADIG-------------------
Rv2215|M.tuberculosis_H37Rv         GVLVSISADEDATVPVGGELARIG-VAADIG-------------------
MUL_3575|M.ulcerans_Agy99           GVLLSITAEEDDVVQVGGELARIG-SGSAAAAPPESKPAPAPEAAPETKA
Mflv_2935|M.gilvum_PYR-GCK          GTLLSITAEEDDTVEVGGELAKIGDAGAEEESEPEPEPEPEPEPEPEPEP
MSMEG_4710|M.smegmatis_MC2_155      SVLVGYGADDSMDASRRR--------------------------------
TH_0716|M.thermoresistible__bu      PVLVGYGADDAMDTSRRT--------------------------------
MAB_4916c|M.abscessus_ATCC_199      ANLVGYGPSDSAGQTRRRRRSGAG--------------------------
MMAR_3491|M.marinum_M               --RPRKRATPAPTVAAS---------------------------------
Mvan_1410|M.vanbaalenii_PYR-1       PGRPAAVSSGRPAAVSSGRPAAVS--------------------------
                                           .                                          

MLBr_00861|M.leprae_Br4923          -----------------------IATPAPAPRAESVPSRPTPARKEANG-
MAV_2273|M.avium_104                A-------PQPQAQPAPQPQPQPQAQPAPEPKAQPAQAQPAQAQPAAGGE
Mb2238|M.bovis_AF2122/97            ------------AAPAPKPAPKPVPEPAPTPKAEPAPS-PPAAQPAGAAE
Rv2215|M.tuberculosis_H37Rv         ------------AAPAPKPAPKPVPEPAPTPKAEPAPS-PPAAQPAGAAE
MUL_3575|M.ulcerans_Agy99           A-------PEPKAAPEPKAAPEPKAAPEPKP-APAATPQPAAAPAPSAGD
Mflv_2935|M.gilvum_PYR-GCK          KQTKPESKPSEEAAPEPKSESKPEAESKPEPKPKPEPEPKRESKPEAESS
MSMEG_4710|M.smegmatis_MC2_155      ----------------------------------------------THGP
TH_0716|M.thermoresistible__bu      ----------------------------------------------PHRA
MAB_4916c|M.abscessus_ATCC_199      -----------------------AAALALVEQTTEPEPAVAAPAAQAESV
MMAR_3491|M.marinum_M               -------------------------------------APAPAHGATAAPR
Mvan_1410|M.vanbaalenii_PYR-1       ---------------------------------SGRPAAVSSGRPAAVPS
                                                                                      

MLBr_00861|M.leprae_Br4923          --APYVTPLVRKLATENNIDLAKVI-GTGVGGRIRKQDVLAAAEQRKQQQ
MAV_2273|M.avium_104                G-TPYVTPLVRKLAAENNIDLSSIT-GTGVGGRIRKQDVLAAAEQKQRQQ
Mb2238|M.bovis_AF2122/97            G-APYVTPLVRKLASENNIDLAGVT-GTGVGGRIRKQDVLAAAEQKKRAK
Rv2215|M.tuberculosis_H37Rv         G-APYVTPLVRKLASENNIDLAGVT-GTGVGGRIRKQDVLAAAEQKKRAK
MUL_3575|M.ulcerans_Agy99           G-TPYVTPLVRKLAEENNIDLDSVT-GTGVGGRIRKQDVLAAAEKKKERP
Mflv_2935|M.gilvum_PYR-GCK          GDSPYVTPLVRKLAGEHGVDLASVK-GTGVGGRIRKQDVLAAAEKSKAPK
MSMEG_4710|M.smegmatis_MC2_155      --RARAKPPVRKLAAELNVDLGALDPGSGPDGIITRDDVLAAAGRSPAAQ
TH_0716|M.thermoresistible__bu      TGRPRAKPPVRRLAADLGVDLTAVAPGSGPDGVITRQDVLAAAGADGADA
MAB_4916c|M.abscessus_ATCC_199      PSRAAAKPSVRKLAAELGVALELIN-GTGIGGSITRQDVEAYTRSLTARA
MMAR_3491|M.marinum_M               -HRRWVSPAARRLAQSLHVDLDAVS-GTGPQGAVTISDVEHAAASAVPAK
Mvan_1410|M.vanbaalenii_PYR-1       GHRRWVSPAARRLASSLHVDLDAVT-GTGPQGAVTITDVEHAAAEAAGSA
                                         ..* .*:** .  : *  :  *:*  * :   **   :       

MLBr_00861|M.leprae_Br4923          APTSAPSAA------------APTPTPVLAHLRGTTQKVSRIRQITAKKT
MAV_2273|M.avium_104                QAAAQPSAAPAPAAAEARKPAAPTPAPALAHLRGTTQKASRIRQITAAKT
Mb2238|M.bovis_AF2122/97            APAPAAQAAAAPAP-----KAPPAPAPALAHLRGTTQKASRIRQITANKT
Rv2215|M.tuberculosis_H37Rv         APAPAAQAAAAPAP-----KAPPAPAPALAHLRGTTQKASRIRQITANKT
MUL_3575|M.ulcerans_Agy99           EAKPAAAQASAPASPS--KAAVPAAAAALAHLRGTKQKASRIRQITAIKT
Mflv_2935|M.gilvum_PYR-GCK          EDAPKAEPAAEAPG---KTTQAPAPEGALAHLRGTTQKANRIRQITAKKT
MSMEG_4710|M.smegmatis_MC2_155      SAGTPQPSQ--------------------------TRDVRGVQAEMARRM
TH_0716|M.thermoresistible__bu      PAAPADAAD--------------------------VVEVGAVQAAMARRM
MAB_4916c|M.abscessus_ATCC_199      PQGAPAEEEPVAGV-------------AVQPGGETRIPIAGVRKHTAAAM
MMAR_3491|M.marinum_M               RPAATAASTSAKSIG-----------AKSTAQNKIAERAAQMRKSIAAAM
Mvan_1410|M.vanbaalenii_PYR-1       AETARPAAETAGPAA-----------AKPAES-----RGAMMRRSIAAAM
                                       .                                     ::   *   

MLBr_00861|M.leprae_Br4923          RESLQATAQLTQTHEVDMAKIVGLRAKAKAAFAEREGVNLTFLPFIAKAA
MAV_2273|M.avium_104                RESLLATAQLTQTHEVDMTRLVGLRARAKAAFAEREGVNLTFLPFIARAV
Mb2238|M.bovis_AF2122/97            RESLQATAQLTQTHEVDMTKIVGLRARAKAAFAEREGVNLTFLPFFAKAV
Rv2215|M.tuberculosis_H37Rv         RESLQATAQLTQTHEVDMTKIVGLRARAKAAFAEREGVNLTFLPFFAKAV
MUL_3575|M.ulcerans_Agy99           RESLQATAQLTQTHEVDMTRIVALRARAKGSFAEREGVNLTFLPFIARAV
Mflv_2935|M.gilvum_PYR-GCK          RESLQTTAQLTQVHEVDMTRIVALRAKAKAGFAEREGVNLTYLPFIARAV
MSMEG_4710|M.smegmatis_MC2_155      ALSRREIPDAHARVDVDCTALLRLRDRIRSAET---ELPITPFVLTLRLL
TH_0716|M.thermoresistible__bu      TQSRREIPDAHGRVEVDCRALLELCAQLG-------ERTVTPFVLTLRLL
MAB_4916c|M.abscessus_ATCC_199      VRSAFTAPHVTEFLTVDMTSTMGLLAELKAKSP---DLKLTPMTLVARMV
MMAR_3491|M.marinum_M               SRSKREIPHYYLADEILMEKSLNWLTTRNAQRS--ITERVLPAVLLLKAV
Mvan_1410|M.vanbaalenii_PYR-1       GRSKREIPHYYLANEILLDASSQWLAERNAQRS--ITERVLPAALLLKAV
                                      *    ..      :                       :    :  :  

MLBr_00861|M.leprae_Br4923          IDALKIHPNINASYNEDTK--EITYYDAEHLGFAIDTDKG-LLSPVIHYA
MAV_2273|M.avium_104                IDALKIHPNINASYNEETK--EITYYDAEHLGFAVDTEQG-LLSPVVHNA
Mb2238|M.bovis_AF2122/97            IDALKIHPNINASYNEDTK--EITYYDAEHLGFAVDTEQG-LLSPVIHDA
Rv2215|M.tuberculosis_H37Rv         IDALKIHPNINASYNEDTK--EITYYDAEHLGFAVDTEQG-LLSPVIHDA
MUL_3575|M.ulcerans_Agy99           IDALKIHPNINASYNEETK--EITYYDAEHLGFAVDTDQG-LLSPVIHNA
Mflv_2935|M.gilvum_PYR-GCK          IDALKLHPNVNASYNEESK--EITYHEAEHLGIAVDTEQG-LLSPVIHNA
MSMEG_4710|M.smegmatis_MC2_155      TVALRRHVVLNATWMETTGGPQIHQHSAVHLGIGVAAPRG-LLVPVVRDA
TH_0716|M.thermoresistible__bu      GIALQHHPNLNATWRDTDDGPRIHRHRAVHLGIAVSAPRG-LLVPVVADA
MAB_4916c|M.abscessus_ATCC_199      LLALRSHPSLNSAWDEQAG--EIIVKHYVNLGIAAATERG-LVVPNVKGA
MMAR_3491|M.marinum_M               GLAAQRFGEFNGFWRDDGF----QAATGVHVGVGISLRGGGLVAPAIHDV
Mvan_1410|M.vanbaalenii_PYR-1       GVAAQRFQELNGFWRDDGF----VPADAVHVGVGISLRGGGLVAPAIHDV
                                      * : .  .*. : :             ::*..     * *: * :  .

MLBr_00861|M.leprae_Br4923          GDLSLAGLARAIVDIAARARSGNLKPEELSGGTFTITNIGSQGALFDTPI
MAV_2273|M.avium_104                GDLSLAGLARAIADIAARARSGNLKPDELSGGTFTITNIGSQGALFDTPI
Mb2238|M.bovis_AF2122/97            GDLSLAGLARAIADIAARARSGNLKPDELSGGTFTITNIGSQGALFDTPI
Rv2215|M.tuberculosis_H37Rv         GDLSLAGLARAIADIAARARSGNLKPDELSGGTFTITNIGSQGALFDTPI
MUL_3575|M.ulcerans_Agy99           GDLSLAGLARAIADIAARARSGNLKPDELSGGTFTITNIGSQGALFDTPI
Mflv_2935|M.gilvum_PYR-GCK          GDLSLGGLARAISDIAGRARSGNLKPDELSGGTFTITNIGSQGALFDTPI
MSMEG_4710|M.smegmatis_MC2_155      QGMTTRQLAVTVARLVESARAGTLSPAELTGSTFTVSNFGALGVDDGVPV
TH_0716|M.thermoresistible__bu      HRMTLPQLGAAVERLVDRARAGTLTPAELTGSTFTVSNFGALGLDDGVPV
MAB_4916c|M.abscessus_ATCC_199      DAMSLGELATAIAQLVSTARAGKTAPTDMSGGTFTLTNIGVFGVDAGTPI
MMAR_3491|M.marinum_M               ADKKLDELMGDLTDLVARARAGSLRSSEMSDPTITVTNLGDQGVDTVFGV
Mvan_1410|M.vanbaalenii_PYR-1       PGKKLDEVMSELTDLVARARAGSLRSSEMSDPTITVTNLGDQGVDTVFGI
                                       .   :   :  :.  **:*.  . :::. *:*::*:*  *      :

MLBr_00861|M.leprae_Br4923          LVPPQAAMLGIGAIVKRPRVVIDASGNESIGVRAICYLPLTYDHRLIDGA
MAV_2273|M.avium_104                LVPPQAAMLGTGAIVKRPRVIVDEFGNESIGVRSVCYLPLTYDHRLIDGA
Mb2238|M.bovis_AF2122/97            LVPPQAAMLGTGAIVKRPRVVVDASGNESIGVRSVCYLPLTYDHRLIDGA
Rv2215|M.tuberculosis_H37Rv         LVPPQAAMLGTGAIVKRPRVVVDASGNESIGVRSVCYLPLTYDHRLIDGA
MUL_3575|M.ulcerans_Agy99           LVPPQAAMLGTGAIVKRPRVVVDDTGNESIGVRSVCYLPLTYDHRLVDGA
Mflv_2935|M.gilvum_PYR-GCK          LVPPQAAMLGTGAIVKRPRIIIDEFGNESIGVRSVSYLPLTYDHRLIDGA
MSMEG_4710|M.smegmatis_MC2_155      INYPEAAILGMGSLRERPVVVDG-----AVVARPTMSLTCVFDHRIADGA
TH_0716|M.thermoresistible__bu      INYPEAAILGMGMIKPRPVVIDD-----AVVARPTMTLTCAFDHRVADGA
MAB_4916c|M.abscessus_ATCC_199      INPGEAAILALGSVAKRPWVVNG-----ELAVRDVTTLALSFDHRLVDGE
MMAR_3491|M.marinum_M               IYPPQVAIVGFGKPAQRVCVIDG-----GIRVVTTVQGTLAADHRASDGH
Mvan_1410|M.vanbaalenii_PYR-1       IYPPQVALVGFGKPAQRVCAVDG-----GIRIATTVHATLAADHRASDGH
                                    :   :.*::. *    *   : .      :        .   ***  ** 

MLBr_00861|M.leprae_Br4923          DAGRFLTTIKHRLEEGAFEADLGL
MAV_2273|M.avium_104                DAGRFLTTIKHRLEEGAFEADLGL
Mb2238|M.bovis_AF2122/97            DAGRFLTTIKHRLEEGAFEADLGL
Rv2215|M.tuberculosis_H37Rv         DAGRFLTTIKHRLEEGAFEADLGL
MUL_3575|M.ulcerans_Agy99           DAGRFLTTIKHRLEKGAFEADLGL
Mflv_2935|M.gilvum_PYR-GCK          DAGRFVTTIKRRLEEGAFEADLGL
MSMEG_4710|M.smegmatis_MC2_155      QAAAFLGELRGLIEEPDLALLDL-
TH_0716|M.thermoresistible__bu      QVAAFLDELRGLIESPSRALLFLR
MAB_4916c|M.abscessus_ATCC_199      QGSKFLADLGAMLTDPRMALVV--
MMAR_3491|M.marinum_M               RGALFLAAINELLQQPDLLEK---
Mvan_1410|M.vanbaalenii_PYR-1       RGAMFLAAIDQLLQQPDQLEK---
                                      . *:  :   : .