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MRIDRVIGAAFGPFRGETLEFAPGLNVVHGPNEAGKSSWFNATYAALAGRRKYKGRGSAAETEFRNRHKP WSGSKWAVGLAVTLDDDRRLAITQDLAKGEWKIVDGSTAQAVSEAQLLTDTSLDGTRLLGLNRQSARSTI FTGQADILRVRDDAGELQELLERAASTGATDATADAALAWLKERRSEWVGVAHGKKPLAATRAALNASRA LAQTRRDDLAELLETIANRQKLAAPLVKARAKVELSERLVKWQSVYELRNRVEKAVELSTRVAESREADL TVDEEKVAAATKVLVVFDRGTDVVPLGEGPTAVDLQAQIDELPQVPEGDREPRQDVIDAHSELVKAQTAL DTHMQAAPPDVEPTPSTTLSADELRTLADILALPPPEVDTAAVEAFQQNREQRTAQLAALQREVDDHDAT YRQAKVDYDAAVESGAMALELAALHAIERSAAEDVMAASRRQVALLAEALSAQENQAGAMAQEVALRRHQ ERVGAAHAQVRGDSLEADPEALKRIAREIDAAGAARIAAAKHADQAAEFRAARDDRVRALSSLLGGQDPL NTEDPVAQTLQMFTDYVDACKSRAEVAQQAARRADLVEAHSQRLQLEANHRQALSIRETQGREVVELAAA LDLTADSLEAAIEQLRRWVGEQEEKRVALTTWKTDVALLEQLLGGRELTDLQSDLAALTADAGDEPEEPM PPDLNTFVAEAKALYDRMIDLDGQLKGKIQALGNALGSVADAVEVEADAQRAADQVETLASCLDAAAAEL ANAKERANASIAPALADRMRPWLPRVTNGRYRDVTVDPGDLTIHVTETTGQVRQADRLSLGTTEQIYLLL RVTLSQVLSGGTETAPLIFDDVTTQSDTTRTVAVMELLHELSAEHQVILFSQEDEVVEWAQRNIDPTRDK IIPLPAP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1098 | - | - | 100% (917) | SMC domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_2175 | - | 8e-17 | 24.42% (868) | chromosome segregation protein SMC |
| M. vanbaalenii PYR-1 | Mvan_4435 | - | 3e-15 | 23.37% (933) | hypothetical protein Mvan_4435 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1309 | - | 2e-09 | 23.39% (778) | hypothetical protein Mb1309 |
| M. gilvum PYR-GCK | Mflv_4188 | - | 5e-18 | 24.23% (871) | chromosome segregation protein SMC |
| M. tuberculosis H37Rv | Rv1278 | - | 2e-09 | 23.39% (778) | hypothetical protein Rv1278 |
| M. leprae Br4923 | MLBr_01120 | - | 8e-10 | 21.82% (779) | hypothetical protein MLBr_01120 |
| M. abscessus ATCC 19977 | MAB_1421 | - | 2e-17 | 24.63% (678) | hypothetical protein MAB_1421 |
| M. marinum M | MMAR_1785 | smc | 2e-12 | 23.18% (893) | chromosome partition protein Smc |
| M. avium 104 | MAV_3777 | smc | 3e-17 | 24.19% (868) | chromosome segregation protein SMC |
| M. smegmatis MC2 155 | MSMEG_2423 | smc | 3e-13 | 24.13% (866) | chromosome segregation protein SMC |
| M. thermoresistible (build 8) | TH_1853 | - | 5e-15 | 23.88% (783) | conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_2033 | smc | 5e-12 | 22.96% (893) | chromosome partition protein Smc |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4188|M.gilvum_PYR-GCK MHLKSLTLKGFKSFASPTTLRFEPGITCVVGPNGSGKSNVVDALTWVMGE
MSMEG_2423|M.smegmatis_MC2_155 MHLKSLTLKGFKSFASPTTLRFEPGITCVVGPNGSGKSNVVDALTWVMGE
MMAR_1785|M.marinum_M MYLKSLTLKGFKSFAAPTTLRFEPGITAVVGPNGSGKSNVVDALAWVMGE
MUL_2033|M.ulcerans_Agy99 MYLKSLTLKGFKSFAAPTTLRFEPGITAVVGPNGSGKSNVVDALAWVMGE
MAV_3777|M.avium_104 MYLKSLTLKGFKSFASPTTLRFEPGITAVVGPNGSGKSNVVDALAWVMGE
Mb1309|M.bovis_AF2122/97 MKLHRLALTNYRGIAHRDVEFPDHGVVVVCGANEIGKSSMVEALDLLLEY
Rv1278|M.tuberculosis_H37Rv MKLHRLALTNYRGIAHRDVEFPDHGVVVVCGANEIGKSSMVEALDLLLEY
MLBr_01120|M.leprae_Br4923 MKLHRLALTNYRGTARREIEFPDRGVILVCGANEIGKSSMIEALDLLLEF
TH_1853|M.thermoresistible__bu MRLHRLALTNYRGIARREVEFPDRGVVVVSGANEIGKSSMIEALDLLFHA
MAB_1421|M.abscessus_ATCC_1997 MKLHRLSVTNYRGITHRDITFPERGVVVVGGANEVGKTSMIEALDLLIES
Mvan_1098|M.vanbaalenii_PYR-1 MRIDRVIGAAFGPFRG-ETLEFAPGLNVVHGPNEAGKSSWFNATYAALAG
* :. : : *: * *.* **:. .:* :
Mflv_4188|M.gilvum_PYR-GCK QGAKTLRGGKMEDVIFAGTSSRAPLGRAEVTLTIDNSDNALPIEYSEVSI
MSMEG_2423|M.smegmatis_MC2_155 QGAKTLRGGKMEDVIFAGTSSRAPLGRAEVTLTIDNSDNALPIEYSEVSI
MMAR_1785|M.marinum_M QGAKTLRGGKMEDVIFAGTSSRAPLGRAEVTVTIDNSDNALPIEYTEVSI
MUL_2033|M.ulcerans_Agy99 QGAKTLRGGKMEDVIFAGTSLRAPLGRAEVTVTIDNSDNALPIEYTEVSI
MAV_3777|M.avium_104 QGAKTLRGGKMEDVIFAGTSSRAPLGRAEVTVTIDNSDNALPIEYSEVSI
Mb1309|M.bovis_AF2122/97 KDRSTKKEVKQVKPTNADVG-------SEVIAEISSGP-------YRFVY
Rv1278|M.tuberculosis_H37Rv KDRSTKKEVKQVKPTNADVG-------SEVIAEISSGP-------YRFVY
MLBr_01120|M.leprae_Br4923 RDRSTKKEVKQVKPANADIG-------SEVCAEISSGT-------YRFVY
TH_1853|M.thermoresistible__bu KDRSTKKEVKQVKPTHADVG-------AEITAEISTGP-------YRFVY
MAB_1421|M.abscessus_ATCC_1997 KDRSTKKDVKQVKPTFADVG-------SEVEAEISCGP-------YRFVY
Mvan_1098|M.vanbaalenii_PYR-1 R-RKYKGRGSAAETEFRNRHKPWSGSKWAVGLAVTLDDDRRLAITQDLAK
: . . . . : : . .
Mflv_4188|M.gilvum_PYR-GCK TRRMFRDGAGEYEINGSRCR---LADVQELLSDSGIGREMHVIVGQGKLS
MSMEG_2423|M.smegmatis_MC2_155 TRRMFRDGAGEYEINGASCR---LMDVQELLSDSGIGREMHVIVGQGKLS
MMAR_1785|M.marinum_M TRRMFRDGASEYEINGSSCR---LMDVQELLSDSGIGREMHVIVGQGKLD
MUL_2033|M.ulcerans_Agy99 TRRMFRDGASEYEINGSSCR---LMDVQELLSDSGIGREMHVIVGQGKLD
MAV_3777|M.avium_104 TRRMFRDGASEYEINGSSCR---LMDVQELLSDSGIGREMHVIVGQGKLD
Mb1309|M.bovis_AF2122/97 RKRFHKRCETELTVLAPRR--------EQLTGDEAHERVRTMLAETVDTE
Rv1278|M.tuberculosis_H37Rv RKRFHKRCETELTVLAPRR--------EQLTGDEAHERVRTMLAETVDTE
MLBr_01120|M.leprae_Br4923 RKRFNKKCETALTVLAPHR--------EQLTGDEAHERVRAMLAETVDND
TH_1853|M.thermoresistible__bu HKRFHKKCATQLTILAPRR--------EELSGDEAHERALAMLSETVDME
MAB_1421|M.abscessus_ATCC_1997 RKRFHKRAETHLTVIEPRR--------EQLSGDEAHQRVLDMLDQSIDMN
Mvan_1098|M.vanbaalenii_PYR-1 GEWKIVDGSTAQAVSEAQLLTDTSLDGTRLLGLNRQSARSTIFTGQADIL
. : . .* . . :: .
Mflv_4188|M.gilvum_PYR-GCK EILESRPEDRRAFIEEAAGVLKHRKRKEKAVRKLDSMAANLARLTDLTTE
MSMEG_2423|M.smegmatis_MC2_155 EILESRPEDRRAFIEEAAGVLKHRKRKEKAVRKLDSMAANLARLTDLTTE
MMAR_1785|M.marinum_M EILQSRPEDRRAFIEEAAGVLKHRKRKEKALRKLDAMSANLARLTDLTTE
MUL_2033|M.ulcerans_Agy99 EILQSRPEDRRAFIEEAAGVLKHRKRKEKALRKLDAMSANLARLTDLTTE
MAV_3777|M.avium_104 EILQSRPEDRRAFIEEAAGVLKHRKRKEKALRKLDAMSANLARLTDLTTE
Mb1309|M.bovis_AF2122/97 LWHAQR------VLQAASTAAVDLSGCDALSRALDLAAGDDAALSGTESL
Rv1278|M.tuberculosis_H37Rv LWHAQR------VLQAASTAAVDLSGCDALSRALDLAAGDDAALSGTESL
MLBr_01120|M.leprae_Br4923 LWHAQR------VLQAASTAAVDLSGCDALSRALDLAAGDHAELSGTEPL
TH_1853|M.thermoresistible__bu LWRTQR------VLQAGSTAPVDLSGCDALSRALDAVAGEAVQTSGTEPL
MAB_1421|M.abscessus_ATCC_1997 LWKAQR------VLQSAGAGVLDLSSSDALTRALDLAAGQSVALSGSEPD
Mvan_1098|M.vanbaalenii_PYR-1 RVRDDAGELQELLERAASTGATDATADAALAWLKERRSEWVGVAHGKKPL
. . . .. . . : : . .
Mflv_4188|M.gilvum_PYR-GCK LRRQLKPLGRQAEMARRAQTIQADLRDARLRLAADDLVARKAEFDDTDQA
MSMEG_2423|M.smegmatis_MC2_155 LRRQLKPLGRQAEMARRAATIQADLRDARLRLAADDLVRRQVEFQNTNQA
MMAR_1785|M.marinum_M LRRQLKPLGRQAEVARRAQTIQADLRDARLRLAADDVVSRRAEREAIFEA
MUL_2033|M.ulcerans_Agy99 LRRQLKPLGRQAEVARRAQTIQADLRDARLRLAADDVVSRRAEREAIFEA
MAV_3777|M.avium_104 LRRQLKPLGRQAEVARRAQTIQADLRDARLRLAADDLVNRRGEREAIFEA
Mb1309|M.bovis_AF2122/97 LIERIE-----------------------------------AEYARYFTP
Rv1278|M.tuberculosis_H37Rv LIERIE-----------------------------------AEYARYFTP
MLBr_01120|M.leprae_Br4923 LIERIE-----------------------------------AEYRRYFTS
TH_1853|M.thermoresistible__bu LIDRID-----------------------------------AEYRKYFTA
MAB_1421|M.abscessus_ATCC_1997 LVERID-----------------------------------AEYALYFTG
Mvan_1098|M.vanbaalenii_PYR-1 AATRAALNASRALAQTR----------------------RDDLAELLETI
:
Mflv_4188|M.gilvum_PYR-GCK ETTLRREHDELTERLQERAAELDAHETAVEDLSERADAAQQRWFRLSALA
MSMEG_2423|M.smegmatis_MC2_155 ETALRKEHEELTVRLQSATVELQAHEAAVAELTRRAEAAQQTWFRASALA
MMAR_1785|M.marinum_M EATMRREHDEAAARLTVAAEELAAHEAALAELTSRAESVQHTWFGLSALA
MUL_2033|M.ulcerans_Agy99 EATMRREHDEAAARLTVAAEELAAHEATLAELTSRAESVQHTWFGLSALA
MAV_3777|M.avium_104 EAAMRREHDEASARLAVASEELAAHEKALGELSGRAESVQQTWFALSALA
Mb1309|M.bovis_AF2122/97 TGRPTGEWSAAVSRLAAAEAAVADCAAAVAEVDDGVRRHTELTEQVAELS
Rv1278|M.tuberculosis_H37Rv TGRPTGEWSAAVSRLAAAEAAVADCAAAVAEVDDGVRRHTELTEQVAELS
MLBr_01120|M.leprae_Br4923 TGRPTGEWAVAISRLSDAETAVGECAAAVAEVDDRVRRHAVLTERVAGLA
TH_1853|M.thermoresistible__bu TGRPTGEWLAATKRLQAADEQVARCAARVAEVEDAVRRHATLTESLAELE
MAB_1421|M.abscessus_ATCC_1997 TGRPTGEWARAGARLTAAEDALASARAAMAEVDQQVREHDELTQELASVI
Mvan_1098|M.vanbaalenii_PYR-1 ANRQKLAAPLVKARAKVELSERLVKWQSVYELRNRVEKAVELSTRVAESR
* : :: . :
Mflv_4188|M.gilvum_PYR-GCK ER-VSATVRIASERAQHLDGDPDFSAGPDPDELEAQADAVAEQEQQLLDE
MSMEG_2423|M.smegmatis_MC2_155 ER-VGATVRIATDRAQMLDSEPEMSSGRDPDALEAEAEEVAELEAQLLDE
MMAR_1785|M.marinum_M ER-VGTTVRIANERAQHLDVEPVTNSDTDPDALDAEAEQVAIAEQQLLVE
MUL_2033|M.ulcerans_Agy99 ER-VGTTVRIANERAQHLDVEPVTNSDTDPDALDAEAEQVAIAEQQLLVE
MAV_3777|M.avium_104 ER-VAATVRIASERAQHLDLGPVTAGDTDPDALDAEAERVAAAEQQLLAE
Mb1309|M.bovis_AF2122/97 QQLLAHQLRLEAARVAAEKIAAITDDAREAKLIATAAAATSGASTAAHAG
Rv1278|M.tuberculosis_H37Rv QQLLAHQLRLEAARVAAEKIAAITDDAREAKLIATAAAATSGASTAAHAG
MLBr_01120|M.leprae_Br4923 QQRFAAGPRLAVAQAAADKVAVLTRQAREAELVAAAATATNAAAVAAHTS
TH_1853|M.thermoresistible__bu DGRRTADAQLAAAREAAEAVERLTRQLAEAQLAAEAAEATHTASVAALNE
MAB_1421|M.abscessus_ATCC_1997 ADRAEVNRRLAPLEEASQAVTTLVQQHDNAVVVAEAAQAAAVAAQTKRDE
Mvan_1098|M.vanbaalenii_PYR-1 EADLTVDE-----EKVAAATKVLVVFDRGTDVVPLGEGPTAVDLQAQIDE
. . .
Mflv_4188|M.gilvum_PYR-GCK LAESQERLEAAREELAEREQAAAEAERAHMAAARAEADRREGLARLSGQV
MSMEG_2423|M.smegmatis_MC2_155 LSEARIALETARAELAEREQIAADAERAHMAAARAEADRREGLARLAGQV
MMAR_1785|M.marinum_M LAEARDRLDAARAELADREHRAAEADRAHLAAVRAEADRREGLARLAGQV
MUL_2033|M.ulcerans_Agy99 LAEARDRLDAARAELADREHRAAEADRAHLAAVRAEADRREGLARLAGQV
MAV_3777|M.avium_104 LAAARSRLETARAELAEREREAAEADRAHMAAVRAEADRREGLARLAGQV
Mb1309|M.bovis_AF2122/97 RLGLLTEIDTRTAAVVAAEAKARQAADEQATARAEAEACDAALTEATQVL
Rv1278|M.tuberculosis_H37Rv RLGLLTEIDTRTAAVVAAEAKARQAADEQATARAEAEACDAALTEATQVL
MLBr_01120|M.leprae_Br4923 RLRLLAEIDTRAVVLAATQDEAQEAVDAVSTMRADAEASDAAVEESTEAL
TH_1853|M.thermoresistible__bu RRRLRAEIEERTAAVAALQPEVDAALEAEATAREVQQEADTAAERAREAA
MAB_1421|M.abscessus_ATCC_1997 RAQLVADIRARRVSIDMLAEQLSATAEAHGTAQQVCEAAEAAAAQATESV
Mvan_1098|M.vanbaalenii_PYR-1 LPQVPEGDREPRQDVIDAHSELVKAQTALDTHMQAAPPDVEPTPSTTLSA
: : :
Mflv_4188|M.gilvum_PYR-GCK DTMRTRVESVDETVARLTANIDDAAARAQLTQ-AEFETVQARVGELDAGE
MSMEG_2423|M.smegmatis_MC2_155 DTMRTRVESIDEGVLRLSVSIEEAAAKAEHAQ-AEFEDVQSRVGELDAGE
MMAR_1785|M.marinum_M ETMRARVESIDDSVARLSERIEHAAARAQQTR-AEFETVQARVGELDQGE
MUL_2033|M.ulcerans_Agy99 ETMRARVESIDDSVARLSERIEHAAARAQQTR-AEFETVQARVGELDQGE
MAV_3777|M.avium_104 ETMRARVESIDDSVARLSERIEAAAARAQQAK-AEFETVQGRVGELDQGE
Mb1309|M.bovis_AF2122/97 TAVRLRAESARRTLDQLADCEEADRLAARLAR-IDDIEGDRDRVCAELSA
Rv1278|M.tuberculosis_H37Rv TAVRLRAESARRTLDQLADCEEADRLAARLAR-IDDIEGDRDRVCAELSA
MLBr_01120|M.leprae_Br4923 MAAQQRADIARSTVDQLVDRQEADRLSTRLAK-IDAIQGERDLICAELSA
TH_1853|M.thermoresistible__bu DAARERVDTARQAVQRLADRAERDTLADRLRR-IDAAATELARVDGELAT
MAB_1421|M.abscessus_ATCC_1997 DAARVQLEAARGTLDRALARDEVDGLAARVSR-IDLTNRQLASVGAELSS
Mvan_1098|M.vanbaalenii_PYR-1 DELRTLADILALPPPEVDTAAVEAFQQNREQRTAQLAALQREVDDHDATY
: : . . : : : :
Mflv_4188|M.gilvum_PYR-GCK VGLDEHHDRSVAALRLADERVAELLAAERAAERQVASLQARIDALSVGLD
MSMEG_2423|M.smegmatis_MC2_155 VGLDEHHDRTVAALRLADERVAELQAAERAAERQVASLRARIEALSVGLD
MMAR_1785|M.marinum_M VGLDEQHERTVAALRLAEQRLAELQVAERDAERQVASLRARIEALSVGLD
MUL_2033|M.ulcerans_Agy99 VGLDEQHERTVAALRLAEQRLAELQVAERDAERQVASLRARIGALSVGLD
MAV_3777|M.avium_104 VGLDEHHERTVAALRLADERVAELQAAERDAERKVASLRARIDALAVGLE
Mb1309|M.bovis_AF2122/97 VTLTEELLSRIERAAAAVDRGGAQLASISAAVEFTAAVDIELGVGDQRVS
Rv1278|M.tuberculosis_H37Rv VTLTEELLSRIERAAAAVDRGGAQLASISAAVEFTAAVDIELGVGDQRVS
MLBr_01120|M.leprae_Br4923 VTLTEQLLQRIENAAAIVDRTGEQLKLISAAVEFTATADIEISVGQQRVS
TH_1853|M.thermoresistible__bu LTVTEAALRQIEAAELAVERAAGQAELASAHIELTAAVDLELRVGDEQLT
MAB_1421|M.abscessus_ATCC_1997 LVITAQSLGAIETAARAVGMAEAALETASAQVELRALVDVDIAVNGEQLR
Mvan_1098|M.vanbaalenii_PYR-1 RQAKVDYDAAVESGAMALELAALHAIERSAAEDVMAASRRQVALLAEALS
: * : :
Mflv_4188|M.gilvum_PYR-GCK RRDGAAWLQENHSGAGLFGSIANLVKVRAGHEAAIAAMLGAAADALAAED
MSMEG_2423|M.smegmatis_MC2_155 RRDGAAWLQKNHSGGGLFGSIGDFLRVQPGYEVAVAAVLGAAADALAAEN
MMAR_1785|M.marinum_M RKDGAAWLARNHSDAGLFGSVAQLVKVRSGYEAAVAAVLGSAAEALAADS
MUL_2033|M.ulcerans_Agy99 RKDGAAWLARNHSDAGLFGSVAQLVKVRSGYEAAVAAVLGSAAEALAADS
MAV_3777|M.avium_104 RKDGTAWLTENHSGAGILGPMAKLVKVRSGYEAAVAAVLGSAADALAADG
Mb1309|M.bovis_AF2122/97 LSAGQSWSVT----------------------------------------
Rv1278|M.tuberculosis_H37Rv LSAGQSWSVT----------------------------------------
MLBr_01120|M.leprae_Br4923 LEAGQSWSTT----------------------------------------
TH_1853|M.thermoresistible__bu IPAGGSWTAG----------------------------------------
MAB_1421|M.abscessus_ATCC_1997 VAAGDRWSSA----------------------------------------
Mvan_1098|M.vanbaalenii_PYR-1 AQENQAGAMA----------------------------------------
.
Mflv_4188|M.gilvum_PYR-GCK FGAARAAVAALKESDGGRAALVLGDWP-AQEAVT-GQLPAGAAWAVDLVE
MSMEG_2423|M.smegmatis_MC2_155 FGAAAAAVAALKESDGGRAAIVLGDWN-AIGSSPQAALPPGATWATDLVS
MMAR_1785|M.marinum_M FGAARSAVTALKQADGGRAALVLGDWPDANDHRAAGGLPSGTLWALDLIE
MUL_2033|M.ulcerans_Agy99 FGAARSAVTALKQADGGRAALVLGDWPDAHDHRAAGGLPSGTLWALDLIE
MAV_3777|M.avium_104 LGAARSALGALKQADGGRAALVLGDWP--ADPPAPQPAPAGALWALDLID
Mb1309|M.bovis_AF2122/97 --------------------------------------------------
Rv1278|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01120|M.leprae_Br4923 --------------------------------------------------
TH_1853|M.thermoresistible__bu --------------------------------------------------
MAB_1421|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_1098|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4188|M.gilvum_PYR-GCK PADRVRGAVTAMLSGVAVVENLTAALDLVAAQPRLRAVTADGDLVGAGWV
MSMEG_2423|M.smegmatis_MC2_155 VPDRLRGAVTAMLTGVAVVPDMAAGLALVSSRPELRAVTTEGDLVGPGWV
MMAR_1785|M.marinum_M VPSRLRPAMTAMLSGVVVVNDLSEALDLVQAQPQLRAVTLDGDLVGAGWV
MUL_2033|M.ulcerans_Agy99 VPSRLRPAMTAMLSGVVVVNDLSEALDLVQAQPQLRAVTLDGDLVGAGWV
MAV_3777|M.avium_104 APERLRGAITAMLSGVAVVDDLDRALALVAEHPRLRAVTLDGDLVGAGWV
Mb1309|M.bovis_AF2122/97 -------------------------------------ATGPTEVKVPGVL
Rv1278|M.tuberculosis_H37Rv -------------------------------------ATGPTEVKVPGVL
MLBr_01120|M.leprae_Br4923 -------------------------------------ATGPTEVEVLGVL
TH_1853|M.thermoresistible__bu -------------------------------------ATAPTEIELPGLL
MAB_1421|M.abscessus_ATCC_1997 -------------------------------------ATDTIEITAPGVA
Mvan_1098|M.vanbaalenii_PYR-1 -------------------------------------QEVALRRHQERVG
Mflv_4188|M.gilvum_PYR-GCK SGGSDRKPSTLEIQSEVDRARSELVDAERRTGELSAALSGALAEQAARQD
MSMEG_2423|M.smegmatis_MC2_155 SGGSDRKPSTLEIASEIDKARAELEQAERQTSELGAALSGALAEQSARQD
MMAR_1785|M.marinum_M SGGSDRKPSTLEITSEIDKARSELAAAEVRVAELGAALSGALTDQTARQD
MUL_2033|M.ulcerans_Agy99 SGGSDRKPSTLEITSEIDKARRELAAAEVRVAELGAALSGALTDQTARQD
MAV_3777|M.avium_104 SGGSDRKLSTLEVTSEIDKASAELAAAEAQVAQLSAALSGALAEQAARQD
Mb1309|M.bovis_AF2122/97 TARIVPGATALDFQAKYAAAQQELADALAAGEVADLAAARSADLCRRELL
Rv1278|M.tuberculosis_H37Rv TARIVPGATALDFQAKYAAAQQELADALAAGEVADLAAARSADLCRRELL
MLBr_01120|M.leprae_Br4923 TACVIPGATALDAQSKYVAAQEELSVALADGGVVDLAAARCANQRRRELQ
TH_1853|M.thermoresistible__bu TARIVPGAPAAQMQETLDVARAALADALQHAGVADVASARSQVERRRELS
MAB_1421|M.abscessus_ATCC_1997 VARIIPGPNAAQLRDKLDTARQTLSGALADAGVADVGEAQKQFERRTELN
Mvan_1098|M.vanbaalenii_PYR-1 AAHAQVRGDSLEADPEALKRIAREIDAAGAARIAAAKHADQAAEFRAARD
. : : * :
Mflv_4188|M.gilvum_PYR-GCK AAEHALAALNESDAAISAIYEQLGRLGQDARAADDEW--QRLIRQRDEME
MSMEG_2423|M.smegmatis_MC2_155 AAEQALAALNESDAAISAIYEQLARLGQEARGAHQEW--QRLIKQRDELE
MMAR_1785|M.marinum_M AAEQALAALNESDTAISAMYEQLGRIGQDARGAEEEW--TRLLRQREELE
MUL_2033|M.ulcerans_Agy99 AAEQALAALNESDTAISAMYEQLGRIGQDARGAEEEW--TRLLRQREELE
MAV_3777|M.avium_104 SAEQALAALNESDSAISGMYEQLGRLGQEARTSEDEW--SRLLRQREELE
Mb1309|M.bovis_AF2122/97 SRRDQLTATLAGLCGDEQVDQLRSRLEQLCAGQPAEL--DLV--------
Rv1278|M.tuberculosis_H37Rv SRRDQLTATLAGLCGDEQVDQLRSRLEQLCAGQPAEL--DLV--------
MLBr_01120|M.leprae_Br4923 SSLDQLSAALAGVCGDDQIDQLRARLEQLRDGYPGEP--DLL--------
TH_1853|M.thermoresistible__bu TARETFAATVVALTGEDTLERLRARLAELDAAASDDT--GEL--------
MAB_1421|M.abscessus_ATCC_1997 AERDRLTALLDGLMGPESLEALREKLSRLRELVPEAT--GLWD-------
Mvan_1098|M.vanbaalenii_PYR-1 DRVRALSSLLGGQDPLNTEDPVAQTLQMFTDYVDACKSRA----------
::: . . :
Mflv_4188|M.gilvum_PYR-GCK AGRNRTVSELAELELRLQNAQREP-MFDAEVVDRTEFTAAAEAARSAEVE
MSMEG_2423|M.smegmatis_MC2_155 AGRTKTVEELRELESRLSNAEQTP-MFDIEPVDRQETVAAAEAARAVEVE
MMAR_1785|M.marinum_M VGRTQTLEEVLELESRLRNAQESQHVQAAEPVDRQEIAAAAESARAIEVE
MUL_2033|M.ulcerans_Agy99 VGRTQTLEEVLELESRLRNAQESQHVQAAEPVDRQEIAAAAESARAIEVE
MAV_3777|M.avium_104 AGRTQTVAEVTELENRLRNAQETPQEPAAEPVNRQQIAAATDAARSAEVE
Mb1309|M.bovis_AF2122/97 -------------------------------------STDTATARAELDA
Rv1278|M.tuberculosis_H37Rv -------------------------------------STDTATARAELDA
MLBr_01120|M.leprae_Br4923 -------------------------------------AVDIGSARAELEA
TH_1853|M.thermoresistible__bu -------------------------------------GVD--DAQAELTA
MAB_1421|M.abscessus_ATCC_1997 -------------------------------------AIDPAQARAEVAR
Mvan_1098|M.vanbaalenii_PYR-1 ------------------------------------EVAQQAARRADLVE
::
Mflv_4188|M.gilvum_PYR-GCK ARLSVRTAEERANAVRGRADSLRRAAVAEREARVRAQRAREARVHAAAVA
MSMEG_2423|M.smegmatis_MC2_155 ARLAVRTAEERANAVRGRADSLRRAAAAEREARVRAQRAREAREYAARVA
MMAR_1785|M.marinum_M ARLTVRTAEERANALRGRADSLRRAAAAEREARVRAELARAVRLRSAAVA
MUL_2033|M.ulcerans_Agy99 ARLTVRTAEERANALRGRADSLRRVAAAEREARVRAELARAVRLRSAAVA
MAV_3777|M.avium_104 ARLAVRTAEERANAVRGRADSLRRAAAAEREARVRAQQAREARLRAAAVA
Mb1309|M.bovis_AF2122/97 VEAARIAAEKDCETRR------QIAAGAARRLAETSTRATVLQNAAAAES
Rv1278|M.tuberculosis_H37Rv VEAARIAAEKDCETRR------QIAAGAARRLAETSTRATVLQNAAAAES
MLBr_01120|M.leprae_Br4923 AETVRAAVDFEREVCR------RTAAAANCRLVETSARANFLLKKAETQR
TH_1853|M.thermoresistible__bu AERAYQQAHTDCETHR------KAAVLAARRLAEKSQTAAALREKLTAAR
MAB_1421|M.abscessus_ATCC_1997 LVGEVERLQAEEVTHR------RAVQTAGQQLAEKAAEAMAAREKHAARA
Mvan_1098|M.vanbaalenii_PYR-1 AHSQRLQLEAN---HR------QALSIRETQGREVVELAAALDLTADSLE
. * : . *
Mflv_4188|M.gilvum_PYR-GCK AAVAESGRAVAQRLADAVSVASRIRDEVAAERQVRAGALTKAREEVNELT
MSMEG_2423|M.smegmatis_MC2_155 AAVSECGRQIAGKLSAVVAAAARSRDELATERQLRVNALGEIREEVTALN
MMAR_1785|M.marinum_M AAVAESGRLLAWRLNRVVDAASQLRDELAAERQQRSAAMSAVREETSSLS
MUL_2033|M.ulcerans_Agy99 AAVAESGRLLAWRLNRVVDAASQLRDELAAERQQRSAAMSAVREETSSLS
MAV_3777|M.avium_104 AAVADSGRLLATRLNAVVAAASRIRDALAAERQQRATAMTAVRDEVNALS
Mb1309|M.bovis_AF2122/97 AELGAAMTRLACERASVGDDELAAKAEADLR-------------VLQTAE
Rv1278|M.tuberculosis_H37Rv AELGAAMTRLACERASVGDDELAAKAEADLR-------------VLQTAE
MLBr_01120|M.leprae_Br4923 AELDQDIDQLAQQRASVSDEDLASAAEAGLR-------------AVQIAE
TH_1853|M.thermoresistible__bu TELDTAAARLAAQRADVDDETLVVRAAAHGE-------------EAERAA
MAB_1421|M.abscessus_ATCC_1997 EELAAAEQRLAHVRSSASDDLLTERHERAVQ-------------AADLTS
Mvan_1098|M.vanbaalenii_PYR-1 AAIEQLRRWVGEQEEKRVALTTWKTDVALLEQLLGG-------RELTDLQ
: :. .
Mflv_4188|M.gilvum_PYR-GCK ARITALTDALHRDEVAKAQAALRIEQLEQQVLEQFGMAVADLVAEYGPDV
MSMEG_2423|M.smegmatis_MC2_155 NRINTLTDALHRDEMAKAQAQLRIEQLEAQVLEQFGMSAGDLVAEYGPQV
MMAR_1785|M.marinum_M ARVATLTDSLHRDEVANAQAALRIEQVEQMVLEQFGMAPSDLVAEYGPDV
MUL_2033|M.ulcerans_Agy99 ARVATLTDSLHRDEVANAQAALRIEQVEQMVLEQFGMAPSDLVAEYGPDV
MAV_3777|M.avium_104 ARVAALTDSLHRDEVANAQAALRIEQLEQMVLEQFGMAPADLIAEYGPHI
Mb1309|M.bovis_AF2122/97 QRVIDLADELAATAPDAVAAELAEAADAVELLRERHDEAIRALHEVGVEL
Rv1278|M.tuberculosis_H37Rv QRVIDLADELAATAPDAVAAELAEAADAVELLRERHDEAIRALHEVGVEL
MLBr_01120|M.leprae_Br4923 QRVAKLTEELVAAEPEAVTAELVAATAAAESLRDQHEDAAGALREISIEL
TH_1853|M.thermoresistible__bu VRVAQLNAELSAAQPDQVAAALDTAARHAETVHAEHRRTADALRELNAQL
MAB_1421|M.abscessus_ATCC_1997 RRVTDLVSQLAALEADRVRAELAEVSARAQALDRRHEATRDRLRDISVRL
Mvan_1098|M.vanbaalenii_PYR-1 SDLAALTADAGDEPEEPMPPDLNTFVAEAKALYDRMIDLDGQLKGKIQAL
: * . * : : :
Mflv_4188|M.gilvum_PYR-GCK ALPPSELEMAEYEQARERGEQVTAPAPMPYDRPTQERRAKRAERELKELG
MSMEG_2423|M.smegmatis_MC2_155 ALPPSELEMAEYEQAKERGEQVTAPAPMPFDRATQERRAKRAERELAELG
MMAR_1785|M.marinum_M ALPPTELEMAEFEQARERGEQVVAPAPMPFDRATQQRRAKRAERELTELG
MUL_2033|M.ulcerans_Agy99 ALPPTELEMAEFEQARERGEQVVAPAPMPFDRATQQRRAKRAERELTELG
MAV_3777|M.avium_104 ALPPSELEMAEYEQAKERGEQVFAPAPIPFDRPTQERRAKRAERELAELG
Mb1309|M.bovis_AF2122/97 SVFGTQGRKGKLDAAETERE--------------------HAASHHARVG
Rv1278|M.tuberculosis_H37Rv SVFGTQGRKGKLDAAETERE--------------------HAASHHARVG
MLBr_01120|M.leprae_Br4923 SVFGTEGRQGKLDTAEAERE--------------------HAISQHTQIG
TH_1853|M.thermoresistible__bu EVYGSEGRKGELDAAKAERE--------------------QAEAEFLRIG
MAB_1421|M.abscessus_ATCC_1997 EVFGRQGRQDQLDAAASERE--------------------YAATEFARIG
Mvan_1098|M.vanbaalenii_PYR-1 GNALGSVADAVEVEADAQ-------------------RAADQVETLASC-
. * .
Mflv_4188|M.gilvum_PYR-GCK RVNPLALEEFAALEERYNFLSTQLEDVKAARKDLLDVIAEVDTRILQVFT
MSMEG_2423|M.smegmatis_MC2_155 RVNPLALEEFAALEERYNFLSTQLEDVKAARADLLDVIADVDNRILQVFT
MMAR_1785|M.marinum_M RVNPLALEEFAALEERYNFLSTQLEDVKAARKDLLDVVADVDARILQVFS
MUL_2033|M.ulcerans_Agy99 RVNPLALEEFAALEERYNFLSTQLEDVKAARKDLLDVVADVDARILQVFS
MAV_3777|M.avium_104 RVNPLALEEFAALEERYNFLSTQLEDVKAARKDLLGVVDEVDARILQVFS
Mb1309|M.bovis_AF2122/97 RR------------------------ARAARLLRSVMARHRDTTRLRYVE
Rv1278|M.tuberculosis_H37Rv RR------------------------ARAARLLRSVMARHRDTTRLRYVE
MLBr_01120|M.leprae_Br4923 RR------------------------ARAAQLLRSVMARHRDTTRLRYVE
TH_1853|M.thermoresistible__bu RL------------------------ARAVKLLRETMLRHRDASRRRYVD
MAB_1421|M.abscessus_ATCC_1997 AK------------------------ARAVDTLRSVMMRHRDGMRLRYVD
Mvan_1098|M.vanbaalenii_PYR-1 -------------------------LDAAAAELANAKERANASIAPALAD
*.
Mflv_4188|M.gilvum_PYR-GCK EAYMDVEREFTQVFSTLFPGGEGRLLLTNPSDMLTTGIEVEARPPGKKIK
MSMEG_2423|M.smegmatis_MC2_155 EAYADVEREFEQVFATLFPGGEGRLLLTDPSDMLTTGIEVEARPPGKKIK
MMAR_1785|M.marinum_M DAFVDVEREFQIVFSSLFPGGEGRLRLTAPEDMLTTGIEVEARPPGKKVS
MUL_2033|M.ulcerans_Agy99 DAFVDVEREFQIVFSSLFPGGEGRLRLTAPEDMLTTGIEVEARPPGKKVS
MAV_3777|M.avium_104 EAYTDVEREFSDVFGVLFPGGEGRLRLTDPSNMLTTGIEVEARPPGKKIT
Mb1309|M.bovis_AF2122/97 PYRAELHRLGRPVFGPSFEVEVDTDLRIRSRTLDDRTVPYECLSGG-AKE
Rv1278|M.tuberculosis_H37Rv PYRAELHRLGRPVFGPSFEVEVDTDLRIRSRTLDDRTVPYECLSGG-AKE
MLBr_01120|M.leprae_Br4923 PYRTELQRLGRPVFGPTFEVDIDSDLRIRSRTLDGITVPFESLSGG-AKE
TH_1853|M.thermoresistible__bu PFRAEVERLGRIVFGDSFEVEIDSDLCIRSRTLAGRTVDYESLSGG-AKE
MAB_1421|M.abscessus_ATCC_1997 PFRAELERLGRMVFGPTFEVDIDSDLSIRSRTLEGRTVPYESLSGG-AKE
Mvan_1098|M.vanbaalenii_PYR-1 RMRPWLPRVTNGRYRDVTVDP--GDLTIHVTETTGQVRQADRLSLG-TTE
: * : : . *
Mflv_4188|M.gilvum_PYR-GCK RLSLLSGGEKSLTAVAMLVAIFRARPSPFYVMDEVEAALDDVNLRRLISL
MSMEG_2423|M.smegmatis_MC2_155 RLSLLSGGEKSLTAVAMLVAIFRARPSPFYVMDEVEAALDDVNLRRLISL
MMAR_1785|M.marinum_M RLSLLSGGEKALTAVAMLVAIFRARPSPFYIMDEVEAALDDTNLRRLIGL
MUL_2033|M.ulcerans_Agy99 RLSLLSGGEKALTAVAILVAIFRARPSPFYIMDEVEAALDDTNLRRLIGL
MAV_3777|M.avium_104 RLSLLSGGEKALTAVAMLVAIFRARPSPFYIMDEVEAALDDTNLRRLISL
Mb1309|M.bovis_AF2122/97 QLGILAR-----LAGAALVAKEDAVP---VLIDDALGFTDPERLAKMGEV
Rv1278|M.tuberculosis_H37Rv QLGILAR-----LAGAALVAKEDAVP---VLIDDALGFTDPERLAKMGEV
MLBr_01120|M.leprae_Br4923 QLGILAR-----FAGATLVAKEDNVP---VVVDDALGFTDPDRLAKMGEM
TH_1853|M.thermoresistible__bu QLGIVAR-----LAGAALVARDDTVP---VVIDDALGFTDAERLVKMGAV
MAB_1421|M.abscessus_ATCC_1997 QLGIVAR-----LASAALVAPQDAVP---VIIDDALGFTDSDRLERMGEV
Mvan_1098|M.vanbaalenii_PYR-1 QIYLLLR----VTLSQVLSGGTETAP---LIFDDVTTQSDTTRTVAVMEL
:: :: * . * :.*:. * . : :
Mflv_4188|M.gilvum_PYR-GCK FEQLRERSQLIVITHQKPTMEVADALYGVTMQGDGITTVISQRMRGQ---
MSMEG_2423|M.smegmatis_MC2_155 FEQLREKSQLIVITHQKPTMEIADALYGVTMRGDGITTVISQRMRGQ---
MMAR_1785|M.marinum_M FEMLRDRSQLIIITHQKPTMEVADALYGVTMQGDGITAVISQRIRGQQVD
MUL_2033|M.ulcerans_Agy99 FEMLRDRSQLIIITHQKPTMEVADALYGVTMQGDGITAVISQRIRGQQVD
MAV_3777|M.avium_104 FELLRARSQLIIITHQKPTMEVADALYGVTMQGDGITAVISQRMRGQQVD
Mb1309|M.bovis_AF2122/97 FDTIGADGQVIVLTCSPTRYGGVKGAHRIDLDAIQ---------------
Rv1278|M.tuberculosis_H37Rv FDTIGADGQVIVLTCSPTRYGGVKGAHRIDLDAIQ---------------
MLBr_01120|M.leprae_Br4923 FDTVGAHGQVIVLTCSPDRYDGFTGAHRIDLNV-----------------
TH_1853|M.thermoresistible__bu FDAVGGDGQVIVLTCSPDRYAGISDAHRIELTA-----------------
MAB_1421|M.abscessus_ATCC_1997 FGAVGTETQVIVLTCSPDRYRAVTGAQRISLSA-----------------
Mvan_1098|M.vanbaalenii_PYR-1 LHELSAEHQVILFSQEDEVVEWAQRNIDPTRDKIIPLPAP----------
: : *:*::: .
Mflv_4188|M.gilvum_PYR-GCK ELVTSSS
MSMEG_2423|M.smegmatis_MC2_155 ELVSNPS
MMAR_1785|M.marinum_M RLVANSS
MUL_2033|M.ulcerans_Agy99 RLVANSS
MAV_3777|M.avium_104 QLVTT--
Mb1309|M.bovis_AF2122/97 -------
Rv1278|M.tuberculosis_H37Rv -------
MLBr_01120|M.leprae_Br4923 -------
TH_1853|M.thermoresistible__bu -------
MAB_1421|M.abscessus_ATCC_1997 -------
Mvan_1098|M.vanbaalenii_PYR-1 -------