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VYLKSLTLKGFKSFAAPTTLRFEPGITAVVGPNGSGKSNVVDALAWVMGEQGAKTLRGGKMEDVIFAGTS LRAPLGRAEVTVTIDNSDNALPIEYTEVSITRRMFRDGASEYEINGSSCRLMDVQELLSDSGIGREMHVI VGQGKLDEILQSRPEDRRAFIEEAAGVLKHRKRKEKALRKLDAMSANLARLTDLTTELRRQLKPLGRQAE VARRAQTIQADLRDARLRLAADDVVSRRAEREAIFEAEATMRREHDEAAARLTVAAEELAAHEATLAELT SRAESVQHTWFGLSALAERVGTTVRIANERAQHLDVEPVTNSDTDPDALDAEAEQVAIAEQQLLVELAEA RDRLDAARAELADREHRAAEADRAHLAAVRAEADRREGLARLAGQVETMRARVESIDDSVARLSERIEHA AARAQQTRAEFETVQARVGELDQGEVGLDEQHERTVAALRLAEQRLAELQVAERDAERQVASLRARIGAL SVGLDRKDGAAWLARNHSDAGLFGSVAQLVKVRSGYEAAVAAVLGSAAEALAADSFGAARSAVTALKQAD GGRAALVLGDWPDAHDHRAAGGLPSGTLWALDLIEVPSRLRPAMTAMLSGVVVVNDLSEALDLVQAQPQL RAVTLDGDLVGAGWVSGGSDRKPSTLEITSEIDKARRELAAAEVRVAELGAALSGALTDQTARQDAAEQA LAALNESDTAISAMYEQLGRIGQDARGAEEEWTRLLRQREELEVGRTQTLEEVLELESRLRNAQESQHVQ AAEPVDRQEIAAAAESARAIEVEARLTVRTAEERANALRGRADSLRRVAAAEREARVRAELARAVRLRSA AVAAAVAESGRLLAWRLNRVVDAASQLRDELAAERQQRSAAMSAVREETSSLSARVATLTDSLHRDEVAN AQAALRIEQVEQMVLEQFGMAPSDLVAEYGPDVALPPTELEMAEFEQARERGEQVVAPAPMPFDRATQQR RAKRAERELTELGRVNPLALEEFAALEERYNFLSTQLEDVKAARKDLLDVVADVDARILQVFSDAFVDVE REFQIVFSSLFPGGEGRLRLTAPEDMLTTGIEVEARPPGKKVSRLSLLSGGEKALTAVAILVAIFRARPS PFYIMDEVEAALDDTNLRRLIGLFEMLRDRSQLIIITHQKPTMEVADALYGVTMQGDGITAVISQRIRGQ QVDRLVANSS
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. ulcerans Agy99 | MUL_2033 | smc | - | 100% (1200) | chromosome partition protein Smc |
M. ulcerans Agy99 | MUL_4005 | - | 3e-11 | 25.07% (714) | hydrolase |
M. ulcerans Agy99 | MUL_1685 | recN | 3e-08 | 24.18% (455) | DNA repair protein, RecN |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2946c | smc | 0.0 | 83.57% (1205) | chromosome partition protein Smc |
M. gilvum PYR-GCK | Mflv_4188 | - | 0.0 | 76.92% (1200) | chromosome segregation protein SMC |
M. tuberculosis H37Rv | Rv2922c | smc | 0.0 | 83.73% (1205) | chromosome partition protein Smc |
M. leprae Br4923 | MLBr_01629 | smc | 0.0 | 78.39% (1203) | putative cell division protein |
M. abscessus ATCC 19977 | MAB_3246c | - | 0.0 | 69.11% (1159) | chromosome partition protein Smc |
M. marinum M | MMAR_1785 | smc | 0.0 | 99.42% (1200) | chromosome partition protein Smc |
M. avium 104 | MAV_3777 | smc | 0.0 | 84.87% (1196) | chromosome segregation protein SMC |
M. smegmatis MC2 155 | MSMEG_2423 | smc | 0.0 | 76.00% (1200) | chromosome segregation protein SMC |
M. thermoresistible (build 8) | TH_1649 | smc | 1e-123 | 83.27% (263) | PROBABLE CHROMOSOME PARTITION PROTEIN SMC |
M. vanbaalenii PYR-1 | Mvan_2175 | - | 0.0 | 76.25% (1200) | chromosome segregation protein SMC |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_4188|M.gilvum_PYR-GCK MHLKSLTLKGFKSFASPTTLRFEPGITCVVGPNGSGKSNVVDALTWVMGE Mvan_2175|M.vanbaalenii_PYR-1 MHLKSLTLKGFKSFASPTTLRFEPGITCVVGPNGSGKSNVVDALTWVMGE MSMEG_2423|M.smegmatis_MC2_155 MHLKSLTLKGFKSFASPTTLRFEPGITCVVGPNGSGKSNVVDALTWVMGE TH_1649|M.thermoresistible__bu -------------------------------------------------- Mb2946c|M.bovis_AF2122/97 MYLKSLTLKGFKSFAAPTTLRFEPGITAVVGPNGSGKSNVVDALAWVMGE Rv2922c|M.tuberculosis_H37Rv MYLKSLTLKGFKSFAAPTTLRFEPGITAVVGPNGSGKSNVVDALAWVMGE MUL_2033|M.ulcerans_Agy99 MYLKSLTLKGFKSFAAPTTLRFEPGITAVVGPNGSGKSNVVDALAWVMGE MMAR_1785|M.marinum_M MYLKSLTLKGFKSFAAPTTLRFEPGITAVVGPNGSGKSNVVDALAWVMGE MAV_3777|M.avium_104 MYLKSLTLKGFKSFASPTTLRFEPGITAVVGPNGSGKSNVVDALAWVMGE MLBr_01629|M.leprae_Br4923 MYLKSLTLKGFKSFASPTTLRFEPGITAVVGPNGSGKSNVVDALAWVMGE MAB_3246c|M.abscessus_ATCC_199 ----------------------------------------MDALTWVMGE Mflv_4188|M.gilvum_PYR-GCK QGAKTLRGGKMEDVIFAGTSSRAPLGRAEVTLTIDNSDNALPIEYSEVSI Mvan_2175|M.vanbaalenii_PYR-1 QGAKTLRGGKMEDVIFAGTSSRAPLGRAEVTLTIDNSDNALPIEYSEVSI MSMEG_2423|M.smegmatis_MC2_155 QGAKTLRGGKMEDVIFAGTSSRAPLGRAEVTLTIDNSDNALPIEYSEVSI TH_1649|M.thermoresistible__bu -------------------------------------------------- Mb2946c|M.bovis_AF2122/97 QGAKTLRGGKMEDVIFAGTSSRAPLGRAEVTVSIDNSDNALPIEYTEVSI Rv2922c|M.tuberculosis_H37Rv QGAKTLRGGKMEDVIFAGTSSRAPLGRAEVTVSIDNSDNALPIEYTEVSI MUL_2033|M.ulcerans_Agy99 QGAKTLRGGKMEDVIFAGTSLRAPLGRAEVTVTIDNSDNALPIEYTEVSI MMAR_1785|M.marinum_M QGAKTLRGGKMEDVIFAGTSSRAPLGRAEVTVTIDNSDNALPIEYTEVSI MAV_3777|M.avium_104 QGAKTLRGGKMEDVIFAGTSSRAPLGRAEVTVTIDNSDNALPIEYSEVSI MLBr_01629|M.leprae_Br4923 QGAKTLRGSKMEDVIFAGTLSRAPLGRAEVTLIIDNSDNVLPIEYSEVSI MAB_3246c|M.abscessus_ATCC_199 QGAKALRGGKMEDVIFAGTSSRAPLGRAEVTLTIDNSDHALPIEYSEVSI Mflv_4188|M.gilvum_PYR-GCK TRRMFRDGAGEYEINGSRCRLADVQELLSDSGIGREMHVIVGQGKLSEIL Mvan_2175|M.vanbaalenii_PYR-1 TRRMFRDGAGEYEINGSSCRLMDVQELLSDSGIGREMHVIVGQGKLSEIL MSMEG_2423|M.smegmatis_MC2_155 TRRMFRDGAGEYEINGASCRLMDVQELLSDSGIGREMHVIVGQGKLSEIL TH_1649|M.thermoresistible__bu -------------------------------------------------- Mb2946c|M.bovis_AF2122/97 TRRMFRDGASEYEINGSSCRLMDVQELLSDSGIGREMHVIVGQGKLEEIL Rv2922c|M.tuberculosis_H37Rv TRRMFRDGASEYEINGSSCRLMDVQELLSDSGIGREMHVIVGQGKLEEIL MUL_2033|M.ulcerans_Agy99 TRRMFRDGASEYEINGSSCRLMDVQELLSDSGIGREMHVIVGQGKLDEIL MMAR_1785|M.marinum_M TRRMFRDGASEYEINGSSCRLMDVQELLSDSGIGREMHVIVGQGKLDEIL MAV_3777|M.avium_104 TRRMFRDGASEYEINGSSCRLMDVQELLSDSGIGREMHVIVGQGKLDEIL MLBr_01629|M.leprae_Br4923 TRRMFRDGASEYEINGSSCRLMDVQELLSDSGIGREMHVIVGQGKLDQIL MAB_3246c|M.abscessus_ATCC_199 TRRMFRDGAGEYEINGQTCRLMDVQELLSDSGIGREMHVIVGQGRLSQIL Mflv_4188|M.gilvum_PYR-GCK ESRPEDRRAFIEEAAGVLKHRKRKEKAVRKLDSMAANLARLTDLTTELRR Mvan_2175|M.vanbaalenii_PYR-1 ESRPEDRRAFIEEAAGVLKHRKRKEKAVRKLDSMSANLARLTDLTTELRR MSMEG_2423|M.smegmatis_MC2_155 ESRPEDRRAFIEEAAGVLKHRKRKEKAVRKLDSMAANLARLTDLTTELRR TH_1649|M.thermoresistible__bu -------------------------------------------------- Mb2946c|M.bovis_AF2122/97 QSRPEDRRAFIEEAAGVLKHRKRKEKALRKLDTMAANLARLTDLTTELRR Rv2922c|M.tuberculosis_H37Rv QSRPEDRRAFIEEAAGVLKHRKRKEKALRKLDTMAANLARLTDLTTELRR MUL_2033|M.ulcerans_Agy99 QSRPEDRRAFIEEAAGVLKHRKRKEKALRKLDAMSANLARLTDLTTELRR MMAR_1785|M.marinum_M QSRPEDRRAFIEEAAGVLKHRKRKEKALRKLDAMSANLARLTDLTTELRR MAV_3777|M.avium_104 QSRPEDRRAFIEEAAGVLKHRKRKEKALRKLDAMSANLARLTDLTTELRR MLBr_01629|M.leprae_Br4923 QSRPEDRRTFIEEAAGILKYRRRKEKALRKLDAMSANLARLTDLTTELRR MAB_3246c|M.abscessus_ATCC_199 ESRPEDRRAFVEEAAGVLKHRKRKEKAVRKLESMAANLARLTDLTTELRR Mflv_4188|M.gilvum_PYR-GCK QLKPLGRQAEMARRAQTIQADLRDARLRLAADDLVARKAEFDDTDQAETT Mvan_2175|M.vanbaalenii_PYR-1 QLKPLGRQAEMARRAQTIQADLRDARLRLAADDLVTRKAEFDDTNQAETT MSMEG_2423|M.smegmatis_MC2_155 QLKPLGRQAEMARRAATIQADLRDARLRLAADDLVRRQVEFQNTNQAETA TH_1649|M.thermoresistible__bu -------------------------------------------------- Mb2946c|M.bovis_AF2122/97 QLKPLGRQAEAAQRAAAIQADLRDARLRLAADDLVSRRAEREAVFQAEAA Rv2922c|M.tuberculosis_H37Rv QLKPLGRQAEAAQRAAAIQADLRDARLRLAADDLVSRRAEREAVFQAEAA MUL_2033|M.ulcerans_Agy99 QLKPLGRQAEVARRAQTIQADLRDARLRLAADDVVSRRAEREAIFEAEAT MMAR_1785|M.marinum_M QLKPLGRQAEVARRAQTIQADLRDARLRLAADDVVSRRAEREAIFEAEAT MAV_3777|M.avium_104 QLKPLGRQAEVARRAQTIQADLRDARLRLAADDLVNRRGEREAIFEAEAA MLBr_01629|M.leprae_Br4923 QLKPLSRQAEVARRAATIQADLRDARLRLAADDLVSRQGQRDAIVEAETM MAB_3246c|M.abscessus_ATCC_199 QLKPLGRQAEVARRAATVQADLRDARLRLAADDLVSRRADFDGTNDAETA Mflv_4188|M.gilvum_PYR-GCK LRREHDELTERLQERAAELDAHETAVEDLSERADAAQQRWFRLSALAERV Mvan_2175|M.vanbaalenii_PYR-1 LRREHDELTERMEARTLELDAHESAVADLSERADAAQQRWFRLSALAERV MSMEG_2423|M.smegmatis_MC2_155 LRKEHEELTVRLQSATVELQAHEAAVAELTRRAEAAQQTWFRASALAERV TH_1649|M.thermoresistible__bu -------------------------------------------------- Mb2946c|M.bovis_AF2122/97 MRREHDEAAARLAVASEELAAHESAVAELSTRAESIQHTWFGLSALAERV Rv2922c|M.tuberculosis_H37Rv MRREHDEAAARLAVASEELAAHESAVAELSTRAESIQHTWFGLSALAERV MUL_2033|M.ulcerans_Agy99 MRREHDEAAARLTVAAEELAAHEATLAELTSRAESVQHTWFGLSALAERV MMAR_1785|M.marinum_M MRREHDEAAARLTVAAEELAAHEAALAELTSRAESVQHTWFGLSALAERV MAV_3777|M.avium_104 MRREHDEASARLAVASEELAAHEKALGELSGRAESVQQTWFALSALAERV MLBr_01629|M.leprae_Br4923 MRRDHDEAAARLAVASEELAAHEAALTELSGRAESVQQIWFGLSTLVERV MAB_3246c|M.abscessus_ATCC_199 LRKEHAEITDRLEVATALLAEHETALGELLPQAELAQQTWFRLSALAERV Mflv_4188|M.gilvum_PYR-GCK SATVRIASERAQHLDGDPDFSAGPDP---DELEAQADAVAEQEQQLLDEL Mvan_2175|M.vanbaalenii_PYR-1 SATVRIASERAQHLDAEPDFSAGPDP---DELEAQADAVAEQEQLLLDEL MSMEG_2423|M.smegmatis_MC2_155 GATVRIATDRAQMLDSEPEMSSGRDP---DALEAEAEEVAELEAQLLDEL TH_1649|M.thermoresistible__bu -------------------------------------------------- Mb2946c|M.bovis_AF2122/97 DATVRIASERAHHLDIEPVAVSDTDPRKPEELEAEAQQVAVAEQQLLAEL Rv2922c|M.tuberculosis_H37Rv DATVRIASERAHHLDIEPVAVSDTDPRKPEELEAEAQQVAVAEQQLLAEL MUL_2033|M.ulcerans_Agy99 GTTVRIANERAQHLDVEPVTNSDTDP---DALDAEAEQVAIAEQQLLVEL MMAR_1785|M.marinum_M GTTVRIANERAQHLDVEPVTNSDTDP---DALDAEAEQVAIAEQQLLVEL MAV_3777|M.avium_104 AATVRIASERAQHLDLGPVTAGDTDP---DALDAEAERVAAAEQQLLAEL MLBr_01629|M.leprae_Br4923 SATIRIAGERAYHLDVDPATPSDTDP---DVLEAEAQQMEVAEQQLLAEL MAB_3246c|M.abscessus_ATCC_199 SATVRIAGERASHLDEVAAAPTGPDP---EELEAQAERVAEQERLLIAQL Mflv_4188|M.gilvum_PYR-GCK AESQERLEAAREELAEREQAAAEAERAHMAAARAEADRREGLARLSGQVD Mvan_2175|M.vanbaalenii_PYR-1 AESQARLESARAELGEREQAAAEAERAHMAAARAEADRREGLARLSGQVD MSMEG_2423|M.smegmatis_MC2_155 SEARIALETARAELAEREQIAADAERAHMAAARAEADRREGLARLAGQVD TH_1649|M.thermoresistible__bu -------------------------------------------------- Mb2946c|M.bovis_AF2122/97 DAARARLDAARAERADRERRAAEADRAHLAAVREEADRREGLARLAGQVE Rv2922c|M.tuberculosis_H37Rv DAARARLDAARAELADRERRAAEADRAHLAAVREEADRREGLARLAGQVE MUL_2033|M.ulcerans_Agy99 AEARDRLDAARAELADREHRAAEADRAHLAAVRAEADRREGLARLAGQVE MMAR_1785|M.marinum_M AEARDRLDAARAELADREHRAAEADRAHLAAVRAEADRREGLARLAGQVE MAV_3777|M.avium_104 AAARSRLETARAELAEREREAAEADRAHMAAVRAEADRREGLARLAGQVE MLBr_01629|M.leprae_Br4923 AVARTQLEAARAELADRERHAVEADKAHLEAVRAEADRREGLALLAGQVE MAB_3246c|M.abscessus_ATCC_199 ETVTEQLATAKAELSARESAVAQAQRQHMAAVAAEADRREGLARLTGQVD Mflv_4188|M.gilvum_PYR-GCK TMRTRVESVDETVARLTANIDDAAARAQLTQAEFETVQARVGELDAGEVG Mvan_2175|M.vanbaalenii_PYR-1 TMRTRVDSVDETVARLTASIDEAGARAQQTQAEFETVQGRVAELDSGEVG MSMEG_2423|M.smegmatis_MC2_155 TMRTRVESIDEGVLRLSVSIEEAAAKAEHAQAEFEDVQSRVGELDAGEVG TH_1649|M.thermoresistible__bu -------------------------------------------------- Mb2946c|M.bovis_AF2122/97 TMRARVESIDESVARLSERIEDAAMRAQQTRAEFETVQGRIGELDQGEVG Rv2922c|M.tuberculosis_H37Rv TMRARVESIDESVARLSERIEDAAMRAQQTRAEFETVQGRIGELDQGEVG MUL_2033|M.ulcerans_Agy99 TMRARVESIDDSVARLSERIEHAAARAQQTRAEFETVQARVGELDQGEVG MMAR_1785|M.marinum_M TMRARVESIDDSVARLSERIEHAAARAQQTRAEFETVQARVGELDQGEVG MAV_3777|M.avium_104 TMRARVESIDDSVARLSERIEAAAARAQQAKAEFETVQGRVGELDQGEVG MLBr_01629|M.leprae_Br4923 TMRARIESIDDSVARLSERIEEVTARTQQILAEFETVQGRVGELDQSEVH MAB_3246c|M.abscessus_ATCC_199 TMRTRLESIDGQAQRLTESIVEATVRGEAAQTEFDTVKARVAELDQGEVG Mflv_4188|M.gilvum_PYR-GCK LDEHHDRSVAALRLADERVAELLAAERAAERQVASLQARIDALSVGLDRR Mvan_2175|M.vanbaalenii_PYR-1 LDEHHDRTVAALRLADERVTELQAAERAAERRVASLQARIDALSVGLDRK MSMEG_2423|M.smegmatis_MC2_155 LDEHHDRTVAALRLADERVAELQAAERAAERQVASLRARIEALSVGLDRR TH_1649|M.thermoresistible__bu -------------------------------------------------- Mb2946c|M.bovis_AF2122/97 LDEHHERTVAALRLADERVAELQSAERAAERQVASLRARIDALAVGLQRK Rv2922c|M.tuberculosis_H37Rv LDEHHERTVAALRLADERVAELQSAERAAERQVASLRARIDALAVGLQRK MUL_2033|M.ulcerans_Agy99 LDEQHERTVAALRLAEQRLAELQVAERDAERQVASLRARIGALSVGLDRK MMAR_1785|M.marinum_M LDEQHERTVAALRLAEQRLAELQVAERDAERQVASLRARIEALSVGLDRK MAV_3777|M.avium_104 LDEHHERTVAALRLADERVAELQAAERDAERKVASLRARIDALAVGLERK MLBr_01629|M.leprae_Br4923 LDEQHERAVAALRFANERVAELQSAERDAERQVVSLRARIDALTMGLERK MAB_3246c|M.abscessus_ATCC_199 LDEHHERSISSLSIANERVAELQSAERQAERQIASLKARIDALAIGLERK Mflv_4188|M.gilvum_PYR-GCK DGAAWLQENHSGAGLFGSIANLVKVRAGHEAAIAAMLGAAADALAAEDFG Mvan_2175|M.vanbaalenii_PYR-1 DGAAWLKENRSGAGLFDSLANLVKVRPGHEAAIAAVLGAAADALAAENSG MSMEG_2423|M.smegmatis_MC2_155 DGAAWLQKNHSGGGLFGSIGDFLRVQPGYEVAVAAVLGAAADALAAENFG TH_1649|M.thermoresistible__bu -------------------------------------------------- Mb2946c|M.bovis_AF2122/97 DGAAWLAHNRSGAGLFGSIAQLVKVRSGYEAALAAALGPAADALAVDGLT Rv2922c|M.tuberculosis_H37Rv DGAAWLAHNRSGAGLFGSIAQLVKVRSGYEAALAAALGPAADALAVDGLT MUL_2033|M.ulcerans_Agy99 DGAAWLARNHSDAGLFGSVAQLVKVRSGYEAAVAAVLGSAAEALAADSFG MMAR_1785|M.marinum_M DGAAWLARNHSDAGLFGSVAQLVKVRSGYEAAVAAVLGSAAEALAADSFG MAV_3777|M.avium_104 DGTAWLTENHSGAGILGPMAKLVKVRSGYEAAVAAVLGSAADALAADGLG MLBr_01629|M.leprae_Br4923 DGAAWLARNYSDTGLLGSIAKLVKVRPGYEAALAAVLGPAADALAVDSLG MAB_3246c|M.abscessus_ATCC_199 DGSAWLAENRSGAGIFGSIAQLVKVRPGYQGAIATAMGPAADAVAAENPA Mflv_4188|M.gilvum_PYR-GCK AARAAVAALKESDGGRAALVLGDWP---AQEAVTG-QLPAGAAWAVDLVE Mvan_2175|M.vanbaalenii_PYR-1 AARDALAALKESDGGRAAIVLGDWP---ARTPATG-QLPAGAAWAVDLVD MSMEG_2423|M.smegmatis_MC2_155 AAAAAVAALKESDGGRAAIVLGDWN---AIGSSPQAALPPGATWATDLVS TH_1649|M.thermoresistible__bu -------------------------------------------------- Mb2946c|M.bovis_AF2122/97 AAGSAVSALKQADGGRAVLVLSDWPAPQAPQSASGEMLPSGAQWALDLVE Rv2922c|M.tuberculosis_H37Rv AAGSAVSALKQADGGRAVLVLSDWPAPQAPQSASGEMLPSGAQWALDLVE MUL_2033|M.ulcerans_Agy99 AARSAVTALKQADGGRAALVLGDWPDAHDHRAAG--GLPSGTLWALDLIE MMAR_1785|M.marinum_M AARSAVTALKQADGGRAALVLGDWPDANDHRAAG--GLPSGTLWALDLIE MAV_3777|M.avium_104 AARSALGALKQADGGRAALVLGDWP--ADPPAPQ--PAPAGALWALDLID MLBr_01629|M.leprae_Br4923 AARSALTALKEADAGRATLVLADWLADAGPACVT--GLPDGAQRALDLIE MAB_3246c|M.abscessus_ATCC_199 AAHEAVKALKSSDGGRAAIVFGDWPAHTGARPAVT--LPPGAHWANDLVE Mflv_4188|M.gilvum_PYR-GCK PADRVRGAVTAMLSGVAVVENLTAALDLVAAQPRLRAVTADGDLVGAGWV Mvan_2175|M.vanbaalenii_PYR-1 PAPRIQGAVTAMLGGVAVVGDLTAALELVAAQPELRAVTADGDLVGAGWV MSMEG_2423|M.smegmatis_MC2_155 VPDRLRGAVTAMLTGVAVVPDMAAGLALVSSRPELRAVTTEGDLVGPGWV TH_1649|M.thermoresistible__bu -------------------------------------------------- Mb2946c|M.bovis_AF2122/97 SPPQLVGAMIAMLSGVAVVNDLTEAMGLVEIRPELRAVTVDGDLVGAGWV Rv2922c|M.tuberculosis_H37Rv SPPQLVGAMIAMLSGVAVVNDLTEAMGLVEIRPELRAVTVDGDLVGAGWV MUL_2033|M.ulcerans_Agy99 VPSRLRPAMTAMLSGVVVVNDLSEALDLVQAQPQLRAVTLDGDLVGAGWV MMAR_1785|M.marinum_M VPSRLRPAMTAMLSGVVVVNDLSEALDLVQAQPQLRAVTLDGDLVGAGWV MAV_3777|M.avium_104 APERLRGAITAMLSGVAVVDDLDRALALVAEHPRLRAVTLDGDLVGAGWV MLBr_01629|M.leprae_Br4923 APPWLQGALIAMLYGVVVVNYLAEALGVVDICPQLRVVTVDGDLVGAGWV MAB_3246c|M.abscessus_ATCC_199 APQRLAAAVSAMLASVVVVDELGAAIDVVLANPLLRAVTIDGDRVGAGWV Mflv_4188|M.gilvum_PYR-GCK SGGSDRKPSTLEIQSEVDRARSELVDAERRTGELSAALSGALAEQAARQD Mvan_2175|M.vanbaalenii_PYR-1 SGGSDRKPSTLEITSEVDKARAELVDAERQTGELSAALSGALAEQAARQD MSMEG_2423|M.smegmatis_MC2_155 SGGSDRKPSTLEIASEIDKARAELEQAERQTSELGAALSGALAEQSARQD TH_1649|M.thermoresistible__bu -------------------------------------------------- Mb2946c|M.bovis_AF2122/97 SGGSDRKLSTLEVTSEIDKARSELAAAEALAAQLNAALAGALTEQSAGQD Rv2922c|M.tuberculosis_H37Rv SGGSDRKLSTLEVTSEIDKARSELAAAEALAAQLNAALAGALTEQSARQD MUL_2033|M.ulcerans_Agy99 SGGSDRKPSTLEITSEIDKARRELAAAEVRVAELGAALSGALTDQTARQD MMAR_1785|M.marinum_M SGGSDRKPSTLEITSEIDKARSELAAAEVRVAELGAALSGALTDQTARQD MAV_3777|M.avium_104 SGGSDRKLSTLEVTSEIDKASAELAAAEAQVAQLSAALSGALAEQAARQD MLBr_01629|M.leprae_Br4923 SGGSGRRLSTLEVTSEIDKAGAELAAAEAHMAQLNAALSGALSEQVAHSD MAB_3246c|M.abscessus_ATCC_199 AGGSDKKQSTLEVQAAIEAAREELRATETQVGEISAALAGALAEQTARQD Mflv_4188|M.gilvum_PYR-GCK AAEHALAALNESDAAISAIYEQLGRLGQDARAADDEWQRLIRQRDEMEAG Mvan_2175|M.vanbaalenii_PYR-1 AAEQALAALNESDAAISAIYEQLGRLGQDARAADDEWQRLIKQRDELEAG MSMEG_2423|M.smegmatis_MC2_155 AAEQALAALNESDAAISAIYEQLARLGQEARGAHQEWQRLIKQRDELEAG TH_1649|M.thermoresistible__bu -------------------------------------------------- Mb2946c|M.bovis_AF2122/97 AAEQALAALNESDTAISAMYEQLGRLGQEARAAEEEWNRLLQQRTEQEAV Rv2922c|M.tuberculosis_H37Rv AAEQALAALNESDTAISAMYEQLGRLGQEARAAEEEWNRLLQQRTEQEAV MUL_2033|M.ulcerans_Agy99 AAEQALAALNESDTAISAMYEQLGRIGQDARGAEEEWTRLLRQREELEVG MMAR_1785|M.marinum_M AAEQALAALNESDTAISAMYEQLGRIGQDARGAEEEWTRLLRQREELEVG MAV_3777|M.avium_104 SAEQALAALNESDSAISGMYEQLGRLGQEARTSEDEWSRLLRQREELEAG MLBr_01629|M.leprae_Br4923 ATEQALVALNESDTAILSMYDQLGRLGQEVRAAEAEWESLLAQREELEAR MAB_3246c|M.abscessus_ATCC_199 TAEQALAALNESDAAISAVYEQLGRVGQEVRAAAEEVKKLTLQRDQLERG Mflv_4188|M.gilvum_PYR-GCK RNRTVSELAELELRLQNAQREP-MFDAEV---VDRTEFTAAAEAARSAEV Mvan_2175|M.vanbaalenii_PYR-1 RNRTVEELAELESRLHNAQQEP-MFDVEV---VDRTEFTAAAEAARSAEV MSMEG_2423|M.smegmatis_MC2_155 RTKTVEELRELESRLSNAEQTP-MFDIEP---VDRQETVAAAEAARAVEV TH_1649|M.thermoresistible__bu -------------------------------------------------- Mb2946c|M.bovis_AF2122/97 RTQTLDDVIQLETQLRKAQETQRVQVAQP---IDRQAISAAADRARGVEV Rv2922c|M.tuberculosis_H37Rv RTQTLDDVIQLETQLRKAQETQRVQVAQP---IDRQAISAAADRARGVEV MUL_2033|M.ulcerans_Agy99 RTQTLEEVLELESRLRNAQESQHVQAAEP---VDRQEIAAAAESARAIEV MMAR_1785|M.marinum_M RTQTLEEVLELESRLRNAQESQHVQAAEP---VDRQEIAAAAESARAIEV MAV_3777|M.avium_104 RTQTVAEVTELENRLRNAQETPQEPAAEP---VNRQQIAAATDAARSAEV MLBr_01629|M.leprae_Br4923 RVSILEEVVELETRLHNVEQIQHVHALDENSAAARQLIVAAAEEARGVEV MAB_3246c|M.abscessus_ATCC_199 RATTLEELAEVESRLRNAEEAPNLFDDEP---LDRDDMAIELEEARSVEI Mflv_4188|M.gilvum_PYR-GCK EARLSVRTAEERANAVRGRADSLRRAAVAEREARVRAQRAREARVHAAAV Mvan_2175|M.vanbaalenii_PYR-1 EARLAVRTAEERANAVRGRADSLRRAAVAEREARARAQRAREARVQAAAV MSMEG_2423|M.smegmatis_MC2_155 EARLAVRTAEERANAVRGRADSLRRAAAAEREARVRAQRAREAREYAARV TH_1649|M.thermoresistible__bu -------------------------------------------------- Mb2946c|M.bovis_AF2122/97 EARLAVRTAEERANAVRGRADSLRRAAAAEREARVRAQQARAARLHAAAV Rv2922c|M.tuberculosis_H37Rv EARLAVRTAEERANAVRGRADSLRRAAAAEREARVRAQQARAARLHAAAV MUL_2033|M.ulcerans_Agy99 EARLTVRTAEERANALRGRADSLRRVAAAEREARVRAELARAVRLRSAAV MMAR_1785|M.marinum_M EARLTVRTAEERANALRGRADSLRRAAAAEREARVRAELARAVRLRSAAV MAV_3777|M.avium_104 EARLAVRTAEERANAVRGRADSLRRAAAAEREARVRAQQAREARLRAAAV MLBr_01629|M.leprae_Br4923 EALLAVRTAEERVNAVCGRANSLRRAAAAEREVRLRDQQAHAARIRAAAV MAB_3246c|M.abscessus_ATCC_199 EARLAVRTSEERVNSVRGKADSLRRAAVAEREARARAARAAAARMRAAAV Mflv_4188|M.gilvum_PYR-GCK AAAVAESGRAVAQRLADAVSVASRIRDEVAAERQVRAGALTKAREEVNEL Mvan_2175|M.vanbaalenii_PYR-1 AAAVAESGRLVAQRLADAVAVASRIRDEVAAERHVRAAALTKAREEVAEL MSMEG_2423|M.smegmatis_MC2_155 AAAVSECGRQIAGKLSAVVAAAARSRDELATERQLRVNALGEIREEVTAL TH_1649|M.thermoresistible__bu -------------------------------------------------- Mb2946c|M.bovis_AF2122/97 AAAVADCGRLLAGRLHRAVDGASQLRDASAAQRQQRLAAMAAVRDEVNTL Rv2922c|M.tuberculosis_H37Rv AAAVADCGRLLAGRLHRAVDGASQLRDASAAQRQQRLAAMAAVRDEVNTL MUL_2033|M.ulcerans_Agy99 AAAVAESGRLLAWRLNRVVDAASQLRDELAAERQQRSAAMSAVREETSSL MMAR_1785|M.marinum_M AAAVAESGRLLAWRLNRVVDAASQLRDELAAERQQRSAAMSAVREETSSL MAV_3777|M.avium_104 AAAVADSGRLLATRLNAVVAAASRIRDALAAERQQRATAMTAVRDEVNAL MLBr_01629|M.leprae_Br4923 AAAVTDCGQLLASRLTQAVDLAARHRDALATERQQRSVAIAAVRYEVNTL MAB_3246c|M.abscessus_ATCC_199 AAAVAESGRMVAARLEHVVAAASARRDELSATRAQHTSAIGAVRDQVREL Mflv_4188|M.gilvum_PYR-GCK TARITALTDALHRDEVAKAQAALRIEQLEQQVLEQFGMAVADLVAEYGPD Mvan_2175|M.vanbaalenii_PYR-1 TARIAALTDSLHRDEVAKAQAALRIEQLEQQVLEQFGIAVADLIAEYGPD MSMEG_2423|M.smegmatis_MC2_155 NNRINTLTDALHRDEMAKAQAQLRIEQLEAQVLEQFGMSAGDLVAEYGPQ TH_1649|M.thermoresistible__bu -------------------------------------MSADDLIAEYGPH Mb2946c|M.bovis_AF2122/97 SARVGELTDSLHRDELANAQAALRIEQLEQMVLEQFGMAPADLITEYGPH Rv2922c|M.tuberculosis_H37Rv SARVGELTDSLHRDELANAQAALRIEQLEQMVLEQFGMAPADLITEYGPH MUL_2033|M.ulcerans_Agy99 SARVATLTDSLHRDEVANAQAALRIEQVEQMVLEQFGMAPSDLVAEYGPD MMAR_1785|M.marinum_M SARVATLTDSLHRDEVANAQAALRIEQVEQMVLEQFGMAPSDLVAEYGPD MAV_3777|M.avium_104 SARVAALTDSLHRDEVANAQAALRIEQLEQMVLEQFGMAPADLIAEYGPH MLBr_01629|M.leprae_Br4923 RVRLATLTDSLHRDEVANVQAALRIEQLEQLVLEQFGIAPVDLIAEYGPQ MAB_3246c|M.abscessus_ATCC_199 TQAQTRLTDALHRDEVAKAQAALRIEQLSEQVLEQFGMAADDLIAEYGPH :: **::****. Mflv_4188|M.gilvum_PYR-GCK VALPPSELEMAEYEQARERGEQVTAPAPMPYDRPTQERRAKRAERELKEL Mvan_2175|M.vanbaalenii_PYR-1 VPLPPSELEMAEYEQAKERGEQVTAPAPMPYDRPTQERRAKRADKELREL MSMEG_2423|M.smegmatis_MC2_155 VALPPSELEMAEYEQAKERGEQVTAPAPMPFDRATQERRAKRAERELAEL TH_1649|M.thermoresistible__bu VPLPPTELEMAEYEQALERGEQVTKPAPMPYDRATQERRAKRAERELAEL Mb2946c|M.bovis_AF2122/97 VALPPTELEMAEFEQARERGEQVIAPAPMPFDRVTQERRAKRAERALAEL Rv2922c|M.tuberculosis_H37Rv VALPPTELEMAEFEQARERGEQVIAPAPMPFDRVTQERRAKRAERALAEL MUL_2033|M.ulcerans_Agy99 VALPPTELEMAEFEQARERGEQVVAPAPMPFDRATQQRRAKRAERELTEL MMAR_1785|M.marinum_M VALPPTELEMAEFEQARERGEQVVAPAPMPFDRATQQRRAKRAERELTEL MAV_3777|M.avium_104 IALPPSELEMAEYEQAKERGEQVFAPAPIPFDRPTQERRAKRAERELAEL MLBr_01629|M.leprae_Br4923 VALLPTELEMAEFQQARERGEQVTSPAPMPYDRATQERRAKRAERELAEL MAB_3246c|M.abscessus_ATCC_199 IELPPSQQEIDEYEQARERGEQVSAPLPMPFDRDTQERRAKRAEKDLREL : * *:: *: *::** ****** * *:*:** **:******:: * ** Mflv_4188|M.gilvum_PYR-GCK GRVNPLALEEFAALEERYNFLSTQLEDVKAARKDLLDVIAEVDTRILQVF Mvan_2175|M.vanbaalenii_PYR-1 GRVNPLALEEFAALEERYNFLSTQLEDVKAARKDLLDVIADVDSRILQVF MSMEG_2423|M.smegmatis_MC2_155 GRVNPLALEEFAALEERYNFLSTQLEDVKAARADLLDVIADVDNRILQVF TH_1649|M.thermoresistible__bu GRVNPLALEEFAALEERYNFLSTQLEDVKAARKDLLDVIADVDQRILQLF Mb2946c|M.bovis_AF2122/97 GRVNPLALEEFAALEERYNFLSTQLEDVKAARKDLLGVVADVDARILQVF Rv2922c|M.tuberculosis_H37Rv GRVNPLALEEFAALEERYNFLSTQLEDVKAARKDLLGVVADVDARILQVF MUL_2033|M.ulcerans_Agy99 GRVNPLALEEFAALEERYNFLSTQLEDVKAARKDLLDVVADVDARILQVF MMAR_1785|M.marinum_M GRVNPLALEEFAALEERYNFLSTQLEDVKAARKDLLDVVADVDARILQVF MAV_3777|M.avium_104 GRVNPLALEEFAALEERYNFLSTQLEDVKAARKDLLGVVDEVDARILQVF MLBr_01629|M.leprae_Br4923 GRVNPLALEEFAALEERYNFLSTQLEDVKGARKDLLDVVAEVDARILQVF MAB_3246c|M.abscessus_ATCC_199 GKVNPLALEEFAALEERYNFLSTQLEDVKAARKDLLDVVADVDERILQVF *:***************************.** ***.*: :** ****:* Mflv_4188|M.gilvum_PYR-GCK TEAYMDVEREFTQVFSTLFPGGEGRLLLTNPSDMLTTGIEVEARPPGKKI Mvan_2175|M.vanbaalenii_PYR-1 TEAYMDVEREFTQVFSTLFPGGEGRLLLTDPSDMLTTGIEVEARPPGKKI MSMEG_2423|M.smegmatis_MC2_155 TEAYADVEREFEQVFATLFPGGEGRLLLTDPSDMLTTGIEVEARPPGKKI TH_1649|M.thermoresistible__bu AEAYTDVEREFREVFATLFPGGEGRLLLTDPNDMLTTGVEVEARPPGKKI Mb2946c|M.bovis_AF2122/97 NDAFVDVEREFRGVFTALFPGGEGRLRLTEPDDMLTTGIEVEARPPGKKI Rv2922c|M.tuberculosis_H37Rv NDAFVDVEREFRGVFTALFPGGEGRLRLTEPDDMLTTGIEVEARPPGKKI MUL_2033|M.ulcerans_Agy99 SDAFVDVEREFQIVFSSLFPGGEGRLRLTAPEDMLTTGIEVEARPPGKKV MMAR_1785|M.marinum_M SDAFVDVEREFQIVFSSLFPGGEGRLRLTAPEDMLTTGIEVEARPPGKKV MAV_3777|M.avium_104 SEAYTDVEREFSDVFGVLFPGGEGRLRLTDPSNMLTTGIEVEARPPGKKI MLBr_01629|M.leprae_Br4923 SDAFVDVEREFRGVFTSLFPGGEGRLRLTDPDDMLTTGIEVEARPSGKKV MAB_3246c|M.abscessus_ATCC_199 TEAYADVEREFKGVFSSLFPGGEGRLVLTDPNDMLTTGIEVEARPPGKKV :*: ****** ** ********* ** *.:*****:******.***: Mflv_4188|M.gilvum_PYR-GCK KRLSLLSGGEKSLTAVAMLVAIFRARPSPFYVMDEVEAALDDVNLRRLIS Mvan_2175|M.vanbaalenii_PYR-1 KRLSLLSGGEKSLTAVAMLVAIFRARPSPFYVMDEVEAALDDVNLRRLIS MSMEG_2423|M.smegmatis_MC2_155 KRLSLLSGGEKSLTAVAMLVAIFRARPSPFYVMDEVEAALDDVNLRRLIS TH_1649|M.thermoresistible__bu KRLSLLSGGEKSLTAVAMLVAIFRARPSPFYVMDEVEAALDDVNLRRLIS Mb2946c|M.bovis_AF2122/97 TRLSLLSGGEKALTAVAMLVAIFRARPSPFYIMDEVEAALDDVNLRRLLS Rv2922c|M.tuberculosis_H37Rv TRLSLLSGGEKALTAVAMLVAIFRARPSPFYIMDEVEAALDDVNLRRLLS MUL_2033|M.ulcerans_Agy99 SRLSLLSGGEKALTAVAILVAIFRARPSPFYIMDEVEAALDDTNLRRLIG MMAR_1785|M.marinum_M SRLSLLSGGEKALTAVAMLVAIFRARPSPFYIMDEVEAALDDTNLRRLIG MAV_3777|M.avium_104 TRLSLLSGGEKALTAVAMLVAIFRARPSPFYIMDEVEAALDDTNLRRLIS MLBr_01629|M.leprae_Br4923 SRLSLLSGGEKSLIAVAMLVAIFKARPSPFYIMDEVEAALDDVNLCRLIG MAB_3246c|M.abscessus_ATCC_199 KRLSLLSGGEKSLTAVAMLVAIFRARPSPFYVMDEVEAALDDVNLQRLIG .**********:* ***:*****:*******:**********.** **:. Mflv_4188|M.gilvum_PYR-GCK LFEQLRERSQLIVITHQKPTMEVADALYGVTMQGDGITTVISQRMRGQ-- Mvan_2175|M.vanbaalenii_PYR-1 LFEQLRERSQLIVITHQKPTMEVADALYGVTMRGDGITTVISQRMRGQ-- MSMEG_2423|M.smegmatis_MC2_155 LFEQLREKSQLIVITHQKPTMEIADALYGVTMRGDGITTVISQRMRGQ-- TH_1649|M.thermoresistible__bu LFEQLRERSQLIVITHQKPTMEVADALYGVTMRDDGITTVISQRLRGQ-- Mb2946c|M.bovis_AF2122/97 LFEQLREQSQIIIITHQKPTMEVADALYGVTMQNDGITAVISQRMRGQQV Rv2922c|M.tuberculosis_H37Rv LFEQLREQSQIIIITHQKPTMEVADALYGVTMQNDGITAVISQRMRGQQV MUL_2033|M.ulcerans_Agy99 LFEMLRDRSQLIIITHQKPTMEVADALYGVTMQGDGITAVISQRIRGQQV MMAR_1785|M.marinum_M LFEMLRDRSQLIIITHQKPTMEVADALYGVTMQGDGITAVISQRIRGQQV MAV_3777|M.avium_104 LFELLRARSQLIIITHQKPTMEVADALYGVTMQGDGITAVISQRMRGQQV MLBr_01629|M.leprae_Br4923 VFEQLRGQSQLIIITHQKPTMEVADTLYGVTMQGDGITAVISQRMRGQQV MAB_3246c|M.abscessus_ATCC_199 LFEQLREKSQLIVITHQKPTMEVADALYGVSMRDDGITQVVSQRMRGLET :** ** :**:*:*********:**:****:*:.**** *:***:** Mflv_4188|M.gilvum_PYR-GCK -ELVTSSS Mvan_2175|M.vanbaalenii_PYR-1 -ELVASPS MSMEG_2423|M.smegmatis_MC2_155 -ELVSNPS TH_1649|M.thermoresistible__bu -ELVAQPG Mb2946c|M.bovis_AF2122/97 DQLVTNSS Rv2922c|M.tuberculosis_H37Rv DQLVTNSS MUL_2033|M.ulcerans_Agy99 DRLVANSS MMAR_1785|M.marinum_M DRLVANSS MAV_3777|M.avium_104 DQLVTT-- MLBr_01629|M.leprae_Br4923 ESLVTSSS MAB_3246c|M.abscessus_ATCC_199 -QLASQNA *.: