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RPTSRPDFRSVLFFPVTPMTPSGAVDLDALARHIARGVDAGPGGVFIACGTGEFHALEDNEFGDVVRTAV DVVAGRVPVYAGAGGAVAQAKRFALAAEESGADGLLLMPPYLVEVPQAGLVDYTRAVADTTDLPVIVYNR NNARFTEESAVAVAEIPNVIGFKDGTGNFDLVARIVQAVKTNVDPDFLFFNGLPTAETTQLAYRAIGVPL YSSATFAFAPDLALAFYNALDSGNEQLAEALLNAFFIPLVRLRDTVPGYAVSLVKAGVTMEGIPAGPVRP PLVMPGTDDLTELAAIVKAGRAVLSGALAQAV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1030 | - | - | 100% (313) | 5-dehydro-4-deoxyglucarate dehydratase |
| M. vanbaalenii PYR-1 | Mvan_2387 | - | 4e-28 | 32.53% (289) | dihydrodipicolinate synthase |
| M. vanbaalenii PYR-1 | Mvan_0452 | - | 1e-21 | 29.84% (315) | dihydrodipicolinate synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2774c | dapA | 3e-25 | 30.21% (288) | dihydrodipicolinate synthase |
| M. gilvum PYR-GCK | Mflv_4000 | - | 5e-25 | 30.66% (287) | dihydrodipicolinate synthase |
| M. tuberculosis H37Rv | Rv2753c | dapA | 4e-25 | 30.21% (288) | dihydrodipicolinate synthase |
| M. leprae Br4923 | MLBr_01513 | dapA | 6e-27 | 31.60% (288) | dihydrodipicolinate synthase |
| M. abscessus ATCC 19977 | MAB_1047c | - | 1e-25 | 30.77% (312) | dihydrodipicolinate synthetase DapA |
| M. marinum M | MMAR_1962 | dapA | 5e-28 | 32.64% (288) | dihydrodipicolinate synthase DapA |
| M. avium 104 | MAV_3644 | dapA | 4e-26 | 29.93% (294) | dihydrodipicolinate synthase |
| M. smegmatis MC2 155 | MSMEG_6133 | - | 1e-119 | 71.76% (301) | 5-dehydro-4-deoxyglucarate dehydratase |
| M. thermoresistible (build 8) | TH_0834 | dapA | 6e-27 | 30.51% (295) | PROBABLE DIHYDRODIPICOLINATE SYNTHASE DAPA (DHDPS) |
| M. ulcerans Agy99 | MUL_2184 | dapA | 3e-28 | 32.64% (288) | dihydrodipicolinate synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2774c|M.bovis_AF2122/97 --MTTVGFDVAARLGTLLTAMVTPFSGDGSLDTATAARLANHLVDQGCDG
Rv2753c|M.tuberculosis_H37Rv --MTTVGFDVAARLGTLLTAMVTPFSGDGSLDTATAARLANHLVDQGCDG
MMAR_1962|M.marinum_M --MSTVGFDVPARLGTLLTAMVTPFGSDGALDLAAAARLANHLVDQGCDG
MUL_2184|M.ulcerans_Agy99 --MSTVGFDVPARLGTLLTAMVTPFGSDGALDLAAAARLANHLVDQGCDG
MAV_3644|M.avium_104 --MSTVGFDAPARLGTVLTAMVTPFAADGSLDTAAAARLANHLVDSGCDG
MLBr_01513|M.leprae_Br4923 --MTTVGFDVPARLGTLLTAMVTPFDADGSVDTAAATRLANRLVDAGCDG
Mflv_4000|M.gilvum_PYR-GCK MPVSTSGFDAPARLGTLLTAMATPFKPDGSLDIETAARLATRLVDAGCDG
TH_0834|M.thermoresistible__bu --VSTGGFDVTAQLGTVLTAMVTPFKKDGSLDLDAAASLANRLVDAGCDG
Mvan_1030|M.vanbaalenii_PYR-1 -----MRPTSRPDFRSVLFFPVTPMTPSGAVDLDALARHIARGVDAGPGG
MSMEG_6133|M.smegmatis_MC2_155 ------------MLDGVLFFPVTPFTASGDVDVDLLAQHVARGVEAGPGG
MAB_1047c|M.abscessus_ATCC_199 -------MTSTPQFHGIIAYPVTPFLPDDTVDIDRLAELVSRLVDDGAHA
: :: .**: .. :* : : *: * .
Mb2774c|M.bovis_AF2122/97 LVVSGTTGESPTTTDGEKIELLRAVLEAVGDRARVIAGAGTYDTAHSIRL
Rv2753c|M.tuberculosis_H37Rv LVVSGTTGESPTTTDGEKIELLRAVLEAVGDRARVIAGAGTYDTAHSIRL
MMAR_1962|M.marinum_M LVVSGTTGESPTTTDDEKRELLRVVLEAVGDRARVIAGAGTNDTAHSIGL
MUL_2184|M.ulcerans_Agy99 LVVSGTTGESPTTTDDEKRELLRVVLEAVGDRARVIAGAGTNDTAHSIGL
MAV_3644|M.avium_104 LVVSGTTGESPTTTDDEKRELLRVVLEAVGDRARVIAGAGTYDTAHSVRL
MLBr_01513|M.leprae_Br4923 LVLSGTTGESPTTTDDEKLQLLRVVLEAVGDRARVIAGAGSYDTAHSVRL
Mflv_4000|M.gilvum_PYR-GCK LVVSGTTGESPTTTDDEKILLLRTVLEAVGDRARIVAGAGTYDTAHSIHL
TH_0834|M.thermoresistible__bu LVVSGTTGEAPTTTDDEKLQLLRTVLDAVGDRARIIAGAGTYDTAHSVRL
Mvan_1030|M.vanbaalenii_PYR-1 VFIACGTGEFHALEDNEFGDVVRTAVDVVAGRVPVYAGAGG-AVAQAKRF
MSMEG_6133|M.smegmatis_MC2_155 VFIGCGTGEFHALEPEEMRTVVRTAVDAAAGRVPVYAGAGG-PVASAKAF
MAB_1047c|M.abscessus_ATCC_199 IAPLGSTGESAYLEEREFDAVVDTTVAAVNKRVPVIVGASDLTTANTIRR
: *** * :: ..: .. *. : .**. .* :
Mb2774c|M.bovis_AF2122/97 AKACAAEGAHGLLVVTPYYSKPPQRGLQAHFTAVADATELPMLLYDIPGR
Rv2753c|M.tuberculosis_H37Rv AKACAAEGAHGLLVVTPYYSKPPQRGLQAHFTAVADATELPMLLYDIPGR
MMAR_1962|M.marinum_M AKAAAAEGAHGLLVVTPYYSKPPQSGLLAHFTAVADATELPVLLYDIPGR
MUL_2184|M.ulcerans_Agy99 AKAAAAEGAHGLLVVTPYYSKPPQSGLLAHFTAVADATELPVLLYDIPGR
MAV_3644|M.avium_104 AKACAAEGAHGLLVVTPYYSKPPQRGLIAHFTAVADATELPVLLYDIPGR
MLBr_01513|M.leprae_Br4923 VKACAGEGAHGLLVVTPYYSKPPQTGLFAHFTAVADATELPVLLYDIPGR
Mflv_4000|M.gilvum_PYR-GCK AKASAAEGAHGLLVVTPYYSRPPQAGLVAHFTAVADATDLPNILYDIPPR
TH_0834|M.thermoresistible__bu AKACQDAGAHGLLLVTPYYSRPPQDGLYAHFTTIADAVEVPIVLYDIPPR
Mvan_1030|M.vanbaalenii_PYR-1 ALAAEESGADGLLLMPPYLVEVPQAGLVDYTRAVADTTDLPVIVYN---R
MSMEG_6133|M.smegmatis_MC2_155 AQVAAESGADGLLLLPPYLVEMPQAGLVGYTRAVSAVTDLPLVVYN---R
MAB_1047c|M.abscessus_ATCC_199 ARHAQQAGADAVMVLPISYWKLSDREIAQHYASVAAAIDIPLMAYNNPAT
. . **..::::. . .: : : ::: . ::* : *:
Mb2774c|M.bovis_AF2122/97 SAVPIEPDTIR-ALASHPNIVGVKDAKADLHSGAQIMADTG---------
Rv2753c|M.tuberculosis_H37Rv SAVPIEPDTIR-ALASHPNIVGVKDAKADLHSGAQIMADTG---------
MMAR_1962|M.marinum_M SAVPIESETIR-ALAKHPNIVGVKDAKADLPSGAQIMADTG---------
MUL_2184|M.ulcerans_Agy99 SAVPIESETIR-ALAKHPNIVGVKDAKADLPSGAQIMADTG---------
MAV_3644|M.avium_104 SVVPIESSTIR-ALASHPNIVGVKDAKADLHAGGQIIAETG---------
MLBr_01513|M.leprae_Br4923 SVVPIEPDTIR-ALASHPNIVGVKEAKADLYSGARIMADTG---------
Mflv_4000|M.gilvum_PYR-GCK SVVPIEWDTIR-RLAQHPNIVAIKDAKADLHGGGQIIAETG---------
TH_0834|M.thermoresistible__bu SVVPLAWDTIR-RLSEHRNIVAIKDAKGDLHGAAQIIAETG---------
Mvan_1030|M.vanbaalenii_PYR-1 NNARFTEESAV-AVAEIPNVIGFKDGTGNFDLVARIVQAVKTNVDPD---
MSMEG_6133|M.smegmatis_MC2_155 NNARFTEGSAI-EVAKLPNVVGFKDGTGDFDQVARIVRAVTDALENEGKP
MAB_1047c|M.abscessus_ATCC_199 SGVDMKPELLVSMFGDIDNFTMVKESTGDLNRMLEIKRLTNG-------L
. . : ... *. .*:...:: .* .
Mb2774c|M.bovis_AF2122/97 LAYYSGD---DALNLPWLAMGATGFISVIAHLAAGQLRELLSAFGSG-DI
Rv2753c|M.tuberculosis_H37Rv LAYYSGD---DALNLPWLAMGATGFISVIAHLAAGQLRELLSAFGSG-DI
MMAR_1962|M.marinum_M LAYYSGD---DALNLPWLAMGAIGFISVIGHLAAGQLREMLSAFSSG-DV
MUL_2184|M.ulcerans_Agy99 LAYYSGD---DALNLPWLAMGAIGFISVIGHLAAGQLREMLSAFSSG-DV
MAV_3644|M.avium_104 LAYYSGD---DALNLPWLAMGATGFISVISHVAANQLRELLSAFTSG-DI
MLBr_01513|M.leprae_Br4923 LAYYSGD---DALNLPWLAVGAIGFISVISHLAAGQLRELLSAFGSG-DI
Mflv_4000|M.gilvum_PYR-GCK LAYYSGD---DALNLPWLAMGAVGFISVWGHLAASQLRDMLSAFASG-DV
TH_0834|M.thermoresistible__bu LAYYSGD---DSLNLPWLAVGAVGFISVWGHLAAGQLRDMLTAFNSG-DM
Mvan_1030|M.vanbaalenii_PYR-1 FLFFNGLPTAETTQLAYRAIGVPLYSSATFAFAPDLALAFYNALDSGNEQ
MSMEG_6133|M.smegmatis_MC2_155 FQFFNGLPTAEVSQQAYRAIGVTLYSSATFAFAPDVSLAFYRALEDGKEP
MAB_1047c|M.abscessus_ATCC_199 LPFYNGS---NPLVLDALNAGASGWCTAAPCLAPQPCLDLYEAVRAG-RD
: ::.* : *. : :. .*. : *. *
Mb2774c|M.bovis_AF2122/97 ATARKINIAVAPLCNAMSRLGG--VTLSKAGLRLQGIDVGDPRLPQVAAT
Rv2753c|M.tuberculosis_H37Rv ATARKINIAVAPLCNAMSRLGG--VTLSKAGLRLQGIDVGDPRLPQVAAT
MMAR_1962|M.marinum_M ATARKINVAVSPLCNAMTRLGG--VTLSKAGLRLQGIEVGDPRLPQVAAT
MUL_2184|M.ulcerans_Agy99 ATARKINVAVSPLCNAMTRLGG--VTLSKAGLRLQGIEVGDPRLPQVAAT
MAV_3644|M.avium_104 ATARKINATVAPLCDAMARLGG--VTMSKAGLRLQGIDVGDPRLPQVPAT
MLBr_01513|M.leprae_Br4923 TTARKINVAIGPLCSAMDRLGG--VTMSKAGLRLQGIDVGDPRLPQMPAT
Mflv_4000|M.gilvum_PYR-GCK ATARKINVALGPLSAAQSRLGG--VTLSKAGLRLQGFEVGDPRLPQIPAN
TH_0834|M.thermoresistible__bu TTARKIAVTLSPLNAAQTRLGG--VSMSKAGLRLLGIEVGDPRLPQVPPG
Mvan_1030|M.vanbaalenii_PYR-1 LAEALLNAFFIPLVRLRDTVPGYAVSLVKAGVTMEGIPAGPVRPPLVMPG
MSMEG_6133|M.smegmatis_MC2_155 LVAALLRSFFHPLVRLRNKVPGYAVSLIKAGVTLGGLQAGPVRPPLIDAA
MAB_1047c|M.abscessus_ATCC_199 DDAASLYTALKPLLQFIVAGGLP--TTVKAGLELQGRPVGDPRRPLLPLD
: . ** : ***: : * .* * * :
Mb2774c|M.bovis_AF2122/97 PEQIDALAADMRAASVLR--------
Rv2753c|M.tuberculosis_H37Rv PEQIDALAADMRAASVLR--------
MMAR_1962|M.marinum_M AEQIDVLAADMRAASVLR--------
MUL_2184|M.ulcerans_Agy99 AEQIDVLAADMRAASVLR--------
MAV_3644|M.avium_104 PEQIEALTADMRAASVLR--------
MLBr_01513|M.leprae_Br4923 AEQIDELAVDMRAASVLR--------
Mflv_4000|M.gilvum_PYR-GCK DVQLQALAADMRAASVLR--------
TH_0834|M.thermoresistible__bu PEQLRLLADDMRAAAVLR--------
Mvan_1030|M.vanbaalenii_PYR-1 TDDLTELAAIVKAGRAVLSGALAQAV
MSMEG_6133|M.smegmatis_MC2_155 PDDVDELQRILSAGRAVLADALVH--
MAB_1047c|M.abscessus_ATCC_199 PEGRETLKGILASTP-----------
* : :