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TTVGFDVAARLGTLLTAMVTPFSGDGSLDTATAARLANHLVDQGCDGLVVSGTTGESPTTTDGEKIELLR AVLEAVGDRARVIAGAGTYDTAHSIRLAKACAAEGAHGLLVVTPYYSKPPQRGLQAHFTAVADATELPML LYDIPGRSAVPIEPDTIRALASHPNIVGVKDAKADLHSGAQIMADTGLAYYSGDDALNLPWLAMGATGFI SVIAHLAAGQLRELLSAFGSGDIATARKINIAVAPLCNAMSRLGGVTLSKAGLRLQGIDVGDPRLPQVAA TPEQIDALAADMRAASVLR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2753c | dapA | - | 100% (300) | dihydrodipicolinate synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2774c | dapA | 1e-168 | 100.00% (300) | dihydrodipicolinate synthase |
| M. gilvum PYR-GCK | Mflv_4000 | - | 1e-134 | 80.33% (300) | dihydrodipicolinate synthase |
| M. leprae Br4923 | MLBr_01513 | dapA | 1e-149 | 87.00% (300) | dihydrodipicolinate synthase |
| M. abscessus ATCC 19977 | MAB_3084c | - | 1e-116 | 70.34% (290) | dihydrodipicolinate synthase |
| M. marinum M | MMAR_1962 | dapA | 1e-149 | 89.67% (300) | dihydrodipicolinate synthase DapA |
| M. avium 104 | MAV_3644 | dapA | 1e-150 | 89.00% (300) | dihydrodipicolinate synthase |
| M. smegmatis MC2 155 | MSMEG_2684 | dapA | 1e-127 | 75.33% (300) | dihydrodipicolinate synthase |
| M. thermoresistible (build 8) | TH_0834 | dapA | 1e-124 | 72.67% (300) | PROBABLE DIHYDRODIPICOLINATE SYNTHASE DAPA (DHDPS) |
| M. ulcerans Agy99 | MUL_2184 | dapA | 1e-149 | 89.67% (300) | dihydrodipicolinate synthase |
| M. vanbaalenii PYR-1 | Mvan_2387 | - | 1e-134 | 78.67% (300) | dihydrodipicolinate synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4000|M.gilvum_PYR-GCK MPVSTSGFDAPARLGTLLTAMATPFKPDGSLDIETAARLATRLVDAGCDG
Mvan_2387|M.vanbaalenii_PYR-1 MPVSTSGFDAPARLGTLLTAMVTPFKPNGALDTDTAARLANHLVDAGCDG
MSMEG_2684|M.smegmatis_MC2_155 --MSTSGIDVTAQLGTLLTAMVTPFKPDGSLDLDAAAQLAARLVDSGCDG
TH_0834|M.thermoresistible__bu --VSTGGFDVTAQLGTVLTAMVTPFKKDGSLDLDAAASLANRLVDAGCDG
Rv2753c|M.tuberculosis_H37Rv --MTTVGFDVAARLGTLLTAMVTPFSGDGSLDTATAARLANHLVDQGCDG
Mb2774c|M.bovis_AF2122/97 --MTTVGFDVAARLGTLLTAMVTPFSGDGSLDTATAARLANHLVDQGCDG
MMAR_1962|M.marinum_M --MSTVGFDVPARLGTLLTAMVTPFGSDGALDLAAAARLANHLVDQGCDG
MUL_2184|M.ulcerans_Agy99 --MSTVGFDVPARLGTLLTAMVTPFGSDGALDLAAAARLANHLVDQGCDG
MLBr_01513|M.leprae_Br4923 --MTTVGFDVPARLGTLLTAMVTPFDADGSVDTAAATRLANRLVDAGCDG
MAV_3644|M.avium_104 --MSTVGFDAPARLGTVLTAMVTPFAADGSLDTAAAARLANHLVDSGCDG
MAB_3084c|M.abscessus_ATCC_199 ----------MARLGTVLTAMVTPFDAEGALDVDTAVRLAAHLVDAGCDG
*:***:****.*** :*::* :*. ** :*** ****
Mflv_4000|M.gilvum_PYR-GCK LVVSGTTGESPTTTDDEKILLLRTVLEAVGDRARIVAGAGTYDTAHSIHL
Mvan_2387|M.vanbaalenii_PYR-1 IVVSGTTGESPTTTDDEKIALLRTVLEAVGDRARVIAGAGTYDTAHSVRM
MSMEG_2684|M.smegmatis_MC2_155 LVLSGTTGESPTTSDDEKIALLRTVVDAVGDRARVIAGAGSYDTAHSVHL
TH_0834|M.thermoresistible__bu LVVSGTTGEAPTTTDDEKLQLLRTVLDAVGDRARIIAGAGTYDTAHSVRL
Rv2753c|M.tuberculosis_H37Rv LVVSGTTGESPTTTDGEKIELLRAVLEAVGDRARVIAGAGTYDTAHSIRL
Mb2774c|M.bovis_AF2122/97 LVVSGTTGESPTTTDGEKIELLRAVLEAVGDRARVIAGAGTYDTAHSIRL
MMAR_1962|M.marinum_M LVVSGTTGESPTTTDDEKRELLRVVLEAVGDRARVIAGAGTNDTAHSIGL
MUL_2184|M.ulcerans_Agy99 LVVSGTTGESPTTTDDEKRELLRVVLEAVGDRARVIAGAGTNDTAHSIGL
MLBr_01513|M.leprae_Br4923 LVLSGTTGESPTTTDDEKLQLLRVVLEAVGDRARVIAGAGSYDTAHSVRL
MAV_3644|M.avium_104 LVVSGTTGESPTTTDDEKRELLRVVLEAVGDRARVIAGAGTYDTAHSVRL
MAB_3084c|M.abscessus_ATCC_199 LVLSGTTGESPVTSDAEKLTLLREVVAAVGDRARIIAGSGTYDTAHSIKL
:*:******:*.*:* ** *** *: *******::**:*: *****: :
Mflv_4000|M.gilvum_PYR-GCK AKASAAEGAHGLLVVTPYYSRPPQAGLVAHFTAVADATDLPNILYDIPPR
Mvan_2387|M.vanbaalenii_PYR-1 AKASAAEGAHGLLVVTPYYSRPPQAGLAAHFTAVADATDRPVILYDIPPR
MSMEG_2684|M.smegmatis_MC2_155 AKASAEAGAHGLLVVTPYYSRPAQAGLLAHFTAVADATDLPVVLYDIPPR
TH_0834|M.thermoresistible__bu AKACQDAGAHGLLLVTPYYSRPPQDGLYAHFTTIADAVEVPIVLYDIPPR
Rv2753c|M.tuberculosis_H37Rv AKACAAEGAHGLLVVTPYYSKPPQRGLQAHFTAVADATELPMLLYDIPGR
Mb2774c|M.bovis_AF2122/97 AKACAAEGAHGLLVVTPYYSKPPQRGLQAHFTAVADATELPMLLYDIPGR
MMAR_1962|M.marinum_M AKAAAAEGAHGLLVVTPYYSKPPQSGLLAHFTAVADATELPVLLYDIPGR
MUL_2184|M.ulcerans_Agy99 AKAAAAEGAHGLLVVTPYYSKPPQSGLLAHFTAVADATELPVLLYDIPGR
MLBr_01513|M.leprae_Br4923 VKACAGEGAHGLLVVTPYYSKPPQTGLFAHFTAVADATELPVLLYDIPGR
MAV_3644|M.avium_104 AKACAAEGAHGLLVVTPYYSKPPQRGLIAHFTAVADATELPVLLYDIPGR
MAB_3084c|M.abscessus_ATCC_199 SRECEAAGAHGLLVVTPYYSRPSQAGLLAHFTAVADAVNVPVILYDIPPR
: . ******:******:*.* ** ****::***.: * :***** *
Mflv_4000|M.gilvum_PYR-GCK SVVPIEWDTIRRLAQHPNIVAIKDAKADLHGGGQIIAETGLAYYSGDDAL
Mvan_2387|M.vanbaalenii_PYR-1 SVVPIEWETIRALAGHPNIVAIKDAKGDLHGGGQIIAETGLAYYSGDDAL
MSMEG_2684|M.smegmatis_MC2_155 SVVPIAWDTLRKLAEHPNIVAVKDAKGDLPGGGQIIAETGLAYYSGDDAL
TH_0834|M.thermoresistible__bu SVVPLAWDTIRRLSEHRNIVAIKDAKGDLHGAAQIIAETGLAYYSGDDSL
Rv2753c|M.tuberculosis_H37Rv SAVPIEPDTIRALASHPNIVGVKDAKADLHSGAQIMADTGLAYYSGDDAL
Mb2774c|M.bovis_AF2122/97 SAVPIEPDTIRALASHPNIVGVKDAKADLHSGAQIMADTGLAYYSGDDAL
MMAR_1962|M.marinum_M SAVPIESETIRALAKHPNIVGVKDAKADLPSGAQIMADTGLAYYSGDDAL
MUL_2184|M.ulcerans_Agy99 SAVPIESETIRALAKHPNIVGVKDAKADLPSGAQIMADTGLAYYSGDDAL
MLBr_01513|M.leprae_Br4923 SVVPIEPDTIRALASHPNIVGVKEAKADLYSGARIMADTGLAYYSGDDAL
MAV_3644|M.avium_104 SVVPIESSTIRALASHPNIVGVKDAKADLHAGGQIIAETGLAYYSGDDAL
MAB_3084c|M.abscessus_ATCC_199 SVVPIDFHIIRELAAHPNIVAVKDAKGDLHGGAQIIAGTDLVYYSGDDPL
*.**: :* *: * ***.:*:**.** ...:*:* *.*.******.*
Mflv_4000|M.gilvum_PYR-GCK NLPWLAMGAVGFISVWGHLAASQLRDMLSAFASGDVATARKINVALGPLS
Mvan_2387|M.vanbaalenii_PYR-1 NLPWLAMGAVGFISVWGHLAASALRDMMTAFASGDIATARKINVTLGPLS
MSMEG_2684|M.smegmatis_MC2_155 NLPWLAMGALGFISVWGHLAAGQLRDMLTAFNSGDVATARKINVNLAPLA
TH_0834|M.thermoresistible__bu NLPWLAVGAVGFISVWGHLAAGQLRDMLTAFNSGDMTTARKIAVTLSPLN
Rv2753c|M.tuberculosis_H37Rv NLPWLAMGATGFISVIAHLAAGQLRELLSAFGSGDIATARKINIAVAPLC
Mb2774c|M.bovis_AF2122/97 NLPWLAMGATGFISVIAHLAAGQLRELLSAFGSGDIATARKINIAVAPLC
MMAR_1962|M.marinum_M NLPWLAMGAIGFISVIGHLAAGQLREMLSAFSSGDVATARKINVAVSPLC
MUL_2184|M.ulcerans_Agy99 NLPWLAMGAIGFISVIGHLAAGQLREMLSAFSSGDVATARKINVAVSPLC
MLBr_01513|M.leprae_Br4923 NLPWLAVGAIGFISVISHLAAGQLRELLSAFGSGDITTARKINVAIGPLC
MAV_3644|M.avium_104 NLPWLAMGATGFISVISHVAANQLRELLSAFTSGDIATARKINATVAPLC
MAB_3084c|M.abscessus_ATCC_199 NLPWLSVGAVGFVSVISHFVAGPLRELLAAYNAGDVETARKLNAQVAPIT
*****::** **:** .*..*. **::::*: :**: ****: :.*:
Mflv_4000|M.gilvum_PYR-GCK AAQSRLGGVTLSKAGLRLQGFEVGDPRLPQIPANDVQLQALAADMRAASV
Mvan_2387|M.vanbaalenii_PYR-1 QAQARLGGVTLSKAGLRLQGFEVGEPRLPQIPATDEQVEELAADMRAAGV
MSMEG_2684|M.smegmatis_MC2_155 AAQARLGGVTMSKAGLRLQGFDAGEPRLPQIPATTEEVEALAADMRAATV
TH_0834|M.thermoresistible__bu AAQTRLGGVSMSKAGLRLLGIEVGDPRLPQVPPGPEQLRLLADDMRAAAV
Rv2753c|M.tuberculosis_H37Rv NAMSRLGGVTLSKAGLRLQGIDVGDPRLPQVAATPEQIDALAADMRAASV
Mb2774c|M.bovis_AF2122/97 NAMSRLGGVTLSKAGLRLQGIDVGDPRLPQVAATPEQIDALAADMRAASV
MMAR_1962|M.marinum_M NAMTRLGGVTLSKAGLRLQGIEVGDPRLPQVAATAEQIDVLAADMRAASV
MUL_2184|M.ulcerans_Agy99 NAMTRLGGVTLSKAGLRLQGIEVGDPRLPQVAATAEQIDVLAADMRAASV
MLBr_01513|M.leprae_Br4923 SAMDRLGGVTMSKAGLRLQGIDVGDPRLPQMPATAEQIDELAVDMRAASV
MAV_3644|M.avium_104 DAMARLGGVTMSKAGLRLQGIDVGDPRLPQVPATPEQIEALTADMRAASV
MAB_3084c|M.abscessus_ATCC_199 EACRRLGAVGAVKAGLRLQGIEVGDPRLPNVPPSPEQIEGLAADMRAAGV
* ***.* ****** *::.*:****::.. :: *: ***** *
Mflv_4000|M.gilvum_PYR-GCK LR-
Mvan_2387|M.vanbaalenii_PYR-1 LRQ
MSMEG_2684|M.smegmatis_MC2_155 LR-
TH_0834|M.thermoresistible__bu LR-
Rv2753c|M.tuberculosis_H37Rv LR-
Mb2774c|M.bovis_AF2122/97 LR-
MMAR_1962|M.marinum_M LR-
MUL_2184|M.ulcerans_Agy99 LR-
MLBr_01513|M.leprae_Br4923 LR-
MAV_3644|M.avium_104 LR-
MAB_3084c|M.abscessus_ATCC_199 L--
*