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TSTPQFHGIIAYPVTPFLPDDTVDIDRLAELVSRLVDDGAHAIAPLGSTGESAYLEEREFDAVVDTTVAA VNKRVPVIVGASDLTTANTIRRARHAQQAGADAVMVLPISYWKLSDREIAQHYASVAAAIDIPLMAYNNP ATSGVDMKPELLVSMFGDIDNFTMVKESTGDLNRMLEIKRLTNGLLPFYNGSNPLVLDALNAGASGWCTA APCLAPQPCLDLYEAVRAGRDDDAASLYTALKPLLQFIVAGGLPTTVKAGLELQGRPVGDPRRPLLPLDP EGRETLKGILASTP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1047c | - | - | 100% (295) | dihydrodipicolinate synthetase DapA |
| M. abscessus ATCC 19977 | MAB_3084c | - | 4e-33 | 32.01% (278) | dihydrodipicolinate synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2774c | dapA | 9e-31 | 32.60% (273) | dihydrodipicolinate synthase |
| M. gilvum PYR-GCK | Mflv_4000 | - | 2e-28 | 32.32% (263) | dihydrodipicolinate synthase |
| M. tuberculosis H37Rv | Rv2753c | dapA | 9e-31 | 32.60% (273) | dihydrodipicolinate synthase |
| M. leprae Br4923 | MLBr_01513 | dapA | 8e-29 | 32.46% (268) | dihydrodipicolinate synthase |
| M. marinum M | MMAR_2154 | dapA_1 | 1e-112 | 71.18% (288) | dihydrodipicolinate synthase DapA_1 |
| M. avium 104 | MAV_3450 | - | 1e-114 | 71.63% (289) | dihydrodipicolinate synthetase family protein |
| M. smegmatis MC2 155 | MSMEG_2684 | dapA | 1e-32 | 33.45% (284) | dihydrodipicolinate synthase |
| M. thermoresistible (build 8) | TH_0834 | dapA | 9e-31 | 30.82% (279) | PROBABLE DIHYDRODIPICOLINATE SYNTHASE DAPA (DHDPS) |
| M. ulcerans Agy99 | MUL_1739 | dapA_1 | 1e-111 | 70.83% (288) | dihydrodipicolinate synthase DapA_1 |
| M. vanbaalenii PYR-1 | Mvan_0452 | - | 1e-118 | 73.29% (292) | dihydrodipicolinate synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4000|M.gilvum_PYR-GCK MPVSTSGFDAPARLGTLLTAMATPFKPDGS-LDIETAARLATRLVDAGCD
MSMEG_2684|M.smegmatis_MC2_155 --MSTSGIDVTAQLGTLLTAMVTPFKPDGS-LDLDAAAQLAARLVDSGCD
TH_0834|M.thermoresistible__bu --VSTGGFDVTAQLGTVLTAMVTPFKKDGS-LDLDAAASLANRLVDAGCD
Mb2774c|M.bovis_AF2122/97 --MTTVGFDVAARLGTLLTAMVTPFSGDGS-LDTATAARLANHLVDQGCD
Rv2753c|M.tuberculosis_H37Rv --MTTVGFDVAARLGTLLTAMVTPFSGDGS-LDTATAARLANHLVDQGCD
MLBr_01513|M.leprae_Br4923 --MTTVGFDVPARLGTLLTAMVTPFDADGS-VDTAAATRLANRLVDAGCD
MMAR_2154|M.marinum_M -----MAEPGAPTIHGIIAYPVTPFTAEGD-VDARRLAALVDRLVCSGVH
MUL_1739|M.ulcerans_Agy99 -----MAEPGAPTIHGIIAYPVTPFTAEGD-VDARRLAALVDRLVCSGVH
MAV_3450|M.avium_104 -----MTEP---KIHGIIAYPVTPFADNG--IDTQRLAALVERLVSAGVH
Mvan_0452|M.vanbaalenii_PYR-1 -----MTTATT-EIHGIIAYPVTPFTSNGEDIDTGKLAALVEQLVATGAH
MAB_1047c|M.abscessus_ATCC_199 -----MTSTP--QFHGIIAYPVTPFLPDDT-VDIDRLAELVSRLVDDGAH
: ::: .*** :. :* : *. :** * .
Mflv_4000|M.gilvum_PYR-GCK GLVVSGTTGESPTTTDDEKILLLRTVLEAVGDRARIVAGAGTYDTAHSIH
MSMEG_2684|M.smegmatis_MC2_155 GLVLSGTTGESPTTSDDEKIALLRTVVDAVGDRARVIAGAGSYDTAHSVH
TH_0834|M.thermoresistible__bu GLVVSGTTGEAPTTTDDEKLQLLRTVLDAVGDRARIIAGAGTYDTAHSVR
Mb2774c|M.bovis_AF2122/97 GLVVSGTTGESPTTTDGEKIELLRAVLEAVGDRARVIAGAGTYDTAHSIR
Rv2753c|M.tuberculosis_H37Rv GLVVSGTTGESPTTTDGEKIELLRAVLEAVGDRARVIAGAGTYDTAHSIR
MLBr_01513|M.leprae_Br4923 GLVLSGTTGESPTTTDDEKLQLLRVVLEAVGDRARVIAGAGSYDTAHSVR
MMAR_2154|M.marinum_M AIAALGSTGELAYLDEAEFDTAVDTAVAAVSGRLPVVVGVSDVTTAKTIR
MUL_1739|M.ulcerans_Agy99 AIAALGSTGELAYLDEAEFDTAVDTAVAAVSGRLPVVVGVSDVTTAKTIR
MAV_3450|M.avium_104 AIAPLGSTGELAYLEEPEVDAVIDTTLSAVAGRVPVIVGVSDVTTAKTIR
Mvan_0452|M.vanbaalenii_PYR-1 AIAPLGSTGESAYLTEAEFDTVVDTTVGVVNGRVPVIVGASDLTTANTIR
MAB_1047c|M.abscessus_ATCC_199 AIAPLGSTGESAYLEEREFDAVVDTTVAAVNKRVPVIVGASDLTTANTIR
.:. *:*** . : * : ..: .* * ::.*.. **::::
Mflv_4000|M.gilvum_PYR-GCK LAKASAAEGAHGLLVVTPYYSRPPQAGLVAHFTAVADATDLPNILYDIPP
MSMEG_2684|M.smegmatis_MC2_155 LAKASAEAGAHGLLVVTPYYSRPAQAGLLAHFTAVADATDLPVVLYDIPP
TH_0834|M.thermoresistible__bu LAKACQDAGAHGLLLVTPYYSRPPQDGLYAHFTTIADAVEVPIVLYDIPP
Mb2774c|M.bovis_AF2122/97 LAKACAAEGAHGLLVVTPYYSKPPQRGLQAHFTAVADATELPMLLYDIPG
Rv2753c|M.tuberculosis_H37Rv LAKACAAEGAHGLLVVTPYYSKPPQRGLQAHFTAVADATELPMLLYDIPG
MLBr_01513|M.leprae_Br4923 LVKACAGEGAHGLLVVTPYYSKPPQTGLFAHFTAVADATELPVLLYDIPG
MMAR_2154|M.marinum_M RARYAQHVGADAVMILPVSYWKLNEHEIFQHYRSVGDAITIPIMAYNNPA
MUL_1739|M.ulcerans_Agy99 RARYAQHVGADAVMILPVSYWKLNEHEIFQHYRSVGDAITIPIMAYNNPA
MAV_3450|M.avium_104 RAQYAQRAGADAVMILPVSYWKLTEREIFHHYRSISDAISIPIMAYNNPA
Mvan_0452|M.vanbaalenii_PYR-1 RGKYAQRAGADALMILPVSYWKLTDREIARHYASVAAATDLPIMAYNNPA
MAB_1047c|M.abscessus_ATCC_199 RARHAQQAGADAVMVLPISYWKLSDREIAQHYASVAAAIDIPLMAYNNPA
: . **..::::. * : : : *: ::. * :* : *: *
Mflv_4000|M.gilvum_PYR-GCK RSVVPIEWDTIRRLAQHPN-IVAIKDAKADLHGGGQIIAETG--LAYYSG
MSMEG_2684|M.smegmatis_MC2_155 RSVVPIAWDTLRKLAEHPN-IVAVKDAKGDLPGGGQIIAETG--LAYYSG
TH_0834|M.thermoresistible__bu RSVVPLAWDTIRRLSEHRN-IVAIKDAKGDLHGAAQIIAETG--LAYYSG
Mb2774c|M.bovis_AF2122/97 RSAVPIEPDTIRALASHPN-IVGVKDAKADLHSGAQIMADTG--LAYYSG
Rv2753c|M.tuberculosis_H37Rv RSAVPIEPDTIRALASHPN-IVGVKDAKADLHSGAQIMADTG--LAYYSG
MLBr_01513|M.leprae_Br4923 RSVVPIEPDTIRALASHPN-IVGVKEAKADLYSGARIMADTG--LAYYSG
MMAR_2154|M.marinum_M TSGVDMRPELLVRMFESIDNLTMVKESTGDLSRMRRIAELSGGRLPFYNG
MUL_1739|M.ulcerans_Agy99 TSGVDMRPELLVRMFESIDNLTMVKESTGDLSRMRRIAELSGGRLPFYNG
MAV_3450|M.avium_104 TSGVDMPPELLVRMFESIDNVAMVKESTGDLTRMRRIAELSGNRLPFYNG
Mvan_0452|M.vanbaalenii_PYR-1 TSGIDMSPELLVRMFTDIDNVAMVKESTGDLSRMQRIKELTGGALPFYNG
MAB_1047c|M.abscessus_ATCC_199 TSGVDMKPELLVSMFGDIDNFTMVKESTGDLNRMLEIKRLTNGLLPFYNG
* : : : : : : .. :*::..** .* :. *.:*.*
Mflv_4000|M.gilvum_PYR-GCK DDALNLPWLAMGAVGFISVWGHLAASQLRDMLSAFASGDVATARKINVAL
MSMEG_2684|M.smegmatis_MC2_155 DDALNLPWLAMGALGFISVWGHLAAGQLRDMLTAFNSGDVATARKINVNL
TH_0834|M.thermoresistible__bu DDSLNLPWLAVGAVGFISVWGHLAAGQLRDMLTAFNSGDMTTARKIAVTL
Mb2774c|M.bovis_AF2122/97 DDALNLPWLAMGATGFISVIAHLAAGQLRELLSAFGSGDIATARKINIAV
Rv2753c|M.tuberculosis_H37Rv DDALNLPWLAMGATGFISVIAHLAAGQLRELLSAFGSGDIATARKINIAV
MLBr_01513|M.leprae_Br4923 DDALNLPWLAVGAIGFISVISHLAAGQLRELLSAFGSGDITTARKINVAI
MMAR_2154|M.marinum_M SNPLVLDALKVGAAGWCTAAPNLWPQPCIDLYEAVCAGDLEKAQILYDDL
MUL_1739|M.ulcerans_Agy99 SNPLVLDALKVGAAGWCTAAPNLWPQPCIDLYEAVCAGDLEKAQILYDDL
MAV_3450|M.avium_104 SNPLVLDALKAGASGWCTAAPCLRPQPCIDLYDAVRANDLDTAQRLYDDL
Mvan_0452|M.vanbaalenii_PYR-1 SNPLVLDALTEGAAGWCTAAPNLRPQPCLDLYTAVRDGERSRAQEIYDDL
MAB_1047c|M.abscessus_ATCC_199 SNPLVLDALNAGASGWCTAAPCLAPQPCLDLYEAVRAGRDDDAASLYTAL
.:.* * * ** *: :. * . :: *. . * : :
Mflv_4000|M.gilvum_PYR-GCK GPLSAAQSRLGGVTLSKAGLRLQGFEVGDPRLPQIPANDVQLQALAADMR
MSMEG_2684|M.smegmatis_MC2_155 APLAAAQARLGGVTMSKAGLRLQGFDAGEPRLPQIPATTEEVEALAADMR
TH_0834|M.thermoresistible__bu SPLNAAQTRLGGVSMSKAGLRLLGIEVGDPRLPQVPPGPEQLRLLADDMR
Mb2774c|M.bovis_AF2122/97 APLCNAMSRLGGVTLSKAGLRLQGIDVGDPRLPQVAATPEQIDALAADMR
Rv2753c|M.tuberculosis_H37Rv APLCNAMSRLGGVTLSKAGLRLQGIDVGDPRLPQVAATPEQIDALAADMR
MLBr_01513|M.leprae_Br4923 GPLCSAMDRLGGVTMSKAGLRLQGIDVGDPRLPQMPATAEQIDELAVDMR
MMAR_2154|M.marinum_M KPLLEFIVAGGLATTVKAGLGLLGFPVGDPRPPLLPLDEHGRAKLGRLLA
MUL_1739|M.ulcerans_Agy99 KPLLEFIVAGRLATTVKAGLGLLGFPVGDPRPPLLPLDEHGRAKLGRLLA
MAV_3450|M.avium_104 KPLLTFIVAGGLATTVKAGLELLDFKVGDPRAPLLPLDEQGRAELRKLLA
Mvan_0452|M.vanbaalenii_PYR-1 APLLRFIVAGGLPTTVKAGLELLGVSVGDPRAPLLALDDTGRAELKTLLA
MAB_1047c|M.abscessus_ATCC_199 KPLLQFIVAGGLPTTVKAGLELQGRPVGDPRRPLLPLDPEGRETLKGILA
** : **** * . .*:** * :. * :
Mflv_4000|M.gilvum_PYR-GCK AASVLR
MSMEG_2684|M.smegmatis_MC2_155 AATVLR
TH_0834|M.thermoresistible__bu AAAVLR
Mb2774c|M.bovis_AF2122/97 AASVLR
Rv2753c|M.tuberculosis_H37Rv AASVLR
MLBr_01513|M.leprae_Br4923 AASVLR
MMAR_2154|M.marinum_M GC----
MUL_1739|M.ulcerans_Agy99 GC----
MAV_3450|M.avium_104 A-----
Mvan_0452|M.vanbaalenii_PYR-1 VA----
MAB_1047c|M.abscessus_ATCC_199 STP---