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MNSLKDPDFEHTGPGRPAGHLLRQRWQPVYASEELEAGRAVPLKILHEELTLYRGEDGVAHIVAGRCAHR GVLLAVGTVEGDCVRCRYHGWRYDGAGQCVDQPAERRSFADKVRIASYPVEEYFGFIWTYLGESPVPELP RWPELEEYGRFHVIEHRKWNYFHDLENTVDDVHQYWVHKTGIYQDDGNAGQIPEMSAELADFGLTQTSTF SNGFVRRLALLMPNTLYFNSGAGVLRGFKSFLWNVPIDDENHMMFFLFIAAHLPPDVGARLAAGVREGRK YLSQLRPVDDIIRAVLSGRERWEDIEDRPDQVLIEDGVVLLGQGVLPDRSLNRLGSSDAAIILLRRLYAR ELAAIEAGHPLTKFPTPDAAALTRLDSSTP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1001 | - | - | 100% (380) | Rieske (2Fe-2S) domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_2012 | - | 7e-16 | 30.46% (174) | Rieske (2Fe-2S) domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_2869 | - | 5e-12 | 25.61% (164) | Rieske (2Fe-2S) domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3556 | - | 3e-10 | 26.83% (164) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_4333 | - | 5e-14 | 33.59% (131) | Rieske (2Fe-2S) domain-containing protein |
| M. tuberculosis H37Rv | Rv3526 | - | 3e-10 | 26.83% (164) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0080c | - | 3e-10 | 26.99% (163) | putative oxygenase |
| M. marinum M | MMAR_3971 | - | 6e-18 | 30.22% (268) | oxidoreductase |
| M. avium 104 | MAV_1638 | - | 4e-18 | 29.10% (268) | Rieske (2Fe-2S) domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_4372 | - | 6e-18 | 37.50% (160) | capreomycidine hydroxylase |
| M. thermoresistible (build 8) | TH_4222 | - | 1e-13 | 28.98% (176) | PUTATIVE Rieske [2Fe-2S] domain protein |
| M. ulcerans Agy99 | MUL_3829 | - | 2e-17 | 32.54% (209) | oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3971|M.marinum_M MAPSTSNSASSSAEEHSEQEFGPSGIALSPYRFPTG-WFIVAFSSELGAG
MUL_3829|M.ulcerans_Agy99 MAPSTSNSASNSAEELSEQEFGPSGIALSPYRFPTG-WFIVAFSSELGAG
MAV_1638|M.avium_104 MARTVSDSAPDSAEDPSEREFGQAGIALSTYRFPTG-WFIVAFGSDLAPG
Mflv_4333|M.gilvum_PYR-GCK -------------------------MKVPFTWKVTG-WFMIGWSAEFEVG
TH_4222|M.thermoresistible__bu -------------------------VKVPFTWKVTG-WFMIGWAPEFPVG
Mb3556|M.bovis_AF2122/97 ------MSTDTSG-----VGVREIDAGALPTRYARG-WHCLGVAKDYLEG
Rv3526|M.tuberculosis_H37Rv ------MSTDTSG-----VGVREIDAGALPTRYARG-WHCLGVAKDYLEG
MAB_0080c|M.abscessus_ATCC_199 ------MTTAQSATEFDPATVRSIEADAAPARFARG-WYCLGLIKDFGDG
MSMEG_4372|M.smegmatis_MC2_155 ------------------MKQDVLTPEKLREAYQHV-WFVVARSCDIDT-
Mvan_1001|M.vanbaalenii_PYR-1 ------------MNSLKDPDFEHTGPGRPAGHLLRQRWQPVYASEELEAG
* : :
MMAR_3971|M.marinum_M EVKRVHYFGEELVLFRTASGRVHALDAYCQHLGANLGVGGTVEGEHIVCP
MUL_3829|M.ulcerans_Agy99 EVKRVHSFGEELVLFRTASGRVHALDAYCQHLGANLGVGGTVEGEHIVCP
MAV_1638|M.avium_104 QVKRAHYFGEELVLFRTASGRVHVMDAYCQHLGANLGVGGTVEGENIVCP
Mflv_4333|M.gilvum_PYR-GCK DVKALRYFGEDLAAYRDESGRLHVLEAHCKHLGAHIGHGGKVVDDCIECP
TH_4222|M.thermoresistible__bu EVRPLRYFGEDLVAYRDESGALHVMEAHCKHLGAHIGHGGTVIGDCVECP
Mb3556|M.bovis_AF2122/97 KPHGVEAFGTKLVVFADSHGDLKVLDGYCRHMGGDLSEG-TVKGDEVACP
Rv3526|M.tuberculosis_H37Rv KPHGVEAFGTKLVVFADSHGDLKVLDGYCRHMGGDLSEG-TVKGDEVACP
MAB_0080c|M.abscessus_ATCC_199 KPHAVNAFGQKLVVFRPAGGKVSVLDAYCRHMGGDLSQG-EVKGDEIACP
MSMEG_4372|M.smegmatis_MC2_155 -PQSATLLDHNLVVFRDSTGAARVTDRRCIHRGANLADG-KVVGDSIACP
Mvan_1001|M.vanbaalenii_PYR-1 RAVPLKILHEELTLYRGEDGVAHIVAGRCAHRGVLLAVG-TVEGDCVRCR
: .*. : * * * * :. * * .: : *
MMAR_3971|M.marinum_M WHGWQWRGD-GTNALIPYSKI--GCKNNVGIRSYPSIQWYGFILVWHERH
MUL_3829|M.ulcerans_Agy99 WHGWQWRGD-GTNALIPYSKI--GCKKNVRIRSYPSIQWYGFILVWQERH
MAV_1638|M.avium_104 WHGWQWRGD-GSNALIPYSKI--GCKNNVRIRTYPSMEWYGFVLAWHERH
Mflv_4333|M.gilvum_PYR-GCK FHGWRWGPD-GSNTYIPYQPD--RPNRGLRLRSYPVEEQYGCIFMWYQPQ
TH_4222|M.thermoresistible__bu FHGWRWGPD-GRNTHIPYQPD--RPNKALTLRVYPVLEQYDCVFIWHHPH
Mb3556|M.bovis_AF2122/97 FHDWRWGGD-GRCKLVPYAR---RTPRMARTRSWTTDVRSGLLFVWHDHE
Rv3526|M.tuberculosis_H37Rv FHDWRWGGD-GRCKLVPYAR---RTPRMARTRSWTTDVRSGLLFVWHDHE
MAB_0080c|M.abscessus_ATCC_199 FHDWRWGGD-GRCKKVPYSR---RTPKLARTATWITLEQDGMLFIWHDPQ
MSMEG_4372|M.smegmatis_MC2_155 YHGWQFDGQTGQCSAIPSLKEGGRIPPKAAIKSYPVIERFEHVWTCLG--
Mvan_1001|M.vanbaalenii_PYR-1 YHGWRYDGA-GQCVDQPAERR--SFADKVRIASYPVEEYFGFIWTYLGES
:*.*:: * * : :
MMAR_3971|M.marinum_M --GRPPYWEPP----VLPELETN---EYYPLHPHTRMLNRVKVHPQMIIE
MUL_3829|M.ulcerans_Agy99 --GRPPYWQPP----VLPELETN---EYYSLHPHTRMLNRVKVHPQMIIE
MAV_1638|M.avium_104 --GRAPYWQPP----VLPELETG---EYYPLHPHTQMVNRVKVHPQMIIE
Mflv_4333|M.gilvum_PYR-GCK --GKEPQWELPDIFHKFPQFETDANAYYRPYPEFSSRADAIPVHPQIVAE
TH_4222|M.thermoresistible__bu --GKEPQWEMPDIFRSFPQFDTDPQRYYRPYPEFSRFAGNEPVHPQIVAE
Mb3556|M.bovis_AF2122/97 --GNPPDPAVR-----IPEIPEAASDEWTDWRWNRILIEG--SNCRDIID
Rv3526|M.tuberculosis_H37Rv --GNPPDPAVR-----IPEIPEAASDEWTDWRWNRILIEG--SNCRDIID
MAB_0080c|M.abscessus_ATCC_199 --GNPPPEDVA-----IPRIEGATSPEWTDWHWYTTVVN---TNCREIID
MSMEG_4372|M.smegmatis_MC2_155 ----DPVFDLP-----NPPEIADLELEWRPADPIHADCG-----FMAATE
Mvan_1001|M.vanbaalenii_PYR-1 PVPELPRWPELEEYGRFHVIEHRKWNYFHDLENTVDDVHQYWVHKTGIYQ
* : :
MMAR_3971|M.marinum_M NAADPYHVQYVHKAASPANTASFE--VSGYHLHATVNANFGGGRTKTWLT
MUL_3829|M.ulcerans_Agy99 NAADPYHVQYVHKAASPANTASFE--VSGYHLHATVNANFGGGRTKTWLT
MAV_1638|M.avium_104 NAADPYHVQYVHKAANPATTASFE--VSGYHLHATVNAHFGGGRAQTWLT
Mflv_4333|M.gilvum_PYR-GCK NGPDSSHFRYVHGATVTPVCLHWE--HVDEEWRFLT------GWPDARSD
TH_4222|M.thermoresistible__bu NGPDSAHFRYVHRATVTPRMLEWK--IVDQQWQFLT------GWPAESSD
Mb3556|M.bovis_AF2122/97 NVTDMAHFFYIHFGLPTYFKNVFEGHIASQYLHNVGRPDVDD-LGTSYGE
Rv3526|M.tuberculosis_H37Rv NVTDMAHFFYIHFGLPTYFKNVFEGHIASQYLHNVGRPDVDD-LGTSYGE
MAB_0080c|M.abscessus_ATCC_199 NVVDMAHFFYVHGAVPTYFKNIFEGHIATQYMN-TGEPRADLPIPEGVQM
MSMEG_4372|M.smegmatis_MC2_155 NFRDMAHFPFVHEPSMGDVNPVVPDLEVKREGREVWASYFYAQVEESDFS
Mvan_1001|M.vanbaalenii_PYR-1 DDGNAGQIPEMSAELADFGLTQTSTFSNGFVRRLALLMPNTLYFNSGAGV
: : :. : .
MMAR_3971|M.marinum_M PNGPVDAKIIYDNYSLGLGIVRFPSELVATVQVTGQTPVDEDYTDYFYTQ
MUL_3829|M.ulcerans_Agy99 PNGPVDAKIVYDNYSLGLGIVRFPSELVATVQVTGQTPVDEDYTDYFYTQ
MAV_1638|M.avium_104 PNGPVDAKIIYDNYSLGLGVVRFPSELVATVQVTGQTPVDEDYTDYFYTQ
Mflv_4333|M.gilvum_PYR-GCK DPDKMALRIHSHFSGLGFAMSAFE-GSSNHRLIFACTPVDDEVSDMFYSI
TH_4222|M.thermoresistible__bu DPDKMALRIHSHMFGLGGAISAFE-GASNHRLIFAVTPVDDEYSNMFYSI
Mb3556|M.bovis_AF2122/97 AHLDSEASYFGPSFMINWLHNRYGNYKSESILINCHYPVTQNSFVLQWGV
Rv3526|M.tuberculosis_H37Rv AHLDSEASYFGPSFMINWLHNRYGNYKSESILINCHYPVTQNSFVLQWGV
MAB_0080c|M.abscessus_ATCC_199 TGQTSVASYYGPSFMIDDLTYHFVGYDSNSILINCHYPIDANSFVLQYGI
MSMEG_4372|M.smegmatis_MC2_155 GVGDAWMHYHSYAPGIATILYDFGPEIGKRYLVDFPSPVSYDKCIIFWGV
Mvan_1001|M.vanbaalenii_PYR-1 LRGFKSFLWNVPIDDENHMMFFLFIAAHLPPDVGARLAAGVREGRKYLSQ
: .
MMAR_3971|M.marinum_M ASIREPGDAGDVPTG-RAARFLALQQEVIKQDFFTWENMKYLEKPNLAPE
MUL_3829|M.ulcerans_Agy99 ASIRELGDAGDVPTG-RAARFLALQQEVIKQDFFTWENMKYLEKPYLAPE
MAV_1638|M.avium_104 ASVREPGDTGDVPTG-RAARFLALQKEVIKQDFFTWENMKYLEKPNLAPE
Mflv_4333|M.gilvum_PYR-GCK WWPKLPGETSDIPPAEVIEKVERQFLKTVWEDCDIWRYQKYVENPPLAKI
TH_4222|M.thermoresistible__bu WWPRNPGDPSDVPPDDVRARVEKQYLVTVWDDLEIWRYQKYVENPALSRV
Mb3556|M.bovis_AF2122/97 IVEKPKGMSEEMTDK-LSRVFTEGVSKGFLQDVEIWKHKTRIDNPLLVEE
Rv3526|M.tuberculosis_H37Rv IVEKPKGMSEEMTDK-LSRVFTEGVSKGFLQDVEIWKHKTRIDNPLLVEE
MAB_0080c|M.abscessus_ATCC_199 IVKKSAGLSDDDALA-AAITLGDWIKAGFEQDVQIWKNKARIDNPLLCEE
MSMEG_4372|M.smegmatis_MC2_155 ATDKDFR--GGTVDEILEIETKVFNEDTPVLEGLEPKEVPLAGQAFEVSA
Mvan_1001|M.vanbaalenii_PYR-1 LRPVDDIIRAVLSGRERWEDIEDRPDQVLIEDGVVLLGQGVLPDRSLNRL
: .
MMAR_3971|M.marinum_M EAR--DYAALRRWAHRFYPAAQTSTADFGYTADGLPDPAASKA-------
MUL_3829|M.ulcerans_Agy99 EAR--DYAALRRWAHRFYPGAQTSPADFGYTADGLPDPAASKA-------
MAV_1638|M.avium_104 EAH--DYAALRRWAHRFYPGPQPAPTDFGYTADGEPDPAAAKA-------
Mflv_4333|M.gilvum_PYR-GCK DAK--PYMAMRKWAQRFYEVPPVG------------DPVASR--------
TH_4222|M.thermoresistible__bu DAK--PYMALRKWAQQFYEVAPTG------------APAGLP--------
Mb3556|M.bovis_AF2122/97 DG---AVYQLRRWYEQFYVDVADIKPEMVERFEIEVDTKRANEFWNAEVE
Rv3526|M.tuberculosis_H37Rv DG---AVYQLRRWYEQFYVDVADIKPEMVERFEIEVDTKRANEFWNAEVE
MAB_0080c|M.abscessus_ATCC_199 DG---PVYQLRRWYEQFYVDVADVTAEMTDRFEYEVDTTRPGEAWKAQVE
MSMEG_4372|M.smegmatis_MC2_155 PAD--IYTLNYRRATQFAVQTIRQERGLDAGTDTEADAANAQTNGHARAA
Mvan_1001|M.vanbaalenii_PYR-1 GSSDAAIILLRRLYARELAAIEAGHPLTKFPTPDAAALTRLDSSTP----
. : :
MMAR_3971|M.marinum_M -----------------
MUL_3829|M.ulcerans_Agy99 -----------------
MAV_1638|M.avium_104 -----------------
Mflv_4333|M.gilvum_PYR-GCK -----------------
TH_4222|M.thermoresistible__bu -----------------
Mb3556|M.bovis_AF2122/97 KNLKSREVSDDVPAEQH
Rv3526|M.tuberculosis_H37Rv KNLKSREVSDDVPAEQH
MAB_0080c|M.abscessus_ATCC_199 ENLAA--MAGGAPS---
MSMEG_4372|M.smegmatis_MC2_155 TAAPAQ-----------
Mvan_1001|M.vanbaalenii_PYR-1 -----------------