For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
KQDVLTPEKLREAYQHVWFVVARSCDIDTPQSATLLDHNLVVFRDSTGAARVTDRRCIHRGANLADGKVV GDSIACPYHGWQFDGQTGQCSAIPSLKEGGRIPPKAAIKSYPVIERFEHVWTCLGDPVFDLPNPPEIADL ELEWRPADPIHADCGFMAATENFRDMAHFPFVHEPSMGDVNPVVPDLEVKREGREVWASYFYAQVEESDF SGVGDAWMHYHSYAPGIATILYDFGPEIGKRYLVDFPSPVSYDKCIIFWGVATDKDFRGGTVDEILEIET KVFNEDTPVLEGLEPKEVPLAGQAFEVSAPADIYTLNYRRATQFAVQTIRQERGLDAGTDTEADAANAQT NGHARAATAAPAQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4372 | - | - | 100% (364) | capreomycidine hydroxylase |
| M. smegmatis MC2 155 | MSMEG_2870 | - | 6e-16 | 33.33% (156) | oxygenase KshA |
| M. smegmatis MC2 155 | MSMEG_5925 | - | 1e-14 | 27.49% (251) | Rieske (2Fe-2S) domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3556 | - | 6e-16 | 27.31% (271) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_4566 | - | 1e-15 | 31.85% (157) | Rieske (2Fe-2S) domain-containing protein |
| M. tuberculosis H37Rv | Rv3526 | - | 6e-16 | 27.31% (271) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3627c | - | 1e-14 | 29.39% (245) | oxidoreductase |
| M. marinum M | MMAR_5015 | - | 2e-16 | 27.31% (271) | oxidoreductase |
| M. avium 104 | MAV_0633 | - | 3e-17 | 26.85% (298) | Rieske (2Fe-2S) domain-containing protein |
| M. thermoresistible (build 8) | TH_0323 | - | 8e-16 | 32.05% (156) | POSSIBLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_4089 | - | 2e-16 | 27.31% (271) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_1001 | - | 6e-18 | 37.50% (160) | Rieske (2Fe-2S) domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3556|M.bovis_AF2122/97 ------MSTDTSGVGVREIDAGALPTRYARG-WHCLGVAKDYLEGKPHGV
Rv3526|M.tuberculosis_H37Rv ------MSTDTSGVGVREIDAGALPTRYARG-WHCLGVAKDYLEGKPHGV
MMAR_5015|M.marinum_M ------MSTDTTAVGVREIDAGILPNRYARG-WHCLGVAKDFMDGKPHGV
MUL_4089|M.ulcerans_Agy99 ------MSTDTTAVGVREIDAGILPNRYARG-WHCLGVAKDFMDGKPHGV
MAV_0633|M.avium_104 ------MATDTKPVGIREIDPGALPTRYARG-WHCLGVAKDFQDGKPHSI
MAB_3627c|M.abscessus_ATCC_199 -------MTDG---AIREIDSGAPMTRFARG-WHCLGLAETFLDGQPHGI
Mflv_4566|M.gilvum_PYR-GCK -MGMTVQPP---ADEVRLIEADAAPTRFARG-WHCLGLIRDFGDGTPHQV
TH_0323|M.thermoresistible__bu MAGMTSLQSDRDTGEVRQIEAQAVPTRFARG-WHCLGLIDDLGDGKPHAI
MSMEG_4372|M.smegmatis_MC2_155 -------------MKQDVLTPEKLREAYQHV-WFVVARSCDID--TPQSA
Mvan_1001|M.vanbaalenii_PYR-1 -------MNSLKDPDFEHTGPGRPAGHLLRQRWQPVYASEELEAGRAVPL
. : * : .
Mb3556|M.bovis_AF2122/97 EAFGTKLVVFADSHGDLKVLDGYCRHMGGDLSEGTVKGDEVACPFHDWRW
Rv3526|M.tuberculosis_H37Rv EAFGTKLVVFADSHGDLKVLDGYCRHMGGDLSEGTVKGDEVACPFHDWRW
MMAR_5015|M.marinum_M EAFGTKLVVFTDSHGDLKILDSYCRHMGGDLSEGTIKGDEVACPFHDWRW
MUL_4089|M.ulcerans_Agy99 EAFGTKLVVFTDSHGDLKILDSYCRHMGGDLSEGTIKGDEVACPFHDWRW
MAV_0633|M.avium_104 EAFGTKLVVFADSHGDIHVLDGYCRHMGGDLSEGTIKGDEVACPFHDWRW
MAB_3627c|M.abscessus_ATCC_199 EAFGTKLVVFADSHGDIKVLDGYCRHMGGDLSQGTVKDDTVACPFHDWRW
Mflv_4566|M.gilvum_PYR-GCK NAFGQKLVVFRAEDGSINVLDSYCRHMGGDLSQGTVKGNEIACPFHDWRW
TH_0323|M.thermoresistible__bu NAFGGKLVVFRGGDGKINVLDAYCRHMGGDLSDGEVKGNEIACPFHDWRW
MSMEG_4372|M.smegmatis_MC2_155 TLLDHNLVVFRDSTGAARVTDRRCIHRGANLADGKVVGDSIACPYHGWQF
Mvan_1001|M.vanbaalenii_PYR-1 KILHEELTLYRGEDGVAHIVAGRCAHRGVLLAVGTVEGDCVRCRYHGWRY
: :*.:: * .: * * * *: * : .: : * :*.*::
Mb3556|M.bovis_AF2122/97 GGD-GRCKLVPYAR---RTPRMARTRSWTTDVRSGLLFVWHDHEGNPPDP
Rv3526|M.tuberculosis_H37Rv GGD-GRCKLVPYAR---RTPRMARTRSWTTDVRSGLLFVWHDHEGNPPDP
MMAR_5015|M.marinum_M GGD-GRCKLVPYAK---RTPRMARTRSWTTDVRGGLLFVWHDHEGNPPDP
MUL_4089|M.ulcerans_Agy99 GGD-GRCKLVPYAK---RTPRMARTRSWTTDVRGGLFFVWHDHEGNPPDP
MAV_0633|M.avium_104 GGD-GRCKLVPYAK---RTPKTARTRSWTTDVRGGLLFVWHDHENNPPDP
MAB_3627c|M.abscessus_ATCC_199 GGD-GRCTLVPYAK---RTPKLARTRSWPTLEVNGQLLVWHDPEGSAPPA
Mflv_4566|M.gilvum_PYR-GCK GGD-GRCKQVPYAK---RVPRLARTQTWPTLEQDGMLFVWNDPQRKPPPD
TH_0323|M.thermoresistible__bu GGD-GRCKKVPYSR---RVPKLARTATWPTLEQDGMLFVWNDPENNPPPP
MSMEG_4372|M.smegmatis_MC2_155 DGQTGQCSAIPSLKEGGRIPPKAAIKSYPVIER--FEHVWTCLG----DP
Mvan_1001|M.vanbaalenii_PYR-1 DGA-GQCVDQPAERR--SFADKVRIASYPVEEY--FGFIWTYLGESPVPE
.* *:* * : . . ::.. :*
Mb3556|M.bovis_AF2122/97 AVRIPEIPEAASDEWTDWRWNRILIEGSNCRDIIDNVTDMAHFFYIHFGL
Rv3526|M.tuberculosis_H37Rv AVRIPEIPEAASDEWTDWRWNRILIEGSNCRDIIDNVTDMAHFFYIHFGL
MMAR_5015|M.marinum_M AVRIPEIPEAASDDWTQWRWNRILIEGSNCRDIIDNVTDMAHFFYIHFGL
MUL_4089|M.ulcerans_Agy99 AVRIPEIPEAASDDWTQWRWNRILIEGSNCRDIIDNVTDMAHFFYIHFGL
MAV_0633|M.avium_104 AVRIPEIPEAHSDEWTDWRWNRILIEGSNCRDIIDNVTDMAHFFYIHFGL
MAB_3627c|M.abscessus_ATCC_199 ELTPPTIEGYGEGKWSPWQWNSILIEGSHCREIVDNNVDMAHFFYIHHAY
Mflv_4566|M.gilvum_PYR-GCK DVTIPRIEGATSDEWTDWHWYTTVVH-TNCREIIDNVVDMAHFFYIHGSL
TH_0323|M.thermoresistible__bu DVTIPRIEGVGTDRWTDWHWYSTVVH-TNCREIIDNIVDMAHFFYIHGGL
MSMEG_4372|M.smegmatis_MC2_155 VFDLPNPPEIA-DLELEWRPADPIHADCGFMAATENFRDMAHFPFVHEPS
Mvan_1001|M.vanbaalenii_PYR-1 LPRWPELEEYGRFHVIEHRKWNYFHDLENTVDDVHQYWVHKTGIYQDDGN
* : . .: : .
Mb3556|M.bovis_AF2122/97 PTYFKNVFEGHIASQYLHNVGRPD-VDDLGTSYGEAHLDSEASYFGPSFM
Rv3526|M.tuberculosis_H37Rv PTYFKNVFEGHIASQYLHNVGRPD-VDDLGTSYGEAHLDSEASYFGPSFM
MMAR_5015|M.marinum_M PTYFKNVFEGHIASQYLHNVGRPD-VDDLGTAYGEAHLDSEASYFGPSFM
MUL_4089|M.ulcerans_Agy99 PTYFKNVFEGHIASQYLHNVGRPD-VDDLGTAYGEAHLDSEASYFGPSFM
MAV_0633|M.avium_104 PTYFKNVFEGHIASQYLHNVGRPD-VNDLGTSYGEAHLDSEASYFGPSFM
MAB_3627c|M.abscessus_ATCC_199 PTYFKNVIEGQTASQFMESKPRPDYVPNPEKLWEGTGVRSEATYFGPAYM
Mflv_4566|M.gilvum_PYR-GCK PTQFKNIFEGHTATQFMSSGGRPD-LGQAEGGVKLLGTTSLAAYHGPSFM
TH_0323|M.thermoresistible__bu PTEFKNVFEGHVATQYYKSEARPD-LGSGEG-AKILGTTSVASYYGPSFM
MSMEG_4372|M.smegmatis_MC2_155 MGDVNPVVPDLEVKREGREVWASYFYAQVEESDFSGVGDAWMHYHSYAPG
Mvan_1001|M.vanbaalenii_PYR-1 AGQIPEMSAELADFGLTQTSTFSN---GFVRRLALLMPNTLYFNSGAGVL
. : . : . .
Mb3556|M.bovis_AF2122/97 INWLHNRYG-NYKSESILINCHYPVTQNSFVLQWGVIVEKPKGMSEEMTD
Rv3526|M.tuberculosis_H37Rv INWLHNRYG-NYKSESILINCHYPVTQNSFVLQWGVIVEKPKGMSEEMTD
MMAR_5015|M.marinum_M INWLHNSYG-GYKSESILINCHYPVTQDSFVLQWGVIVEKPKGMDEKMTD
MUL_4089|M.ulcerans_Agy99 INWLHNSYG-GYKSESILINCHYPVTQDSFVLQWGVIVEKPKGMDEKMTD
MAV_0633|M.avium_104 INWLHNSYG-DYKAESILINCHYPVTQNSFVLQWGVIVEKPKGMDEEMTD
MAB_3627c|M.abscessus_ATCC_199 IDWIHNDLGPGFTVEVALINCHYPVTHDSFVLQWGVAIQEMPDLPPDNAR
Mflv_4566|M.gilvum_PYR-GCK IDDLTYHYEHGDTK-TVLINCHYPIDANSFVLQYGIVVQKSADLPEDLAV
TH_0323|M.thermoresistible__bu IDDLTYHYEHGDQR-TVLINCHYPIDANSFVLQYGITVEISDTAPRDIAM
MSMEG_4372|M.smegmatis_MC2_155 IATILYDFG-PEIGKRYLVDFPSPVSYDKCIIFWGVATDK------DFRG
Mvan_1001|M.vanbaalenii_PYR-1 RGFKSFLWNVPIDDENHMMFFLFIAAH----LPPDVGARLAAGVREGRKY
:: : .:
Mb3556|M.bovis_AF2122/97 KLSRVFTEGVSKGFLQDVEIWKHKTRIDNPLLVEEDGAVYQLRRWYEQFY
Rv3526|M.tuberculosis_H37Rv KLSRVFTEGVSKGFLQDVEIWKHKTRIDNPLLVEEDGAVYQLRRWYEQFY
MMAR_5015|M.marinum_M KLSRVFTEGVSKGFLQDVEIWKHKTRIDNPLLVEEDGAVYQMRRWYEQFY
MUL_4089|M.ulcerans_Agy99 KLSRVFTEGVSKGFLQDVEIWKHKTRIDNPLLVEEDGAVYQMRRWYEQFY
MAV_0633|M.avium_104 KLSRVFTEGVSKGFLQDVEIWKHKTRIDNPLLVEEDGAVYQLRRWYQQFY
MAB_3627c|M.abscessus_ATCC_199 KLAAAMAKSFGDGFLEDVEIWKNKTRIDNPLLTHEDGAVYQHRRWYEQFY
Mflv_4566|M.gilvum_PYR-GCK QTAVALGDFVKMGFEQDVQIWRNKARIDNPLLVEEDGPVYQLRRWYEQFY
TH_0323|M.thermoresistible__bu QMAVALGDFVKMGFEQDVAIWKRKARIDNPLLCEEDGPVYQVRRWYEQFY
MSMEG_4372|M.smegmatis_MC2_155 GTVDEILEIETKVFNEDTPVLEGLEPKEVPLAG-QAFEVSAPADIYTLNY
Mvan_1001|M.vanbaalenii_PYR-1 LSQLRPVDDIIRAVLSGRERWEDIEDRPDQVLIEDGVVLLGQGVLPDRSL
. . .. . : : :
Mb3556|M.bovis_AF2122/97 VDVADIKPEMVERFEIEVDTKRANEFWNAEVEKNLKSR--------EVSD
Rv3526|M.tuberculosis_H37Rv VDVADIKPEMVERFEIEVDTKRANEFWNAEVEKNLKSR--------EVSD
MMAR_5015|M.marinum_M VDAADVTPEMVERFEMEVDTTRANEFWRAEVQQNLETKKLQEQQAESVPD
MUL_4089|M.ulcerans_Agy99 VDAADVTPEMVERFEMEVDTTRANEFWRAEVQQNLETKKLQEQQAESVPD
MAV_0633|M.avium_104 VDVADIEPEMVERFEIEVDTTRANEYWNAEVAQNLKAK---------ESE
MAB_3627c|M.abscessus_ATCC_199 VDLADVTSDMTERFELEVDTTHAHGVWVHEVEENLVEH------------
Mflv_4566|M.gilvum_PYR-GCK VDVEDVTPDMVDRFEFEIDTTRPRESWMKEVEDNIAAG--------RIPK
TH_0323|M.thermoresistible__bu VDVADVTPDMVDRFEFEIDTTRPREAWMKEVEDNIAAG--------RLPR
MSMEG_4372|M.smegmatis_MC2_155 RRATQFAVQTIR-QERGLDAGTDTEADAANAQTNGHAR---------AAT
Mvan_1001|M.vanbaalenii_PYR-1 NRLGSSDAAIILLRRLYARELAAIEAGHPLTKFPTPDA--------AALT
. . .
Mb3556|M.bovis_AF2122/97 DVPAEQH
Rv3526|M.tuberculosis_H37Rv DVPAEQH
MMAR_5015|M.marinum_M DVPAEQH
MUL_4089|M.ulcerans_Agy99 DVPAEQH
MAV_0633|M.avium_104 DVPAEQH
MAB_3627c|M.abscessus_ATCC_199 -AATASH
Mflv_4566|M.gilvum_PYR-GCK LASGTT-
TH_0323|M.thermoresistible__bu LVGVNK-
MSMEG_4372|M.smegmatis_MC2_155 AAPAQ--
Mvan_1001|M.vanbaalenii_PYR-1 RLDSSTP