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ELLLVVVGAILVTAIAHHRGFEPALMIVVVGSAVSFLPDFEPPELDSHILLSVVLPPLLYSAALNFSFPT FLRHIRPILGLGVGLVVVSAFAVAAVSSWLVIVPLTFGTALVLGAIVAPPDAVTAVAVGRKLGLPKRMMA ILTGESLINDAAALTLFSIAVTQVAGGHIFIENPLLLFGYSATVGPLVGAVLGYVTLWIRKRLANPGLET VQGLVVPFAAFITAEELHASGVLAVVVAGFVVGNGNLGAGYQTRLQERYVWNSVDVLLEAFVFAYIGLHL RFVLEHLNEAHESLTEVITASAVVLLIVLVIRPLSVFAIFGRNKLSRHVEKKLSVPAPDGSRSSLGAAVR KQRKKKRRANWRTMVDRRTLSWQENVVLSWTGMRGVVTLAAAAAIPAYTESGEPFPERATIQAIAFVVAV GTLLLQGSTLPWLIRKLHISRFNDDHEADRAEEVKAERVAHDAAEKILVEFQANPPANLNPALVEEIYIR IARHTQDVDEMPDPEAPIKRAAAFTTLYREVLAAQRAALIDQRDAGHIEDEAVRAMLERLDLQEAGVTAR LESRL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4682 | - | - | 100% (566) | Na+/H+ antiporter |
| M. smegmatis MC2 155 | MSMEG_0764 | - | 2e-92 | 39.65% (565) | Na+/H+ antiporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2309 | yjcE | 2e-49 | 27.43% (565) | integral membrane transport protein YjcE |
| M. gilvum PYR-GCK | Mflv_2583 | - | 0.0 | 75.61% (570) | sodium/hydrogen exchanger |
| M. tuberculosis H37Rv | Rv2287 | yjcE | 2e-49 | 27.43% (565) | integral membrane transport protein YjcE |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4246 | - | 6e-92 | 37.96% (569) | putative Na+/H+ antiporter |
| M. marinum M | MMAR_3437 | yjcE | 6e-52 | 27.30% (564) | integral membrane transport protein YjcE |
| M. avium 104 | MAV_3491 | - | 1e-66 | 33.75% (563) | Na+/H+ antiporter |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_3177 | - | 6e-25 | 27.49% (491) | potassium/proton antiporter |
| M. vanbaalenii PYR-1 | Mvan_4050 | - | 0.0 | 76.15% (566) | sodium/hydrogen exchanger |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2583|M.gilvum_PYR-GCK ------------------------MSLENLPVELILVVVGAIVVT-AMAQ
Mvan_4050|M.vanbaalenii_PYR-1 -------------------------------MELILVVVGAIVVT-AIAQ
MSMEG_4682|M.smegmatis_MC2_155 -------------------------------MELLLVVVGAILVT-AIAH
MAB_4246|M.abscessus_ATCC_1997 MIHAETAASYLSSRMPTWMLQPLCAQNTNVNVSLLAVLTAALVLA-AISR
MAV_3491|M.avium_104 ----------------------MSSMGAQTALTLLLAAIAVIVLVDWISE
Mb2309|M.bovis_AF2122/97 ----------------MNGRRTIGEDGLVFGLVVIVALVAAVVVGTVLGH
Rv2287|M.tuberculosis_H37Rv ----------------MNGRRTIGEDGLVFGLVVIVALVAAVVVGTVLGH
MMAR_3437|M.marinum_M ----------------------------MFGLVVIVALVATVVIGTVLGR
MUL_3177|M.ulcerans_Agy99 ----------------------MSLQQLYLAMLIGGFVLLASIVGTRLAT
: : . :: :.
Mflv_2583|M.gilvum_PYR-GCK RRGLEPALVIVVVGIAVS---FIPGFEAPELDSHILLSVVLPPLLYSAAL
Mvan_4050|M.vanbaalenii_PYR-1 RRGLEPALIIVVVGIAVS---FVPGFEAPELDSHILLSVVLPPLLYSAAL
MSMEG_4682|M.smegmatis_MC2_155 HRGFEPALMIVVVGSAVS---FLPDFEPPELDSHILLSVVLPPLLYSAAL
MAB_4246|M.abscessus_ATCC_1997 RFGLATPLVLVVTGLAAT---AIPGLPSIEMDPDLVLFVILPPLLYTTAL
MAV_3491|M.avium_104 RTRLPSATLLVLVGIGQA---LLPG-PTIGLEPDVVMTCILPPLLYHAAL
Mb2309|M.bovis_AF2122/97 RYRVGPPVLLILSGSLLG---LIPRFGDVQIDGEVVLLLFLPAILYWESM
Rv2287|M.tuberculosis_H37Rv RYRVGPPVLLILSGSLLG---LIPRFGDVQIDGEVVLLLFLPAILYWESM
MMAR_3437|M.marinum_M RYRVGPPVLLILLGALLG---LVPRFGDVQIDGEIVLLLFLPAILYWESL
MUL_3177|M.ulcerans_Agy99 RVGFPSMLLFLLVGVIVGEDGFGLRFDDVELARNMG-TAALAVILVEGGL
: . . :::: * : .: *. :* .:
Mflv_2583|M.gilvum_PYR-GCK NFSFPTFLRNIKPILGLGVGLVVVTAFTVAMVSAWLVVVPLTFATALVLG
Mvan_4050|M.vanbaalenii_PYR-1 DFSFPTFLRNIKPILGLGVGLVVVTAFTVAAVSSWLVVVPLTFATALVLG
MSMEG_4682|M.smegmatis_MC2_155 NFSFPTFLRHIRPILGLGVGLVVVSAFAVAAVSSWLVIVPLTFGTALVLG
MAB_4246|M.abscessus_ATCC_1997 ESSYVNLRKNVRAVASLAVLLPLVTTVAVGFV-AFYAVPELPLAGAMVLG
MAV_3491|M.avium_104 ESSLVGIRRNLRTVVSLSVVLVLLTAASVGVAFSLLVGG-ATLAVGMVLG
Mb2309|M.bovis_AF2122/97 NTSFREIRWNLRVIVMFSIGLVIATAVAVSWT---ARALGMESHAAAVLG
Rv2287|M.tuberculosis_H37Rv NTSFREIRWNLRVIVMFSIGLVIATAVAVSWT---ARALGMESHAAAVLG
MMAR_3437|M.marinum_M NTSFRELRWNLRIVIMFSIGLVIATAVAVSWT---ARALGMESHAAAVLG
MUL_3177|M.ulcerans_Agy99 TTRFSDIRKVLAPAATLATVGVMVSMVVTAVG--VHLVLGVSWQPALLLG
: : :. : : .. . :**
Mflv_2583|M.gilvum_PYR-GCK AIVAPPDAVTAVAVGRKLGLPKRVMTILTGESLINDAAALALFSVAVAQV
Mvan_4050|M.vanbaalenii_PYR-1 AVVAPPDAVTAVAVGRKLGLPKRVMSILTGESLINDAAALALFSVAVAQV
MSMEG_4682|M.smegmatis_MC2_155 AIVAPPDAVTAVAVGRKLGLPKRMMAILTGESLINDAAALTLFSIAVTQV
MAB_4246|M.abscessus_ATCC_1997 AIVAPPDAVSATAIGRRLGLPRNIMTLLGGESLLNDATALTAYRVAIAAA
MAV_3491|M.avium_104 AAVAPTDPVAALAVARKEGLPLNIVTLIEGEGLLNDATALTTLAVAVTVA
Mb2309|M.bovis_AF2122/97 AVLSPTDAAAVAGLAKR--LPRRALTVLRGESLINDGTALVLFAVTVAVA
Rv2287|M.tuberculosis_H37Rv AVLSPTDAAAVAGLAKR--LPRRALTVLRGESLINDGTALVLFAVTVAVA
MMAR_3437|M.marinum_M AVLSPTDAAAVAGLAKR--LPRRALTVLRGESLINDGTALVLFAVTVAVA
MUL_3177|M.ulcerans_Agy99 AIVSSTDAAAVFSVLRVLPLPRRVAGLLEAESGFNDAPAVILVLMFSEVP
* ::..*..:. .: : ** . :: .*. :**..*: :
Mflv_2583|M.gilvum_PYR-GCK AGSHTFIENPLL-LFTYSAVLGPLVGAALGYITLWIRRRLAHPALET--V
Mvan_4050|M.vanbaalenii_PYR-1 AGSHTFIENPLL-LFAYSAVLGPLVGAALGYITLWIRRRLANPALET--V
MSMEG_4682|M.smegmatis_MC2_155 AGGHIFIENPLL-LFGYSATVGPLVGAVLGYVTLWIRKRLANPGLET--V
MAB_4246|M.abscessus_ATCC_1997 IGLGATVADGFR-IFALAAVGGVFVGFVIGKLVNIIRCKLDDPLSES--A
MAV_3491|M.avium_104 RGAAFSAPSAIR-EFVLAAVGGLVVGQVFAYARRLLRRWRHDVLTAN--A
Mb2309|M.bovis_AF2122/97 EGAAGIGPAALVGRFVVSYLGGIMAGLLVGGLVTLLRRRIDAPLEEG--A
Rv2287|M.tuberculosis_H37Rv EGAAGIGPAALVGRFVVSYLGGIMAGLLVGGLVTLLRRRIDAPLEEG--A
MMAR_3437|M.marinum_M EGSAQLGPAALAGRFVVSYLGGIVAGLLVGGLVTMLRRKIDAPLEEG--A
MUL_3177|M.ulcerans_Agy99 F---AFRPAAALEALVFELLVGAAIGLAIGYLGAFTLRRIALPASGLYPI
: * * ..
Mflv_2583|M.gilvum_PYR-GCK QGLMVPFAAFILAEEMHASGVLAVVVAGFIVGSGT--VDAGYQTRLQERY
Mvan_4050|M.vanbaalenii_PYR-1 QGLMVPFAAFILAEEMHASGVLAVVVAGFVVGSGT--VDAGYQTRLQERF
MSMEG_4682|M.smegmatis_MC2_155 QGLVVPFAAFITAEELHASGVLAVVVAGFVVGNGN--LGAGYQTRLQERY
MAB_4246|M.abscessus_ATCC_1997 IGLVVPFFAYLLAEEIHGSGVIAVVVAGLMLGHRS--VHAGYATRLQDDA
MAV_3491|M.avium_104 ISLATPFLTYLVAEKLSASGVLAVVVCGLIVGHDSPRVESG-ASRLQTRA
Mb2309|M.bovis_AF2122/97 LSLLTPFAAFLLAQSLKCSGVVAVLVSALVLTYVG-PTVIRARSRLQAHA
Rv2287|M.tuberculosis_H37Rv LSLLTPFAAFLLAQSLKCSGVVAVLVSALVLTYVG-PTVIRARSRLQAHA
MMAR_3437|M.marinum_M LSLLTPFAAFLLAQSMHCSGVVAVLISALVLTYTG-PRVIRARSRMQSYA
MUL_3177|M.ulcerans_Agy99 ATFGLGLVAFAAAGESHASGFIAAYLAAVVLANTG------LPHRAATRS
: : :: * . **.:*. :...:: *
Mflv_2583|M.gilvum_PYR-GCK VWNSVDVLLEAFVFAYIGLHLRFVLEDLRDAHESLVQVAVASVVVLLIVL
Mvan_4050|M.vanbaalenii_PYR-1 VWNSVDVLLEVFVFAYIGLHLRFVLEDLQQAHESLTQVAVASAVVLLIVL
MSMEG_4682|M.smegmatis_MC2_155 VWNSVDVLLEAFVFAYIGLHLRFVLEHLNEAHESLTEVITASAVVLLIVL
MAB_4246|M.abscessus_ATCC_1997 VWKAVQLLLESFAFLLIGLQLPKVVAGLRG--LSFNTIVLSSVAVLTTVI
MAV_3491|M.avium_104 VWRLVNFLLEGVVFLLIGHQVPVILDELGG--YALSTILVAVGVTVAVVL
Mb2309|M.bovis_AF2122/97 FWDIATFLINGSLWVFVGVQIPGAIDHIAGEDGGLPRATVLALAVTGVVI
Rv2287|M.tuberculosis_H37Rv FWDIATFLINGSLWVFVGVQIPGAIDHIAGEDGGLPRATVLALAVTGVVI
MMAR_3437|M.marinum_M FWDITTFLINGSLWVFVGVQIPGAIDHISNVDGGLRRATFIALAVTGVII
MUL_3177|M.ulcerans_Agy99 FAEGVGWLAQIGLFVLLGLLVEPIEV--------IHDLIAAIVVGLLLLL
. . * : : :* : : . ::
Mflv_2583|M.gilvum_PYR-GCK VIRPLSVFAMFGRRKLANQVEKRLSVPVPERG-RGALGARRRDPD----R
Mvan_4050|M.vanbaalenii_PYR-1 VIRPLSVFAMFGRGVLARQVERRLSVPIPEGGGRGALGVRRQSQP----P
MSMEG_4682|M.smegmatis_MC2_155 VIRPLSVFAIFGRNKLSRHVEKKLSVPAPDGS-RSSLGAAVRKQRKKKRR
MAB_4246|M.abscessus_ATCC_1997 VVRIVFVFAFAYLR--------------PPGQRPSARGV-----------
MAV_3491|M.avium_104 LVRPLWLLLTQALPRSLHTRLGNVDDSATDDAEPRPERTRER--------
Mb2309|M.bovis_AF2122/97 ATRIAWVQATTVLG---------HTVDRVLKKPTRHVGFRQR--------
Rv2287|M.tuberculosis_H37Rv ATRIAWVQATTVLG---------HTVDRVLKKPTRHVGFRQR--------
MMAR_3437|M.marinum_M ATRIVWVEVTTVLG---------VALDRFLKKDTRHVGFRQR--------
MUL_3177|M.ulcerans_Agy99 VARPLSVVLS-----------------------LSGFRIPWR--------
* :
Mflv_2583|M.gilvum_PYR-GCK PRRRFGSDNRTLSWQENVVVSWTGMRGVVTLAAAAAIPATTAAGEPFPER
Mvan_4050|M.vanbaalenii_PYR-1 AKWRSRIDNRALSWQENVVVSWTGMRGVVTLAAAAAIPATTAAGAPFPER
MSMEG_4682|M.smegmatis_MC2_155 ANWRTMVDRRTLSWQENVVLSWTGMRGVVTLAAAAAIPAYTESGEPFPER
MAB_4246|M.abscessus_ATCC_1997 -----------------FVVAWAGMRGVVSLAMAFAVPLSTVTGEPLPGH
MAV_3491|M.avium_104 -----------LSGREIVVLSWAGTRGVVSLAAIFAVPVLTEGNAPFPDR
Mb2309|M.bovis_AF2122/97 -----------------CVTSWAGFRGAVSLAAALAVPMTTNSGAPFPDR
Rv2287|M.tuberculosis_H37Rv -----------------CVTSWAGFRGAVSLAAALAVPMTTNSGAPFPDR
MMAR_3437|M.marinum_M -----------------CITSWAGFRGAVSLAAALAVPMTTHSGAPFPDR
MUL_3177|M.ulcerans_Agy99 ---------------DQVFLSWAGLRGAVPIVLATFPIVAG-----VPDS
. :*:* **.*.:. .*
Mflv_2583|M.gilvum_PYR-GCK ATIQAISFVVAVATLLLQGWTLPLLIRRLKVS-AEADRAYTVAETEKAEL
Mvan_4050|M.vanbaalenii_PYR-1 ATIQAIAFVVSVGTLLLQGWTLPLLIRRLKLS-ADADQAYTSAETQKAEQ
MSMEG_4682|M.smegmatis_MC2_155 ATIQAIAFVVAVGTLLLQGSTLPWLIRKLHISRFNDDHEADRAEEVKAER
MAB_4246|M.abscessus_ATCC_1997 PHIVFLTFVVVVGTLLLHGLTLPWVIRVLGVQ-SDDERKDALAEAAAQDK
MAV_3491|M.avium_104 DLLLFCTLVVVLVTLIGQGVTFGPLVRALGLR---AKTTDELRLRNRARA
Mb2309|M.bovis_AF2122/97 NLIIFVVSVVILVTVLVQGTSLPTVVRWARMPEDVAHANELQLARTRSAQ
Rv2287|M.tuberculosis_H37Rv NLIIFVVSVVILVTVLVQGTSLPTVVRWARMPEDVAHANELQLARTRSAQ
MMAR_3437|M.marinum_M NLIIFVVSVVILVTVLVQGSSLPAVVRWARVPGDVAHADEVQLARTRSAE
MUL_3177|M.ulcerans_Agy99 YRLLNIVFMLVVVFTLVQGPSLRPIAHLLGLI------SREATREIQVEA
: :: : : :* :: : : :
Mflv_2583|M.gilvum_PYR-GCK VVHEAADEVFEVFRAN---PPQGLDPRTLAEIRGIVERHSQDADEMP---
Mvan_4050|M.vanbaalenii_PYR-1 VVHAAADEVLAEFRAN---PPDGLDPRVLAEIGGIVARHSQDADEMP---
MSMEG_4682|M.smegmatis_MC2_155 VAHDAAEKILVEFQAN---PPANLNPALVEEIYIRIARHTQDVDEMP---
MAB_4246|M.abscessus_ATCC_1997 AARAAADRLEELLDDNDGIEDTNVRSRAAEILRHWNTRRRNAAWERLGRS
MAV_3491|M.avium_104 AALRAALDRLDSLDPE---DGADVDPRVIDVVRQQLSAQLERYEHRLTLL
Mb2309|M.bovis_AF2122/97 AALDALPTVADELGVA-----PDLVKHLEKEYEERAVLVMADGADSA---
Rv2287|M.tuberculosis_H37Rv AALDALPTVADELGVA-----PDLVKHLEKEYEERAVLVMADGADSA---
MMAR_3437|M.marinum_M AALEVLPDVASELGVS-----PDLLKRLTKEYEERATIIRENGDDSA---
MUL_3177|M.ulcerans_Agy99 APLDVLDAELVTMTVQ---PPSRLHNVTMLELRLPDPAVITLIIRKG---
. . : :
Mflv_2583|M.gilvum_PYR-GCK ---DPEGRTRRAEVFGQLYRDVLAAQRAALIGERDAGRIDDEAVRAMLER
Mvan_4050|M.vanbaalenii_PYR-1 ---DPEAPTLRAEVFGQLYRDVLAAQRVALIGERDAGRIDEEAVRAMLVR
MSMEG_4682|M.smegmatis_MC2_155 ---DPEAPIKRAAAFTTLYREVLAAQRAALIDQRDAGHIEDEAVRAMLER
MAB_4246|M.abscessus_ATCC_1997 ---DEDAGESPMAAFRNLRLEMLETERAVFIAERDAGNIDDEVLRTVLRG
MAV_3491|M.avium_104 SDVDELPAAPAYEAAVGLRRVAIDAQRDELVRWRDAGMLPDQSLRAIERE
Mb2309|M.bovis_AF2122/97 ----TSDLAERNDLVRRVRLGVLQHQRQAVTTLRNQNLIDDIVLRELQAA
Rv2287|M.tuberculosis_H37Rv ----TSDLAERNDLVRRVRLGVLQHQRQAVTTLRNQNLIDDIVLRELQAA
MMAR_3437|M.marinum_M ----PSDLAQRTDLVRRVRLGVLEHQRHAITALRNQNLIDDIVLREVQAD
MUL_3177|M.ulcerans_Agy99 -----------HTFVPMPDTRIQRGDELLIVTTSTTRAAAESRLRAVSRR
:. . : :* :
Mflv_2583|M.gilvum_PYR-GCK LDLQEAGVSARLESRL
Mvan_4050|M.vanbaalenii_PYR-1 LDLQEAGVSARLESRF
MSMEG_4682|M.smegmatis_MC2_155 LDLQEAGVTARLESRL
MAB_4246|M.abscessus_ATCC_1997 LDLEEA--TMNQADR-
MAV_3491|M.avium_104 LDHEESMLPMG-----
Mb2309|M.bovis_AF2122/97 MDLEEVQLLDPADAE-
Rv2287|M.tuberculosis_H37Rv MDLEEVQLLDPADAE-
MMAR_3437|M.marinum_M MDLEEVQLLDPVEHD-
MUL_3177|M.ulcerans_Agy99 GKLAYWFDEYGEPD--
.