For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
FGLVLIVALVSTVIVGTVIGRRYRVGPPVLLIVLGVLLGLVPQFGHVRIDGEIVLLLFLPAILYWEGLNI SFREIRANARIIVFLSVALVIATAVAVSWTARALGMDPHAAGVLGAVLSPTDAAAVAGLAKKLPRRSLTV LKAESLINDGTALVLFAVSVHVAIGAPAISPPEVTLRFIGSYLGGIAAGLLVGGAVTLVRKRIDAPQEEG ALSLVTPFAAFLLAQSVECSGVVAVVVSALVLAYSGPVVIRARSRLQSYAFWDIATFLLNGSLWVFVGVQ IPGALRGIAGVDGGVRHALFVALVITGVVIVSRIFWGEFTTMLIRLIDRRAVQRERRVGWRQRFVTAWAG FRGAVSLAAAVAVPMTTLSGAPFPDRSLLIFIVTVVILVTVLVQGSTLPAVVRWARLPADVAHAEELQLA RTRAARAALDALPAVADEVGVSDELRRRLHKEYEEKAALVLATENGSPDNRILKTREKVRQVRLGVLEHK RREVTALRNQNRIDDTVLRELQNEMDLEEVQLLAAAADEDDGDTE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2145 | - | - | 100% (536) | Na+/H+ antiporter |
| M. avium 104 | MAV_3491 | - | 8e-67 | 34.12% (554) | Na+/H+ antiporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2309 | yjcE | 0.0 | 72.26% (530) | integral membrane transport protein YjcE |
| M. gilvum PYR-GCK | Mflv_2583 | - | 2e-58 | 29.79% (564) | sodium/hydrogen exchanger |
| M. tuberculosis H37Rv | Rv2287 | yjcE | 0.0 | 72.26% (530) | integral membrane transport protein YjcE |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4246 | - | 1e-68 | 32.66% (542) | putative Na+/H+ antiporter |
| M. marinum M | MMAR_3437 | yjcE | 0.0 | 71.76% (524) | integral membrane transport protein YjcE |
| M. smegmatis MC2 155 | MSMEG_0764 | - | 1e-71 | 35.99% (539) | Na+/H+ antiporter |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_3177 | - | 3e-22 | 27.91% (498) | potassium/proton antiporter |
| M. vanbaalenii PYR-1 | Mvan_4050 | - | 2e-58 | 31.44% (563) | sodium/hydrogen exchanger |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2583|M.gilvum_PYR-GCK ------------------------MSLENLPVELILVVVGAIVVTAMAQR
Mvan_4050|M.vanbaalenii_PYR-1 -------------------------------MELILVVVGAIVVTAIAQR
MAB_4246|M.abscessus_ATCC_1997 MIHAETAASYLSSRMPTWMLQPLCAQNTNVNVSLLAVLTAALVLAAISRR
MSMEG_0764|M.smegmatis_MC2_155 -----------------------------MGASLLAALVVAVLVAAVARR
Mb2309|M.bovis_AF2122/97 ---------------MNGRRTIGEDGLVFGLVVIVALVAAVVVGTVLGHR
Rv2287|M.tuberculosis_H37Rv ---------------MNGRRTIGEDGLVFGLVVIVALVAAVVVGTVLGHR
MMAR_3437|M.marinum_M ---------------------------MFGLVVIVALVATVVIGTVLGRR
MAV_2145|M.avium_104 ---------------------------MFGLVLIVALVSTVIVGTVIGRR
MUL_3177|M.ulcerans_Agy99 ---------------------MSLQQLYLAMLIGGFVLLASIVGTRLATR
: :: : :. *
Mflv_2583|M.gilvum_PYR-GCK RGLEPALVIVVVGIAVS---FIPGFEAPELDSHILLSVVLPPLLYSAALN
Mvan_4050|M.vanbaalenii_PYR-1 RGLEPALIIVVVGIAVS---FVPGFEAPELDSHILLSVVLPPLLYSAALD
MAB_4246|M.abscessus_ATCC_1997 FGLATPLVLVVTGLAAT---AIPGLPSIEMDPDLVLFVILPPLLYTTALE
MSMEG_0764|M.smegmatis_MC2_155 FDVSAPLVLVVAGLAGS---TLPGFGDVALDPDLVLFVILPPLLWSAGME
Mb2309|M.bovis_AF2122/97 YRVGPPVLLILSGSLLG---LIPRFGDVQIDGEVVLLLFLPAILYWESMN
Rv2287|M.tuberculosis_H37Rv YRVGPPVLLILSGSLLG---LIPRFGDVQIDGEVVLLLFLPAILYWESMN
MMAR_3437|M.marinum_M YRVGPPVLLILLGALLG---LVPRFGDVQIDGEIVLLLFLPAILYWESLN
MAV_2145|M.avium_104 YRVGPPVLLIVLGVLLG---LVPQFGHVRIDGEIVLLLFLPAILYWEGLN
MUL_3177|M.ulcerans_Agy99 VGFPSMLLFLLVGVIVGEDGFGLRFDDVELARNMG-TAALAVILVEGGLT
. . ::::: * : : .: *. :* .:
Mflv_2583|M.gilvum_PYR-GCK FSFPTFLRNIKPILGLGVGLVVVTAFTVAMVSAWLVVVPLTFATALVLGA
Mvan_4050|M.vanbaalenii_PYR-1 FSFPTFLRNIKPILGLGVGLVVVTAFTVAAVSSWLVVVPLTFATALVLGA
MAB_4246|M.abscessus_ATCC_1997 SSYVNLRKNVRAVASLAVLLPLVTTVAVGFV-AFYAVPELPLAGAMVLGA
MSMEG_0764|M.smegmatis_MC2_155 SSYVALRRNMRSIGLLAVGLPLVTTFVVGIV-AYHTVPELTLAAALTLGA
Mb2309|M.bovis_AF2122/97 TSFREIRWNLRVIVMFSIGLVIATAVAVSWT---ARALGMESHAAAVLGA
Rv2287|M.tuberculosis_H37Rv TSFREIRWNLRVIVMFSIGLVIATAVAVSWT---ARALGMESHAAAVLGA
MMAR_3437|M.marinum_M TSFRELRWNLRIVIMFSIGLVIATAVAVSWT---ARALGMESHAAAVLGA
MAV_2145|M.avium_104 ISFREIRANARIIVFLSVALVIATAVAVSWT---ARALGMDPHAAGVLGA
MUL_3177|M.ulcerans_Agy99 TRFSDIRKVLAPAATLATVGVMVSMVVTAVG--VHLVLGVSWQPALLLGA
: : :. :.: .... . : * ***
Mflv_2583|M.gilvum_PYR-GCK IVAPPDAVTAVAVGRKLGLPKRVMTILTGESLINDAAALALFSVAVAQVA
Mvan_4050|M.vanbaalenii_PYR-1 VVAPPDAVTAVAVGRKLGLPKRVMSILTGESLINDAAALALFSVAVAQVA
MAB_4246|M.abscessus_ATCC_1997 IVAPPDAVSATAIGRRLGLPRNIMTLLGGESLLNDATALTAYRVAIAAAI
MSMEG_0764|M.smegmatis_MC2_155 IVAPPDAVSATAVGRRLGLPRRTMTLLGGESLLNDATALTAYKVALAAAI
Mb2309|M.bovis_AF2122/97 VLSPTDAAAVAGLAKRL--PRRALTVLRGESLINDGTALVLFAVTVAVAE
Rv2287|M.tuberculosis_H37Rv VLSPTDAAAVAGLAKRL--PRRALTVLRGESLINDGTALVLFAVTVAVAE
MMAR_3437|M.marinum_M VLSPTDAAAVAGLAKRL--PRRALTVLRGESLINDGTALVLFAVTVAVAE
MAV_2145|M.avium_104 VLSPTDAAAVAGLAKKL--PRRSLTVLKAESLINDGTALVLFAVSVHVAI
MUL_3177|M.ulcerans_Agy99 IVSSTDAAAVFSVLRVLPLPRRVAGLLEAESGFNDAPAVILVLMFSEVPF
:::..**.:. .: : * *:. :* .** :**..*: :
Mflv_2583|M.gilvum_PYR-GCK GSHTFIENPLL-LFTYSAVLGPLVGAALGYITLWIRRRLAHPAL--ETVQ
Mvan_4050|M.vanbaalenii_PYR-1 GSHTFIENPLL-LFAYSAVLGPLVGAALGYITLWIRRRLANPAL--ETVQ
MAB_4246|M.abscessus_ATCC_1997 GLGATVADGFR-IFALAAVGGVFVGFVIGKLVNIIRCKLDDPLS--ESAI
MSMEG_0764|M.smegmatis_MC2_155 GAATSWGTALG-TFALAAVGGLVVGLVLGMLVHYVRTRLDDPLV--ESAI
Mb2309|M.bovis_AF2122/97 GAAGIGPAALVGRFVVSYLGGIMAGLLVGGLVTLLRRRIDAPLE--EGAL
Rv2287|M.tuberculosis_H37Rv GAAGIGPAALVGRFVVSYLGGIMAGLLVGGLVTLLRRRIDAPLE--EGAL
MMAR_3437|M.marinum_M GSAQLGPAALAGRFVVSYLGGIVAGLLVGGLVTMLRRKIDAPLE--EGAL
MAV_2145|M.avium_104 GAPAISPPEVTLRFIGSYLGGIAAGLLVGGAVTLVRKRIDAPQE--EGAL
MUL_3177|M.ulcerans_Agy99 ---AFRPAAALEALVFELLVGAAIGLAIGYLGAFTLRRIALPASGLYPIA
: : * * :* :: *
Mflv_2583|M.gilvum_PYR-GCK GLMVPFAAFILAEEMHASGVLAVVVAGFIVGSG-TVDAGYQTRLQERYVW
Mvan_4050|M.vanbaalenii_PYR-1 GLMVPFAAFILAEEMHASGVLAVVVAGFVVGSG-TVDAGYQTRLQERFVW
MAB_4246|M.abscessus_ATCC_1997 GLVVPFFAYLLAEEIHGSGVIAVVVAGLMLGHR-SVHAGYATRLQDDAVW
MSMEG_0764|M.smegmatis_MC2_155 GLVAPFSIYLIAEEAHGSGVIAVVVAALLLGQR-ETQASYATRLQDKAVW
Mb2309|M.bovis_AF2122/97 SLLTPFAAFLLAQSLKCSGVVAVLVSALVLTYVGPTVIRARSRLQAHAFW
Rv2287|M.tuberculosis_H37Rv SLLTPFAAFLLAQSLKCSGVVAVLVSALVLTYVGPTVIRARSRLQAHAFW
MMAR_3437|M.marinum_M SLLTPFAAFLLAQSMHCSGVVAVLISALVLTYTGPRVIRARSRMQSYAFW
MAV_2145|M.avium_104 SLVTPFAAFLLAQSVECSGVVAVVVSALVLAYSGPVVIRARSRLQSYAFW
MUL_3177|M.ulcerans_Agy99 TFGLGLVAFAAAGESHASGFIAAYLAAVVLANT-----GLPHRAATRSFA
: : : * . . **.:*. ::..:: * .
Mflv_2583|M.gilvum_PYR-GCK NSVDVLLEAFVFAYIGLHLRFVLEDLRDAHESLVQVAVASVVVLLIVLVI
Mvan_4050|M.vanbaalenii_PYR-1 NSVDVLLEVFVFAYIGLHLRFVLEDLQQAHESLTQVAVASAVVLLIVLVI
MAB_4246|M.abscessus_ATCC_1997 KAVQLLLESFAFLLIGLQLPKVVAGLRG--LSFNTIVLSSVAVLTTVIVV
MSMEG_0764|M.smegmatis_MC2_155 KALQLVLESFAFLLIGLQLPAVVGELAG--ISAATLAISSAAVLAAVIGV
Mb2309|M.bovis_AF2122/97 DIATFLINGSLWVFVGVQIPGAIDHIAGEDGGLPRATVLALAVTGVVIAT
Rv2287|M.tuberculosis_H37Rv DIATFLINGSLWVFVGVQIPGAIDHIAGEDGGLPRATVLALAVTGVVIAT
MMAR_3437|M.marinum_M DITTFLINGSLWVFVGVQIPGAIDHISNVDGGLRRATFIALAVTGVIIAT
MAV_2145|M.avium_104 DIATFLLNGSLWVFVGVQIPGALRGIAGVDGGVRHALFVALVITGVVIVS
MUL_3177|M.ulcerans_Agy99 EGVGWLAQIGLFVLLGLLVEPIEV--------IHDLIAAIVVGLLLLLVA
. : : : :*: : . ::
Mflv_2583|M.gilvum_PYR-GCK RPLSVFAMFGRRKLANQVEKRLSVPVPERG-RGALGARRRDPDRPRRRFG
Mvan_4050|M.vanbaalenii_PYR-1 RPLSVFAMFGRGVLARQVERRLSVPIPEGGGRGALGVRRQSQPPAKWRSR
MAB_4246|M.abscessus_ATCC_1997 RIVFVFAFAYLRPPGQR---------------------------------
MSMEG_0764|M.smegmatis_MC2_155 RIVWVYGCTYLGRLFTKNHE------------------------------
Mb2309|M.bovis_AF2122/97 RIAWVQATTVLGHTVDRVLKK-----------------------------
Rv2287|M.tuberculosis_H37Rv RIAWVQATTVLGHTVDRVLKK-----------------------------
MMAR_3437|M.marinum_M RIVWVEVTTVLGVALDRFLKK-----------------------------
MAV_2145|M.avium_104 RIFWGEFTTMLIRLIDRRAVQ-----------------------------
MUL_3177|M.ulcerans_Agy99 RPLSVVLSLSGFR-------------------------------------
*
Mflv_2583|M.gilvum_PYR-GCK SDNRTLSWQENVVVSWTGMRGVVTLAAAAAIPATTAAGEPFPERATIQAI
Mvan_4050|M.vanbaalenii_PYR-1 IDNRALSWQENVVVSWTGMRGVVTLAAAAAIPATTAAGAPFPERATIQAI
MAB_4246|M.abscessus_ATCC_1997 -----PSARGVFVVAWAGMRGVVSLAMAFAVPLSTVTGEPLPGHPHIVFL
MSMEG_0764|M.smegmatis_MC2_155 ---PPPSHAQVFILSWAGMRGVVSLAAAFGIPLITLSGEQFPGRAQLCFL
Mb2309|M.bovis_AF2122/97 -PTRHVGFRQRCVTSWAGFRGAVSLAAALAVPMTTNSGAPFPDRNLIIFV
Rv2287|M.tuberculosis_H37Rv -PTRHVGFRQRCVTSWAGFRGAVSLAAALAVPMTTNSGAPFPDRNLIIFV
MMAR_3437|M.marinum_M -DTRHVGFRQRCITSWAGFRGAVSLAAALAVPMTTHSGAPFPDRNLIIFV
MAV_2145|M.avium_104 -RERRVGWRQRFVTAWAGFRGAVSLAAAVAVPMTTLSGAPFPDRSLLIFI
MUL_3177|M.ulcerans_Agy99 -----IPWRDQVFLSWAGLRGAVPIVLATFP---IVAG--VPDSYRLLNI
. :*:*:**.*.:. * :* .* : :
Mflv_2583|M.gilvum_PYR-GCK SFVVAVATLLLQGWTLPLLIRRLKVSAEADRAYTVAETEKAELVVHEAAD
Mvan_4050|M.vanbaalenii_PYR-1 AFVVSVGTLLLQGWTLPLLIRRLKLSADADQAYTSAETQKAEQVVHAAAD
MAB_4246|M.abscessus_ATCC_1997 TFVVVVGTLLLHGLTLPWVIRVLGVQSDDERKDALAEAAAQDKAARAAAD
MSMEG_0764|M.smegmatis_MC2_155 TFVVVVGTLLLHGLTLPWFIRVLGAEGDEAHSDAIATAAAQDKAARAAAE
Mb2309|M.bovis_AF2122/97 VSVVILVTVLVQGTSLPTVVRWARMPEDVAHANELQLAR--TRSAQAALD
Rv2287|M.tuberculosis_H37Rv VSVVILVTVLVQGTSLPTVVRWARMPEDVAHANELQLAR--TRSAQAALD
MMAR_3437|M.marinum_M VSVVILVTVLVQGSSLPAVVRWARVPGDVAHADEVQLAR--TRSAEAALE
MAV_2145|M.avium_104 VTVVILVTVLVQGSTLPAVVRWARLPADVAHAEELQLAR--TRAARAALD
MUL_3177|M.ulcerans_Agy99 VFMLVVVFTLVQGPSLRPIAHLLGLISREATR--------EIQVEAAPLD
:: : *::* :* . : . :
Mflv_2583|M.gilvum_PYR-GCK EVFEVFRANP---PQGLDPRTLAEIRGIVERHSQDADEMP---DPEGRTR
Mvan_4050|M.vanbaalenii_PYR-1 EVLAEFRANP---PDGLDPRVLAEIGGIVARHSQDADEMP---DPEAPTL
MAB_4246|M.abscessus_ATCC_1997 RLEELLDDNDGIEDTNVRSRAAEILRHWNTRRRNAAWERLGRSDEDAGES
MSMEG_0764|M.smegmatis_MC2_155 RLDALLAEQP--ASAEVSHRAADVLRAWNTRRRNAAWERLGRDEEDIGES
Mb2309|M.bovis_AF2122/97 ALPTVADELG------VAPDLVKHLEKEYEERAVLVMADGADSATSDLAE
Rv2287|M.tuberculosis_H37Rv ALPTVADELG------VAPDLVKHLEKEYEERAVLVMADGADSATSDLAE
MMAR_3437|M.marinum_M VLPDVASELG------VSPDLLKRLTKEYEERATIIRENGDDSAPSDLAQ
MAV_2145|M.avium_104 ALPAVADEVG------VSDELRRRLHKEYEEKAALVLATENGSPDNRILK
MUL_3177|M.ulcerans_Agy99 VLDAELVTMT------VQPPSRLHNVTMLELRLPDPAVITLIIRKGHTFV
: : :
Mflv_2583|M.gilvum_PYR-GCK RAEVFGQLYRDVLAAQRAALIGERDAGRIDDEAVRAMLERLDLQEAGVSA
Mvan_4050|M.vanbaalenii_PYR-1 RAEVFGQLYRDVLAAQRVALIGERDAGRIDEEAVRAMLVRLDLQEAGVSA
MAB_4246|M.abscessus_ATCC_1997 PMAAFRNLRLEMLETERAVFIAERDAGNIDDEVLRTVLRGLDLEEATMNQ
MSMEG_0764|M.smegmatis_MC2_155 PTSAFRRLRLEMLAAERETFIAERDAGHIDDEVLRTVLHGLDLEEATLNR
Mb2309|M.bovis_AF2122/97 RNDLVRRVRLGVLQHQRQAVTTLRNQNLIDDIVLRELQAAMDLEEVQLLD
Rv2287|M.tuberculosis_H37Rv RNDLVRRVRLGVLQHQRQAVTTLRNQNLIDDIVLRELQAAMDLEEVQLLD
MMAR_3437|M.marinum_M RTDLVRRVRLGVLEHQRHAITALRNQNLIDDIVLREVQADMDLEEVQLLD
MAV_2145|M.avium_104 TREKVRQVRLGVLEHKRREVTALRNQNRIDDTVLRELQNEMDLEEVQLLA
MUL_3177|M.ulcerans_Agy99 PMPDTRIQRGDELLIVTTSTTRAAAESRLRAVSRRGKLAYWFDEYGEPD-
* . : * :
Mflv_2583|M.gilvum_PYR-GCK RLESRL-----
Mvan_4050|M.vanbaalenii_PYR-1 RLESRF-----
MAB_4246|M.abscessus_ATCC_1997 ADR--------
MSMEG_0764|M.smegmatis_MC2_155 D----------
Mb2309|M.bovis_AF2122/97 PADAE------
Rv2287|M.tuberculosis_H37Rv PADAE------
MMAR_3437|M.marinum_M PVEHD------
MAV_2145|M.avium_104 AAADEDDGDTE
MUL_3177|M.ulcerans_Agy99 -----------