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VAMNVQYDVIVVGAGFGGMGAAIQLKKMGYDNILIVDREDDLGGTWHVNHYPGLAVDIPSATYSYWFEPN PNWSRLYAPGTELKTYADHVADKYDVRRHMRFNSPVDGARWDDDGKYWQVTLSNGETLTSRFLITATGYL SQPRKPDIPGIEDFAGRIVHSMDWDDDYSPAGERIALIGTGATAVQLIPELSKSAAELTVYQRTPIHVVP KFDFPIPVLLRRLFARVPLLQRAFRFTTDANLEVMMILSVLNYKYFRQLNVGASYLSQALRFVSIRDKQL RDKLTPDYDFGCKRPTYSNSYYRTFASPHVHLQTSGIERVEADGIVAYDGTKTRIDTLVLCTGFDIWEAN IPAIEVIGRDARNLGKWWRDNGFRTYQGVAVPAFPNFLSLAGPYATSGLSFFNTMEYQMRHMDRLFGELK RRDAATFEVTEDATNRFSERMLKLLGKTVFRQGDCSRSRSYYFSPSGETLVRPASTNQTNRENDNFPLTD YVFA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3104 | - | - | 100% (494) | cyclohexanone monooxygenase |
| M. vanbaalenii PYR-1 | Mvan_0721 | - | 0.0 | 65.09% (487) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_3109 | - | 0.0 | 62.45% (490) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1428c | - | 1e-106 | 39.27% (494) | monoxygenase |
| M. gilvum PYR-GCK | Mflv_3372 | - | 0.0 | 82.82% (489) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. tuberculosis H37Rv | Rv1393c | - | 1e-106 | 39.27% (494) | monoxygenase |
| M. leprae Br4923 | MLBr_00065 | - | 4e-29 | 26.33% (395) | putative monooxygenase |
| M. abscessus ATCC 19977 | MAB_2477c | - | 0.0 | 60.45% (493) | monooxygenase |
| M. marinum M | MMAR_2207 | - | 1e-112 | 41.16% (498) | monoxygenase |
| M. avium 104 | MAV_2172 | - | 0.0 | 66.80% (491) | FAD dependent oxidoreductase, putative |
| M. smegmatis MC2 155 | MSMEG_0816 | - | 0.0 | 64.56% (491) | flavin-binding monooxygenase |
| M. thermoresistible (build 8) | TH_4080 | - | 9e-82 | 36.75% (468) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_1793 | - | 1e-108 | 41.10% (489) | monoxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1428c|M.bovis_AF2122/97 ------------------MMPDYHALIVGAGFSGIGAAIKLD-RAGFSDY
Rv1393c|M.tuberculosis_H37Rv ------------------MMPDYHALIVGAGFSGIGAAIKLD-RAGFSDY
MMAR_2207|M.marinum_M ----------------MSIEPDYQIVIVGAGFSGIGAAISLD-KAGFGDY
MUL_1793|M.ulcerans_Agy99 -------------------------MIVGAGFSGIGAAISLD-KAGFGDY
Mvan_3104|M.vanbaalenii_PYR-1 ----------------MAMNVQYDVIVVGAGFGGMGAAIQLK-KMGYDNI
Mflv_3372|M.gilvum_PYR-GCK -----------------MVEPQYDVIVVGAGFGGMGAAIQLK-KMGYENI
MAV_2172|M.avium_104 -----------------MVTDRFDAIIVGAGFGGIGAAIQLK-RLGFDNI
MSMEG_0816|M.smegmatis_MC2_155 -----------------MRPVVHDAVIVGAGFAGLGAAIQLK-KMSFDDF
MAB_2477c|M.abscessus_ATCC_199 ------------------MTTQFDAVIVGAGFGGMGAAIQLK-ELGLTNL
TH_4080|M.thermoresistible__bu MTVTEPSADITPANTPTQPPVRTRALIVGTGFSGLGMAIALQ-RRGID-F
MLBr_00065|M.leprae_Br4923 -------------MVVMAETEYLDVVIVGAGISGVSAAWHLQDRCPNKSY
::**:*:.*:. * *. .
Mb1428c|M.bovis_AF2122/97 LVVEAGDGVGGTWHWNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGHEL
Rv1393c|M.tuberculosis_H37Rv LVVEAGDGVGGTWHWNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGHEL
MMAR_2207|M.marinum_M LVIEAGDGVGGTWFWNTYPGIAVDIPSFSYQFSFEQSPDWSRSYAPGREL
MUL_1793|M.ulcerans_Agy99 LVIEAGDAVGGTWFWNTYPGIAVDIPSFSYQFSFEQSPDWSRSYAPGREL
Mvan_3104|M.vanbaalenii_PYR-1 LIVDREDDLGGTWHVNHYPGLAVDIPSATYSYWFEPNPNWSRLYAPGTEL
Mflv_3372|M.gilvum_PYR-GCK LIVDREDDLGGTWHVNHYPGLAVDIPSPTYSYWFEPNPYWSRLYAPGSEL
MAV_2172|M.avium_104 VILDREDDLGGTWHVNHYPGIAVDIPSTTYSYWFEPNPGWSRLFAPGGEV
MSMEG_0816|M.smegmatis_MC2_155 VILEREDDLGGTWYVNHYPGLAVDVPTTTYSYFFEPNPSWSRLFSTGREI
MAB_2477c|M.abscessus_ATCC_199 AILDREDDLGGTWHVNHYPGLAVDIPSATYSYSFEPNPYWSRLFAPGSEL
TH_4080|M.thermoresistible__bu LMLEKADDIGGTWRDNTYPGCACDIPSHLYSFSFEPKADWRHLFSYQDEI
MLBr_00065|M.leprae_Br4923 VILEKRAGMGGTWDLFRYPGIRSDSDMYTLGFRFRPWTKCQAIAD-GKPI
::: :**** *** * : *. :
Mb1428c|M.bovis_AF2122/97 KAYAEHCVDKYGIRSRIRLNTKVLAAEFDDEHSLWRVQTDPGGE---ITA
Rv1393c|M.tuberculosis_H37Rv KAYAEHCVDKYGIRSRIRLNTKVLAAEFDDEHSLWRVQTDPGGE---ITA
MMAR_2207|M.marinum_M RAYAEHCADKYGIRPRIRFNTKVLGAEFDDERSLWRLQTDPGGE---LTT
MUL_1793|M.ulcerans_Agy99 RAYAEHCADKYGIRPRIRFNTKVLGAELDDERSLWRLQTDPGGD---LIT
Mvan_3104|M.vanbaalenii_PYR-1 KTYADHVADKYDVRRHMRFNSPVDGARWDDDGKYWQVTLSNGET---LTS
Mflv_3372|M.gilvum_PYR-GCK KKYAEHVADKYDVRRHMRFNSPVDGARWDDDTESWQVALSGGET---LTA
MAV_2172|M.avium_104 KQYAADVADKYDVRRHMRFNTTVEGAQWDEDAEVWRVALAGGES---LTT
MSMEG_0816|M.smegmatis_MC2_155 KRYADDVADKYDVRRHIRFGTTVTGARWDEDDNVWQVSLTDGEQ---LQA
MAB_2477c|M.abscessus_ATCC_199 KQYASHVADKHDLRKYMRFNTPVSGARWDEEHQHWVVATESGDT---VTG
TH_4080|M.thermoresistible__bu QEYLQGVTAKYGLRRYIHFDSLVDRAHWDDTEHRWHVFTADGRE---YIA
MLBr_00065|M.leprae_Br4923 LEYIKSTAVMHGIDKYIRLNHKVTGADWSSIENRWTVQVENNGTPRMISC
* . :.: :::. * * .. * : .
Mb1428c|M.bovis_AF2122/97 RFLISACGILTVPK--LPDIDGVDSFEGVTMHTARWDHTQDLTGKRVGII
Rv1393c|M.tuberculosis_H37Rv RFLISACGILTVPK--LPDIDGVDSFEGVTMHTARWDHTQDLTGKRVGII
MMAR_2207|M.marinum_M RFIINASGVLTVPK--LPDIAGVDSFAGVTMHTARWDHSQELTGKRVGII
MUL_1793|M.ulcerans_Agy99 RFIINASGVLTVPK--LPDIAGVDSFAGVTMHTARWDHSQELTGKRVGII
Mvan_3104|M.vanbaalenii_PYR-1 RFLITATGYLSQPR--KPDIPGIEDFAGRIVHSMDWDDDYSPAGERIALI
Mflv_3372|M.gilvum_PYR-GCK KFLITATGYLSQPR--KPEIPGIEDFAGRVLHSMDWDDSYSPAGERVGLI
MAV_2172|M.avium_104 RFLITATGFLSQPH--TPDIPGIGSFGGKVVHTTAWDHDYRYQGRRIAVI
MSMEG_0816|M.smegmatis_MC2_155 RFLITATGFLSQPH--TPDIPGITEFDGKVIHTTDWDDGCSLYGRRAAVV
MAB_2477c|M.abscessus_ATCC_199 KYLLTATGYLSQPK--MPDIEGIESFAGKVIHTTKWDNSYRAAGHRIGLI
TH_4080|M.thermoresistible__bu QFLISCAGALHIPS--IPDFPGRDQFAGPAFHSAQWDHSVDLTGKRVAVI
MLBr_00065|M.leprae_Br4923 SFLFLCSGYYNYEQGYAPTFLGSEDFTGPIIHPQHWPEDLDYAAKNIVVI
::: . * * : * .* * .*. * . ... ::
Mb1428c|M.bovis_AF2122/97 GTGASAVQVIPEMAPI-VSHLTVFQRTPIWCFPKFDVPLPTAVR-WAMRI
Rv1393c|M.tuberculosis_H37Rv GTGASAVQVIPEMAPI-VSHLTVFQRTPIWCFPKFDVPLPTAVR-WAMRI
MMAR_2207|M.marinum_M GTGASAVQVIPEIAPI-VKHLTVFQRTPIWCFPKFDFPLPAALR-WAMRI
MUL_1793|M.ulcerans_Agy99 GTGASAVQVIPEIAPI-VKHLTVFQRTPIWCFPKFDFPLPAALR-WAMRI
Mvan_3104|M.vanbaalenii_PYR-1 GTGATAVQLIPELSKS-AAELTVYQRTPIHVVPKFDFPIPVLLRRLFARV
Mflv_3372|M.gilvum_PYR-GCK GTGATAVQLIPQLSKD-AAALTVYQRTPIHVVPKIDFAIPPAMRRILARV
MAV_2172|M.avium_104 GTGASAVQVVPELAKE-AEELTVYQRTATHVLPKVDFEFDPAVRRLFARV
MSMEG_0816|M.smegmatis_MC2_155 GTGATAVQLIPELAER-VAELTVYQRTPIWVVPKVDVRFPPAVRALFARV
MAB_2477c|M.abscessus_ATCC_199 GTGATAVQLIPELAKD-AQHLTVYQRTPIWVVPKADAKVPGVVKKLFAKV
TH_4080|M.thermoresistible__bu GTGASAIQIVPEIIDR-VAQLQLYQRTPAWVVPRTNDELPAWLRRALENI
MLBr_00065|M.leprae_Br4923 GSGATAVTLVPALANSGAKHVTMLQRSPTYIVSQPAKDKIAARLNRWLPD
*:**:*: ::* : . : : **:. ..:
Mb1428c|M.bovis_AF2122/97 PGGKAVHRLLSQAFVEATFPIAAHYFAVFP--LAKHMESAGRRYLRQQVH
Rv1393c|M.tuberculosis_H37Rv PGGKAVHRLLSQAFVEATFPIAAHYFAVFP--LAKHMESAGRRYLRQQVH
MMAR_2207|M.marinum_M PGGKALQRLLSQAYVEATFPISAHYFTVFP--LARWSAVLGRRYLRQRVN
MUL_1793|M.ulcerans_Agy99 PGGKALQRLLSQAYVEATFPISAHYFTVFP--LARWSAVLGRRYLRQRVD
Mvan_3104|M.vanbaalenii_PYR-1 PLLQRAFRFTTDANLEVMMILSVLNYKYFR-QLNVGASYLSQALRFVSIR
Mflv_3372|M.gilvum_PYR-GCK PLMQRAFRASSDVGLEAMMILSVLNFKYFR-KLNSVANWLSRALRFVSIR
MAV_2172|M.avium_104 PAAQRALRWVTDVLLEIIMIVGALHFKESRGRGNISASDLAKINRFRWIR
MSMEG_0816|M.smegmatis_MC2_155 PLTQRVVRAITDAIYAFMVDTAVLKHRYFR-RLNIAAADLGRLHLAASIR
MAB_2477c|M.abscessus_ATCC_199 PRTQKIARTVGSAILEVIMVGGVLHFRQFR-QANHGASLLAKAHLFAQVR
TH_4080|M.thermoresistible__bu PGLRLALRGGIYALQEALAVGMTKYPGMLR-----IGHLLGKWNINRSVK
MLBr_00065|M.leprae_Br4923 KYAYTAVRWKNILRQSALYGACQKWPQRMR---NILLGHVARRLPKGYDV
* .:
Mb1428c|M.bovis_AF2122/97 DPVVREQLTPRYAVGCKRPGFHNTYLSTFNRDNVRLVTEPIDKITPTAVA
Rv1393c|M.tuberculosis_H37Rv DPVVREQLTPRYAVGCKRPGFHNTYLSTFNRDNVRLVTEPIDKITPTAVA
MMAR_2207|M.marinum_M DPVVRDQLTPRYAVGCKRPGFHNGYLSTFNRDNVQLVTEPIEKITPTAVA
MUL_1793|M.ulcerans_Agy99 DPVVRDQLTPRYAVDCKRPGFHNGYLSTFNRDNVQLVTEPIEKITPTSVA
Mvan_3104|M.vanbaalenii_PYR-1 DKQLRDKLTPDYDFGCKRPTYSNSYYRTFASPHVHLQTSGIERVEADGIV
Mflv_3372|M.gilvum_PYR-GCK DKELRAKLTPQYEFGCKRPTYSNSYYRMFTKPNVHLQAAGIDHVEADGIV
MAV_2172|M.avium_104 DKELRAKLTPDYDCGCKRPTFSNSFYRVLTQPNVHLETNPIERIEPDGIV
MSMEG_0816|M.smegmatis_MC2_155 DPDLRSKLTPDYDFGCKRPTFSNSYYRTFTKPHVHLQADGIDHVEPDGIV
MAB_2477c|M.abscessus_ATCC_199 DRELRRKLTPDYDFGCKRPTFSNTYFRAFTKKNVSLETASIARIEADGIV
TH_4080|M.thermoresistible__bu DPQLRAKLTPDYRLGCKRILNSSTYYPAVADPRTEVITESIDRITTDGIV
MLBr_00065|M.leprae_Br4923 QKHFGPHYNPWEQRLCLVP--DGDLFRAIRKGTVDMVTDAIDRFTSTGIR
: . : .* * . . . : : * :. . .:
Mb1428c|M.bovis_AF2122/97 TTDGASHEIDVLVLATGFKVLDTDSIPTYAVTGTGGASLSRFWDEHRLQA
Rv1393c|M.tuberculosis_H37Rv TTDGASHEIDVLVLATGFKVLDTDSIPTYAVTGTGGASLSRFWDEHRLQA
MMAR_2207|M.marinum_M TDDGTDHEIDVLILATGFKVLDTDDVLTYPVIGRAGRSLSQFWEEHRAQA
MUL_1793|M.ulcerans_Agy99 TDDGTDHEIDVLILATGFKVLDTDDVLTYPVIGRAGRSLSQFWEEHRAQA
Mvan_3104|M.vanbaalenii_PYR-1 AYDGTKTRIDTLVLCTGFDIWEAN-IPAIEVIGRDARNLGKWWRDNGFRT
Mflv_3372|M.gilvum_PYR-GCK ACDGTKTQIDTLVLCTGFDLWEAN-IPAIEIIGRDARNLGKWWRDYGFQA
MAV_2172|M.avium_104 TADGRKNVIDTLVLATGFDLWEAN-FPAIEVIGRKGRNLGKWWRETRFQA
MSMEG_0816|M.smegmatis_MC2_155 NADGSKTVIDTLVLATGFDLWEAN-FPAIEVIGRQGRDLGKWWRETRFQA
MAB_2477c|M.abscessus_ATCC_199 TADGRKTVIDTLVLATGFNLWEST-FPAFEVIGREDYNLGKFWRDNRFQA
TH_4080|M.thermoresistible__bu TSDGTERAVDVIVYATGFHVSDSY--KYVQIKGLNGEDIVDRFNREGPMA
MLBr_00065|M.leprae_Br4923 LKSGNELRADIIVTATGLNLQLFG--------GAVATVDGQPVDLAQTMS
.* . * :: .**:.: * :
Mb1428c|M.bovis_AF2122/97 YEGVSVPGYPNFFTVFGPYGYVGSS-YFALIETQAHHIIRCLKRARRTGA
Rv1393c|M.tuberculosis_H37Rv YEGVSVPGYPNFFTVFGPYGYVGSS-YFALIETQAHHIIRCLKRARRTGA
MMAR_2207|M.marinum_M YQGVSVPGYPNFFAVFGPYGYVGSS-YFALIETQTHHILRCLKRARRDGA
MUL_1793|M.ulcerans_Agy99 YQGVSVPGYRNFFAVFGPYGYVGSS-YFALIETQTHHILRCLKRARRDGA
Mvan_3104|M.vanbaalenii_PYR-1 YQGVAVPAFPNFLSLAGPYATSGLS-FFNTMEYQMRHMDRLFGELKRRDA
Mflv_3372|M.gilvum_PYR-GCK YQGVSIPSFPNFLSLAGPYASSGLS-FFNTVEYQMRHMDRLFGELKRRNA
MAV_2172|M.avium_104 YQGVSMPYFPNYLSLASPFAFSGLS-FFHTIEYQMRHMDRLLGEVKRRGA
MSMEG_0816|M.smegmatis_MC2_155 YQGVSMPYFPNYLSLAGPYAFLGLN-FFNTMEYQMRLMERLLGEVARRDA
MAB_2477c|M.abscessus_ATCC_199 FEGIAVPKFPNLLTLNGPYSYSGLS-YFDTIESQMRHIKRLFAEMARTGT
TH_4080|M.thermoresistible__bu HRGTAVADLPNAYLLLGPNTGLGHNSMVYMIESQINYVIEAIKAVDKAGA
MLBr_00065|M.leprae_Br4923 YKGMMLSGLPNMIYTVG-YTNASWTLKADLVSEFFCRLLNYMNANDFDTV
..* :. * . . . :. : . : .
Mb1428c|M.bovis_AF2122/97 TRIEVTEEANARYFAEVMRRRHRQVFWQDSCRLANSYYFDKNGD-VPLRP
Rv1393c|M.tuberculosis_H37Rv TRIEVTEEANARYFAEVMRRRHRQVFWQDSCRLANSYYFDKNGD-VPLRP
MMAR_2207|M.marinum_M TRVEVTEEANARYFAEMMRRRYRQVFWQDSCRRANSYYFDKNGD-VPLRP
MUL_1793|M.ulcerans_Agy99 TRVEVTEEANARYFAEMMRRRYRQVFWQDSCRRANSYYFDKNGD-VPLRP
Mvan_3104|M.vanbaalenii_PYR-1 ATFEVTEDATNRFSERMLKLLGKTVFRQGDCSRSRSYYFSPSGE-TLVRP
Mflv_3372|M.gilvum_PYR-GCK TTFEVTPEANAKFRDRMSKLLGKTVFGLGDCAGSRSYYFSPSGE-TLVRP
MAV_2172|M.avium_104 TTFEVTEEANDRFMERMTKLLDNSVFYAGNCATSRSYYFSPSGEASLLRP
MSMEG_0816|M.smegmatis_MC2_155 RTFEVTEEANRRYLDRMTDALGDSLFTLGNCASARSYYFNPSGEATLLRP
MAB_2477c|M.abscessus_ATCC_199 EVFEVTDEANTEFLDRMTRNLDNSVFYLGSCQTSRSYYFNQHGEAALLRP
TH_4080|M.thermoresistible__bu QALAPTREAQDRYNAELQARLGRSVWNTGGCR---SWYLDEHGNNRVLWG
MLBr_00065|M.leprae_Br4923 AVEYPGSDVEERPFMDFTPGYVLRSLDALPKQGSRTPWRLNQNYLRDIRL
:. . . : : . :
Mb1428c|M.bovis_AF2122/97 TTTVEAYWRSRRFDLGDYRISS
Rv1393c|M.tuberculosis_H37Rv TTTVEAYWRSRRFDLGDYRISS
MMAR_2207|M.marinum_M TTTVEAYWRGRHFDLDNYRFGR
MUL_1793|M.ulcerans_Agy99 TTTVEAYWRGRHFDLDDYRFGR
Mvan_3104|M.vanbaalenii_PYR-1 ASTNQTNRENDNFPLTDYVFA-
Mflv_3372|M.gilvum_PYR-GCK ASTHQTNRENDTFPLTDYTFA-
MAV_2172|M.avium_104 TSTLNSIREASSFPLSDYVIA-
MSMEG_0816|M.smegmatis_MC2_155 MTTRRAVAEASRFPLSDYTFA-
MAB_2477c|M.abscessus_ATCC_199 TSTASAYKEQESFPLEAYQLA-
TH_4080|M.thermoresistible__bu GFTWQYRLATRTLDPAEYRFWG
MLBr_00065|M.leprae_Br4923 IRRGKVADEGLLFAKKTTPVTV
: .