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VTVELIGELVDSFRRTGRIVIVGASLAGLRAAEALRDGGFSGSLTIIGDEPHEPYDRPPLSKQVLKGWVP ADHTKLPRLRRVDADWRLGVAATGLDRRAKRVLLADGSAVEYDRLLIATGVRARQWPNPDEAALDGVFTL RTRDDAAALQAALHARPNRVLVVGSGFIGSEMASVCRELDLAVTVAERGPAPLVGALGGVIGELAAAMQR DAGVDLRTGVSVLGLDGDDTGHVRSARLSDGTTLPVDVVVASLGSIRNVEWLDDAGLATGFWGVACDAGC RAFDVNGVVTDNIFVAGDVARAPHVLYEYQFMSLEHWDNAVSGGEVAANNMINLETGRRPHLPLPSFWSG QFGVNIKGVGVCSFGDEIVFTQGSPGEYRFAAAYGRRGRIVGAVTFNHGKWLPYYADLIERSAPFPPPPP GFDRPVLGEPMPARFPDPRVPTGIPDVVLTGHDPTDRGAEFLRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0400 | - | - | 100% (464) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_1290 | - | 4e-54 | 38.70% (385) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_0467 | - | 7e-53 | 38.35% (399) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0707 | - | 1e-58 | 41.36% (382) | putative ferredoxin reductase |
| M. gilvum PYR-GCK | Mflv_5068 | - | 3e-54 | 37.34% (383) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. tuberculosis H37Rv | Rv0688 | - | 1e-58 | 41.36% (382) | putative ferredoxin reductase |
| M. leprae Br4923 | MLBr_02387 | lpd | 9e-07 | 25.99% (227) | dihydrolipoamide dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3838c | - | 2e-54 | 37.43% (382) | putative ferredoxin reductase |
| M. marinum M | MMAR_2931 | - | 0.0 | 81.30% (460) | ferredoxin reductase |
| M. avium 104 | MAV_4485 | - | 3e-57 | 40.53% (380) | ferredoxin reductase |
| M. smegmatis MC2 155 | MSMEG_3594 | - | 3e-53 | 36.23% (403) | anthranilate dioxygenase reductase |
| M. thermoresistible (build 8) | TH_3739 | - | 3e-58 | 39.79% (382) | PUTATIVE Pyridine nucleotide-disulphide oxidoreductase |
| M. ulcerans Agy99 | MUL_0769 | - | 1e-59 | 40.36% (384) | ferredoxin reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0400|M.vanbaalenii_PYR-1 -------MTVELIGELVDSFRRTG--------RIVIVG----ASLAGLRA
MMAR_2931|M.marinum_M ------MNPGSLVGQLVDTFKAQG--------RVVIVG----ASLAGLRA
Mb0707|M.bovis_AF2122/97 -----------MNAHVTSREGVN-----EFDDGIVIVG----GGLAAART
Rv0688|M.tuberculosis_H37Rv -----------MNAHVTSREGVN-----EFDDGIVIVG----GGLAAART
MUL_0769|M.ulcerans_Agy99 ----------MYEHHVTSSEGVTQDPGATAANGIVIIG----GGLAAART
MAV_4485|M.avium_104 -----------MSSDASAS------------NGIVIVG----GGLAAART
Mflv_5068|M.gilvum_PYR-GCK ----------MGTSEVSGGSG-----------GVVIVG----GGLAAART
TH_3739|M.thermoresistible__bu ---------------VSTTAG------------IIIVG----GGLAAART
MAB_3838c|M.abscessus_ATCC_199 ---------------MTDAER-----------GVLIIG----GGLGAVRT
MSMEG_3594|M.smegmatis_MC2_155 ---------------MTAAST------------FVIIG----GGLAGAKA
MLBr_02387|M.leprae_Br4923 MTHYDVVVLGAGPGGYVAAIRAAQLG-----LSTAVVEPKYWGGICLNVG
:: ..:
Mvan_0400|M.vanbaalenii_PYR-1 AEALRDGGFSGSLTIIGDEPHEPYDRP---PLSKQVLKG--WVPADHTKL
MMAR_2931|M.marinum_M AEALRDRGFAGHLTIIGDEQYEPYDRP---PLSKQVLKG--WVPAHHTKL
Mb0707|M.bovis_AF2122/97 AEQLRRAGYSGRLTIVSDEVHLPYDRP---PLSKEVLR---SEVDDVALK
Rv0688|M.tuberculosis_H37Rv AEQLRRAGYSGRLTIVSDEVHLPYDRP---PLSKEVLR---SEVDDVALK
MUL_0769|M.ulcerans_Agy99 AEQLRRAGYEGQLTIVSDEVHLPYDRP---PLSKEVLR---SEVDDVSLK
MAV_4485|M.avium_104 AEQLRRSEYSGPITIVSDEVHLPYDRP---PLSKEVLR---KEVDDTALK
Mflv_5068|M.gilvum_PYR-GCK AEQLRRAEYPGAITIVSDEDHLPYDRP---PLSKEVLR---AETDDVTLK
TH_3739|M.thermoresistible__bu AEQLRRSEFGGPITIVSDEDHLPYDRP---PLSKDVLS---GKTDDVTLK
MAB_3838c|M.abscessus_ATCC_199 AEQLRRAEFTGPITIVSSETHLPYDRP---PLSKDVLRDAEKTIDAVVLK
MSMEG_3594|M.smegmatis_MC2_155 AEALRDNDFDGQVLLFAAEEKLPYERP---PLSKDYLAG-KKTLDEFTVA
MLBr_02387|M.leprae_Br4923 CIPSKVLLHNAELAHIFTKEAKTFGISGDASFDYGIAYDRSRKVSEGRVA
. : . . : . : .: . .:.
Mvan_0400|M.vanbaalenii_PYR-1 PR--LRRVDADWRLGVAATGLDRRAKRVLLADGS-----AVEYDRLLIAT
MMAR_2931|M.marinum_M PR--LRPVDAQWRLGVAAVGLDRSTRQVLLANGE-----RVEYDRLLIAT
Mb0707|M.bovis_AF2122/97 PREFYDEKDIALRLGSAAVSLDTGEQTVTLADGT-----VLGYDELVIAT
Rv0688|M.tuberculosis_H37Rv PREFYDEKDIALRLGSAAVSLDTGEQTVTLADGT-----VLGYDELVIAT
MUL_0769|M.ulcerans_Agy99 PREWYDEKGITLRLGSAATGLDTAAQTVTLADGT-----VLGYDELVIAT
MAV_4485|M.avium_104 PRQWYDDNDITLRLGSAARSLDTAAQTLTLEDGT-----TLGYDELVIAT
Mflv_5068|M.gilvum_PYR-GCK PAEFYDENNITVLLGNGAKSVDTAAQTLTLADGS-----TLGYDELVIAT
TH_3739|M.thermoresistible__bu PAEFYAENDITLLLGTAATALDPQARKLTLADGR-----ALEYDELIIAT
MAB_3838c|M.abscessus_ATCC_199 PREFYDEKQIELRLGSEVTALDPVARTVTLSDGG-----TLEYGEVIIAT
MSMEG_3594|M.smegmatis_MC2_155 APAWYRDHDVTLRLGTEVAAINPADHTVTLPDGS-----AVGYDKLLLAT
MLBr_02387|M.leprae_Br4923 GVHFLMKKNKITEIHGYGRFTDANTLSVELSEGVPETPLKVTFNNVIIAT
: : : * :* : :..:::**
Mvan_0400|M.vanbaalenii_PYR-1 GVRARQWPNPDEAALDGVFTLRTRDDAAALQAALHARPNRVLVVGSGFIG
MMAR_2931|M.marinum_M GTRARPWFNPQEAALEGLFTVRTCDDAEKLAAALKRRPRRVLIVGSGFVG
Mb0707|M.bovis_AF2122/97 GLVPR--RIPSLPDLDGIRVLRSFDESMALRKHAS-AARHAVVVGAGFIG
Rv0688|M.tuberculosis_H37Rv GLVPR--RIPSLPDLDGIRVLRSFDESMALRKHAS-AARHAVVVGAGFIG
MUL_0769|M.ulcerans_Agy99 GLVPR--RIPAFPELEGIRVLRSFDECMALRSHAS-AAKRAVVIGAGFIG
MAV_4485|M.avium_104 GLVPR--RIPTIPDLDGIRVLRTFDESLALREHAS-AAQRAVIIGAGFIG
Mflv_5068|M.gilvum_PYR-GCK GLVPK--RIPSFPDLPGIHVLRNFDESLALRREAA-SASRAVVVGAGFIG
TH_3739|M.thermoresistible__bu GLVPK--RIPTLPDLEGIRVLRTYDESMALRKHAG-SARNAVVIGAGFIG
MAB_3838c|M.abscessus_ATCC_199 GLVPR--RIPTFPDLAGVHVLRTADDSFALRGDAE-NARRAVVVGAGFIG
MSMEG_3594|M.smegmatis_MC2_155 GSASRRLPIPG-ADASGVHYLRTVDDAAALDAVLT-EGASLAVVGAGWIG
MLBr_02387|M.leprae_Br4923 GSKTR-----LVPGTLLSTNVITYEEQILTRELPD----SIVIVGAGAIG
* .: . : . :: ::*:* :*
Mvan_0400|M.vanbaalenii_PYR-1 SEMASVCRELDLAVTVAERGPAPLVGALGGVIGELAAAMQRDAGVDLRTG
MMAR_2931|M.marinum_M SEIASVCRDLDLPVTVAERGKAPLVGALGGVIGDIAAKMQLEAGVDLRTG
Mb0707|M.bovis_AF2122/97 CEVAASLRGLGVDVVLVEPQPAPLASVLGEQIGQLVTRLHRDEGVDVRTG
Rv0688|M.tuberculosis_H37Rv CEVAASLRGLGVDVVLVEPQPAPLASVLGEQIGQLVTRLHRDEGVDVRTG
MUL_0769|M.ulcerans_Agy99 CEVAASLRGLGVEVVLVEPQPTPLAAVLGEQIGELVARLHRSEGVDVRTG
MAV_4485|M.avium_104 CEVAASLRSLGVDVVLVEPQPTPLAAVLGQQIGELVARLHRAEGVDVRLG
Mflv_5068|M.gilvum_PYR-GCK CEVAASLRKLGVEVTLVEPQPAPLASILGQQIGDLVTRLHRAEGVDVRCG
TH_3739|M.thermoresistible__bu CEVAASLRGLGVHVVLVEPQPTPLAGVLGEQIGALVARLHRDEGVDLRCG
MAB_3838c|M.abscessus_ATCC_199 CEVAATLRANGVEVVLVEPQPAPLLAAIGQQLGDLVARLHRNEGVDVRVG
MSMEG_3594|M.smegmatis_MC2_155 LEVAASARTRGVNVTVVEAARLPLLGALGAEVAEVFAQLHREHGVDLRLE
MLBr_02387|M.leprae_Br4923 IEFGYVLKNYGVDVTIVEFLPRAMPNED-AEVSKEIEKQFKKMGIKILTG
*.. : .: *.:.* .: :. *:.:
Mvan_0400|M.vanbaalenii_PYR-1 VSVLGLDGDDTGHVRSARLSDG--TTLPVDVVVASLGSIRNVEWLDDAGL
MMAR_2931|M.marinum_M VAVEGLEGDAEGHVRAARLSDG--TVLDVDVVVASLGSIRNVEWLEGAQL
Mb0707|M.bovis_AF2122/97 VTVAEVRGK--GHVDAVVLTDG--TELPADLVVVGIGSTPATEWLEGSGV
Rv0688|M.tuberculosis_H37Rv VTVAEVRGK--GHVDAVVLTDG--TELPADLVVVGIGSTPATEWLEGSGV
MUL_0769|M.ulcerans_Agy99 VGVAEVRGD--GHVDTVVLADG--TQLDADLVVVGIGSHPATGWLDGSGI
MAV_4485|M.avium_104 VGVSEVRGD--RHVEAVVLTDG--TELAADVVVIGIGSRPATDWLEGSGV
Mflv_5068|M.gilvum_PYR-GCK VGVSEVSGD--DRVRKVTLGDG--TDVEADVVIVGIGSHPATSWLEGSGL
TH_3739|M.thermoresistible__bu VGVADVRGT--GAVEKVVLDDG--TELDADLVVVGIGSTPATDWLQGSGV
MAB_3838c|M.abscessus_ATCC_199 VGVDAVEGQ--DRVQSVTLSDG--TRLDTDLVVLGIGSRPAIDWLDGSGV
MSMEG_3594|M.smegmatis_MC2_155 QTVEEITTAD-GRATGLRLGDG--STIAADAVLVAVGAAPNIGLAERAGL
MLBr_02387|M.leprae_Br4923 TKVESISDNG-SHVLVAVSKDGQFQELKADKVLQAIGFAPNVDGYGLDKV
* : . ** : .* *: .:* :
Mvan_0400|M.vanbaalenii_PYR-1 ATG--FWGVACDAGCRAFDVNGVVTDNIFVAGDVARAPHVLYEYQFMSLE
MMAR_2931|M.marinum_M ASG--FWGVACDAGCRAFDINGVVTDNIFVAGDVARAPHVLYEYEFMSQE
Mb0707|M.bovis_AF2122/97 EVD---NGVICDKAG------RTSAPNVWALGDVASWRDPMGH--QARVE
Rv0688|M.tuberculosis_H37Rv EVD---NGVICDKAG------RTSAPNVWALGDVASWRDPMGH--QARVE
MUL_0769|M.ulcerans_Agy99 AVD---NGVVCDAAG------RTSAPNVWAFGDVASWRDQMGH--QVRVE
MAV_4485|M.avium_104 AIDSVDRGVLCDEAG------RTSAPNVWALGDVASWRDATGH--QGRVE
Mflv_5068|M.gilvum_PYR-GCK ELD---NGVVCDEAG------RASAPHVWAIGDVASWRDTVGG--QVRVE
TH_3739|M.thermoresistible__bu EVD---NGVVCDAVG------RTNVEHVWAIGDVASWRNTVGK--QVRVE
MAB_3838c|M.abscessus_ATCC_199 AVD---NGVVCDAVG------ATGTPHVWALGDVAAWAGADGR--PNRVE
MSMEG_3594|M.smegmatis_MC2_155 ATAD--GGVLVDASL------RTSDPDIYAVGDIAAAQHPLFG-VRIRTE
MLBr_02387|M.leprae_Br4923 GVA-----LTADKAVDIDDYMQTNVSHIYAIGDVTGKLQLAHVAEAQGVV
: * . .::. **::
Mvan_0400|M.vanbaalenii_PYR-1 HWDNAVSGGEVAANNMINLETGRRPHLPLPSF-------WSGQFGVNIKG
MMAR_2931|M.marinum_M HWDNAVFGAEVAANNMISLEMGRRPHLPLPSF-------WSGQFGVNIKS
Mb0707|M.bovis_AF2122/97 HWSNVADQARVVVPAMLGTDVPT--GVVVPYF-------WSDQYDVKIQC
Rv0688|M.tuberculosis_H37Rv HWSNVADQARVVVPAMLGTDVPT--GVVVPYF-------WSDQYDVKIQC
MUL_0769|M.ulcerans_Agy99 HWSNVADQARVVVPAMLGREVSS--NVVVPYF-------WSDQYDVKIQC
MAV_4485|M.avium_104 HWSNVADQARVVVPAMLGKEVPP--VVVVPYF-------WSDQYDVKIQC
Mflv_5068|M.gilvum_PYR-GCK HWSNVADQARVLVPTMLGQEPPA--AVSVPYF-------WSDQYDVKIQA
TH_3739|M.thermoresistible__bu HWSNVADQARVLVPALLGQEVPV--AATVPYF-------WSDQYDVKIQC
MAB_3838c|M.abscessus_ATCC_199 HWSNVADQVRALVPALLGQETSAN-TVAVPYF-------WSDQYDVKIQS
MSMEG_3594|M.smegmatis_MC2_155 HWANALKQPAVAVAGMLGRPAEY---AELPYF-------FTDQYDLGMEY
MLBr_02387|M.leprae_Br4923 AAEAIAGAETLALSDYRMMPRATFCQPNVASFGLTEQQARDGGYDVVVAK
:. * . :.: :
Mvan_0400|M.vanbaalenii_PYR-1 VGVCSFGDEIVFTQGSPGEYRFAAAYGRRGRIVG--AVTFNHGKWLPYYA
MMAR_2931|M.marinum_M VGVCSFGDEIVFTQGSIEQRRFAAAYGYRGRIVG--AVTFDHGKWLPYYA
Mb0707|M.bovis_AF2122/97 LGEPHATDVVHLVED--DGRKFLAYYERDGVLVG--VVGGGMAGKVMKVR
Rv0688|M.tuberculosis_H37Rv LGEPHATDVVHLVED--DGRKFLAYYERDGVLVG--VVGGGMAGKVMKVR
MUL_0769|M.ulcerans_Agy99 LGEPHSTDVVHLVED--DGRKLLAYYQRDGVLVG--VVGGGVPGKVMKVR
MAV_4485|M.avium_104 LGEPEADDIVHIVED--DGRKFLAYYERDGALVG--VVGGGMPGKVMKTR
Mflv_5068|M.gilvum_PYR-GCK LGEPEATDTVHIVED--DGRKFLAYYERDGAVVA--VVGGGFPGKVMKTR
TH_3739|M.thermoresistible__bu LGEPEAGDTVHVVSD--DGRKFLAYYERDGVLTG--VVGGGMPGKVMKAR
MAB_3838c|M.abscessus_ATCC_199 LGHLGSSDTVHLISD--DGRKFLAYLERDGVLTG--VVGCGMAGPVMKMR
MSMEG_3594|M.smegmatis_MC2_155 AGHAPSYERVVFRGDVPGREFVSFWLDGDNRVLA--GMNVNIWDVLDDVK
MLBr_02387|M.leprae_Br4923 FPFTANAKAHGMGDP--SGFVKLVADAKYGELLGGHMIGHNVSELLPELT
. . . : . : . :
Mvan_0400|M.vanbaalenii_PYR-1 DLIERSAPFPPPPPGFDRPVLGEPMPARFPDPRVPTGIPDVVLTGHDPTD
MMAR_2931|M.marinum_M SLIEQSAPFPPPPPGYDCPVSCEPMPARFPDPREPTAMPDVVLTGHDPTS
Mb0707|M.bovis_AF2122/97 GKIAAGAPIAEVLDQTQA--------------------------------
Rv0688|M.tuberculosis_H37Rv GKIAAGAPIAEVLDQTQA--------------------------------
MUL_0769|M.ulcerans_Agy99 AKIAAAVPISEMLDESQGQTSARIPARGAGPGGPLVRWPTLTKSGRWRAE
MAV_4485|M.avium_104 AKIAAAVPIAEMLG------------------------------------
Mflv_5068|M.gilvum_PYR-GCK AKIAAGAPISDLLG------------------------------------
TH_3739|M.thermoresistible__bu AKIAAGAPISEVLE------------------------------------
MAB_3838c|M.abscessus_ATCC_199 AKIAAGTPIAEVLAGS----------------------------------
MSMEG_3594|M.smegmatis_MC2_155 ALIRSREPVDPDLLADPGRPLNAPG-------------------------
MLBr_02387|M.leprae_Br4923 LAQKWDLTATELVRNVHTHPTLSEALQECFHGLIGHMINF----------
.
Mvan_0400|M.vanbaalenii_PYR-1 RGAEFLRR------------------------
MMAR_2931|M.marinum_M RGAEFRPRRG----------------------
Mb0707|M.bovis_AF2122/97 --------------------------------
Rv0688|M.tuberculosis_H37Rv --------------------------------
MUL_0769|M.ulcerans_Agy99 KATASSPVARVDGIGLEPGPRRTASWPDVPGT
MAV_4485|M.avium_104 --------------------------------
Mflv_5068|M.gilvum_PYR-GCK --------------------------------
TH_3739|M.thermoresistible__bu --------------------------------
MAB_3838c|M.abscessus_ATCC_199 --------------------------------
MSMEG_3594|M.smegmatis_MC2_155 --------------------------------
MLBr_02387|M.leprae_Br4923 --------------------------------