For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
NPGSLVGQLVDTFKAQGRVVIVGASLAGLRAAEALRDRGFAGHLTIIGDEQYEPYDRPPLSKQVLKGWVP AHHTKLPRLRPVDAQWRLGVAAVGLDRSTRQVLLANGERVEYDRLLIATGTRARPWFNPQEAALEGLFTV RTCDDAEKLAAALKRRPRRVLIVGSGFVGSEIASVCRDLDLPVTVAERGKAPLVGALGGVIGDIAAKMQL EAGVDLRTGVAVEGLEGDAEGHVRAARLSDGTVLDVDVVVASLGSIRNVEWLEGAQLASGFWGVACDAGC RAFDINGVVTDNIFVAGDVARAPHVLYEYEFMSQEHWDNAVFGAEVAANNMISLEMGRRPHLPLPSFWSG QFGVNIKSVGVCSFGDEIVFTQGSIEQRRFAAAYGYRGRIVGAVTFDHGKWLPYYASLIEQSAPFPPPPP GYDCPVSCEPMPARFPDPREPTAMPDVVLTGHDPTSRGAEFRPRRG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2931 | - | - | 100% (467) | ferredoxin reductase |
| M. marinum M | MMAR_1017 | - | 5e-54 | 37.43% (382) | ferredoxin reductase |
| M. marinum M | MMAR_3153 | - | 3e-37 | 33.25% (385) | ferredoxin reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0707 | - | 2e-51 | 37.04% (378) | putative ferredoxin reductase |
| M. gilvum PYR-GCK | Mflv_0680 | - | 7e-49 | 36.56% (372) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. tuberculosis H37Rv | Rv0688 | - | 2e-51 | 37.04% (378) | putative ferredoxin reductase |
| M. leprae Br4923 | MLBr_02387 | lpd | 3e-06 | 25.50% (302) | dihydrolipoamide dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3838c | - | 1e-47 | 33.76% (394) | putative ferredoxin reductase |
| M. avium 104 | MAV_4485 | - | 1e-49 | 36.98% (384) | ferredoxin reductase |
| M. smegmatis MC2 155 | MSMEG_3594 | - | 3e-47 | 34.32% (373) | anthranilate dioxygenase reductase |
| M. thermoresistible (build 8) | TH_3739 | - | 1e-50 | 35.84% (385) | PUTATIVE Pyridine nucleotide-disulphide oxidoreductase |
| M. ulcerans Agy99 | MUL_0769 | - | 1e-52 | 36.60% (388) | ferredoxin reductase |
| M. vanbaalenii PYR-1 | Mvan_0400 | - | 0.0 | 81.30% (460) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2931|M.marinum_M MNPGSLVGQLVDTFKAQG--------RVVIVGASLAGLRAAEALRDRGFA
Mvan_0400|M.vanbaalenii_PYR-1 -MTVELIGELVDSFRRTG--------RIVIVGASLAGLRAAEALRDGGFS
Mb0707|M.bovis_AF2122/97 -----MNAHVTSREGVN-----EFDDGIVIVGGGLAAARTAEQLRRAGYS
Rv0688|M.tuberculosis_H37Rv -----MNAHVTSREGVN-----EFDDGIVIVGGGLAAARTAEQLRRAGYS
MUL_0769|M.ulcerans_Agy99 ----MYEHHVTSSEGVTQDPGATAANGIVIIGGGLAAARTAEQLRRAGYE
MAV_4485|M.avium_104 -----MSSDASAS------------NGIVIVGGGLAAARTAEQLRRSEYS
TH_3739|M.thermoresistible__bu ---------VSTT------------AGIIIVGGGLAAARTAEQLRRSEFG
MAB_3838c|M.abscessus_ATCC_199 ---------MTDAER-----------GVLIIGGGLGAVRTAEQLRRAEFT
Mflv_0680|M.gilvum_PYR-GCK ---------MTSR--------------VVIVGSSVGGVRTAQALRSQGYD
MSMEG_3594|M.smegmatis_MC2_155 ---------MTAAS------------TFVIIGGGLAGAKAAEALRDNDFD
MLBr_02387|M.leprae_Br4923 ---------MTHYD-------------VVVLGAGPGGYVAAIRAAQLGLS
.:::*.. .. :*
MMAR_2931|M.marinum_M GHLTIIGDEQYEPYDRPPLSKQVLKG--WVPAHHTKLPR--LRPVDAQWR
Mvan_0400|M.vanbaalenii_PYR-1 GSLTIIGDEPHEPYDRPPLSKQVLKG--WVPADHTKLPR--LRRVDADWR
Mb0707|M.bovis_AF2122/97 GRLTIVSDEVHLPYDRPPLSKEVLR---SEVDDVALKPREFYDEKDIALR
Rv0688|M.tuberculosis_H37Rv GRLTIVSDEVHLPYDRPPLSKEVLR---SEVDDVALKPREFYDEKDIALR
MUL_0769|M.ulcerans_Agy99 GQLTIVSDEVHLPYDRPPLSKEVLR---SEVDDVSLKPREWYDEKGITLR
MAV_4485|M.avium_104 GPITIVSDEVHLPYDRPPLSKEVLR---KEVDDTALKPRQWYDDNDITLR
TH_3739|M.thermoresistible__bu GPITIVSDEDHLPYDRPPLSKDVLS---GKTDDVTLKPAEFYAENDITLL
MAB_3838c|M.abscessus_ATCC_199 GPITIVSSETHLPYDRPPLSKDVLRDAEKTIDAVVLKPREFYDEKQIELR
Mflv_0680|M.gilvum_PYR-GCK GGIVLVGEETALPYDKPPLSKALLAG-TSDIAAATLLTRDAAAADAIELL
MSMEG_3594|M.smegmatis_MC2_155 GQVLLFAAEEKLPYERPPLSKDYLAG-KKTLDEFTVAAPAWYRDHDVTLR
MLBr_02387|M.leprae_Br4923 TAVVEPKYWGGICLNVGCIPSKVLLHNAELAHIFTKEAKTFGISGDASFD
: : :.. * .
MMAR_2931|M.marinum_M LGVAAVGLDRSTR-------------QVLLANGERVEYDRLLIATGTRAR
Mvan_0400|M.vanbaalenii_PYR-1 LGVAATGLDRRAK-------------RVLLADGSAVEYDRLLIATGVRAR
Mb0707|M.bovis_AF2122/97 LGSAAVSLDTGEQ-------------TVTLADGTVLGYDELVIATGLVPR
Rv0688|M.tuberculosis_H37Rv LGSAAVSLDTGEQ-------------TVTLADGTVLGYDELVIATGLVPR
MUL_0769|M.ulcerans_Agy99 LGSAATGLDTAAQ-------------TVTLADGTVLGYDELVIATGLVPR
MAV_4485|M.avium_104 LGSAARSLDTAAQ-------------TLTLEDGTTLGYDELVIATGLVPR
TH_3739|M.thermoresistible__bu LGTAATALDPQAR-------------KLTLADGRALEYDELIIATGLVPK
MAB_3838c|M.abscessus_ATCC_199 LGSEVTALDPVAR-------------TVTLSDGGTLEYGEVIIATGLVPR
Mflv_0680|M.gilvum_PYR-GCK LGRRAIGVDVAAC-------------QVEFADDEPLHYDHLVVATGASAR
MSMEG_3594|M.smegmatis_MC2_155 LGTEVAAINPADH-------------TVTLPDGSAVGYDKLLLATGSASR
MLBr_02387|M.leprae_Br4923 YGIAYDRSRKVSEGRVAGVHFLMKKNKITEIHGYGRFTDANTLSVELSEG
* : .. . ::.
MMAR_2931|M.marinum_M PWFNPQEAALEGLFTVRTCDDAEKLAAALKR-------------RPRRVL
Mvan_0400|M.vanbaalenii_PYR-1 QWPNPDEAALDGVFTLRTRDDAAALQAALHA-------------RPNRVL
Mb0707|M.bovis_AF2122/97 --RIPSLPDLDGIRVLRSFDESMALRKHAS--------------AARHAV
Rv0688|M.tuberculosis_H37Rv --RIPSLPDLDGIRVLRSFDESMALRKHAS--------------AARHAV
MUL_0769|M.ulcerans_Agy99 --RIPAFPELEGIRVLRSFDECMALRSHAS--------------AAKRAV
MAV_4485|M.avium_104 --RIPTIPDLDGIRVLRTFDESLALREHAS--------------AAQRAV
TH_3739|M.thermoresistible__bu --RIPTLPDLEGIRVLRTYDESMALRKHAG--------------SARNAV
MAB_3838c|M.abscessus_ATCC_199 --RIPTFPDLAGVHVLRTADDSFALRGDAE--------------NARRAV
Mflv_0680|M.gilvum_PYR-GCK --PSP-WGHGSGVHVLRTLEDCLRLRADLV--------------AGARLV
MSMEG_3594|M.smegmatis_MC2_155 RLPIP-GADASGVHYLRTVDDAAALDAVLT--------------EGASLA
MLBr_02387|M.leprae_Br4923 VPETPLKVTFNNVIIATGSKTRLVPGTLLSTNVITYEEQILTRELPDSIV
* .: .
MMAR_2931|M.marinum_M IVGSGFVGSEIASVCRDLDLPVTVAERGKAPLVGALGGVIGDIAAKMQLE
Mvan_0400|M.vanbaalenii_PYR-1 VVGSGFIGSEMASVCRELDLAVTVAERGPAPLVGALGGVIGELAAAMQRD
Mb0707|M.bovis_AF2122/97 VVGAGFIGCEVAASLRGLGVDVVLVEPQPAPLASVLGEQIGQLVTRLHRD
Rv0688|M.tuberculosis_H37Rv VVGAGFIGCEVAASLRGLGVDVVLVEPQPAPLASVLGEQIGQLVTRLHRD
MUL_0769|M.ulcerans_Agy99 VIGAGFIGCEVAASLRGLGVEVVLVEPQPTPLAAVLGEQIGELVARLHRS
MAV_4485|M.avium_104 IIGAGFIGCEVAASLRSLGVDVVLVEPQPTPLAAVLGQQIGELVARLHRA
TH_3739|M.thermoresistible__bu VIGAGFIGCEVAASLRGLGVHVVLVEPQPTPLAGVLGEQIGALVARLHRD
MAB_3838c|M.abscessus_ATCC_199 VVGAGFIGCEVAATLRANGVEVVLVEPQPAPLLAAIGQQLGDLVARLHRN
Mflv_0680|M.gilvum_PYR-GCK VIGAGFIGAEVASTARSLGLQVTVVDPVPVPMSRVLTEEIGGWFVDLHRD
MSMEG_3594|M.smegmatis_MC2_155 VVGAGWIGLEVAASARTRGVNVTVVEAARLPLLGALGAEVAEVFAQLHRE
MLBr_02387|M.leprae_Br4923 IVGAGAIGIEFGYVLKNYGVDVTIVEFLPRAMPNED-AEVSKEIEKQFKK
::*:* :* *.. : .: *.:.: .: :.
MMAR_2931|M.marinum_M AGVDLRTGVAVEGLEGDAEGHVRAARLSDG--TVLDVDVVVASLGSIRNV
Mvan_0400|M.vanbaalenii_PYR-1 AGVDLRTGVSVLGLDGDDTGHVRSARLSDG--TTLPVDVVVASLGSIRNV
Mb0707|M.bovis_AF2122/97 EGVDVRTGVTVAEVRGK--GHVDAVVLTDG--TELPADLVVVGIGSTPAT
Rv0688|M.tuberculosis_H37Rv EGVDVRTGVTVAEVRGK--GHVDAVVLTDG--TELPADLVVVGIGSTPAT
MUL_0769|M.ulcerans_Agy99 EGVDVRTGVGVAEVRGD--GHVDTVVLADG--TQLDADLVVVGIGSHPAT
MAV_4485|M.avium_104 EGVDVRLGVGVSEVRGD--RHVEAVVLTDG--TELAADVVVIGIGSRPAT
TH_3739|M.thermoresistible__bu EGVDLRCGVGVADVRGT--GAVEKVVLDDG--TELDADLVVVGIGSTPAT
MAB_3838c|M.abscessus_ATCC_199 EGVDVRVGVGVDAVEGQ--DRVQSVTLSDG--TRLDTDLVVLGIGSRPAI
Mflv_0680|M.gilvum_PYR-GCK HGVHTRFGVGVENIEGE--RGNLKIGLTDG--TVLEADTVVVGIGAVPND
MSMEG_3594|M.smegmatis_MC2_155 HGVDLRLEQTVEEITTAD-GRATGLRLGDG--STIAADAVLVAVGAAPNI
MLBr_02387|M.leprae_Br4923 MGIKILTGTKVESISDNG-SHVLVAVSKDGQFQELKADKVLQAIGFAPN-
*:. * : ** : .* *: .:*
MMAR_2931|M.marinum_M EWLEGAQLASG--FWGVACDAGCRAFDINGVVTDNIFVAGDVARAPHVLY
Mvan_0400|M.vanbaalenii_PYR-1 EWLDDAGLATG--FWGVACDAGCRAFDVNGVVTDNIFVAGDVARAPHVLY
Mb0707|M.bovis_AF2122/97 EWLEGSGVEVD---NGVICDKAG------RTSAPNVWALGDVASWRD-PM
Rv0688|M.tuberculosis_H37Rv EWLEGSGVEVD---NGVICDKAG------RTSAPNVWALGDVASWRD-PM
MUL_0769|M.ulcerans_Agy99 GWLDGSGIAVD---NGVVCDAAG------RTSAPNVWAFGDVASWRD-QM
MAV_4485|M.avium_104 DWLEGSGVAIDSVDRGVLCDEAG------RTSAPNVWALGDVASWRD-AT
TH_3739|M.thermoresistible__bu DWLQGSGVEVD---NGVVCDAVG------RTNVEHVWAIGDVASWRN-TV
MAB_3838c|M.abscessus_ATCC_199 DWLDGSGVAVD---NGVVCDAVG------ATGTPHVWALGDVAAWAG-AD
Mflv_0680|M.gilvum_PYR-GCK GWLMPSGLVVD---DGLVCDEFCR-----AVTSQNIYAVGDVSRWFHRAR
MSMEG_3594|M.smegmatis_MC2_155 GLAERAGLATAD--GGVLVDASLR------TSDPDIYAVGDIAAAQHPLF
MLBr_02387|M.leprae_Br4923 --VDGYGLDKVG--VALTADKAVDIDDYMQTNVSHIYAIGDVTGKLQLAH
: .: * . .::. **::
MMAR_2931|M.marinum_M EYEFMSQEHWDNAVFGAEVAANNMISLEMGRRPHLPLPSF-------WSG
Mvan_0400|M.vanbaalenii_PYR-1 EYQFMSLEHWDNAVSGGEVAANNMINLETGRRPHLPLPSF-------WSG
Mb0707|M.bovis_AF2122/97 GHQAR-VEHWSNVADQARVVVPAMLGTDVPT--GVVVPYF-------WSD
Rv0688|M.tuberculosis_H37Rv GHQAR-VEHWSNVADQARVVVPAMLGTDVPT--GVVVPYF-------WSD
MUL_0769|M.ulcerans_Agy99 GHQVR-VEHWSNVADQARVVVPAMLGREVSS--NVVVPYF-------WSD
MAV_4485|M.avium_104 GHQGR-VEHWSNVADQARVVVPAMLGKEVPP--VVVVPYF-------WSD
TH_3739|M.thermoresistible__bu GKQVR-VEHWSNVADQARVLVPALLGQEVPV--AATVPYF-------WSD
MAB_3838c|M.abscessus_ATCC_199 GRPNR-VEHWSNVADQVRALVPALLGQETSAN-TVAVPYF-------WSD
Mflv_0680|M.gilvum_PYR-GCK GVTMR-IEHWTNAVDQASCVAHNILYPDELRC-YEPVEYV-------WSD
MSMEG_3594|M.smegmatis_MC2_155 GVRIR-TEHWANALKQPAVAVAGMLGRPAEY---AELPYF-------FTD
MLBr_02387|M.leprae_Br4923 VAEAQGVVAAEAIAGAETLALSDYRMMPRATFCQPNVASFGLTEQQARDG
: . .
MMAR_2931|M.marinum_M QFGVNIKSVGVCSFGDEIVFTQGSI-EQRRFAAAYGYRGRIVG--AVTFD
Mvan_0400|M.vanbaalenii_PYR-1 QFGVNIKGVGVCSFGDEIVFTQGSP-GEYRFAAAYGRRGRIVG--AVTFN
Mb0707|M.bovis_AF2122/97 QYDVKIQCLGEPHATDVVHLVED---DGRKFLAYYERDGVLVG--VVGGG
Rv0688|M.tuberculosis_H37Rv QYDVKIQCLGEPHATDVVHLVED---DGRKFLAYYERDGVLVG--VVGGG
MUL_0769|M.ulcerans_Agy99 QYDVKIQCLGEPHSTDVVHLVED---DGRKLLAYYQRDGVLVG--VVGGG
MAV_4485|M.avium_104 QYDVKIQCLGEPEADDIVHIVED---DGRKFLAYYERDGALVG--VVGGG
TH_3739|M.thermoresistible__bu QYDVKIQCLGEPEAGDTVHVVSD---DGRKFLAYYERDGVLTG--VVGGG
MAB_3838c|M.abscessus_ATCC_199 QYDVKIQSLGHLGSSDTVHLISD---DGRKFLAYLERDGVLTG--VVGCG
Mflv_0680|M.gilvum_PYR-GCK QYDWKIQFCGQTTHLGEPLVVGDRLSDNRFTVLYPDGEQRLGG--AAVVN
MSMEG_3594|M.smegmatis_MC2_155 QYDLGMEYAGHAPSYERVVFRGDVP-GREFVSFWLDGDNRVLA--GMNVN
MLBr_02387|M.leprae_Br4923 GYDVVVAKFPFTANAKAHGMGDP---SGFVKLVADAKYGELLGGHMIGHN
:. : . : . .
MMAR_2931|M.marinum_M HGKWLPYYASLIEQSAPFPPPPPGYDCPVSCEPMPARFPDPREPTAMPDV
Mvan_0400|M.vanbaalenii_PYR-1 HGKWLPYYADLIERSAPFPPPPPGFDRPVLGEPMPARFPDPRVPTGIPDV
Mb0707|M.bovis_AF2122/97 MAGKVMKVRGKIAAGAPIAEVLDQTQA-----------------------
Rv0688|M.tuberculosis_H37Rv MAGKVMKVRGKIAAGAPIAEVLDQTQA-----------------------
MUL_0769|M.ulcerans_Agy99 VPGKVMKVRAKIAAAVPISEMLDESQGQTSARIPARGAGPGGPLVRWPTL
MAV_4485|M.avium_104 MPGKVMKTRAKIAAAVPIAEMLG---------------------------
TH_3739|M.thermoresistible__bu MPGKVMKARAKIAAGAPISEVLE---------------------------
MAB_3838c|M.abscessus_ATCC_199 MAGPVMKMRAKIAAGTPIAEVLAGS-------------------------
Mflv_0680|M.gilvum_PYR-GCK WPRALIECRRALQAGSDLESVRGRLEVLTNPPDTAATRSP----------
MSMEG_3594|M.smegmatis_MC2_155 IWDVLDDVKALIRSREPVDPDLLADPGRPLNAPG----------------
MLBr_02387|M.leprae_Br4923 VSELLPELTLAQKWDLTATELVRNVHTHPTLSEALQECFHGLIGHMINF-
:
MMAR_2931|M.marinum_M VLTGHDPTSRGAEFRPRRG----------------------
Mvan_0400|M.vanbaalenii_PYR-1 VLTGHDPTDRGAEFLRR------------------------
Mb0707|M.bovis_AF2122/97 -----------------------------------------
Rv0688|M.tuberculosis_H37Rv -----------------------------------------
MUL_0769|M.ulcerans_Agy99 TKSGRWRAEKATASSPVARVDGIGLEPGPRRTASWPDVPGT
MAV_4485|M.avium_104 -----------------------------------------
TH_3739|M.thermoresistible__bu -----------------------------------------
MAB_3838c|M.abscessus_ATCC_199 -----------------------------------------
Mflv_0680|M.gilvum_PYR-GCK -----------------------------------------
MSMEG_3594|M.smegmatis_MC2_155 -----------------------------------------
MLBr_02387|M.leprae_Br4923 -----------------------------------------