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AITDIAKYTHLSPEDIESLGRELDAIRSDIEESLGSRDAAYIRRTIAFQRTLDVAARALIATTRSTAGWL LGTAALGVAKSVENMEIGHNVSHGQWDWMNDPAIHSSTWEWDMVAVSSQWRSSHNYRHHVFTNVLGEDDD LGFGVMRVTPEQPWTKAHLLQPLQNLFLALTFEWGIALHGVDLGRTRPEKIAQVKAVVGKVARQGVKDYA LWPALSLRRWRRTLKANVVANLMRNLWAYVVIFCGHFPDGTQKFMPEVLESETRAEWYLRQMLGTANFKA GRLLGFASGNLCYQIEHHLFPDLPSNRLAEISRRVRPLCEKYDLPYFTGSLARQYASTLRTIHRLALPNG VAAAAV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5213 | - | - | 100% (357) | fatty acid desaturase |
| M. gilvum PYR-GCK | Mflv_5222 | - | e-149 | 70.14% (355) | fatty acid desaturase |
| M. gilvum PYR-GCK | Mflv_5195 | - | e-145 | 67.97% (359) | fatty acid desaturase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3258c | - | 1e-116 | 55.00% (360) | linoleoyl-CoA desaturase |
| M. tuberculosis H37Rv | Rv3229c | - | 1e-116 | 55.00% (360) | linoleoyl-CoA desaturase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3548c | - | 1e-118 | 55.28% (360) | putative fatty acid desaturase |
| M. marinum M | MMAR_1315 | desA3 | 1e-118 | 55.56% (360) | linoleoyl-CoA desaturase, DesA3 |
| M. avium 104 | MAV_4192 | - | 1e-119 | 56.67% (360) | Fatty acid desaturase |
| M. smegmatis MC2 155 | MSMEG_1211 | - | 1e-147 | 71.19% (354) | Fatty acid desaturase |
| M. thermoresistible (build 8) | TH_0650 | desA3 | 1e-117 | 56.11% (360) | POSSIBLE LINOLEOYL-CoA DESATURASE (DELTA(6)-DESATURASE) |
| M. ulcerans Agy99 | MUL_2565 | desA3 | 1e-117 | 55.28% (360) | linoleoyl-CoA desaturase, DesA3 |
| M. vanbaalenii PYR-1 | Mvan_1055 | - | 0.0 | 87.96% (357) | fatty acid desaturase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3258c|M.bovis_AF2122/97 MAITDVDVFAHLTDADIENLAAELDAIRRDVEESRGERDARYIRRTIAAQ
Rv3229c|M.tuberculosis_H37Rv MAITDVDVFAHLTDADIENLAAELDAIRRDVEESRGERDARYIRRTIAAQ
MMAR_1315|M.marinum_M MAITDVDVFAHLTDADIENLAIELDAIRQDIEDSRGERDARYIRRTIAAQ
MUL_2565|M.ulcerans_Agy99 MVITDVDVFAHLTDADIENLAIELDAIRQDIEDSRGERDARYIRRTIAAQ
MAV_4192|M.avium_104 MAITDVDVFAHLTDADIENLAVELDAIRQDVEDSRGERDARYIRRTIAAQ
TH_0650|M.thermoresistible__bu MAITDVPAYAHLTEVDIDALAVELDAIRRDIEDSLGERDARYIRRTIATQ
MAB_3548c|M.abscessus_ATCC_199 MAISDIQEFAHLTEADVEALGHELDAIRRDVEESLGAADARYIRRTIAAQ
Mflv_5213|M.gilvum_PYR-GCK MAITDIAKYTHLSPEDIESLGRELDAIRSDIEESLGSRDAAYIRRTIAFQ
Mvan_1055|M.vanbaalenii_PYR-1 MAITDIAHYTHLSPEDIESLGRELDTIRSDIEESLGSRDAAYIRRTISFQ
MSMEG_1211|M.smegmatis_MC2_155 MAISDVAVYAKLTPAEIEAFGAELDTIRADIEESLGTRDAAYIRRTIAFQ
*.*:*: :::*: ::: :. ***:** *:*:* * ** ******: *
Mb3258c|M.bovis_AF2122/97 RALEVSGRLLLAGSSRRLAWWTGALTLGVAKIIENMEIGHNVMHGQWDWM
Rv3229c|M.tuberculosis_H37Rv RALEVSGRLLLAGSSRRLAWWTGALTLGVAKIIENMEIGHNVMHGQWDWM
MMAR_1315|M.marinum_M RALEVSGRLMLAASSRRSAWWAGALTLGVAKIVENMEIGHNVMHGQWDWM
MUL_2565|M.ulcerans_Agy99 RALEVSGRLMLAASSRRSAWWAGALTLGVAKIVENMEIGHNVMHGQWDWM
MAV_4192|M.avium_104 RALEVTGRLLLAASSRRSAWWAGTVTLGVAKIIENMEIGHNVMHGQWDWM
TH_0650|M.thermoresistible__bu RGLEVAGRLLLAASSRRSAWWAGAVTLAAAKIIENMEIGHNVMHGQWDWM
MAB_3548c|M.abscessus_ATCC_199 RTLELTGRILLAASKKRSAWWAGAVTLGVAKIVENMEIGHNVMHGQWDWM
Mflv_5213|M.gilvum_PYR-GCK RTLDVAARALIATTRSTAGWLLGTAALGVAKSVENMEIGHNVSHGQWDWM
Mvan_1055|M.vanbaalenii_PYR-1 RTLDVAARLLIATTRSTAGWVLGTAALGFAKSVENMEIGHNVSHGQWDWM
MSMEG_1211|M.smegmatis_MC2_155 RSLDVAARLLIAGTRSKAGWLAGTAALAYAKSVENMEIGHNVSHGQWDWM
* *:::.* ::* : .* *: :*. ** :********* *******
Mb3258c|M.bovis_AF2122/97 NDPEIHSSTWEWDMSGSSKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVT
Rv3229c|M.tuberculosis_H37Rv NDPEIHSSTWEWDMSGSSKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVT
MMAR_1315|M.marinum_M NDPEIHSSSWEWDITGASKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVT
MUL_2565|M.ulcerans_Agy99 NDPEIHSSSWEWDITGASKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVT
MAV_4192|M.avium_104 NDPEIHSSTWEWDMSGSSKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVT
TH_0650|M.thermoresistible__bu NDPEIHSSTWEWDMTGASKHWRFTHNFMHHKYTNILGMDDDVGYGLLRVT
MAB_3548c|M.abscessus_ATCC_199 NDPEIHSSSWEWDMVDPAEHWKQTHNYIHHKYTNVLGMDDDVGYGLLRVT
Mflv_5213|M.gilvum_PYR-GCK NDPAIHSSTWEWDMVAVSSQWRSSHNYRHHVFTNVLGEDDDLGFGVMRVT
Mvan_1055|M.vanbaalenii_PYR-1 NDPEIHSSTWEWDMVAVSSQWRSSHNYRHHVFSNVLGEDDDLGFGVMRVT
MSMEG_1211|M.smegmatis_MC2_155 NDPEIHSSTWEWDMVGPSAQWRYSHNYRHHVFSNVLGVDDDLGFGVLRMS
*** ****:****: : :*: :**: ** ::*:** ***:*:*::*::
Mb3258c|M.bovis_AF2122/97 RDQRWKRYNIFNVVWNTILAIGFEWGVALQHLEIGKIFKGRAD-REAAKT
Rv3229c|M.tuberculosis_H37Rv RDQRWKRYNIFNVVWNTILAIGFEWGVALQHLEIGKIFKGRAD-REAAKT
MMAR_1315|M.marinum_M RDQRWKRYNIFNLVWNTLLALGFEWGVALQHLEIGKLLKGRLD-RDTART
MUL_2565|M.ulcerans_Agy99 RDQRWKRYNIFNLVWNTLLALGFEWGVALQHLEIGKLLKGRLD-RDTAET
MAV_4192|M.avium_104 RDQRWKRFNLFNLVWNTLLALLFEWGVGLQHVEIGKILKRRMD-HEEARQ
TH_0650|M.thermoresistible__bu RDQKWKPFNLGNLLYNTLLALAFEWGVGLQHVELGKIFKRRHD-PDESRV
MAB_3548c|M.abscessus_ATCC_199 RDKKWKPFNLGNLLYNTLLMLLFEWGVGTQHLELGKVAQGRAD-KEEFRV
Mflv_5213|M.gilvum_PYR-GCK PEQPWTKAHLLQPLQNLFLALTFEWGIALHGVDLG---RTRPE----KIA
Mvan_1055|M.vanbaalenii_PYR-1 SDQPWRRRYLLQPLQNLFLALTFEWGIALHGVNLD---RSRAE----KLS
MSMEG_1211|M.smegmatis_MC2_155 RDQKWEPQHLIQPLRNLLLAAVFEWGIGLHDYYSE---RDRADTQDGKDA
:: * : : : * :* ****:. : : * :
Mb3258c|M.bovis_AF2122/97 RLREFSAKAGRQVFKDYVAFPALTSLSPGATYRSTLTANVVANVIRNVWS
Rv3229c|M.tuberculosis_H37Rv RLREFSAKAGRQVFKDYVAFPALTSLSPGATYRSTLTANVVANVIRNVWS
MMAR_1315|M.marinum_M RVREFSRKAGRQVFKDYVAFPALTSVSPGATYRSTLTANVTANVLRNVWT
MUL_2565|M.ulcerans_Agy99 RVREFSRKAGRQVFKDYVAFPALTSVSPGATYRSTLTANVTANVLRNVWT
MAV_4192|M.avium_104 RIDEFLAKAGRQVVKDYVAFPALTSLSPGATFLSTLKANAMANVIRNVWA
TH_0650|M.thermoresistible__bu RVREFLRKAGRQVFKDYVAYPALSSLSPAASYRSTLTANAMANVIRNVWS
MAB_3548c|M.abscessus_ATCC_199 KRQAALTKMGKQVAKDYVAFPALSALSPAGSYRKTVTANLLANVIRNIWS
Mflv_5213|M.gilvum_PYR-GCK QVKAVVGKVARQGVKDYALWPALSLRR----WRRTLKANVVANLMRNLWA
Mvan_1055|M.vanbaalenii_PYR-1 QTRALVGKVARQGFKDYALWPALSLRR----WRRTLKANAVANLLRNLWA
MSMEG_1211|M.smegmatis_MC2_155 ARTAFRRKIGRQVAKDYVLLPALSLRR----WRRTLLANLTANLVRNVWA
* .:* ***. ***: : *: ** **::**:*:
Mb3258c|M.bovis_AF2122/97 NAVIFCGHFPDGAEKFTKTDMIGEPKGQWYLRQMLGSANFNAGPALRFMS
Rv3229c|M.tuberculosis_H37Rv NAVIFCGHFPDGAEKFTKTDMIGEPKGQWYLRQMLGSANFNAGPALRFMS
MMAR_1315|M.marinum_M NAVIFCGHFPDGAEKFTKTDMVGETKGQWYLRQMLGSANFEAGPALRFMS
MUL_2565|M.ulcerans_Agy99 NAVIFCGHFPDGAEKFTKADMVGETKGQWYLRQMLGSANFEAGPALRFMS
MAV_4192|M.avium_104 NAVIFCGHFPDGAEKFTKTDMIGETKGQWYLRQMLGSANFEAGPVLRFMS
TH_0650|M.thermoresistible__bu NAVIFCGHFPDGAEKFTKTDMVGESKGQWYLRQMLGSANFEGGWLLRFMS
MAB_3548c|M.abscessus_ATCC_199 NAVIFCGHFPDGAEKFTKQDLENETQGQWYLRQMLGSANFDAGPAMAFMS
Mflv_5213|M.gilvum_PYR-GCK YVVIFCGHFPDGTQKFMPEVLESETRAEWYLRQMLGTANFKAGRLLGFAS
Mvan_1055|M.vanbaalenii_PYR-1 YVVIFCGHFPEGTQKFTADVLETETRAEWYLRQMLGAANFKAGRFLGFAS
MSMEG_1211|M.smegmatis_MC2_155 CVVIFCGHFPDGAEKFTPESLERETKGEWYLRQMLGAANFKAGRVLAFSS
.********:*::** : *.:.:********:***..* : * *
Mb3258c|M.bovis_AF2122/97 GNLCHQIEHHLYPDLPSNRLHEISVRVREVCDRYDLPYTTGSFLVQYGKT
Rv3229c|M.tuberculosis_H37Rv GNLCHQIEHHLYPDLPSNRLHEISVRVREVCDRYDLPYTTGSFLVQYGKT
MMAR_1315|M.marinum_M GNLCHQIEHHLYPDLPSNRLAEVSVRVREICDKYDLPYTTGSFLVQYGKT
MUL_2565|M.ulcerans_Agy99 GNLCHQIEHHLYPDLPSNRLAEVSVRVREICDKYDLPYTTGSFLVQYGKT
MAV_4192|M.avium_104 GNLCHQIEHHLYPDLPSNRLHEISVRVRQVCDKYDLPYTTGSFLFQYAKT
TH_0650|M.thermoresistible__bu GNLCHQIEHHLYPDLPSNRLHEASIRVREVCDKYDLPYTTGPFLVQYAKT
MAB_3548c|M.abscessus_ATCC_199 GNLCHQIEHHLFPDLPSNRLSAVSVRVRELCDKYDLPYTSGPFLVQYAKA
Mflv_5213|M.gilvum_PYR-GCK GNLCYQIEHHLFPDLPSNRLAEISRRVRPLCEKYDLPYFTGSLARQYAST
Mvan_1055|M.vanbaalenii_PYR-1 GNLCYQIEHHLFPDLPSNRLAEISRRVRPLCEKYGLPYLTGSLAHQYGST
MSMEG_1211|M.smegmatis_MC2_155 GNLCYQIEHHLFPDLPSNRLAQIAGRVSALCDKYDLPYTTGPMPRQYLQT
****:******:******** : ** :*::*.*** :*.: ** .:
Mb3258c|M.bovis_AF2122/97 WRTLAKLSLPDKYLRDNADDAPETRSERMFAGLGPGFAGADPVTGRRRGL
Rv3229c|M.tuberculosis_H37Rv WRTLAKLSLPDKYLRDNADDAPETRSERMFAGLGPGFAGADPVTGRRRGL
MMAR_1315|M.marinum_M WRTLAKLSLPNKYLRDNADNAPETRSERMFADLEPGFAGADPRTGRRRGL
MUL_2565|M.ulcerans_Agy99 WRTLAKLSLPNKYLRDNADDAPETRSERMFADLEPGFAGADPRTGRRRGL
MAV_4192|M.avium_104 WRTLAKLSLPNKYLRDDADNAPETRSERMFAELDPDFLGTDPATGRRRGL
TH_0650|M.thermoresistible__bu WRTLAKLSLPDRFLKATADNAPETRSERMFAELGPGFAGVDPATGRRRGL
MAB_3548c|M.abscessus_ATCC_199 WRTIAKLSLPDKYLTYTADNAQETRSVKMFDELEP---------HERRGL
Mflv_5213|M.gilvum_PYR-GCK LRTIHRLALPN---------------------------------------
Mvan_1055|M.vanbaalenii_PYR-1 LRIIHRLALPD---------------------------------------
MSMEG_1211|M.smegmatis_MC2_155 LRIIFTLALPD---------------------------------------
* : *:**:
Mb3258c|M.bovis_AF2122/97 KTAIAAVRGRRRSKRMAKSVTE-PDDLAA---------------------
Rv3229c|M.tuberculosis_H37Rv KTAIAAVRGRRRSKRMAKSVTE-PDDLAA---------------------
MMAR_1315|M.marinum_M KSAIAAVRGRRRGKRVPEVRDSGTNDLAA---------------------
MUL_2565|M.ulcerans_Agy99 KSAIAAVRGRRRGKRVPEVRDSGTNDLAA---------------------
MAV_4192|M.avium_104 KSAIAAVRGWRRGKRASVARRT-GGELAA---------------------
TH_0650|M.thermoresistible__bu KSAFAAVRNWRRDKQAAKAXXX--GELYPRPGTLRRDVGVRLRRGGVPGP
MAB_3548c|M.abscessus_ATCC_199 KSAFAAVRARRKARHKV---------------------------------
Mflv_5213|M.gilvum_PYR-GCK GVAAAAV-------------------------------------------
Mvan_1055|M.vanbaalenii_PYR-1 RPAVAAIASSAAVSRISTQ-------------------------------
MSMEG_1211|M.smegmatis_MC2_155 TGWRGIFRR-----------------------------------------
. .
Mb3258c|M.bovis_AF2122/97 -----------------------------------------
Rv3229c|M.tuberculosis_H37Rv -----------------------------------------
MMAR_1315|M.marinum_M -----------------------------------------
MUL_2565|M.ulcerans_Agy99 -----------------------------------------
MAV_4192|M.avium_104 -----------------------------------------
TH_0650|M.thermoresistible__bu AGLWSGEHDRRGHRPPRSGPQRIRRPRGHAVLRRRDRAVRR
MAB_3548c|M.abscessus_ATCC_199 -----------------------------------------
Mflv_5213|M.gilvum_PYR-GCK -----------------------------------------
Mvan_1055|M.vanbaalenii_PYR-1 -----------------------------------------
MSMEG_1211|M.smegmatis_MC2_155 -----------------------------------------