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AIADVSTYTHLSSRDIEAIADELDAIRRDVEESLGQRDADYIRRIILFQRALDVGARLVIAGSRSKAGWL LGTASLAYAKSIENMELGHNISHGQWDWMNDPEIHSSNWEWDMVGSSAQWRYSHNYRHHVFSNVLGMDED IGYRWLRVTTDQPWRRAHLSTPVRNLVLAATFEWGIALHGLRSERDRGETPAAVAVEKRKFFGKAARQLS KDYVVLPALSLRRWRRTLAANLTANLLRNVWVYVNIICGHIPDGAETFDPAVLDGETRGEWYLRQMLGAA NFKAGPLLAFSGGHLCYQIEHHLFPDLPSNRLAQVSVRVRELCEKYDLPYNTGSFPRQYFRTQRTIHKLA VPDGLLTAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5195 | - | - | 100% (360) | fatty acid desaturase |
| M. gilvum PYR-GCK | Mflv_5222 | - | e-146 | 66.39% (360) | fatty acid desaturase |
| M. gilvum PYR-GCK | Mflv_5213 | - | e-145 | 67.97% (359) | fatty acid desaturase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3258c | - | 1e-122 | 57.97% (364) | linoleoyl-CoA desaturase |
| M. tuberculosis H37Rv | Rv3229c | - | 1e-122 | 57.97% (364) | linoleoyl-CoA desaturase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2148 | - | 1e-118 | 55.49% (364) | putative linoleoyl-CoA desaturase |
| M. marinum M | MMAR_1315 | desA3 | 1e-122 | 56.91% (369) | linoleoyl-CoA desaturase, DesA3 |
| M. avium 104 | MAV_4192 | - | 1e-119 | 56.13% (367) | Fatty acid desaturase |
| M. smegmatis MC2 155 | MSMEG_1211 | - | 1e-149 | 70.06% (354) | Fatty acid desaturase |
| M. thermoresistible (build 8) | TH_0650 | desA3 | 1e-121 | 56.16% (365) | POSSIBLE LINOLEOYL-CoA DESATURASE (DELTA(6)-DESATURASE) |
| M. ulcerans Agy99 | MUL_2565 | desA3 | 1e-123 | 57.18% (369) | linoleoyl-CoA desaturase, DesA3 |
| M. vanbaalenii PYR-1 | Mvan_1045 | - | 1e-144 | 65.56% (360) | fatty acid desaturase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3258c|M.bovis_AF2122/97 MAITDVDVFAHLTDADIENLAAELDAIRRDVEESRGERDARYIRRTIAAQ
Rv3229c|M.tuberculosis_H37Rv MAITDVDVFAHLTDADIENLAAELDAIRRDVEESRGERDARYIRRTIAAQ
MMAR_1315|M.marinum_M MAITDVDVFAHLTDADIENLAIELDAIRQDIEDSRGERDARYIRRTIAAQ
MUL_2565|M.ulcerans_Agy99 MVITDVDVFAHLTDADIENLAIELDAIRQDIEDSRGERDARYIRRTIAAQ
MAV_4192|M.avium_104 MAITDVDVFAHLTDADIENLAVELDAIRQDVEDSRGERDARYIRRTIAAQ
TH_0650|M.thermoresistible__bu MAITDVPAYAHLTEVDIDALAVELDAIRRDIEDSLGERDARYIRRTIATQ
MAB_2148|M.abscessus_ATCC_1997 MAITDISAFAHLTSEDVENLAVELDGLRREIEESRGARDARYIRRTIAAQ
MSMEG_1211|M.smegmatis_MC2_155 MAISDVAVYAKLTPAEIEAFGAELDTIRADIEESLGTRDAAYIRRTIAFQ
Mvan_1045|M.vanbaalenii_PYR-1 MAIADLAAYAHLSKEDIEALGRELDEVRREIEGSLGERDAAYIRRTIRFQ
Mflv_5195|M.gilvum_PYR-GCK MAIADVSTYTHLSSRDIEAIADELDAIRRDVEESLGQRDADYIRRIILFQ
*.*:*: .:::*: ::: :. *** :* ::* * * *** **** * *
Mb3258c|M.bovis_AF2122/97 RALEVSGRLLLAGSSRRLAWWTGALTLGVAKIIENMEIGHNVMHGQWDWM
Rv3229c|M.tuberculosis_H37Rv RALEVSGRLLLAGSSRRLAWWTGALTLGVAKIIENMEIGHNVMHGQWDWM
MMAR_1315|M.marinum_M RALEVSGRLMLAASSRRSAWWAGALTLGVAKIVENMEIGHNVMHGQWDWM
MUL_2565|M.ulcerans_Agy99 RALEVSGRLMLAASSRRSAWWAGALTLGVAKIVENMEIGHNVMHGQWDWM
MAV_4192|M.avium_104 RALEVTGRLLLAASSRRSAWWAGTVTLGVAKIIENMEIGHNVMHGQWDWM
TH_0650|M.thermoresistible__bu RGLEVAGRLLLAASSRRSAWWAGAVTLAAAKIIENMEIGHNVMHGQWDWM
MAB_2148|M.abscessus_ATCC_1997 RALELGGRVLLAASTKRAAWWAGTVTLAVAKIIENMEIGHNVLHGQWDWM
MSMEG_1211|M.smegmatis_MC2_155 RSLDVAARLLIAGTRSKAGWLAGTAALAYAKSVENMEIGHNVSHGQWDWM
Mvan_1045|M.vanbaalenii_PYR-1 RMLEVVARVGIAVTGSRAGWMAGTAALAFAKSVENMEIGHNVSHGQWDWM
Mflv_5195|M.gilvum_PYR-GCK RALDVGARLVIAGSRSKAGWLLGTASLAYAKSIENMELGHNISHGQWDWM
* *:: .*: :* : : .* *: :*. ** :****:***: *******
Mb3258c|M.bovis_AF2122/97 NDPEIHSSTWEWDMSGSSKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVT
Rv3229c|M.tuberculosis_H37Rv NDPEIHSSTWEWDMSGSSKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVT
MMAR_1315|M.marinum_M NDPEIHSSSWEWDITGASKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVT
MUL_2565|M.ulcerans_Agy99 NDPEIHSSSWEWDITGASKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVT
MAV_4192|M.avium_104 NDPEIHSSTWEWDMSGSSKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVT
TH_0650|M.thermoresistible__bu NDPEIHSSTWEWDMTGASKHWRFTHNFMHHKYTNILGMDDDVGYGLLRVT
MAB_2148|M.abscessus_ATCC_1997 NDPEIHSSTWEWDMAGAAKHWRITHNVEHHKYTNILDLDDDVGYGLLRVT
MSMEG_1211|M.smegmatis_MC2_155 NDPEIHSSTWEWDMVGPSAQWRYSHNYRHHVFSNVLGVDDDLGFGVLRMS
Mvan_1045|M.vanbaalenii_PYR-1 NDPEIHSATWEWDMVAVSSQWRYSHNYRHHMMTNIVGVDDDLGFGIMRMT
Mflv_5195|M.gilvum_PYR-GCK NDPEIHSSNWEWDMVGSSAQWRYSHNYRHHVFSNVLGMDEDIGYRWLRVT
*******:.****: . : :** :** ** :*::.:*:*:*: :*::
Mb3258c|M.bovis_AF2122/97 RDQRWKRYNIFNVVWNTILAIGFEWGVALQHLEIGKIFKGRADREAAKTR
Rv3229c|M.tuberculosis_H37Rv RDQRWKRYNIFNVVWNTILAIGFEWGVALQHLEIGKIFKGRADREAAKTR
MMAR_1315|M.marinum_M RDQRWKRYNIFNLVWNTLLALGFEWGVALQHLEIGKLLKGRLDRDTARTR
MUL_2565|M.ulcerans_Agy99 RDQRWKRYNIFNLVWNTLLALGFEWGVALQHLEIGKLLKGRLDRDTAETR
MAV_4192|M.avium_104 RDQRWKRFNLFNLVWNTLLALLFEWGVGLQHVEIGKILKRRMDHEEARQR
TH_0650|M.thermoresistible__bu RDQKWKPFNLGNLLYNTLLALAFEWGVGLQHVELGKIFKRRHDPDESRVR
MAB_2148|M.abscessus_ATCC_1997 RDESWKIRNLFNIPFNFMLAAGFEWGIALQHLELRKIWK-KETREATKQR
MSMEG_1211|M.smegmatis_MC2_155 RDQKWEPQHLIQPLRNLLLAAVFEWGIGLHDYYS-ERDR-ADTQDGKDAA
Mvan_1045|M.vanbaalenii_PYR-1 RDEPWQPVHLLQPLRNMLLAVIFEWGIALHGIHS-ERDRLMPDADRLAEQ
Mflv_5195|M.gilvum_PYR-GCK TDQPWRRAHLSTPVRNLVLAATFEWGIALHGLRS-ERDR-GETPAAVAVE
*: *. :: * :** ****:.*: : :
Mb3258c|M.bovis_AF2122/97 LREFSAKAGRQVFKDYVAFPALTSLSPGATYRSTLTANVVANVIRNVWSN
Rv3229c|M.tuberculosis_H37Rv LREFSAKAGRQVFKDYVAFPALTSLSPGATYRSTLTANVVANVIRNVWSN
MMAR_1315|M.marinum_M VREFSRKAGRQVFKDYVAFPALTSVSPGATYRSTLTANVTANVLRNVWTN
MUL_2565|M.ulcerans_Agy99 VREFSRKAGRQVFKDYVAFPALTSVSPGATYRSTLTANVTANVLRNVWTN
MAV_4192|M.avium_104 IDEFLAKAGRQVVKDYVAFPALTSLSPGATFLSTLKANAMANVIRNVWAN
TH_0650|M.thermoresistible__bu VREFLRKAGRQVFKDYVAYPALSSLSPAASYRSTLTANAMANVIRNVWSN
MAB_2148|M.abscessus_ATCC_1997 LRELVRSAASQLFKDYVAFPAITAASPGATYRSTLTANATANLLRNFWSN
MSMEG_1211|M.smegmatis_MC2_155 RTAFRRKIGRQVAKDYVLLPALS----LRRWRRTLLANLTANLVRNVWAC
Mvan_1045|M.vanbaalenii_PYR-1 RATLRRKIARQAVKDYVMFPAMS----GTRWRRTLVANVTANVVRNLWAY
Mflv_5195|M.gilvum_PYR-GCK KRKFFGKAARQLSKDYVVLPALS----LRRWRRTLAANLTANLLRNVWVY
: . . * **** **:: : ** ** **::**.*
Mb3258c|M.bovis_AF2122/97 AVIFCGHFPDGAEKFTKTDMIGEPKGQWYLRQMLGSANFNAGPALRFMSG
Rv3229c|M.tuberculosis_H37Rv AVIFCGHFPDGAEKFTKTDMIGEPKGQWYLRQMLGSANFNAGPALRFMSG
MMAR_1315|M.marinum_M AVIFCGHFPDGAEKFTKTDMVGETKGQWYLRQMLGSANFEAGPALRFMSG
MUL_2565|M.ulcerans_Agy99 AVIFCGHFPDGAEKFTKADMVGETKGQWYLRQMLGSANFEAGPALRFMSG
MAV_4192|M.avium_104 AVIFCGHFPDGAEKFTKTDMIGETKGQWYLRQMLGSANFEAGPVLRFMSG
TH_0650|M.thermoresistible__bu AVIFCGHFPDGAEKFTKTDMVGESKGQWYLRQMLGSANFEGGWLLRFMSG
MAB_2148|M.abscessus_ATCC_1997 AVIFCGHFPDGAEKFTVTDMENETRGQWYLRQLLGSANFNAGPTMRLMSG
MSMEG_1211|M.smegmatis_MC2_155 VVIFCGHFPDGAEKFTPESLERETKGEWYLRQMLGAANFKAGRVLAFSSG
Mvan_1045|M.vanbaalenii_PYR-1 VVIFCGHFPDGAEKFTPDVIKQETRGEWYLRQILGAANFRAGRLLAFASG
Mflv_5195|M.gilvum_PYR-GCK VNIICGHIPDGAETFDPAVLDGETRGEWYLRQMLGAANFKAGPLLAFSGG
. *:***:*****.* : *.:*:*****:**:***..* : : .*
Mb3258c|M.bovis_AF2122/97 NLCHQIEHHLYPDLPSNRLHEISVRVREVCDRYDLPYTTGSFLVQYGKTW
Rv3229c|M.tuberculosis_H37Rv NLCHQIEHHLYPDLPSNRLHEISVRVREVCDRYDLPYTTGSFLVQYGKTW
MMAR_1315|M.marinum_M NLCHQIEHHLYPDLPSNRLAEVSVRVREICDKYDLPYTTGSFLVQYGKTW
MUL_2565|M.ulcerans_Agy99 NLCHQIEHHLYPDLPSNRLAEVSVRVREICDKYDLPYTTGSFLVQYGKTW
MAV_4192|M.avium_104 NLCHQIEHHLYPDLPSNRLHEISVRVRQVCDKYDLPYTTGSFLFQYAKTW
TH_0650|M.thermoresistible__bu NLCHQIEHHLYPDLPSNRLHEASIRVREVCDKYDLPYTTGPFLVQYAKTW
MAB_2148|M.abscessus_ATCC_1997 NLCHQIEHHIYPDLPSNRLHEISVRVREICERYDLPYTTGSMLFQYAKTW
MSMEG_1211|M.smegmatis_MC2_155 NLCYQIEHHLFPDLPSNRLAQIAGRVSALCDKYDLPYTTGPMPRQYLQTL
Mvan_1045|M.vanbaalenii_PYR-1 NLCYQIEHHLFPELPSNRYAQISVRVRAICRRYDLPYTTGSIVRQYFLTL
Mflv_5195|M.gilvum_PYR-GCK HLCYQIEHHLFPDLPSNRLAQVSVRVRELCEKYDLPYNTGSFPRQYFRTQ
:**:*****::*:***** : : ** :* :*****.**.: ** *
Mb3258c|M.bovis_AF2122/97 RTLAKLSLPDKYLRDNADDAPETRSERMFAGLG-PGFAGADPVTGRRRGL
Rv3229c|M.tuberculosis_H37Rv RTLAKLSLPDKYLRDNADDAPETRSERMFAGLG-PGFAGADPVTGRRRGL
MMAR_1315|M.marinum_M RTLAKLSLPNKYLRDNADNAPETRSERMFADLE-PGFAGADPRTGRRRGL
MUL_2565|M.ulcerans_Agy99 RTLAKLSLPNKYLRDNADDAPETRSERMFADLE-PGFAGADPRTGRRRGL
MAV_4192|M.avium_104 RTLAKLSLPNKYLRDDADNAPETRSERMFAELD-PDFLGTDPATGRRRGL
TH_0650|M.thermoresistible__bu RTLAKLSLPDRFLKATADNAPETRSERMFAELG-PGFAGVDPATGRRRGL
MAB_2148|M.abscessus_ATCC_1997 RTIAKLSLPDRFLHATADNAPETRSERMFVVLEQPQVPGVESVP--RRGL
MSMEG_1211|M.smegmatis_MC2_155 RIIFTLALPD----------------------------------------
Mvan_1045|M.vanbaalenii_PYR-1 RTIHKLALPDRLLTATSDDAPETASERKFVGDR-------FAVGGLRTAL
Mflv_5195|M.gilvum_PYR-GCK RTIHKLAVPD----------------------------------------
* : .*::*:
Mb3258c|M.bovis_AF2122/97 KTAIAAVRGRRRSKRMAKSVTE-PDDLAA---------------------
Rv3229c|M.tuberculosis_H37Rv KTAIAAVRGRRRSKRMAKSVTE-PDDLAA---------------------
MMAR_1315|M.marinum_M KSAIAAVRGRRRGKRVPEVRDSGTNDLAA---------------------
MUL_2565|M.ulcerans_Agy99 KSAIAAVRGRRRGKRVPEVRDSGTNDLAA---------------------
MAV_4192|M.avium_104 KSAIAAVRGWRRGKRASVARRT-GGELAA---------------------
TH_0650|M.thermoresistible__bu KSAFAAVRNWRRDKQAAKAXXX--GELYPRPGTLRRDVGVRLRRGGVPGP
MAB_2148|M.abscessus_ATCC_1997 KTAIAMVRERRRNKVAV---------------------------------
MSMEG_1211|M.smegmatis_MC2_155 -TGWRGIFRR----------------------------------------
Mvan_1045|M.vanbaalenii_PYR-1 RDGARARRRRRAA-------------------------------------
Mflv_5195|M.gilvum_PYR-GCK --GLLTAR------------------------------------------
.
Mb3258c|M.bovis_AF2122/97 -----------------------------------------
Rv3229c|M.tuberculosis_H37Rv -----------------------------------------
MMAR_1315|M.marinum_M -----------------------------------------
MUL_2565|M.ulcerans_Agy99 -----------------------------------------
MAV_4192|M.avium_104 -----------------------------------------
TH_0650|M.thermoresistible__bu AGLWSGEHDRRGHRPPRSGPQRIRRPRGHAVLRRRDRAVRR
MAB_2148|M.abscessus_ATCC_1997 -----------------------------------------
MSMEG_1211|M.smegmatis_MC2_155 -----------------------------------------
Mvan_1045|M.vanbaalenii_PYR-1 -----------------------------------------
Mflv_5195|M.gilvum_PYR-GCK -----------------------------------------