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M. thermoresistible (build 8) TH_0650 (desA3)

annotation: POSSIBLE LINOLEOYL-CoA DESATURASE (DELTA(6)-DESATURASE)
coordinates: 1400840 - 1402306
length: 489

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_0650desA3-100% (489)POSSIBLE LINOLEOYL-CoA DESATURASE (DELTA(6)-DESATURASE)

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3258c-0.079.90% (418) linoleoyl-CoA desaturase
M. gilvum PYR-GCKMflv_4698-0.076.60% (423) fatty acid desaturase
M. tuberculosis H37RvRv3229c-0.079.90% (418) linoleoyl-CoA desaturase
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_3548c-0.073.48% (411) putative fatty acid desaturase
M. marinum MMMAR_1315desA30.080.09% (422) linoleoyl-CoA desaturase, DesA3
M. avium 104MAV_4192-0.082.23% (422) Fatty acid desaturase
M. smegmatis MC2 155MSMEG_1886-0.081.10% (418) Fatty acid desaturase
M. ulcerans Agy99MUL_2565desA30.079.15% (422) linoleoyl-CoA desaturase, DesA3
M. vanbaalenii PYR-1Mvan_1768-0.077.99% (418) fatty acid desaturase

CLUSTAL 2.0.9 multiple sequence alignment


Mb3258c|M.bovis_AF2122/97           MAITDVDVFAHLTDADIENLAAELDAIRRDVEESRGERDARYIRRTIAAQ
Rv3229c|M.tuberculosis_H37Rv        MAITDVDVFAHLTDADIENLAAELDAIRRDVEESRGERDARYIRRTIAAQ
MMAR_1315|M.marinum_M               MAITDVDVFAHLTDADIENLAIELDAIRQDIEDSRGERDARYIRRTIAAQ
MUL_2565|M.ulcerans_Agy99           MVITDVDVFAHLTDADIENLAIELDAIRQDIEDSRGERDARYIRRTIAAQ
MAV_4192|M.avium_104                MAITDVDVFAHLTDADIENLAVELDAIRQDVEDSRGERDARYIRRTIAAQ
Mflv_4698|M.gilvum_PYR-GCK          MAITDVPEFAHLTDADIENLGRELDAIRQDIEDSRGAQDARYIRRTIAIQ
Mvan_1768|M.vanbaalenii_PYR-1       MAITDVPQFAHLTEADVENLGRELDAIRQDIEDSRGERDARYIRRTIAIQ
MSMEG_1886|M.smegmatis_MC2_155      MAVTDVPAFAHLTEADIENLGIELDAIRQDIEDSRGERDARYIRRTIAVQ
TH_0650|M.thermoresistible__bu      MAITDVPAYAHLTEVDIDALAVELDAIRRDIEDSLGERDARYIRRTIATQ
MAB_3548c|M.abscessus_ATCC_199      MAISDIQEFAHLTEADVEALGHELDAIRRDVEESLGAADARYIRRTIAAQ
                                    *.::*:  :****:.*:: *. ******:*:*:* *  ********** *

Mb3258c|M.bovis_AF2122/97           RALEVSGRLLLAGSSRRLAWWTGALTLGVAKIIENMEIGHNVMHGQWDWM
Rv3229c|M.tuberculosis_H37Rv        RALEVSGRLLLAGSSRRLAWWTGALTLGVAKIIENMEIGHNVMHGQWDWM
MMAR_1315|M.marinum_M               RALEVSGRLMLAASSRRSAWWAGALTLGVAKIVENMEIGHNVMHGQWDWM
MUL_2565|M.ulcerans_Agy99           RALEVSGRLMLAASSRRSAWWAGALTLGVAKIVENMEIGHNVMHGQWDWM
MAV_4192|M.avium_104                RALEVTGRLLLAASSRRSAWWAGTVTLGVAKIIENMEIGHNVMHGQWDWM
Mflv_4698|M.gilvum_PYR-GCK          RGLEVAGRLMLAGSAKRSYWWAGTATLGVAKIIENMEIGHNVMHGQWDWM
Mvan_1768|M.vanbaalenii_PYR-1       RGLEVTGRLLLAGSAKRRFWWAGTATLGVAKIIENMEIGHNVMHGQWDWM
MSMEG_1886|M.smegmatis_MC2_155      RSLDLAGRLMLTASKRRSAWWAGTATLGVAKIIENMEIGHNVMHGQWDWM
TH_0650|M.thermoresistible__bu      RGLEVAGRLLLAASSRRSAWWAGAVTLAAAKIIENMEIGHNVMHGQWDWM
MAB_3548c|M.abscessus_ATCC_199      RTLELTGRILLAASKKRSAWWAGAVTLGVAKIVENMEIGHNVMHGQWDWM
                                    * *:::**::*:.* :*  **:*: **..***:*****************

Mb3258c|M.bovis_AF2122/97           NDPEIHSSTWEWDMSGSSKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVT
Rv3229c|M.tuberculosis_H37Rv        NDPEIHSSTWEWDMSGSSKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVT
MMAR_1315|M.marinum_M               NDPEIHSSSWEWDITGASKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVT
MUL_2565|M.ulcerans_Agy99           NDPEIHSSSWEWDITGASKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVT
MAV_4192|M.avium_104                NDPEIHSSTWEWDMSGSSKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVT
Mflv_4698|M.gilvum_PYR-GCK          NDPEIHSSSWEWDMSGASKHWRFTHNFMHHKYTNILGMDDDVGYGVIRVT
Mvan_1768|M.vanbaalenii_PYR-1       NDPEIHSSSWEWDMSGASKHWRFTHNFMHHKYTNILGMDDDVGYGVIRVT
MSMEG_1886|M.smegmatis_MC2_155      NDPEIHSSSWEWDMSGASKHWRFTHNFMHHKYTNILGMDDDVGYGLLRVT
TH_0650|M.thermoresistible__bu      NDPEIHSSTWEWDMTGASKHWRFTHNFMHHKYTNILGMDDDVGYGLLRVT
MAB_3548c|M.abscessus_ATCC_199      NDPEIHSSSWEWDMVDPAEHWKQTHNYIHHKYTNVLGMDDDVGYGLLRVT
                                    ********:****: ..::**: ***::******:**********::***

Mb3258c|M.bovis_AF2122/97           RDQRWKRYNIFNVVWNTILAIGFEWGVALQHLEIGKIFKGRADREAAKTR
Rv3229c|M.tuberculosis_H37Rv        RDQRWKRYNIFNVVWNTILAIGFEWGVALQHLEIGKIFKGRADREAAKTR
MMAR_1315|M.marinum_M               RDQRWKRYNIFNLVWNTLLALGFEWGVALQHLEIGKLLKGRLDRDTARTR
MUL_2565|M.ulcerans_Agy99           RDQRWKRYNIFNLVWNTLLALGFEWGVALQHLEIGKLLKGRLDRDTAETR
MAV_4192|M.avium_104                RDQRWKRFNLFNLVWNTLLALLFEWGVGLQHVEIGKILKRRMDHEEARQR
Mflv_4698|M.gilvum_PYR-GCK          RDQRWTPMNLGNLFFNTLLCVAFEWGVGLQHLELGKIFKGRDDRKATMGR
Mvan_1768|M.vanbaalenii_PYR-1       RDQRWRPMNLLNLFFNTLLSVAFEWGVGLQHLELGKIFKGRDDRKATMGR
MSMEG_1886|M.smegmatis_MC2_155      RDQKWKPHNLLNLVYNTMLCIFFEWGVGLQHLEVGKIFKGRDDRNATLVR
TH_0650|M.thermoresistible__bu      RDQKWKPFNLGNLLYNTLLALAFEWGVGLQHVELGKIFKRRHDPDESRVR
MAB_3548c|M.abscessus_ATCC_199      RDKKWKPFNLGNLLYNTLLMLLFEWGVGTQHLELGKVAQGRADKEEFRVK
                                    **::*   *: *:.:**:* : *****. **:*:**: : * * .    :

Mb3258c|M.bovis_AF2122/97           LREFSAKAGRQVFKDYVAFPALTSLSPGATYRSTLTANVVANVIRNVWSN
Rv3229c|M.tuberculosis_H37Rv        LREFSAKAGRQVFKDYVAFPALTSLSPGATYRSTLTANVVANVIRNVWSN
MMAR_1315|M.marinum_M               VREFSRKAGRQVFKDYVAFPALTSVSPGATYRSTLTANVTANVLRNVWTN
MUL_2565|M.ulcerans_Agy99           VREFSRKAGRQVFKDYVAFPALTSVSPGATYRSTLTANVTANVLRNVWTN
MAV_4192|M.avium_104                IDEFLAKAGRQVVKDYVAFPALTSLSPGATFLSTLKANAMANVIRNVWAN
Mflv_4698|M.gilvum_PYR-GCK          VKEFGVKAGQQVVKDYVAYPAITSLSPRATFKSTLTANAVANVIRNVWAN
Mvan_1768|M.vanbaalenii_PYR-1       VKEFGVKAGQQVVKDYVAYPAITSLSPRATFRSTLTANAVANVIRNVWAN
MSMEG_1886|M.smegmatis_MC2_155      LREFGTKAGGQVFKDYVAWPAITSLSPGATFKSTAKANAVANIIRNIWSN
TH_0650|M.thermoresistible__bu      VREFLRKAGRQVFKDYVAYPALSSLSPAASYRSTLTANAMANVIRNVWSN
MAB_3548c|M.abscessus_ATCC_199      RQAALTKMGKQVAKDYVAFPALSALSPAGSYRKTVTANLLANVIRNIWSN
                                          * * ** *****:**::::** .:: .* .**  **::**:*:*

Mb3258c|M.bovis_AF2122/97           AVIFCGHFPDGAEKFTKTDMIGEPKGQWYLRQMLGSANFNAGPALRFMSG
Rv3229c|M.tuberculosis_H37Rv        AVIFCGHFPDGAEKFTKTDMIGEPKGQWYLRQMLGSANFNAGPALRFMSG
MMAR_1315|M.marinum_M               AVIFCGHFPDGAEKFTKTDMVGETKGQWYLRQMLGSANFEAGPALRFMSG
MUL_2565|M.ulcerans_Agy99           AVIFCGHFPDGAEKFTKADMVGETKGQWYLRQMLGSANFEAGPALRFMSG
MAV_4192|M.avium_104                AVIFCGHFPDGAEKFTKTDMIGETKGQWYLRQMLGSANFEAGPVLRFMSG
Mflv_4698|M.gilvum_PYR-GCK          AVIFCGHFPDGAEKFTKTDMIGESRGQWYLRQMLGSANFEGGPLLRFMSG
Mvan_1768|M.vanbaalenii_PYR-1       AVIFCGHFPDGAEKFTKTDMVGESRGQWYLRQMLGSANFEGGPLLRFMSG
MSMEG_1886|M.smegmatis_MC2_155      AVIFCGHFPDGAEKFTKTDMIGESRGQWYLRQMLGSANFEGGWLLRFMSG
TH_0650|M.thermoresistible__bu      AVIFCGHFPDGAEKFTKTDMVGESKGQWYLRQMLGSANFEGGWLLRFMSG
MAB_3548c|M.abscessus_ATCC_199      AVIFCGHFPDGAEKFTKQDLENETQGQWYLRQMLGSANFDAGPAMAFMSG
                                    ***************** *: .*.:**************:.*  : ****

Mb3258c|M.bovis_AF2122/97           NLCHQIEHHLYPDLPSNRLHEISVRVREVCDRYDLPYTTGSFLVQYGKTW
Rv3229c|M.tuberculosis_H37Rv        NLCHQIEHHLYPDLPSNRLHEISVRVREVCDRYDLPYTTGSFLVQYGKTW
MMAR_1315|M.marinum_M               NLCHQIEHHLYPDLPSNRLAEVSVRVREICDKYDLPYTTGSFLVQYGKTW
MUL_2565|M.ulcerans_Agy99           NLCHQIEHHLYPDLPSNRLAEVSVRVREICDKYDLPYTTGSFLVQYGKTW
MAV_4192|M.avium_104                NLCHQIEHHLYPDLPSNRLHEISVRVRQVCDKYDLPYTTGSFLFQYAKTW
Mflv_4698|M.gilvum_PYR-GCK          NLSQQIEHHLFPDLPSNRYYEISLRVRELCDKYDLPYTTGNFLVQYGKSW
Mvan_1768|M.vanbaalenii_PYR-1       NLSQQIEHHLFPDLPSNRYYEISLRVRELCDKYDLPYTTGNFLVQYGKSW
MSMEG_1886|M.smegmatis_MC2_155      NLCHQIEHHLYPDLPSNRLHEISIRVRALCDKYDLPYTTGSFLVQYGKTW
TH_0650|M.thermoresistible__bu      NLCHQIEHHLYPDLPSNRLHEASIRVREVCDKYDLPYTTGPFLVQYAKTW
MAB_3548c|M.abscessus_ATCC_199      NLCHQIEHHLFPDLPSNRLSAVSVRVRELCDKYDLPYTSGPFLVQYAKAW
                                    **.:******:*******    *:*** :**:******:* **.**.*:*

Mb3258c|M.bovis_AF2122/97           RTLAKLSLPDKYLRDNADDAPETRSERMFAGLGPGFAGADPVTGRRRGLK
Rv3229c|M.tuberculosis_H37Rv        RTLAKLSLPDKYLRDNADDAPETRSERMFAGLGPGFAGADPVTGRRRGLK
MMAR_1315|M.marinum_M               RTLAKLSLPNKYLRDNADNAPETRSERMFADLEPGFAGADPRTGRRRGLK
MUL_2565|M.ulcerans_Agy99           RTLAKLSLPNKYLRDNADDAPETRSERMFADLEPGFAGADPRTGRRRGLK
MAV_4192|M.avium_104                RTLAKLSLPNKYLRDDADNAPETRSERMFAELDPDFLGTDPATGRRRGLK
Mflv_4698|M.gilvum_PYR-GCK          RTIAKLSLPDRFLSDTRDDAPETRSERMFDGLE-------PTE--RSGLK
Mvan_1768|M.vanbaalenii_PYR-1       RTIAKLSLPDRFLTDTADDAPETRSERMFDGLE-------PSE--RRGLR
MSMEG_1886|M.smegmatis_MC2_155      RTIAKLSLPDKFLKDTADNAPETRSERMFAELDG-FGVTDPATGRRRGLK
TH_0650|M.thermoresistible__bu      RTLAKLSLPDRFLKATADNAPETRSERMFAELGPGFAGVDPATGRRRGLK
MAB_3548c|M.abscessus_ATCC_199      RTIAKLSLPDKYLTYTADNAQETRSVKMFDELEP---------HERRGLK
                                    **:******:::*    *:* **** :**  *             * **:

Mb3258c|M.bovis_AF2122/97           TAIAAVRGRRRSKRMAKSVTE-PDDLAA----------------------
Rv3229c|M.tuberculosis_H37Rv        TAIAAVRGRRRSKRMAKSVTE-PDDLAA----------------------
MMAR_1315|M.marinum_M               SAIAAVRGRRRGKRVPEVRDSGTNDLAA----------------------
MUL_2565|M.ulcerans_Agy99           SAIAAVRGRRRGKRVPEVRDSGTNDLAA----------------------
MAV_4192|M.avium_104                SAIAAVRGWRRGKRASVARRT-GGELAA----------------------
Mflv_4698|M.gilvum_PYR-GCK          SAIAAVRSRRRAKRAQKAAVKGQDLAA-----------------------
Mvan_1768|M.vanbaalenii_PYR-1       SAIAAVRKRRRAKAAEKAAVK---LAA-----------------------
MSMEG_1886|M.smegmatis_MC2_155      TAIETVRGWRRSSRAKRAA-------------------------------
TH_0650|M.thermoresistible__bu      SAFAAVRNWRRDKQAAKAXXXGELYPRPGTLRRDVGVRLRRGGVPGPAGL
MAB_3548c|M.abscessus_ATCC_199      SAFAAVRARRKARHKV----------------------------------
                                    :*: :**  *:                                       

Mb3258c|M.bovis_AF2122/97           --------------------------------------
Rv3229c|M.tuberculosis_H37Rv        --------------------------------------
MMAR_1315|M.marinum_M               --------------------------------------
MUL_2565|M.ulcerans_Agy99           --------------------------------------
MAV_4192|M.avium_104                --------------------------------------
Mflv_4698|M.gilvum_PYR-GCK          --------------------------------------
Mvan_1768|M.vanbaalenii_PYR-1       --------------------------------------
MSMEG_1886|M.smegmatis_MC2_155      --------------------------------------
TH_0650|M.thermoresistible__bu      WSGEHDRRGHRPPRSGPQRIRRPRGHAVLRRRDRAVRR
MAB_3548c|M.abscessus_ATCC_199      --------------------------------------