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VAISDVAVYAKLTPAEIEAFGAELDTIRADIEESLGTRDAAYIRRTIAFQRSLDVAARLLIAGTRSKAGW LAGTAALAYAKSVENMEIGHNVSHGQWDWMNDPEIHSSTWEWDMVGPSAQWRYSHNYRHHVFSNVLGVDD DLGFGVLRMSRDQKWEPQHLIQPLRNLLLAAVFEWGIGLHDYYSERDRADTQDGKDAARTAFRRKIGRQV AKDYVLLPALSLRRWRRTLLANLTANLVRNVWACVVIFCGHFPDGAEKFTPESLERETKGEWYLRQMLGA ANFKAGRVLAFSSGNLCYQIEHHLFPDLPSNRLAQIAGRVSALCDKYDLPYTTGPMPRQYLQTLRIIFTL ALPDTGWRGIFRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1211 | - | - | 100% (363) | Fatty acid desaturase |
| M. smegmatis MC2 155 | MSMEG_1886 | - | e-120 | 56.39% (360) | Fatty acid desaturase |
| M. smegmatis MC2 155 | MSMEG_1743 | - | 2e-97 | 48.70% (345) | Fatty acid desaturase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3258c | - | 1e-121 | 57.89% (361) | linoleoyl-CoA desaturase |
| M. gilvum PYR-GCK | Mflv_5222 | - | 1e-155 | 72.96% (355) | fatty acid desaturase |
| M. tuberculosis H37Rv | Rv3229c | - | 1e-121 | 57.89% (361) | linoleoyl-CoA desaturase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3548c | - | 1e-125 | 59.00% (361) | putative fatty acid desaturase |
| M. marinum M | MMAR_1315 | desA3 | 1e-121 | 58.17% (361) | linoleoyl-CoA desaturase, DesA3 |
| M. avium 104 | MAV_4192 | - | 1e-121 | 58.33% (360) | Fatty acid desaturase |
| M. thermoresistible (build 8) | TH_0650 | desA3 | 1e-124 | 59.56% (361) | POSSIBLE LINOLEOYL-CoA DESATURASE (DELTA(6)-DESATURASE) |
| M. ulcerans Agy99 | MUL_2565 | desA3 | 1e-120 | 57.62% (361) | linoleoyl-CoA desaturase, DesA3 |
| M. vanbaalenii PYR-1 | Mvan_1045 | - | 1e-153 | 70.70% (355) | fatty acid desaturase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3258c|M.bovis_AF2122/97 MAITDVDVFAHLTDADIENLAAELDAIRRDVEESRGERDARYIRRTIAAQ
Rv3229c|M.tuberculosis_H37Rv MAITDVDVFAHLTDADIENLAAELDAIRRDVEESRGERDARYIRRTIAAQ
MMAR_1315|M.marinum_M MAITDVDVFAHLTDADIENLAIELDAIRQDIEDSRGERDARYIRRTIAAQ
MUL_2565|M.ulcerans_Agy99 MVITDVDVFAHLTDADIENLAIELDAIRQDIEDSRGERDARYIRRTIAAQ
MAV_4192|M.avium_104 MAITDVDVFAHLTDADIENLAVELDAIRQDVEDSRGERDARYIRRTIAAQ
TH_0650|M.thermoresistible__bu MAITDVPAYAHLTEVDIDALAVELDAIRRDIEDSLGERDARYIRRTIATQ
MAB_3548c|M.abscessus_ATCC_199 MAISDIQEFAHLTEADVEALGHELDAIRRDVEESLGAADARYIRRTIAAQ
Mflv_5222|M.gilvum_PYR-GCK MAIGDVAVYAHLSGEDIEALARDLDEVRRDIEGSLGERDAAYIRRTIFFQ
Mvan_1045|M.vanbaalenii_PYR-1 MAIADLAAYAHLSKEDIEALGRELDEVRREIEGSLGERDAAYIRRTIRFQ
MSMEG_1211|M.smegmatis_MC2_155 MAISDVAVYAKLTPAEIEAFGAELDTIRADIEESLGTRDAAYIRRTIAFQ
*.* *: :*:*: ::: :. :** :* ::* * * ** ****** *
Mb3258c|M.bovis_AF2122/97 RALEVSGRLLLAGSSRRLAWWTGALTLGVAKIIENMEIGHNVMHGQWDWM
Rv3229c|M.tuberculosis_H37Rv RALEVSGRLLLAGSSRRLAWWTGALTLGVAKIIENMEIGHNVMHGQWDWM
MMAR_1315|M.marinum_M RALEVSGRLMLAASSRRSAWWAGALTLGVAKIVENMEIGHNVMHGQWDWM
MUL_2565|M.ulcerans_Agy99 RALEVSGRLMLAASSRRSAWWAGALTLGVAKIVENMEIGHNVMHGQWDWM
MAV_4192|M.avium_104 RALEVTGRLLLAASSRRSAWWAGTVTLGVAKIIENMEIGHNVMHGQWDWM
TH_0650|M.thermoresistible__bu RGLEVAGRLLLAASSRRSAWWAGAVTLAAAKIIENMEIGHNVMHGQWDWM
MAB_3548c|M.abscessus_ATCC_199 RTLELTGRILLAASKKRSAWWAGAVTLGVAKIVENMEIGHNVMHGQWDWM
Mflv_5222|M.gilvum_PYR-GCK RTLDVVARVVIARSRSRTGWLAGTAALAFAKCVENMEIGHNVSHGQWDWM
Mvan_1045|M.vanbaalenii_PYR-1 RMLEVVARVGIAVTGSRAGWMAGTAALAFAKSVENMEIGHNVSHGQWDWM
MSMEG_1211|M.smegmatis_MC2_155 RSLDVAARLLIAGTRSKAGWLAGTAALAYAKSVENMEIGHNVSHGQWDWM
* *:: .*: :* : : .* :*: :*. ** :********* *******
Mb3258c|M.bovis_AF2122/97 NDPEIHSSTWEWDMSGSSKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVT
Rv3229c|M.tuberculosis_H37Rv NDPEIHSSTWEWDMSGSSKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVT
MMAR_1315|M.marinum_M NDPEIHSSSWEWDITGASKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVT
MUL_2565|M.ulcerans_Agy99 NDPEIHSSSWEWDITGASKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVT
MAV_4192|M.avium_104 NDPEIHSSTWEWDMSGSSKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVT
TH_0650|M.thermoresistible__bu NDPEIHSSTWEWDMTGASKHWRFTHNFMHHKYTNILGMDDDVGYGLLRVT
MAB_3548c|M.abscessus_ATCC_199 NDPEIHSSSWEWDMVDPAEHWKQTHNYIHHKYTNVLGMDDDVGYGLLRVT
Mflv_5222|M.gilvum_PYR-GCK NDPEIHSTSWEWDMVAVSSQWRYSHNYRHHVLTNIVGVDDDLGFGIMRMT
Mvan_1045|M.vanbaalenii_PYR-1 NDPEIHSATWEWDMVAVSSQWRYSHNYRHHMMTNIVGVDDDLGFGIMRMT
MSMEG_1211|M.smegmatis_MC2_155 NDPEIHSSTWEWDMVGPSAQWRYSHNYRHHVFSNVLGVDDDLGFGVLRMS
*******::****: : :*: :**: ** :*::*:***:*:*::*::
Mb3258c|M.bovis_AF2122/97 RDQRWKRYNIFNVVWNTILAIGFEWGVALQHLEIGKIFKGRADREAAKTR
Rv3229c|M.tuberculosis_H37Rv RDQRWKRYNIFNVVWNTILAIGFEWGVALQHLEIGKIFKGRADREAAKTR
MMAR_1315|M.marinum_M RDQRWKRYNIFNLVWNTLLALGFEWGVALQHLEIGKLLKGRLDRDTARTR
MUL_2565|M.ulcerans_Agy99 RDQRWKRYNIFNLVWNTLLALGFEWGVALQHLEIGKLLKGRLDRDTAETR
MAV_4192|M.avium_104 RDQRWKRFNLFNLVWNTLLALLFEWGVGLQHVEIGKILKRRMDHEEARQR
TH_0650|M.thermoresistible__bu RDQKWKPFNLGNLLYNTLLALAFEWGVGLQHVELGKIFKRRHDPDESRVR
MAB_3548c|M.abscessus_ATCC_199 RDKKWKPFNLGNLLYNTLLMLLFEWGVGTQHLELGKVAQGRADKEEFRVK
Mflv_5222|M.gilvum_PYR-GCK RDEPWQPVHLLQPLRNLLLAVIFEWGIALHGIHS-ERDRVLPDTARLAEV
Mvan_1045|M.vanbaalenii_PYR-1 RDEPWQPVHLLQPLRNMLLAVIFEWGIALHGIHS-ERDRLMPDADRLAEQ
MSMEG_1211|M.smegmatis_MC2_155 RDQKWEPQHLIQPLRNLLLAAVFEWGIGLHDYYS-ERDRADTQDGK-DAA
**: *: :: : : * :* ****:. : : : :
Mb3258c|M.bovis_AF2122/97 LREFSAKAGRQVFKDYVAFPALTSLSPGATYRSTLTANVVANVIRNVWSN
Rv3229c|M.tuberculosis_H37Rv LREFSAKAGRQVFKDYVAFPALTSLSPGATYRSTLTANVVANVIRNVWSN
MMAR_1315|M.marinum_M VREFSRKAGRQVFKDYVAFPALTSVSPGATYRSTLTANVTANVLRNVWTN
MUL_2565|M.ulcerans_Agy99 VREFSRKAGRQVFKDYVAFPALTSVSPGATYRSTLTANVTANVLRNVWTN
MAV_4192|M.avium_104 IDEFLAKAGRQVVKDYVAFPALTSLSPGATFLSTLKANAMANVIRNVWAN
TH_0650|M.thermoresistible__bu VREFLRKAGRQVFKDYVAYPALSSLSPAASYRSTLTANAMANVIRNVWSN
MAB_3548c|M.abscessus_ATCC_199 RQAALTKMGKQVAKDYVAFPALSALSPAGSYRKTVTANLLANVIRNIWSN
Mflv_5222|M.gilvum_PYR-GCK RAELRRKIARQVTKDYVLLPSLS----GTRWRRTLSANLIANLVRNLWAY
Mvan_1045|M.vanbaalenii_PYR-1 RATLRRKIARQAVKDYVMFPAMS----GTRWRRTLVANVTANVVRNLWAY
MSMEG_1211|M.smegmatis_MC2_155 RTAFRRKIGRQVAKDYVLLPALS----LRRWRRTLLANLTANLVRNVWAC
* .:*. **** *::: : *: ** **::**:*:
Mb3258c|M.bovis_AF2122/97 AVIFCGHFPDGAEKFTKTDMIGEPKGQWYLRQMLGSANFNAGPALRFMSG
Rv3229c|M.tuberculosis_H37Rv AVIFCGHFPDGAEKFTKTDMIGEPKGQWYLRQMLGSANFNAGPALRFMSG
MMAR_1315|M.marinum_M AVIFCGHFPDGAEKFTKTDMVGETKGQWYLRQMLGSANFEAGPALRFMSG
MUL_2565|M.ulcerans_Agy99 AVIFCGHFPDGAEKFTKADMVGETKGQWYLRQMLGSANFEAGPALRFMSG
MAV_4192|M.avium_104 AVIFCGHFPDGAEKFTKTDMIGETKGQWYLRQMLGSANFEAGPVLRFMSG
TH_0650|M.thermoresistible__bu AVIFCGHFPDGAEKFTKTDMVGESKGQWYLRQMLGSANFEGGWLLRFMSG
MAB_3548c|M.abscessus_ATCC_199 AVIFCGHFPDGAEKFTKQDLENETQGQWYLRQMLGSANFDAGPAMAFMSG
Mflv_5222|M.gilvum_PYR-GCK VVIFCGHFPDGAEKFTPGVVEQETKGEWYLRQILGAANFKAGRFLAFASG
Mvan_1045|M.vanbaalenii_PYR-1 VVIFCGHFPDGAEKFTPDVIKQETRGEWYLRQILGAANFRAGRLLAFASG
MSMEG_1211|M.smegmatis_MC2_155 VVIFCGHFPDGAEKFTPESLERETKGEWYLRQMLGAANFKAGRVLAFSSG
.*************** : *.:*:*****:**:*** .* : * **
Mb3258c|M.bovis_AF2122/97 NLCHQIEHHLYPDLPSNRLHEISVRVREVCDRYDLPYTTGSFLVQYGKTW
Rv3229c|M.tuberculosis_H37Rv NLCHQIEHHLYPDLPSNRLHEISVRVREVCDRYDLPYTTGSFLVQYGKTW
MMAR_1315|M.marinum_M NLCHQIEHHLYPDLPSNRLAEVSVRVREICDKYDLPYTTGSFLVQYGKTW
MUL_2565|M.ulcerans_Agy99 NLCHQIEHHLYPDLPSNRLAEVSVRVREICDKYDLPYTTGSFLVQYGKTW
MAV_4192|M.avium_104 NLCHQIEHHLYPDLPSNRLHEISVRVRQVCDKYDLPYTTGSFLFQYAKTW
TH_0650|M.thermoresistible__bu NLCHQIEHHLYPDLPSNRLHEASIRVREVCDKYDLPYTTGPFLVQYAKTW
MAB_3548c|M.abscessus_ATCC_199 NLCHQIEHHLFPDLPSNRLSAVSVRVRELCDKYDLPYTSGPFLVQYAKAW
Mflv_5222|M.gilvum_PYR-GCK NLCYQIEHHLFPDLPSNRYAQMAVRVRAICDRYGLSYTTGSLARQYFLTL
Mvan_1045|M.vanbaalenii_PYR-1 NLCYQIEHHLFPELPSNRYAQISVRVRAICRRYDLPYTTGSIVRQYFLTL
MSMEG_1211|M.smegmatis_MC2_155 NLCYQIEHHLFPDLPSNRLAQIAGRVSALCDKYDLPYTTGPMPRQYLQTL
***:******:*:***** : ** :* :*.*.**:*.: ** :
Mb3258c|M.bovis_AF2122/97 RTLAKLSLPDKYLRDNADDAPETRSERMFAGLGPGFAGADPVTGRRRGLK
Rv3229c|M.tuberculosis_H37Rv RTLAKLSLPDKYLRDNADDAPETRSERMFAGLGPGFAGADPVTGRRRGLK
MMAR_1315|M.marinum_M RTLAKLSLPNKYLRDNADNAPETRSERMFADLEPGFAGADPRTGRRRGLK
MUL_2565|M.ulcerans_Agy99 RTLAKLSLPNKYLRDNADDAPETRSERMFADLEPGFAGADPRTGRRRGLK
MAV_4192|M.avium_104 RTLAKLSLPNKYLRDDADNAPETRSERMFAELDPDFLGTDPATGRRRGLK
TH_0650|M.thermoresistible__bu RTLAKLSLPDRFLKATADNAPETRSERMFAELGPGFAGVDPATGRRRGLK
MAB_3548c|M.abscessus_ATCC_199 RTIAKLSLPDKYLTYTADNAQETRSVKMFDELEP---------HERRGLK
Mflv_5222|M.gilvum_PYR-GCK RTIHKLAFPDRFLRATSDDAPETASERKFLG-------------STAGLA
Mvan_1045|M.vanbaalenii_PYR-1 RTIHKLALPDRLLTATSDDAPETASERKFVGDRF----------AVGGLR
MSMEG_1211|M.smegmatis_MC2_155 RIIFTLALPD------------TGWRGIFRR-------------------
* : .*::*: * *
Mb3258c|M.bovis_AF2122/97 TAIAAVRGRRRSKRMAKSVTE-PDDLAA----------------------
Rv3229c|M.tuberculosis_H37Rv TAIAAVRGRRRSKRMAKSVTE-PDDLAA----------------------
MMAR_1315|M.marinum_M SAIAAVRGRRRGKRVPEVRDSGTNDLAA----------------------
MUL_2565|M.ulcerans_Agy99 SAIAAVRGRRRGKRVPEVRDSGTNDLAA----------------------
MAV_4192|M.avium_104 SAIAAVRGWRRGKRASVARRT-GGELAA----------------------
TH_0650|M.thermoresistible__bu SAFAAVRNWRRDKQAAKAXXX--GELYPRPGTLRRDVGVRLRRGGVPGPA
MAB_3548c|M.abscessus_ATCC_199 SAFAAVRARRKARHKV----------------------------------
Mflv_5222|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1045|M.vanbaalenii_PYR-1 TALRDGARARRRRRAA----------------------------------
MSMEG_1211|M.smegmatis_MC2_155 --------------------------------------------------
Mb3258c|M.bovis_AF2122/97 ----------------------------------------
Rv3229c|M.tuberculosis_H37Rv ----------------------------------------
MMAR_1315|M.marinum_M ----------------------------------------
MUL_2565|M.ulcerans_Agy99 ----------------------------------------
MAV_4192|M.avium_104 ----------------------------------------
TH_0650|M.thermoresistible__bu GLWSGEHDRRGHRPPRSGPQRIRRPRGHAVLRRRDRAVRR
MAB_3548c|M.abscessus_ATCC_199 ----------------------------------------
Mflv_5222|M.gilvum_PYR-GCK ----------------------------------------
Mvan_1045|M.vanbaalenii_PYR-1 ----------------------------------------
MSMEG_1211|M.smegmatis_MC2_155 ----------------------------------------