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LAIADLAAYAHLSKEDIEALGRELDEVRREIEGSLGERDAAYIRRTIRFQRMLEVVARVGIAVTGSRAGW MAGTAALAFAKSVENMEIGHNVSHGQWDWMNDPEIHSATWEWDMVAVSSQWRYSHNYRHHMMTNIVGVDD DLGFGIMRMTRDEPWQPVHLLQPLRNMLLAVIFEWGIALHGIHSERDRLMPDADRLAEQRATLRRKIARQ AVKDYVMFPAMSGTRWRRTLVANVTANVVRNLWAYVVIFCGHFPDGAEKFTPDVIKQETRGEWYLRQILG AANFRAGRLLAFASGNLCYQIEHHLFPELPSNRYAQISVRVRAICRRYDLPYTTGSIVRQYFLTLRTIHK LALPDRLLTATSDDAPETASERKFVGDRFAVGGLRTALRDGARARRRRRAA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1045 | - | - | 100% (401) | fatty acid desaturase |
| M. vanbaalenii PYR-1 | Mvan_1055 | - | e-151 | 70.22% (356) | fatty acid desaturase |
| M. vanbaalenii PYR-1 | Mvan_1768 | - | e-131 | 56.45% (411) | fatty acid desaturase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3258c | - | 1e-126 | 55.45% (413) | linoleoyl-CoA desaturase |
| M. gilvum PYR-GCK | Mflv_5222 | - | 0.0 | 85.11% (376) | fatty acid desaturase |
| M. tuberculosis H37Rv | Rv3229c | - | 1e-126 | 55.45% (413) | linoleoyl-CoA desaturase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2148 | - | 1e-128 | 55.99% (409) | putative linoleoyl-CoA desaturase |
| M. marinum M | MMAR_1315 | desA3 | 1e-127 | 55.21% (413) | linoleoyl-CoA desaturase, DesA3 |
| M. avium 104 | MAV_4192 | - | 1e-125 | 53.35% (418) | Fatty acid desaturase |
| M. smegmatis MC2 155 | MSMEG_1211 | - | 1e-153 | 70.70% (355) | Fatty acid desaturase |
| M. thermoresistible (build 8) | TH_0650 | desA3 | 1e-130 | 56.08% (403) | POSSIBLE LINOLEOYL-CoA DESATURASE (DELTA(6)-DESATURASE) |
| M. ulcerans Agy99 | MUL_2565 | desA3 | 1e-127 | 55.21% (413) | linoleoyl-CoA desaturase, DesA3 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3258c|M.bovis_AF2122/97 MAITDVDVFAHLTDADIENLAAELDAIRRDVEESRGERDARYIRRTIAAQ
Rv3229c|M.tuberculosis_H37Rv MAITDVDVFAHLTDADIENLAAELDAIRRDVEESRGERDARYIRRTIAAQ
MMAR_1315|M.marinum_M MAITDVDVFAHLTDADIENLAIELDAIRQDIEDSRGERDARYIRRTIAAQ
MUL_2565|M.ulcerans_Agy99 MVITDVDVFAHLTDADIENLAIELDAIRQDIEDSRGERDARYIRRTIAAQ
MAV_4192|M.avium_104 MAITDVDVFAHLTDADIENLAVELDAIRQDVEDSRGERDARYIRRTIAAQ
TH_0650|M.thermoresistible__bu MAITDVPAYAHLTEVDIDALAVELDAIRRDIEDSLGERDARYIRRTIATQ
MAB_2148|M.abscessus_ATCC_1997 MAITDISAFAHLTSEDVENLAVELDGLRREIEESRGARDARYIRRTIAAQ
Mvan_1045|M.vanbaalenii_PYR-1 MAIADLAAYAHLSKEDIEALGRELDEVRREIEGSLGERDAAYIRRTIRFQ
Mflv_5222|M.gilvum_PYR-GCK MAIGDVAVYAHLSGEDIEALARDLDEVRRDIEGSLGERDAAYIRRTIFFQ
MSMEG_1211|M.smegmatis_MC2_155 MAISDVAVYAKLTPAEIEAFGAELDTIRADIEESLGTRDAAYIRRTIAFQ
*.* *: .:*:*: ::: :. :** :* ::* * * *** ****** *
Mb3258c|M.bovis_AF2122/97 RALEVSGRLLLAGSSRRLAWWTGALTLGVAKIIENMEIGHNVMHGQWDWM
Rv3229c|M.tuberculosis_H37Rv RALEVSGRLLLAGSSRRLAWWTGALTLGVAKIIENMEIGHNVMHGQWDWM
MMAR_1315|M.marinum_M RALEVSGRLMLAASSRRSAWWAGALTLGVAKIVENMEIGHNVMHGQWDWM
MUL_2565|M.ulcerans_Agy99 RALEVSGRLMLAASSRRSAWWAGALTLGVAKIVENMEIGHNVMHGQWDWM
MAV_4192|M.avium_104 RALEVTGRLLLAASSRRSAWWAGTVTLGVAKIIENMEIGHNVMHGQWDWM
TH_0650|M.thermoresistible__bu RGLEVAGRLLLAASSRRSAWWAGAVTLAAAKIIENMEIGHNVMHGQWDWM
MAB_2148|M.abscessus_ATCC_1997 RALELGGRVLLAASTKRAAWWAGTVTLAVAKIIENMEIGHNVLHGQWDWM
Mvan_1045|M.vanbaalenii_PYR-1 RMLEVVARVGIAVTGSRAGWMAGTAALAFAKSVENMEIGHNVSHGQWDWM
Mflv_5222|M.gilvum_PYR-GCK RTLDVVARVVIARSRSRTGWLAGTAALAFAKCVENMEIGHNVSHGQWDWM
MSMEG_1211|M.smegmatis_MC2_155 RSLDVAARLLIAGTRSKAGWLAGTAALAYAKSVENMEIGHNVSHGQWDWM
* *:: .*: :* : : .* :*: :*. ** :********* *******
Mb3258c|M.bovis_AF2122/97 NDPEIHSSTWEWDMSGSSKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVT
Rv3229c|M.tuberculosis_H37Rv NDPEIHSSTWEWDMSGSSKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVT
MMAR_1315|M.marinum_M NDPEIHSSSWEWDITGASKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVT
MUL_2565|M.ulcerans_Agy99 NDPEIHSSSWEWDITGASKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVT
MAV_4192|M.avium_104 NDPEIHSSTWEWDMSGSSKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVT
TH_0650|M.thermoresistible__bu NDPEIHSSTWEWDMTGASKHWRFTHNFMHHKYTNILGMDDDVGYGLLRVT
MAB_2148|M.abscessus_ATCC_1997 NDPEIHSSTWEWDMAGAAKHWRITHNVEHHKYTNILDLDDDVGYGLLRVT
Mvan_1045|M.vanbaalenii_PYR-1 NDPEIHSATWEWDMVAVSSQWRYSHNYRHHMMTNIVGVDDDLGFGIMRMT
Mflv_5222|M.gilvum_PYR-GCK NDPEIHSTSWEWDMVAVSSQWRYSHNYRHHVLTNIVGVDDDLGFGIMRMT
MSMEG_1211|M.smegmatis_MC2_155 NDPEIHSSTWEWDMVGPSAQWRYSHNYRHHVFSNVLGVDDDLGFGVLRMS
*******::****: . : :** :** ** :*::.:***:*:*::*::
Mb3258c|M.bovis_AF2122/97 RDQRWKRYNIFNVVWNTILAIGFEWGVALQHLEIGKIFKGRADREAAKTR
Rv3229c|M.tuberculosis_H37Rv RDQRWKRYNIFNVVWNTILAIGFEWGVALQHLEIGKIFKGRADREAAKTR
MMAR_1315|M.marinum_M RDQRWKRYNIFNLVWNTLLALGFEWGVALQHLEIGKLLKGRLDRDTARTR
MUL_2565|M.ulcerans_Agy99 RDQRWKRYNIFNLVWNTLLALGFEWGVALQHLEIGKLLKGRLDRDTAETR
MAV_4192|M.avium_104 RDQRWKRFNLFNLVWNTLLALLFEWGVGLQHVEIGKILKRRMDHEEARQR
TH_0650|M.thermoresistible__bu RDQKWKPFNLGNLLYNTLLALAFEWGVGLQHVELGKIFKRRHDPDESRVR
MAB_2148|M.abscessus_ATCC_1997 RDESWKIRNLFNIPFNFMLAAGFEWGIALQHLELRKIWK-KETREATKQR
Mvan_1045|M.vanbaalenii_PYR-1 RDEPWQPVHLLQPLRNMLLAVIFEWGIALHGIHSERDRLMPDADRLAEQR
Mflv_5222|M.gilvum_PYR-GCK RDEPWQPVHLLQPLRNLLLAVIFEWGIALHGIHSERDRVLPDTARLAEVR
MSMEG_1211|M.smegmatis_MC2_155 RDQKWEPQHLIQPLRNLLLAAVFEWGIGLHDYYSERDRADTQDGK-DAAR
**: *: :: : * :** ****:.*: : *
Mb3258c|M.bovis_AF2122/97 LREFSAKAGRQVFKDYVAFPALTSLSPGATYRSTLTANVVANVIRNVWSN
Rv3229c|M.tuberculosis_H37Rv LREFSAKAGRQVFKDYVAFPALTSLSPGATYRSTLTANVVANVIRNVWSN
MMAR_1315|M.marinum_M VREFSRKAGRQVFKDYVAFPALTSVSPGATYRSTLTANVTANVLRNVWTN
MUL_2565|M.ulcerans_Agy99 VREFSRKAGRQVFKDYVAFPALTSVSPGATYRSTLTANVTANVLRNVWTN
MAV_4192|M.avium_104 IDEFLAKAGRQVVKDYVAFPALTSLSPGATFLSTLKANAMANVIRNVWAN
TH_0650|M.thermoresistible__bu VREFLRKAGRQVFKDYVAYPALSSLSPAASYRSTLTANAMANVIRNVWSN
MAB_2148|M.abscessus_ATCC_1997 LRELVRSAASQLFKDYVAFPAITAASPGATYRSTLTANATANLLRNFWSN
Mvan_1045|M.vanbaalenii_PYR-1 A-TLRRKIARQAVKDYVMFPAMS----GTRWRRTLVANVTANVVRNLWAY
Mflv_5222|M.gilvum_PYR-GCK A-ELRRKIARQVTKDYVLLPSLS----GTRWRRTLSANLIANLVRNLWAY
MSMEG_1211|M.smegmatis_MC2_155 T-AFRRKIGRQVAKDYVLLPALS----LRRWRRTLLANLTANLVRNVWAC
: . . * **** *::: : ** ** **::**.*:
Mb3258c|M.bovis_AF2122/97 AVIFCGHFPDGAEKFTKTDMIGEPKGQWYLRQMLGSANFNAGPALRFMSG
Rv3229c|M.tuberculosis_H37Rv AVIFCGHFPDGAEKFTKTDMIGEPKGQWYLRQMLGSANFNAGPALRFMSG
MMAR_1315|M.marinum_M AVIFCGHFPDGAEKFTKTDMVGETKGQWYLRQMLGSANFEAGPALRFMSG
MUL_2565|M.ulcerans_Agy99 AVIFCGHFPDGAEKFTKADMVGETKGQWYLRQMLGSANFEAGPALRFMSG
MAV_4192|M.avium_104 AVIFCGHFPDGAEKFTKTDMIGETKGQWYLRQMLGSANFEAGPVLRFMSG
TH_0650|M.thermoresistible__bu AVIFCGHFPDGAEKFTKTDMVGESKGQWYLRQMLGSANFEGGWLLRFMSG
MAB_2148|M.abscessus_ATCC_1997 AVIFCGHFPDGAEKFTVTDMENETRGQWYLRQLLGSANFNAGPTMRLMSG
Mvan_1045|M.vanbaalenii_PYR-1 VVIFCGHFPDGAEKFTPDVIKQETRGEWYLRQILGAANFRAGRLLAFASG
Mflv_5222|M.gilvum_PYR-GCK VVIFCGHFPDGAEKFTPGVVEQETKGEWYLRQILGAANFKAGRFLAFASG
MSMEG_1211|M.smegmatis_MC2_155 VVIFCGHFPDGAEKFTPESLERETKGEWYLRQMLGAANFKAGRVLAFSSG
.*************** : *.:*:*****:**:***..* : : **
Mb3258c|M.bovis_AF2122/97 NLCHQIEHHLYPDLPSNRLHEISVRVREVCDRYDLPYTTGSFLVQYGKTW
Rv3229c|M.tuberculosis_H37Rv NLCHQIEHHLYPDLPSNRLHEISVRVREVCDRYDLPYTTGSFLVQYGKTW
MMAR_1315|M.marinum_M NLCHQIEHHLYPDLPSNRLAEVSVRVREICDKYDLPYTTGSFLVQYGKTW
MUL_2565|M.ulcerans_Agy99 NLCHQIEHHLYPDLPSNRLAEVSVRVREICDKYDLPYTTGSFLVQYGKTW
MAV_4192|M.avium_104 NLCHQIEHHLYPDLPSNRLHEISVRVRQVCDKYDLPYTTGSFLFQYAKTW
TH_0650|M.thermoresistible__bu NLCHQIEHHLYPDLPSNRLHEASIRVREVCDKYDLPYTTGPFLVQYAKTW
MAB_2148|M.abscessus_ATCC_1997 NLCHQIEHHIYPDLPSNRLHEISVRVREICERYDLPYTTGSMLFQYAKTW
Mvan_1045|M.vanbaalenii_PYR-1 NLCYQIEHHLFPELPSNRYAQISVRVRAICRRYDLPYTTGSIVRQYFLTL
Mflv_5222|M.gilvum_PYR-GCK NLCYQIEHHLFPDLPSNRYAQMAVRVRAICDRYGLSYTTGSLARQYFLTL
MSMEG_1211|M.smegmatis_MC2_155 NLCYQIEHHLFPDLPSNRLAQIAGRVSALCDKYDLPYTTGPMPRQYLQTL
***:*****::*:***** : : ** :* :*.*.****.: ** *
Mb3258c|M.bovis_AF2122/97 RTLAKLSLPDKYLRDNADDAPETRSERMFAGLG-PGFAGADPVTGRRRGL
Rv3229c|M.tuberculosis_H37Rv RTLAKLSLPDKYLRDNADDAPETRSERMFAGLG-PGFAGADPVTGRRRGL
MMAR_1315|M.marinum_M RTLAKLSLPNKYLRDNADNAPETRSERMFADLE-PGFAGADPRTGRRRGL
MUL_2565|M.ulcerans_Agy99 RTLAKLSLPNKYLRDNADDAPETRSERMFADLE-PGFAGADPRTGRRRGL
MAV_4192|M.avium_104 RTLAKLSLPNKYLRDDADNAPETRSERMFAELD-PDFLGTDPATGRRRGL
TH_0650|M.thermoresistible__bu RTLAKLSLPDRFLKATADNAPETRSERMFAELG-PGFAGVDPATGRRRGL
MAB_2148|M.abscessus_ATCC_1997 RTIAKLSLPDRFLHATADNAPETRSERMFVVLEQPQVPGVESVP--RRGL
Mvan_1045|M.vanbaalenii_PYR-1 RTIHKLALPDRLLTATSDDAPETASERKFVGDR-----------FAVGGL
Mflv_5222|M.gilvum_PYR-GCK RTIHKLAFPDRFLRATSDDAPETASERKFLG--------------STAGL
MSMEG_1211|M.smegmatis_MC2_155 RIIFTLALPD------------TGWRGIFRR-------------------
* : .*::*: * . *
Mb3258c|M.bovis_AF2122/97 KTAIAAVRGRRRSKRMAKSVTE-PDDLAA---------------------
Rv3229c|M.tuberculosis_H37Rv KTAIAAVRGRRRSKRMAKSVTE-PDDLAA---------------------
MMAR_1315|M.marinum_M KSAIAAVRGRRRGKRVPEVRDSGTNDLAA---------------------
MUL_2565|M.ulcerans_Agy99 KSAIAAVRGRRRGKRVPEVRDSGTNDLAA---------------------
MAV_4192|M.avium_104 KSAIAAVRGWRRGKRASVARRT-GGELAA---------------------
TH_0650|M.thermoresistible__bu KSAFAAVRNWRRDKQAAKAXXX--GELYPRPGTLRRDVGVRLRRGGVPGP
MAB_2148|M.abscessus_ATCC_1997 KTAIAMVRERRRNKVAV---------------------------------
Mvan_1045|M.vanbaalenii_PYR-1 RTALRDGARARRRRRAA---------------------------------
Mflv_5222|M.gilvum_PYR-GCK A-------------------------------------------------
MSMEG_1211|M.smegmatis_MC2_155 --------------------------------------------------
Mb3258c|M.bovis_AF2122/97 -----------------------------------------
Rv3229c|M.tuberculosis_H37Rv -----------------------------------------
MMAR_1315|M.marinum_M -----------------------------------------
MUL_2565|M.ulcerans_Agy99 -----------------------------------------
MAV_4192|M.avium_104 -----------------------------------------
TH_0650|M.thermoresistible__bu AGLWSGEHDRRGHRPPRSGPQRIRRPRGHAVLRRRDRAVRR
MAB_2148|M.abscessus_ATCC_1997 -----------------------------------------
Mvan_1045|M.vanbaalenii_PYR-1 -----------------------------------------
Mflv_5222|M.gilvum_PYR-GCK -----------------------------------------
MSMEG_1211|M.smegmatis_MC2_155 -----------------------------------------