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AAPGFIAVGSGPAGVSAAETFRRRHPRIPVRILSADPALPYSKPPLSKEFLGGGHTNLELHSVGWFARND IDLHLGVTVDHIDVDTQEVVTVGGARYRYWHLVLAPGSAAVPLSVPGGDSAQPLRSFSDAVALKMAARFA DTAAVIGGGLVGCETAARLAGMGLSTTLVVPEPAPLCRRFGPDVGERVHKMLTDAGVRVVTSTTVIEVGS DGVTVATGERIAGEVVVAATGVRPDIRLAAEAGLATERGRVVVDAHMRTSARNVYAAGDVTLAHNVAAGR PVVAEHWRDAAQQGLVAGLTAAGAPAVWDKVPGFSATIGTFTLKYRGWGGRHDTSDLSERAGGFTVAYRA GGRVVGTLDVTANPAP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5127 | - | - | 100% (367) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. gilvum PYR-GCK | Mflv_5068 | - | 4e-38 | 32.32% (362) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. gilvum PYR-GCK | Mflv_4591 | - | 7e-33 | 29.92% (361) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1900c | - | 9e-47 | 35.33% (317) | reductase |
| M. tuberculosis H37Rv | Rv1869c | - | 9e-47 | 35.33% (317) | reductase |
| M. leprae Br4923 | MLBr_02387 | lpd | 2e-09 | 23.85% (218) | dihydrolipoamide dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3838c | - | 8e-36 | 33.06% (360) | putative ferredoxin reductase |
| M. marinum M | MMAR_1017 | - | 3e-42 | 37.29% (303) | ferredoxin reductase |
| M. avium 104 | MAV_2849 | - | 1e-43 | 33.04% (342) | anthranilate dioxygenase reductase |
| M. smegmatis MC2 155 | MSMEG_3594 | - | 1e-44 | 34.23% (336) | anthranilate dioxygenase reductase |
| M. thermoresistible (build 8) | TH_3739 | - | 1e-39 | 32.00% (350) | PUTATIVE Pyridine nucleotide-disulphide oxidoreductase |
| M. ulcerans Agy99 | MUL_0769 | - | 1e-41 | 36.96% (303) | ferredoxin reductase |
| M. vanbaalenii PYR-1 | Mvan_1216 | - | 1e-159 | 74.86% (366) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5127|M.gilvum_PYR-GCK ------------------MAAPGFIAVGSGPAGVSAAETFRRR-------
Mvan_1216|M.vanbaalenii_PYR-1 ------------------MVAPGFLAIGSGPAGVSAAETFRGR-------
Mb1900c|M.bovis_AF2122/97 -----------------MASSTTFVIVGGGLAGAKAVEALRRS-------
Rv1869c|M.tuberculosis_H37Rv -----------------MASSTTFVIVGGGLAGAKAVEALRRS-------
MAV_2849|M.avium_104 -----------------MASATGFVIIGGGLAAAKAVEALRDN-------
MSMEG_3594|M.smegmatis_MC2_155 -----------------MTAASTFVIIGGGLAGAKAAEALRDN-------
MMAR_1017|M.marinum_M MYEHHVTSSEGVTQDPGATAANGIVIIGGGLAAARTAEQLRRA-------
MUL_0769|M.ulcerans_Agy99 MYEHHVTSSEGVTQDPGATAANGIVIIGGGLAAARTAEQLRRA-------
TH_3739|M.thermoresistible__bu -----------------VSTTAGIIIVGGGLAAARTAEQLRRS-------
MAB_3838c|M.abscessus_ATCC_199 ----------------MTDAERGVLIIGGGLGAVRTAEQLRRA-------
MLBr_02387|M.leprae_Br4923 ------------------MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAVV
.: :*.* .. :.
Mflv_5127|M.gilvum_PYR-GCK -------------HPRIPVRILSADPALPYSKPPLSKEFLGG--------
Mvan_1216|M.vanbaalenii_PYR-1 -------------HPHIPVRILSADPALPYAKPPLSKEFLDG--------
Mb1900c|M.bovis_AF2122/97 -------------DFGGRIILFGDEEHLPYDRPPLSKEFLAG--------
Rv1869c|M.tuberculosis_H37Rv -------------DFGGRIILFGDEEHLPYDRPPLSKEFLAG--------
MAV_2849|M.avium_104 -------------NFDGRIIVFADEEHLPYERPPLSKEFLAG--------
MSMEG_3594|M.smegmatis_MC2_155 -------------DFDGQVLLFAAEEKLPYERPPLSKDYLAG--------
MMAR_1017|M.marinum_M -------------GYEGQLTIVSDEVHLPYDRPPLSKEVLR---------
MUL_0769|M.ulcerans_Agy99 -------------GYEGQLTIVSDEVHLPYDRPPLSKEVLR---------
TH_3739|M.thermoresistible__bu -------------EFGGPITIVSDEDHLPYDRPPLSKDVLS---------
MAB_3838c|M.abscessus_ATCC_199 -------------EFTGPITIVSSETHLPYDRPPLSKDVLRDA-------
MLBr_02387|M.leprae_Br4923 EPKYWGGICLNVGCIPSKVLLHNAELAHIFTKEAKTFGISGDASFDYGIA
: : : : : . :
Mflv_5127|M.gilvum_PYR-GCK -----GHTNLELHSVGWFARNDIDLHLGVTVDHIDVDTQEVVTVGGA---
Mvan_1216|M.vanbaalenii_PYR-1 -----GHIDLDLHSAGWFRRHGIDLLLGVTVEHIDVDAQEVITRGGA---
Mb1900c|M.bovis_AF2122/97 ---KKSLSDFTIQTSDWYRDHDVDVRLGVRVSSLDRSAHTVELPDGA---
Rv1869c|M.tuberculosis_H37Rv ---KKSLSDFTIQTSDWYRDHDVDVRLGVRVSSLDRSAHTVELPDGA---
MAV_2849|M.avium_104 ---KKSLTDFTVQNSDWYRDNDVDLRLNTRVCALDAAGHTVGLPDGT---
MSMEG_3594|M.smegmatis_MC2_155 ---KKTLDEFTVAAPAWYRDHDVTLRLGTEVAAINPADHTVTLPDGS---
MMAR_1017|M.marinum_M ----SEVDDVSLKPREWYDEKDIALRLGSAATGLDTAAQTVTLADGT---
MUL_0769|M.ulcerans_Agy99 ----SEVDDVSLKPREWYDEKGITLRLGSAATGLDTAAQTVTLADGT---
TH_3739|M.thermoresistible__bu ----GKTDDVTLKPAEFYAENDITLLLGTAATALDPQARKLTLADGR---
MAB_3838c|M.abscessus_ATCC_199 ---EKTIDAVVLKPREFYDEKQIELRLGSEVTALDPVARTVTLSDGG---
MLBr_02387|M.leprae_Br4923 YDRSRKVSEGRVAGVHFLMKKNKITEIHGYGRFTDANTLSVELSEGVPET
: : : : : : *
Mflv_5127|M.gilvum_PYR-GCK --RYRYWHLVLAPGSAAVPLSVPG--GDSAQPLRSFSDAVALKMAARFAD
Mvan_1216|M.vanbaalenii_PYR-1 --HYPYWHLVLAPGSCAVPLTVPG--GHRAQPLRTFGDAVALKMAARYAA
Mb1900c|M.bovis_AF2122/97 --AVRYDKLLLATGSAPRRPPIPGSDAAGVHYLRSYNDAVALNSVLVQGS
Rv1869c|M.tuberculosis_H37Rv --AVRYDKLLLATGSAPRRPPIPGSDAAGVHYLRSYNDAVALNSVLVQGS
MAV_2849|M.avium_104 --TVAYDKLLLATGSAARRPPIPGSDCAGVHYLRTYEVAVALNSFLGEGK
MSMEG_3594|M.smegmatis_MC2_155 --AVGYDKLLLATGSASRRLPIPGADASGVHYLRTVDDAAALDAVLTEGA
MMAR_1017|M.marinum_M --VLGYDELVIATGLVPRRIPAFP-ELEGIRVLRSFDECMALRSHASAAK
MUL_0769|M.ulcerans_Agy99 --VLGYDELVIATGLVPRRIPAFP-ELEGIRVLRSFDECMALRSHASAAK
TH_3739|M.thermoresistible__bu --ALEYDELIIATGLVPKRIPTLP-DLEGIRVLRTYDESMALRKHAGSAR
MAB_3838c|M.abscessus_ATCC_199 --TLEYGEVIIATGLVPRRIPTFP-DLAGVHVLRTADDSFALRGDAENAR
MLBr_02387|M.leprae_Br4923 PLKVTFNNVIIATGSKTR--LVPG--TLLSTNVITYEEQILTRELP---D
: .:::*.* . : :
Mflv_5127|M.gilvum_PYR-GCK TAAVIGGGLVGCETAARLAGMGLSTTLVVPEPAPLCRRFGPDVGERVHKM
Mvan_1216|M.vanbaalenii_PYR-1 SAVVIGGGLVGCEAASCLTALGVATTVVVPESVPLQRRFGVDVGKRVAEM
Mb1900c|M.bovis_AF2122/97 SLAVVGAGWIGLEVAASARQRGVDVTVVETAIQPLLAALGEAVGKVFADL
Rv1869c|M.tuberculosis_H37Rv SLAVVGAGWIGLEVAASARQRGVDVTVVETAIQPLLAALGEAVGKVFADL
MAV_2849|M.avium_104 SLAVVGAGWIGLEVAAAARQRGVEVTVVEAARQPLTAALGETVGEVFATL
MSMEG_3594|M.smegmatis_MC2_155 SLAVVGAGWIGLEVAASARTRGVNVTVVEAARLPLLGALGAEVAEVFAQL
MMAR_1017|M.marinum_M RAVVIGAGFIGCEVAASLRGLGVEVVLVEPQPTPLAAVLGEQIGELVARL
MUL_0769|M.ulcerans_Agy99 RAVVIGAGFIGCEVAASLRGLGVEVVLVEPQPTPLAAVLGEQIGELVARL
TH_3739|M.thermoresistible__bu NAVVIGAGFIGCEVAASLRGLGVHVVLVEPQPTPLAGVLGEQIGALVARL
MAB_3838c|M.abscessus_ATCC_199 RAVVVGAGFIGCEVAATLRANGVEVVLVEPQPAPLLAAIGQQLGDLVARL
MLBr_02387|M.leprae_Br4923 SIVIVGAGAIGIEFGYVLKNYGVDVTIVEFLPRAMPNED-AEVSKEIEKQ
.::*.* :* * . *: ..:* .: :. .
Mflv_5127|M.gilvum_PYR-GCK LTDAGVRVVTSTTVIEVG-----SDGVTVATG--ERIAGEVVVAATGVRP
Mvan_1216|M.vanbaalenii_PYR-1 LADAGVTVVTSTTVTAVG-----ETEVTLASG--ATVDADVVLAATGVRP
Mb1900c|M.bovis_AF2122/97 HRDQGVDLRLQTQLEEITAADGKATGLKMRDG--STVAADAVLVAVGAKP
Rv1869c|M.tuberculosis_H37Rv HRDQGVDLRLQTQLEEITAADGKATGLKMRDG--STVAADAVLVAVGAKP
MAV_2849|M.avium_104 HREHGVDLRLETQVREITRADGSATGLRTTDG--SAIPADAVLVAVGARP
MSMEG_3594|M.smegmatis_MC2_155 HREHGVDLRLEQTVEEITTADGRATGLRLGDG--STIAADAVLVAVGAAP
MMAR_1017|M.marinum_M HRSEGVDVRTGVGVAEVR-GDGHVDTVVLADG--TQLDADLVVVGIGSHP
MUL_0769|M.ulcerans_Agy99 HRSEGVDVRTGVGVAEVR-GDGHVDTVVLADG--TQLDADLVVVGIGSHP
TH_3739|M.thermoresistible__bu HRDEGVDLRCGVGVADVR-GTGAVEKVVLDDG--TELDADLVVVGIGSTP
MAB_3838c|M.abscessus_ATCC_199 HRNEGVDVRVGVGVDAVE-GQDRVQSVTLSDG--TRLDTDLVVLGIGSRP
MLBr_02387|M.leprae_Br4923 FKKMGIKILTGTKVESISDNGSHVLVAVSKDGQFQELKADKVLQAIGFAP
. *: : : : * : : *: . * *
Mflv_5127|M.gilvum_PYR-GCK DIR---LAAEAGLATERGRVVVDAHMRTSARNVYAAGDVT---LAHNVAA
Mvan_1216|M.vanbaalenii_PYR-1 DIR---LADDAGLATRQGRVVVDEHMRTSVRNVYAAGDVT---IAHNVAA
Mb1900c|M.bovis_AF2122/97 NVE---LAQQAGLAMGEGGVLVDASLRTSDPDIYAVGDIA---AAEHPLL
Rv1869c|M.tuberculosis_H37Rv NVE---LAQQAGLAMGEGGVLVDASLRTSDPDIYAVGDIA---AAEHPLL
MAV_2849|M.avium_104 NIE---LAEAAGLSLADGGVLVDASLRTSDPDIYAVGDIA---AAEHPLL
MSMEG_3594|M.smegmatis_MC2_155 NIG---LAERAGLATADGGVLVDASLRTSDPDIYAVGDIA---AAQHPLF
MMAR_1017|M.marinum_M ATG---WLDGSGIAVDNG-VVCDAAGRTSAPNVWALGDVA---SWRD-QM
MUL_0769|M.ulcerans_Agy99 ATG---WLDGSGIAVDNG-VVCDAAGRTSAPNVWAFGDVA---SWRD-QM
TH_3739|M.thermoresistible__bu ATD---WLQGSGVEVDNG-VVCDAVGRTNVEHVWAIGDVA---SWRN-TV
MAB_3838c|M.abscessus_ATCC_199 AID---WLDGSGVAVDNG-VVCDAVGATGTPHVWALGDVA---AWAG-AD
MLBr_02387|M.leprae_Br4923 NVDGYGLDKVGVALTADKAVDIDDYMQTNVSHIYAIGDVTGKLQLAHVAE
. * * *. .::* **::
Mflv_5127|M.gilvum_PYR-GCK GRPVVAEHWRDAAQQGLVAGLTAAGAPAVWD--KVPGFSATIGT------
Mvan_1216|M.vanbaalenii_PYR-1 GRPVVAEHWRDAVQQGRVAGLTAAGQPAIWG--KVPGFTCRIGA------
Mb1900c|M.bovis_AF2122/97 GTRVRTEHWANALKQPAVAAAGMLGRPGEYA--ELPYLFTDQYD------
Rv1869c|M.tuberculosis_H37Rv GTRVRTEHWANALKQPAVAAAGMLGRPGEYA--ELPYLFTDQYD------
MAV_2849|M.avium_104 RTRIRTEHWANALKQPAIAVAGMLGRPGEYD--ELPYFFTDQYD------
MSMEG_3594|M.smegmatis_MC2_155 GVRIRTEHWANALKQPAVAVAGMLGRPAEYA--ELPYFFTDQYD------
MMAR_1017|M.marinum_M GHQVRVEHWSNVADQARVVVPAMLGREVSSN-VVVPYFWSDQYD------
MUL_0769|M.ulcerans_Agy99 GHQVRVEHWSNVADQARVVVPAMLGREVSSN-VVVPYFWSDQYD------
TH_3739|M.thermoresistible__bu GKQVRVEHWSNVADQARVLVPALLGQEVPVA-ATVPYFWSDQYD------
MAB_3838c|M.abscessus_ATCC_199 GRPNRVEHWSNVADQVRALVPALLGQETSANTVAVPYFWSDQYD------
MLBr_02387|M.leprae_Br4923 AQGVVAAEAIAGAETLALSDYRMMPRATFCQPNVASFGLTEQQARDGGYD
. . . .
Mflv_5127|M.gilvum_PYR-GCK ---------FTLKYRGWGGRHDTSDLSERA--------------------
Mvan_1216|M.vanbaalenii_PYR-1 ---------FTLSYRGWGAGYDTATLTDRA--------------------
Mb1900c|M.bovis_AF2122/97 ---------LGMEYVGHAPSCDRVVFRGNVAGREFLSFWLDGD--SRVLA
Rv1869c|M.tuberculosis_H37Rv ---------LGMEYVGHAPSCDRVVFRGNVAGREFLSFWLDGD--SRVLA
MAV_2849|M.avium_104 ---------LGMEYVGHAPRFERVVFRGDVAAREFVAFWLDAD--DRVLA
MSMEG_3594|M.smegmatis_MC2_155 ---------LGMEYAGHAPSYERVVFRGDVPGREFVSFWLDGD--NRVLA
MMAR_1017|M.marinum_M ---------VKIQCLGEPHSTDVVHLVEDD-GRKFLAYYER----DGVLV
MUL_0769|M.ulcerans_Agy99 ---------VKIQCLGEPHSTDVVHLVEDD-GRKLLAYYQR----DGVLV
TH_3739|M.thermoresistible__bu ---------VKIQCLGEPEAGDTVHVVSDD-GRKFLAYYER----DGVLT
MAB_3838c|M.abscessus_ATCC_199 ---------VKIQSLGHLGSSDTVHLISDD-GRKFLAYLER----DGVLT
MLBr_02387|M.leprae_Br4923 VVVAKFPFTANAKAHGMGDPSGFVKLVADAKYGELLGGHMIGHNVSELLP
. * .
Mflv_5127|M.gilvum_PYR-GCK -----GGFTVAYRAGGRVVGTLDVTANPAP--------------------
Mvan_1216|M.vanbaalenii_PYR-1 -----GGFSVVYRAGGRVVGTLDVRSSPAS--------------------
Mb1900c|M.bovis_AF2122/97 GMN-VNVWDVVDDVKGLIRSGNPVDVDRLVDPQWPLADLTTN--------
Rv1869c|M.tuberculosis_H37Rv GMN-VNVWDVVDDVKGLIRSGNPVDVDRLVDPQWPLADLTTN--------
MAV_2849|M.avium_104 GMN-VNIWDVLDDVKALIRSRAPIDADRLGDPGAPLGELLG---------
MSMEG_3594|M.smegmatis_MC2_155 GMN-VNIWDVLDDVKALIRSREPVDPDLLADPGRPLNAPG----------
MMAR_1017|M.marinum_M GVVGGGVPGKVMKVRAKIAAAVPISEMLDESQG-----------------
MUL_0769|M.ulcerans_Agy99 GVVGGGVPGKVMKVRAKIAAAVPISEMLDESQGQTSARIPARGAGPGGPL
TH_3739|M.thermoresistible__bu GVVGGGMPGKVMKARAKIAAGAPISEVLE---------------------
MAB_3838c|M.abscessus_ATCC_199 GVVGCGMAGPVMKMRAKIAAGTPIAEVLAGS-------------------
MLBr_02387|M.leprae_Br4923 ELTLAQKWDLTATELVRNVHTHPTLSEALQECFHGLIGHMINF-------
Mflv_5127|M.gilvum_PYR-GCK -----------------------------------------------
Mvan_1216|M.vanbaalenii_PYR-1 -----------------------------------------------
Mb1900c|M.bovis_AF2122/97 -----------------------------------------------
Rv1869c|M.tuberculosis_H37Rv -----------------------------------------------
MAV_2849|M.avium_104 -----------------------------------------------
MSMEG_3594|M.smegmatis_MC2_155 -----------------------------------------------
MMAR_1017|M.marinum_M -----------------------------------------------
MUL_0769|M.ulcerans_Agy99 VRWPTLTKSGRWRAEKATASSPVARVDGIGLEPGPRRTASWPDVPGT
TH_3739|M.thermoresistible__bu -----------------------------------------------
MAB_3838c|M.abscessus_ATCC_199 -----------------------------------------------
MLBr_02387|M.leprae_Br4923 -----------------------------------------------